Exudates and optic disk detection in retinal images of diabetic patients

Diabetic retinopathy is the progressive pathological alterations in the retinal microvasculature that very often causes blindness. Because of its clinical significance, it will be helpful to have regular cost‐effective eye screening for diabetic patients by developing algorithms to perform retinal image analysis, fundus image enhancement, and monitoring. The two cost‐effective algorithms are proposed for exudates detection and optic disk extraction aimed for retinal images classification and diagnosis assistance. They represent the effort made to offer a cost‐effective algorithm for optic disk identification, which will enable easier exudates extraction, exudates detection and retinal images classification aimed to assist ophthalmologists while making diagnoses. The proposed algorithms apply mathematical modeling, which enables light intensity levels emphasis, easier optic disk and exudates detection, efficient and correct classification of retinal images. The algorithm is robust to various appearance changes of retinal fundus images and shows very promising results. Fundus images are classified into those that are healthy and those affected by diabetes, based on the detected optic disk and exudates. The obtained results indicate that the proposed algorithm successfully and correctly classifies more than 98% of the observed retinal images because of the changes in the appearance of retinal fundus images typically encountered in clinical environments. Copyright © 2014 John Wiley & Sons, Ltd.

[1]  R. F. Wagner,et al.  Overview of a Unified SNR Analysis of Medical Imaging Systems , 1982, IEEE Transactions on Medical Imaging.

[2]  Hideki Kuga,et al.  A computer method of understanding ocular fundus images , 1982, Pattern Recognit..

[3]  D. DeMets,et al.  The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years. , 1984, Archives of ophthalmology.

[4]  Shinichi Tamura,et al.  Zero-crossing interval correction in tracing eye-fundus blood vessels , 1988, Pattern Recognit..

[5]  T. Williamson,et al.  Automatic detection of diabetic retinopathy using an artificial neural network: a screening tool. , 1996, The British journal of ophthalmology.

[6]  A. Pinz,et al.  Mapping the human retina , 1996, IEEE Transactions on Medical Imaging.

[7]  J. Thiran,et al.  Identification of the optic disk boundary in retinal images using active contours , 1999 .

[8]  Thomas Walter,et al.  Segmentation of Color Fundus Images of the Human Retina: Detection of the Optic Disc and the Vascular Tree Using Morphological Techniques , 2001, ISMDA.

[9]  T. Sano,et al.  [Diabetic retinopathy]. , 2001, Nihon rinsho. Japanese journal of clinical medicine.

[10]  C. Sinthanayothin,et al.  Automated detection of diabetic retinopathy on digital fundus images , 2002, Diabetic medicine : a journal of the British Diabetic Association.

[11]  Pascale Massin,et al.  A contribution of image processing to the diagnosis of diabetic retinopathy-detection of exudates in color fundus images of the human retina , 2002, IEEE Transactions on Medical Imaging.

[12]  Rafael C. González,et al.  Digital image processing using MATLAB , 2006 .

[13]  Lloyd Paul Aiello,et al.  Angiogenic pathways in diabetic retinopathy. , 2005, The New England journal of medicine.

[14]  Mariano Rincón,et al.  Identification of the optic nerve head with genetic algorithms , 2008, Artif. Intell. Medicine.

[15]  Roberto Hornero,et al.  A novel automatic image processing algorithm for detection of hard exudates based on retinal image analysis. , 2008, Medical engineering & physics.

[16]  K. Prasad,et al.  Automatic Detection of Hard Exudates in Diabetic Retinopathy Using Morphological Segmentation and Fuzzy Logic , 2008 .

[17]  C. M. Lim,et al.  Computer-based detection of diabetes retinopathy stages using digital fundus images , 2009, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[18]  Alireza Osareh,et al.  A Computational-Intelligence-Based Approach for Detection of Exudates in Diabetic Retinopathy Images , 2009, IEEE Transactions on Information Technology in Biomedicine.

[19]  U. Acharya,et al.  Assessment of retinopathy severity using digital fundus images , 2011, 2011 1st Middle East Conference on Biomedical Engineering.

[20]  M. Arthanari,et al.  DETECTION OF DIABETIC RETINOPATHY USING RADIAL BASIS FUNCTION , 2011 .

[21]  V. Basevi Diagnosis and Classification of Diabetes Mellitus , 2011, Diabetes Care.

[22]  Ventzeslav Valev,et al.  Machine learning of syndromes for different types of features , 2011, 2011 International Conference on High Performance Computing & Simulation.

[23]  Vesna Zeljkovic,et al.  Classification algorithm of retina images of diabetic patients based on exudates detection , 2012, 2012 International Conference on High Performance Computing & Simulation (HPCS).

[24]  Daniel Palanker,et al.  Panretinal photocoagulation for proliferative diabetic retinopathy. , 2012, American journal of ophthalmology.