VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity
暂无分享,去创建一个
M. J. Vazquez | G. Appendino | M. Tena-Sempere | M. Bellido | I. Velasco | F. Ruíz-Pino | M. A. Sánchez-Garrido | M. Calzado | E. Muñoz | C. Navarrete | Carolina Pavicic | C. Jiménez-Jiménez | Belén Palomares | Inmaculada Velasco
[1] International Association for the Study of Obesity , 2018, The Grants Register 2019.
[2] A. McAinch,et al. Peripheral modulation of the endocannabinoid system in metabolic disease. , 2018, Drug discovery today.
[3] B. Fiebich,et al. Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy , 2018, Journal of Neuroinflammation.
[4] M. Tschöp,et al. Ghrelin regulation of glucose metabolism , 2018, Peptides.
[5] M. García-Arencibia,et al. Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson’s disease: possible involvement of different binding sites at the PPARγ receptor , 2018, Journal of Neuroinflammation.
[6] Y. Im,et al. Structures of PPARγ complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs , 2017, Scientific Reports.
[7] O. Woolcott,et al. Re-visiting the Endocannabinoid System and Its Therapeutic Potential in Obesity and Associated Diseases , 2017, Current Diabetes Reports.
[8] A. Paiardini,et al. Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis , 2017, Scientific Reports.
[9] D. Cota,et al. MECHANISMS IN ENDOCRINOLOGY: Endocannabinoids and metabolism: past, present and future. , 2017, European journal of endocrinology.
[10] J. Wish,et al. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors: A Potential New Treatment for Anemia in Patients With CKD. , 2017, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[11] P. Tanajak,et al. Letter to the Editor: Parameters, Characteristics, and Criteria for Defining the Term "FGF21 Resistance". , 2017, Endocrinology.
[12] M. Doherty,et al. Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice , 2017, Scientific Reports.
[13] M. Tschöp,et al. Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice , 2017, Molecular metabolism.
[14] N. Møller,et al. Acyl Ghrelin Induces Insulin Resistance Independently of GH, Cortisol, and Free Fatty Acids , 2017, Scientific Reports.
[15] Simon,et al. Endocannabinoids and metabolism : past , present and future , 2017 .
[16] A. Lavecchia,et al. Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode , 2016, Scientific Reports.
[17] I. Galve-Roperh,et al. VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington’s disease , 2016, Scientific Reports.
[18] P. Leung,et al. Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus , 2016, Medicinal research reviews.
[19] A. Geerts,et al. Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease , 2016, Cellular and Molecular Life Sciences.
[20] G. Appendino,et al. The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways , 2016, Scientific Reports.
[21] Shufeng Wang,et al. Nonerythropoietic Erythropoietin-Derived Peptide Suppresses Adipogenesis, Inflammation, Obesity and Insulin Resistance , 2015, Scientific Reports.
[22] N. Stefan,et al. Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes , 2015, Molecular metabolism.
[23] S. Kliewer,et al. Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21 , 2015, Trends in Endocrinology & Metabolism.
[24] R. Seeley,et al. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents , 2014, Nature Medicine.
[25] A. Grey. Diabetes Medications and Bone , 2015, Current Osteoporosis Reports.
[26] R. Blanco Sequeiros,et al. HIF Prolyl 4-Hydroxylase-2 Inhibition Improves Glucose and Lipid Metabolism and Protects Against Obesity and Metabolic Dysfunction , 2014, Diabetes.
[27] Travis S. Hughes,et al. An alternate binding site for PPARγ ligands , 2014, Nature Communications.
[28] P. López-Jaramillo,et al. The role of leptin/adiponectin ratio in metabolic syndrome and diabetes , 2014, Hormone molecular biology and clinical investigation.
[29] B. Raaka,et al. Erythropoietin Signaling: A Novel Regulator of White Adipose Tissue Inflammation During Diet-Induced Obesity , 2014, Diabetes.
[30] Jaspinder Kaur. A Comprehensive Review on Metabolic Syndrome , 2014, Cardiology research and practice.
[31] M. H. Rabinowitz,et al. Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses. , 2013, Journal of medicinal chemistry.
[32] K. Borch-Johnsen. Epidemiology of the Metabolic Syndrome , 2013 .
[33] S. Kliewer,et al. FGF21 contributes to neuroendocrine control of female reproduction , 2013, Nature Medicine.
[34] H. Beck-Nielsen. The metabolic syndrome : pharmacology and clinical aspects , 2013 .
[35] Leandro Martínez,et al. Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists , 2012, PloS one.
[36] M. J. Chalmers,et al. Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism. , 2012, Structure.
[37] C. Kahn,et al. The differential role of Hif1β/Arnt and the hypoxic response in adipose function, fibrosis, and inflammation. , 2011, Cell metabolism.
[38] O. Gavrilova,et al. Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet–Fed Mice , 2011, Diabetes.
[39] S. Gortmaker,et al. Health and economic burden of the projected obesity trends in the USA and the UK , 2011, The Lancet.
[40] Brian D. Weitzner,et al. Real-Time PyMOL Visualization for Rosetta and PyRosetta , 2011, PloS one.
[41] Stephen P. H. Alexander,et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 , 2010, Pharmacological Reviews.
[42] K. Morikawa,et al. The nuclear receptor PPARγ individually responds to serotonin‐ and fatty acid‐metabolites , 2010, The EMBO journal.
[43] B. Lecka-Czernik. Bone Loss in Diabetes: Use of Antidiabetic Thiazolidinediones and Secondary Osteoporosis , 2010, Current osteoporosis reports.
[44] C. Rosen. Revisiting the rosiglitazone story--lessons learned. , 2010, The New England journal of medicine.
[45] A. Xu,et al. Adipose Tissue-specific Inhibition of Hypoxia-inducible Factor 1α Induces Obesity and Glucose Intolerance by Impeding Energy Expenditure in Mice* , 2010, The Journal of Biological Chemistry.
[46] M. Eijken,et al. A New Concept Underlying Stem Cell Lineage Skewing That Explains the Detrimental Effects of Thiazolidinediones on Bone , 2010, Stem cells.
[47] I. Hassinen,et al. Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury* , 2010, The Journal of Biological Chemistry.
[48] Arthur J. Olson,et al. AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading , 2009, J. Comput. Chem..
[49] S. Kliewer,et al. Fibroblast growth factor 21: from pharmacology to physiology. , 2010, The American journal of clinical nutrition.
[50] David S. Goodsell,et al. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility , 2009, J. Comput. Chem..
[51] S. Grundy,et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International As , 2009, Circulation.
[52] A. Stofkova. Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity. , 2009, Endocrine regulations.
[53] A. Attie,et al. Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue , 2009, Molecular and Cellular Biology.
[54] F. Ashcroft,et al. PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. , 2008, Genes & development.
[55] Peter Tontonoz,et al. Fat and beyond: the diverse biology of PPARgamma. , 2008, Annual review of biochemistry.
[56] A. Peri,et al. Rosiglitazone stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells , 2007, Journal of endocrinological investigation.
[57] Olivier Michielin,et al. Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators. , 2007, Biochimica et biophysica acta.
[58] M. Matsuda,et al. Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation , 2007, Diabetes.
[59] M. Hyman,et al. Molecular regulation of the PAI‐1 gene by hypoxia: contributions of Egr‐1, HIF‐1 α, and C/EBPα , 2007 .
[60] M. Hyman,et al. Molecular regulation of the PAI-1 gene by hypoxia: contributions of Egr-1, HIF-1alpha, and C/EBPalpha. , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[61] P. Pérez-Martínez,et al. Dietary fat, genes and insulin sensitivity , 2007, Journal of Molecular Medicine.
[62] O. Cummings,et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease , 2005, Hepatology.
[63] J. Lehmann,et al. Printed in U.S.A. Copyright © 2002 by The Endocrine Society Divergent Effects of Selective Peroxisome Proliferator- Activated Receptor-�2 Ligands on Adipocyte Versus Osteoblast Differentiation , 2022 .
[64] J. Lehmann,et al. Divergent Effects of Selective Peroxisome Proliferator-Activated Receptor- (cid:1) 2 Ligands on Adipocyte Versus Osteoblast Differentiation , 2002 .
[65] 北村 聖. "The New England Journal of Medicine". , 1962, British medical journal.