Memory and Skill Acquisition in Parkinson's Disease and Frontal Lobe Dysfunction

Animal experiments and human neuropsychological studies have provided evidence for the hypothesis that skill acquisition may be regulated by the basal ganglia. In the present studies, perceptual and cognitive skill acquisition as well as a number of explicit verbal memory functions were investigated in patients in early and more advanced stages of Parkinson's disease (PD) and in patients with frontal lobe lesions. Patients in more advanced stages of PD were impaired at cognitive skill acquisition as well as during recall conditions that involved active semantic organisation of the stimulus material. Similar explicit memory deficits were present in frontally lesioned patients. PD patients with unilateral symptoms showed a selective impairment in acquiring a cognitive skill. Perceptual skill acquisition was preserved in all groups. The overall pattern of memory impairment in PD is largely consistent with dysfunction of fronto-striatal circuitry.

[1]  M. Moscovitch,et al.  Memory for temporal order and conditional associative-learning in patients with Parkinson's disease , 1990, Neuropsychologia.

[2]  T Jones,et al.  Alterations of regional cerebral blood flow and oxygen metabolism in Parkinson's disease , 1985, Neurology.

[3]  E. Sullivan,et al.  Cognitive impairment in early, untreated Parkinson's disease and its relationship to motor disability. , 1991, Brain : a journal of neurology.

[4]  A. Lang,et al.  Striatal dopamine distribution in Parkinsonian patients during life , 1985, Journal of the Neurological Sciences.

[5]  C. Frith,et al.  Impairments in the learning and performance of a new manual skill in patients with Parkinson's disease. , 1986, Journal of neurology, neurosurgery, and psychiatry.

[6]  J. Saint-Cyr,et al.  Frontal lobe dysfunction in Parkinson's disease. The cortical focus of neostriatal outflow. , 1986, Brain : a journal of neurology.

[7]  L. Squire,et al.  The structure and organization of memory. , 1993, Annual review of psychology.

[8]  H J Sagar,et al.  Temporal ordering and short-term memory deficits in Parkinson's disease. , 1988, Brain : a journal of neurology.

[9]  F Lhermitte,et al.  Cholinergic‐dependent cognitive deficits in Parkinson's disease , 1987, Annals of neurology.

[10]  C. Marsden,et al.  Fronto-striatal cognitive deficits at different stages of Parkinson's disease. , 1992, Brain : a journal of neurology.

[11]  E. Marder,et al.  Procedural memory in Parkinson's disease: impaired motor but not visuoperceptual learning. , 1990, Journal of clinical and experimental neuropsychology.

[12]  N. Birbaumer,et al.  The cerebellum and cognitive functions in humans. , 1993, Behavioral neuroscience.

[13]  C. Marsden,et al.  The performance on learning tasks of patients in the early stages of Parkinson's disease , 1989, Neuropsychologia.

[14]  C. Marsden,et al.  Cognitive function in Parkinson's disease: From description to theory , 1990, Trends in Neurosciences.

[15]  T. Robbins,et al.  A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease. , 1988, Brain : a journal of neurology.

[16]  M. Hoehn,et al.  Parkinsonism , 1967, Neurology.

[17]  L. Cermak,et al.  Memory disorders associated with huntington's disease: Verbal recall, verbal recognition and procedural memory , 1985, Neuropsychologia.

[18]  J. Saint-Cyr,et al.  Memory and learning in early Parkinson's disease: Evidence for a “frontal lobe syndrome” , 1990, Brain and Cognition.

[19]  J. Hanley,et al.  Perception and memory for faces in Parkinson's disease , 1991, Neuropsychologia.

[20]  G. E. Alexander,et al.  Parallel organization of functionally segregated circuits linking basal ganglia and cortex. , 1986, Annual review of neuroscience.

[21]  I. Daum,et al.  Dissociation of declarative and nondeclarative memory after bilateral thalamic lesions: a case report. , 1994, The International journal of neuroscience.

[22]  M. Freedman,et al.  Cognitive deficits in olivopontocerebellar atrophy: Implications for the cholinergic hypothesis of Alzheimer's dementia , 1988, Annals of neurology.

[23]  R. B. Freeman,et al.  A Verbal Long Term Memory Deficit in Frontal Lobe Damaged Patients , 1986, Cortex.

[24]  D. Salmon,et al.  Neuropsychological evidence for multiple implicit memory systems: a comparison of Alzheimer's, Huntington's, and Parkinson's disease patients , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[25]  M. Bondi,et al.  Implicit and explicit memory in Alzheimer's disease and Parkinson's disease. , 1991, Journal of clinical and experimental neuropsychology.

[26]  J. Saint-Cyr,et al.  Procedural learning and neostriatal dysfunction in man. , 1988, Brain : a journal of neurology.

[27]  T. Robbins,et al.  Planning and spatial working memory following frontal lobe lesions in man , 1990, Neuropsychologia.

[28]  Alan J. Parkin,et al.  Implicit and explicit memory in young children and adults , 1988 .

[29]  E. Sullivan,et al.  Double dissociation of short-term and long-term memory for nonverbal material in Parkinson's disease and global amnesia. A further analysis. , 1991, Brain : a journal of neurology.

[30]  T. Robbins,et al.  Planning and spatial working memory in Parkinson's disease. , 1988, Journal of neurology, neurosurgery, and psychiatry.

[31]  K. Flowers,et al.  Recognition memory in Parkinson's disease. , 1984, Journal of neurology, neurosurgery, and psychiatry.

[32]  L. Squire,et al.  Human memory and amnesia , 1984 .

[33]  J. Becker,et al.  Dissociations between skill learning and verbal recognition in amnesia and dementia. , 1984, Archives of neurology.

[34]  H. Weingartner,et al.  Cognitive impairments in Parkinson's disease: Distinguishing between effort-demanding and automatic cognitive processes , 1984, Psychiatry Research.

[35]  A. M. Owen,et al.  Visuospatial memory deficits at different stages of Parkinson's disease , 1993, Neuropsychologia.

[36]  F. Mcdowell,et al.  The effect of semantic relations on the memory deficit associated with Parkinson's disease. , 1982, Journal of clinical neuropsychology.

[37]  N Birbaumer,et al.  Classical conditioning after cerebellar lesions in humans. , 1993, Behavioral neuroscience.

[38]  Antonio Incisa della Rocchetta,et al.  Classification and Recall of Pictures After Unilateral Frontal or Temporal Lobectomy , 1986, Cortex.

[39]  C. Marsden,et al.  'Frontal' cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa. , 1988, Brain : a journal of neurology.

[40]  B. Milner,et al.  Frontal lobes and the temporal organization of memory. , 1985, Human neurobiology.

[41]  C. E. Polkey,et al.  The effect of categorization on verbal memory after temporal lobectomy , 1989, Neuropsychologia.

[42]  I Litvan,et al.  Selective deficits in cognition and memory in high-functioning parkinsonian patients. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[43]  E. Sullivan,et al.  Nonverbal recognition and recency discrimination deficits in Parkinson's disease and Alzheimer's disease. , 1989, Brain : a journal of neurology.

[44]  Y. Agid,et al.  Dopamine deficiency in the cerebral cortex in Parkinson disease , 1982, Neurology.