Protein-based composite materials

Protein-based composite biomaterials have been actively pursued as they can encompass a range of physical properties to accommodate a broader spectrum of functional requirements, such as elasticity to support diverse tissues. By optimizing molecular interfaces between structural proteins, useful composite materials can be fabricated as films, gels, particles, and fibers, as well as for electrical and optical devices. Such systems provide analogies to more traditional synthetic polymers yet with expanded utility due to the material's tunability, mechanical properties, degradability, biocompatibility, and functionalization, such as for drug delivery, biosensors, and tissue regeneration.

[1]  M. McFall-Ngai,et al.  Reflectins: The Unusual Proteins of Squid Reflective Tissues , 2004, Science.

[2]  David L. Kaplan,et al.  Biocompatible Silk Printed Optical Waveguides , 2009 .

[3]  D. Kaplan,et al.  Microphase Separation Controlled β-Sheet Crystallization Kinetics in Fibrous Proteins , 2009 .

[4]  T. Vuocolo,et al.  Synthesis and properties of crosslinked recombinant pro-resilin , 2005, Nature.

[5]  D. Kaplan,et al.  Modular elastic patches: mechanical and biological effects. , 2010, Biomacromolecules.

[6]  Alina Sionkowska,et al.  Current research on the blends of natural and synthetic polymers as new biomaterials: Review , 2011 .

[7]  Ji Seok Lee,et al.  Two-component protein-engineered physical hydrogels for cell encapsulation , 2009, Proceedings of the National Academy of Sciences.

[8]  David L. Kaplan,et al.  Metamaterials on Paper as a Sensing Platform , 2011, Advanced materials.

[9]  D. Kaplan,et al.  Nanofibrous architecture of silk fibroin scaffolds prepared with a mild self-assembly process. , 2011, Biomaterials.

[10]  P. Flory Principles of polymer chemistry , 1953 .

[11]  David L. Kaplan,et al.  A new route for silk , 2008 .

[12]  S. Heilshorn,et al.  Protein-engineered biomaterials: highly tunable tissue engineering scaffolds. , 2010, Tissue engineering. Part B, Reviews.

[13]  Jeffrey M. Caves,et al.  The use of microfiber composites of elastin-like protein matrix reinforced with synthetic collagen in the design of vascular grafts. , 2010, Biomaterials.

[14]  David L. Kaplan,et al.  Dynamic Protein−Water Relationships during β-Sheet Formation , 2008 .

[15]  R. Kreis,et al.  Graft survival and effectiveness of dermal substitution in burns and reconstructive surgery in a one-stage grafting model. , 2000 .

[16]  G. Meyer,et al.  Molecular-weight dependence of the glass transition temperatures of rigid SIS triblock copolymers studied by DSC , 1982 .

[17]  M. V. Van Dyke,et al.  A Review of Keratin-Based Biomaterials for Biomedical Applications , 2010, Materials.

[18]  Sook Hee Ku,et al.  Bone-like peptide/hydroxyapatite nanocomposites assembled with multi-level hierarchical structures , 2011 .

[19]  L. Rigal,et al.  DSC study on the thermal properties of sunflower proteins according to their water content , 2001 .

[20]  A. Weiss,et al.  Engineered tropoelastin and elastin-based biomaterials. , 2009, Advances in protein chemistry and structural biology.

[21]  J. Baum,et al.  Structural biology: Modelling collagen diseases , 2008, Nature.

[22]  Jennifer L. West,et al.  Synthetic Materials in the Study of Cell Response to Substrate Rigidity , 2009, Annals of Biomedical Engineering.

[23]  J. Church,et al.  Honeybee silk: recombinant protein production, assembly and fiber spinning. , 2010, Biomaterials.

[24]  Markus B Linder,et al.  Genetic engineering in biomimetic composites. , 2012, Trends in biotechnology.

[25]  Thomas Scheibel,et al.  Composite materials based on silk proteins , 2010 .

[26]  S. Lindquist,et al.  Hsp104 Catalyzes Formation and Elimination of Self-Replicating Sup35 Prion Conformers , 2004, Science.

[27]  T. Sutherland,et al.  Insect silk: one name, many materials. , 2010, Annual review of entomology.

[28]  David L. Kaplan,et al.  Single Honeybee Silk Protein Mimics Properties of Multi-Protein Silk , 2011, PloS one.

[29]  R. Naik,et al.  The self-organizing properties of squid reflectin protein. , 2007, Nature materials.

[30]  D. Kaplan,et al.  Green process to prepare silk fibroin/gelatin biomaterial scaffolds. , 2010, Macromolecular bioscience.

[31]  D. Kaplan,et al.  Clay enriched silk biomaterials for bone formation. , 2011, Acta biomaterialia.

[32]  Ronald P White,et al.  A simple approach to polymer mixture miscibility , 2010, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[33]  C. Waddington Genes And Proteins , 1960, Nature.

[34]  David L Kaplan,et al.  Electrogelation for Protein Adhesives , 2010, Advanced materials.

[35]  Dennis Claessen,et al.  Amyloids — a functional coat for microorganisms , 2005, Nature Reviews Microbiology.

[36]  S. Gras Amyloid Fibrils: From Disease to Design. New Biomaterial Applications for Self-Assembling Cross-β Fibrils , 2007 .

[37]  A A Poot,et al.  Electrospinning of collagen and elastin for tissue engineering applications. , 2006, Biomaterials.

[38]  Ehud Gazit,et al.  Amyloids: not only pathological agents but also ordered nanomaterials. , 2008, Angewandte Chemie.

[39]  David L Kaplan,et al.  The influence of elasticity and surface roughness on myogenic and osteogenic-differentiation of cells on silk-elastin biomaterials. , 2011, Biomaterials.

[40]  D. Kaplan,et al.  Expression, cross-linking and characterization of recombinant chitin binding resilin , 2009, Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference (NEBEC).

[41]  P. Rayas-Duarte,et al.  The effect of mixing and wheat protein/gluten on the gelatinization of wheat starch ? ? Names are ne , 2003 .

[42]  Ali Khademhosseini,et al.  Synthesis and characterization of photocrosslinkable gelatin and silk fibroin interpenetrating polymer network hydrogels. , 2011, Acta biomaterialia.

[43]  J. Jane,et al.  Mechanical and thermal properties of extruded soy protein sheets , 2001 .

[44]  E. Dufresne,et al.  Development of colour-producing β-keratin nanostructures in avian feather barbs , 2009, Journal of The Royal Society Interface.

[45]  D. Kaplan,et al.  Biomaterials from ultrasonication-induced silk fibroin-hyaluronic acid hydrogels. , 2010, Biomacromolecules.

[46]  Gerd Geerling,et al.  Keratin Films for Ocular Surface Reconstruction , 2011, Biomaterials.

[47]  H. S. Azevedo,et al.  Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends , 2007, Journal of The Royal Society Interface.

[48]  Yonggang Huang,et al.  Waterproof AlInGaP optoelectronics on stretchable substrates with applications in biomedicine and robotics. , 2010, Nature materials.

[49]  Keiji Numata,et al.  Reinforcing silk scaffolds with silk particles. , 2010, Macromolecular bioscience.

[50]  A. Sionkowska,et al.  Surface characterization of collagen/elastin based biomaterials for tissue regeneration , 2009 .

[51]  L. Kamolz,et al.  First experiences with the collagen-elastin matrix Matriderm as a dermal substitute in severe burn injuries of the hand. , 2007, Burns : journal of the International Society for Burn Injuries.

[52]  Steven G Wise,et al.  Elastin-based materials. , 2010, Chemical Society reviews.

[53]  David L. Kaplan,et al.  Mechanism of silk processing in insects and spiders , 2003, Nature.

[54]  G. Bowlin,et al.  Electrospinning of collagen/biopolymers for regenerative medicine and cardiovascular tissue engineering. , 2009, Advanced drug delivery reviews.

[55]  Ivana Fenoglio,et al.  Multiple aspects of the interaction of biomacromolecules with inorganic surfaces. , 2011, Advanced drug delivery reviews.

[56]  Boon Chin Heng,et al.  Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles. , 2010, Biomaterials.

[57]  M. Sakaguchi,et al.  Direct Detection of Effective Glass Transitions in Miscible Polymer Blends by Temperature-Modulated Differential Scanning Calorimetry , 2005 .

[58]  Long Yu,et al.  Polymer blends and composites from renewable resources , 2006 .

[59]  David L Kaplan,et al.  Biomaterials derived from silk-tropoelastin protein systems. , 2010, Biomaterials.

[60]  David L. Kaplan,et al.  New Opportunities for an Ancient Material , 2010, Science.

[61]  David L. Kaplan,et al.  Determining Beta-Sheet Crystallinity in Fibrous Proteins by Thermal Analysis and Infrared Spectroscopy , 2006 .

[62]  David L Kaplan,et al.  Regulation of silk material structure by temperature-controlled water vapor annealing. , 2011, Biomacromolecules.

[63]  David L. Kaplan,et al.  Fabrication of Silk Microneedles for Controlled‐Release Drug Delivery , 2012 .