论文信息 - PINT: Protein–protein Interactions Thermodynamic Database

PINT: Protein–protein Interactions Thermodynamic Database

The first release of Protein–protein Interactions Thermodynamic Database (PINT) contains >1500 data of several thermodynamic parameters along with sequence and structural information, experimental conditions and literature information. Each entry contains numerical data for the free energy change, dissociation constant, association constant, enthalpy change, heat capacity change and so on of the interacting proteins upon binding, which are important for understanding the mechanism of protein–protein interactions. PINT also includes the name and source of the proteins involved in binding, their Protein Information Resource, SWISS-PROT and Protein Data Bank (PDB) codes, secondary structure and solvent accessibility of residues at mutant positions, measuring methods, experimental conditions, such as buffers, ions and additives, and literature information. A WWW interface facilitates users to search data based on various conditions, feasibility to select the terms for output and different sorting options. Further, PINT is cross-linked with other related databases, PIR, SWISS-PROT, PDB and NCBI PUBMED literature database. The database is freely available at

M. Michael Gromiha | M. D. Shaji Kumar | M. Gromiha | M. D. S. Kumar

[1] Ian M. Donaldson,et al. The Biomolecular Interaction Network Database and related tools 2005 update , 2004, Nucleic Acids Res..

[2] R. Russell,et al. Protein complexes: structure prediction challenges for the 21st century. , 2005, Current opinion in structural biology.

[3] Robert S. Ledley,et al. The Protein Information Resource , 2003, Nucleic Acids Res..

[4] Adam J. Smith,et al. The Database of Interacting Proteins: 2004 update , 2004, Nucleic Acids Res..

[5] D. Eisenberg,et al. Computational methods of analysis of protein-protein interactions. , 2003, Current opinion in structural biology.

[6] W. Kabsch,et al. Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features , 1983, Biopolymers.

[7] Ioannis Xenarios,et al. DIP: The Database of Interacting Proteins: 2001 update , 2001, Nucleic Acids Res..

[8] Yu Zong Chen,et al. KDBI: Kinetic Data of Bio-molecular Interactions database , 2003, Nucleic Acids Res..

[9] T. N. Bhat,et al. The Protein Data Bank , 2000, Nucleic Acids Res..

[10] Maria Jesus Martin,et al. The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003 , 2003, Nucleic Acids Res..

[11] Shoshana J Wodak,et al. Prediction of protein-protein interactions: the CAPRI experiment, its evaluation and implications. , 2004, Current opinion in structural biology.