Therapeutic Connection Between Black Tea Theaflavins and Their Benzotropolone Core Structure

[1]  T. Glenn,et al.  Long-term treatment with green tea polyphenols modifies the gut microbiome of female sprague-dawley rats. , 2018, The Journal of nutritional biochemistry.

[2]  Hua-Feng He.  Research progress on theaflavins: efficacy, formation, and preparation , 2017, Food & nutrition research.

[3]  M. Lean,et al.  Bioavailability of Black Tea Theaflavins: Absorption, Metabolism, and Colonic Catabolism. , 2017, Journal of agricultural and food chemistry.

[4]  Yiliang Wang,et al.  In vitro and in vivo anti‐inflammatory effects of theaflavin‐3,3′‐digallate on lipopolysaccharide‐induced inflammation , 2017, European journal of pharmacology.

[5]  Y. Chen,et al.  Theaflavin-3, 3′-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells , 2016, International journal of oncology.

[6]  Daniel Grenier,et al.  Black Tea Extract and Its Theaflavin Derivatives Inhibit the Growth of Periodontopathogens and Modulate Interleukin-8 and β-Defensin Secretion in Oral Epithelial Cells , 2015, PloS one.

[7]  T. Matsui,et al.  Theaflavins enhance intestinal barrier of Caco-2 Cell monolayers through the expression of AMP-activated protein kinase-mediated Occludin, Claudin-1, and ZO-1 , 2015, Bioscience, biotechnology, and biochemistry.

[8]  Chih-Zen Chang,et al.  Purpurogallin, a Natural Phenol, Attenuates High-Mobility Group Box 1 in Subarachnoid Hemorrhage Induced Vasospasm in a Rat Model , 2014, International journal of vascular medicine.

[9]  M. De la Fuente,et al.  Chronic Inflammation and Cytokines in the Tumor Microenvironment , 2014, Journal of immunology research.

[10]  Doris M Jacobs,et al.  Rapid and sustained systemic circulation of conjugated gut microbial catabolites after single-dose black tea extract consumption. , 2014, Journal of proteome research.

[11]  R. D. de Vos,et al.  Interactions of black tea polyphenols with human gut microbiota: implications for gut and cardiovascular health. , 2013, The American journal of clinical nutrition.

[12]  M. Clifford,et al.  Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols. , 2013, The American journal of clinical nutrition.

[13]  Yung-Hyun Choi,et al.  Purpurogallin exerts anti‑inflammatory effects in lipopolysaccharide‑stimulated BV2 microglial cells through the inactivation of the NF‑κB and MAPK signaling pathways. , 2013, International journal of molecular medicine.

[14]  Y. Chen,et al.  Enhancement of (-)-epigallocatechin-3-gallate and theaflavin-3-3'-digallate induced apoptosis by ascorbic acid in human lung adenocarcinoma SPC-A-1 cells and esophageal carcinoma Eca-109 cells via MAPK pathways. , 2013, Biochemical and biophysical research communications.

[15]  T. Matsui,et al.  Theaflavins, dimeric catechins, inhibit peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide transporter PEPT1. , 2013, Food chemistry.

[16]  Michael S. Croft,et al.  Synthesis and evaluation as potential anticancer agents of novel tetracyclic indenoquinoline derivatives. , 2013, Bioorganic & medicinal chemistry.

[17]  W. Aronson,et al.  Phenolic acid concentrations in plasma and urine from men consuming green or black tea and potential chemopreventive properties for colon cancer. , 2013, Molecular nutrition & food research.

[18]  C. Jobin,et al.  The Microbiota Is Essential for the Generation of Black Tea Theaflavins-Derived Metabolites , 2012, PloS one.

[19]  J. Menani,et al.  Blockade of P2X purinergic receptors of the lateral parabrachial nucleus reduces hypoxia‐induced tachypnea , 2012 .

[20]  In-Chul Lee,et al.  Anti-inflammatory functions of purpurogallin in LPS-activated human endothelial cells. , 2012, BMB reports.

[21]  G. Weissmann.  Bully for Science! The FASEB Centennial (1912–2012) , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[22]  C. Jobin,et al.  Structural identification of mouse fecal metabolites of theaflavin 3,3'-digallate using liquid chromatography tandem mass spectrometry. , 2011, Journal of chromatography. A.

[23]  Chi-Tang Ho,et al.  The chemistry and biotransformation of tea constituents. , 2011, Pharmacological research.

[24]  C. Ho,et al.  Effects of the black tea polyphenol theaflavin-2 on apoptotic and inflammatory pathways in vitro and in vivo. , 2011, Molecular nutrition & food research.

[25]  M. Clifford,et al.  Mass spectrometric characterization of black tea thearubigins leading to an oxidative cascade hypothesis for thearubigin formation. , 2010, Rapid communications in mass spectrometry : RCM.

[26]  B. Aggarwal,et al.  Oxidative stress, inflammation, and cancer: how are they linked? , 2010, Free radical biology & medicine.

[27]  E. Richling,et al.  Metabolism of green tea catechins by the human small intestine , 2010, Biotechnology journal.

[28]  T. van de Wiele,et al.  In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability. , 2010, Journal of agricultural and food chemistry.

[29]  Age K. Smilde,et al.  Metabolic fate of polyphenols in the human superorganism , 2010, Proceedings of the National Academy of Sciences.

[30]  M. Clifford,et al.  The chemistry of low molecular weight black tea polyphenols. , 2010, Natural product reports.

[31]  Takashi Tanaka,et al.  Chemistry of Secondary Polyphenols Produced during Processing of Tea and Selected Foods , 2009, International journal of molecular sciences.

[32]  Debra L. Laskin,et al.  Nitrative and Oxidative Stress in Toxicology and Disease , 2009, Toxicological sciences : an official journal of the Society of Toxicology.

[33]  Elvira Gonzalez de Mejia,et al.  Bioactive components of tea: Cancer, inflammation and behavior , 2009, Brain, Behavior, and Immunity.

[34]  Xin Wang,et al.  Cancer prevention by tea: animal studies, molecular mechanisms and human relevance , 2009, Nature Reviews Cancer.

[35]  Vasundhara Sharma,et al.  A Thought on the Biological Activities of Black Tea , 2009, Critical reviews in food science and nutrition.

[36]  Hiroyuki Osada,et al.  Deficiency in Chromosome Congression by the Inhibition of Plk1 Polo Box Domain-dependent Recognition* , 2009, Journal of Biological Chemistry.

[37]  Jen-kun Lin,et al.  Tea and Tea Products : Chemistry and Health-Promoting Properties , 2008 .

[38]  J. K. Kundu,et al.  Inflammation: gearing the journey to cancer. , 2008, Mutation research.

[39]  A. Gosslau,et al.  Trans- and cis-stilbene polyphenols induced rapid perinuclear mitochondrial clustering and p53-independent apoptosis in cancer cells but not normal cells. , 2008, European journal of pharmacology.

[40]  Di Chen,et al.  Tea polyphenols, their biological effects and potential molecular targets. , 2008, Histology and histopathology.

[41]  H. Mukhtar,et al.  Tea polyphenols for health promotion. , 2007, Life sciences.

[42]  Yuan-Kun Lee,et al.  Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota. , 2006, Research in microbiology.

[43]  E. Skrzydlewska,et al.  Antioxidative properties of black tea. , 2005, Preventive medicine.

[44]  H. Lung,et al.  Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells. , 2004, International journal of molecular medicine.

[45]  Chi-Tang Ho,et al.  Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities. , 2004, Bioorganic & medicinal chemistry.

[46]  John Calvin Reed,et al.  Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. , 2003, Journal of medicinal chemistry.

[47]  J. M. V. van Amelsvoort,et al.  Analysis of theaflavins in biological fluids using liquid chromatography-electrospray mass spectrometry. , 2001, Journal of chromatography. B, Biomedical sciences and applications.

[48]  S. Lin-Shiau,et al.  Induction of apoptosis by the oolong tea polyphenol theasinensin A through cytochrome c release and activation of caspase-9 and caspase-3 in human U937 cells. , 2000, Journal of agricultural and food chemistry.

[49]  Chi-Tang Ho,et al.  Differential effects of theaflavin monogallates on cell growth, apoptosis, and Cox-2 gene expression in cancerous versus normal cells. , 2000, Cancer research.

[50]  M. Clifford,et al.  Hippuric acid as a major excretion product associated with black tea consumption , 2000, Xenobiotica; the fate of foreign compounds in biological systems.

[51]  M. Abou-Karam,et al.  Inhibition of oncogene product enzyme activity as an approach to cancer chemoprevention. Tyrosine‐specific protein kinase inhibition by purpurogallin from Quercus sp. Nutgall , 1999, Phytotherapy research : PTR.

[52]  Y. L. Lin,et al.  Theaflavin-3,3'-digallate from black tea blocks the nitric oxide synthase by down-regulating the activation of NF-kappaB in macrophages. , 1999, European journal of pharmacology.

[53]  N. Camerman,et al.  Molecular structure and antioxidant specificity of purpurogallin in three types of human cardiovascular cells. , 1996, Biochemical pharmacology.

[54]  K. Prasad,et al.  Purpurogallin, a scavenger of polymorphonuclear leukocyte-derived oxyradicals , 1994, Molecular and Cellular Biochemistry.

[55]  T. W. Wu,et al.  Purpurogallin is a more powerful protector of kidney cells than Trolox and allopurinol. , 1992, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[56]  T. W. Wu,et al.  Purpurogallin--a natural and effective hepatoprotector in vitro and in vivo. , 1991, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[57]  Mei Cheng,et al.  The modulatory effect of polyphenols from green tea, oolong tea and black tea on human intestinal microbiota in vitro , 2017, Journal of Food Science and Technology.

[58]  Chi-Tang Ho,et al.  Black tea: chemical analysis and stability. , 2013, Food & function.

[59]  Chi-Tang Ho,et al.  The importance of natural product characterization in studies of their anti-inflammatory activity. , 2011, Molecular nutrition & food research.

[60]  N. Seeram,et al.  Tea Polyphenols and Theaflavins Are Present in Prostate Tissue of Humans and Mice after Green and Black Tea Consumption 1,2 , 2006 .

[61]  Klaus Ley,et al.  Physiology of Inflammation , 2001, Methods in Physiology Series.

[62]  K. Fung,et al.  Purpurogallin: in vivo evidence of a novel and effective cardioprotector. , 1994, Life sciences.