Flaxseed supplementation significantly reduces hemoglobin A1c in patients with type 2 diabetes mellitus: A systematic review and meta-analysis.

[1]  Lei Shi,et al.  Prevalence of dyslipidemia, treatment rate and its control among patients with type 2 diabetes mellitus in Northwest China: a cross-sectional study , 2022, Lipids in health and disease.

[2]  J. Muñóz-Valle,et al.  Effect of flaxseed (Linum usitatissimum) supplementation on glycemic control and insulin resistance in prediabetes and type 2 diabetes: A Systematic review and meta-analysis of randomized controlled trials. , 2022, Complementary therapies in medicine.

[3]  Guiju Sun,et al.  Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose–response meta-analysis of randomized controlled trials , 2021, Nutrition & Metabolism.

[4]  S. Asgary,et al.  Effects of Flaxseed on Blood Lipids in Healthy and Dyslipidemic Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. , 2021, Current problems in cardiology.

[5]  M. Chohan,et al.  The effect of a split portion of flaxseed on 24-h blood glucose response , 2020, European Journal of Nutrition.

[6]  Q. Zeng,et al.  Differential Modulation of Markers of Oxidative Stress and Glycation of Hemoglobin in Patients with Type 2 Diabetes Mellitus by Edible Oils Rich in Eicosapentaenoic Acid and Docosahexaenoic Acid , 2020, Current Topics in Nutraceutical Research.

[7]  Moein Askarpour,et al.  Effect of Flaxseed Supplementation on Lipid Profile: An Updated Systematic Review and Dose-Response Meta-Analysis of Sixty-Two Randomized Controlled Trials. , 2019, Pharmacological research.

[8]  G. Shulman,et al.  The integrative biology of type 2 diabetes , 2019, Nature.

[9]  V. Welch,et al.  Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions. , 2019, The Cochrane database of systematic reviews.

[10]  M. Alizadeh,et al.  The Effect of Flaxseed Enriched Yogurt on the Glycemic Status and Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus: Randomized, Open-labeled, Controlled Study , 2019, Clinical nutrition research.

[11]  Natalie S Blencowe,et al.  RoB 2: a revised tool for assessing risk of bias in randomised trials , 2019, BMJ.

[12]  N. Sharifi,et al.  A comparison between the effects of flaxseed oil and fish oil supplementation on cardiovascular health in type 2 diabetic patients with coronary heart disease: A randomized, double‐blinded, placebo‐controlled trial , 2019, Phytotherapy research : PTR.

[13]  K. Aung,et al.  Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes , 2019, Current Cardiology Reports.

[14]  Sharadwata Pan,et al.  Bioprocessing of Functional Ingredients from Flaxseed , 2018, Molecules.

[15]  M. Janghorbani,et al.  A randomized trial of the effects of flaxseed to manage constipation, weight, glycemia, and lipids in constipated patients with type 2 diabetes , 2018, Nutrition & Metabolism.

[16]  Z. Sohrabi,et al.  Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials , 2018, Nutrition reviews.

[17]  T. Netticadan,et al.  Flaxseed: its bioactive components and their cardiovascular benefits. , 2018, American journal of physiology. Heart and circulatory physiology.

[18]  M. Taghizadeh,et al.  Flaxseed Oil Supplementation Improve Gene Expression Levels of PPAR-γ, LP(a), IL-1 and TNF-α in Type 2 Diabetic Patients with Coronary Heart Disease , 2017, Lipids.

[19]  N. Bellissimo,et al.  The effect of flaxseed supplementation on body weight and body composition: a systematic review and meta‐analysis of 45 randomized placebo‐controlled trials , 2017, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[20]  Ralph A. DeFronzo,et al.  Cardiovascular Disease and Type 2 Diabetes: Has the Dawn of a New Era Arrived? , 2017, Diabetes Care.

[21]  N. Marx,et al.  Diabetes Mellitus and Heart Failure. , 2017, The American journal of medicine.

[22]  R. D. de Souza,et al.  The effect of alpha-linolenic acid on glycemic control in individuals with type 2 diabetes , 2017, Medicine.

[23]  Ju-Sheng Zheng,et al.  Effects of n-3 fatty acid supplements on glycemic traits in Chinese type 2 diabetic patients: A double-blind randomized controlled trial. , 2016, Molecular nutrition & food research.

[24]  H. Poustchi,et al.  Flaxseed Supplementation in Metabolic Syndrome Management: A Pilot Randomized, Open‐labeled, Controlled Study , 2016, Phytotherapy research : PTR.

[25]  Y. Katsuragi,et al.  Consumption of alpha-Linolenic Acid-enriched Diacylglycerol Reduces Visceral Fat Area in Overweight and Obese Subjects: a Randomized, Double-blind Controlled, Parallel-group Designed Trial. , 2016, Journal of Oleo Science.

[26]  A. Sahebkar,et al.  Effects of flaxseed supplements on blood pressure: A systematic review and meta-analysis of controlled clinical trial. , 2016, Clinical nutrition.

[27]  M. Foss,et al.  Supplementation of α-linolenic acid improves serum adiponectin levels and insulin sensitivity in patients with type 2 diabetes. , 2015, Nutrition.

[28]  C. Irwin,et al.  Flaxseed consumption may reduce blood pressure: a systematic review and meta-analysis of controlled trials. , 2015, The Journal of nutrition.

[29]  Alka Sharma,et al.  Flaxseed—a potential functional food source , 2015, Journal of Food Science and Technology.

[30]  H. Aukema,et al.  Flaxseed Consumption Reduces Blood Pressure in Patients With Hypertension by Altering Circulating Oxylipins via an &agr;-Linolenic Acid–Induced Inhibition of Soluble Epoxide Hydrolase , 2014, Hypertension.

[31]  Fredrik H. Karlsson,et al.  Gut metagenome in European women with normal, impaired and diabetic glucose control , 2013, Nature.

[32]  D. Barre,et al.  Flaxseed Lignan Complex Administration in Older Human Type 2 Diabetics Manages Central Obesity and Prothrombosis—An Invitation to Further Investigation into Polypharmacy Reduction , 2012, Journal of nutrition and metabolism.

[33]  R. Agrawal,et al.  ‘Metabolic syndrome’ in the brain: deficiency in omega‐3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition , 2012, The Journal of physiology.

[34]  A. Astrup,et al.  Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but magnitude of effect depend on food type , 2012, Nutrition & Metabolism.

[35]  A. Akhmedov,et al.  Dietary &agr;-Linolenic Acid Inhibits Arterial Thrombus Formation, Tissue Factor Expression, and Platelet Activation , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[36]  I. A. A. Syed,et al.  Glycated haemoglobin--a marker and predictor of cardiovascular disease. , 2011, JPMA. The Journal of the Pakistan Medical Association.

[37]  K. K. K. Singh,et al.  Flaxseed: A Potential Source of Food, Feed and Fiber , 2011, Critical reviews in food science and nutrition.

[38]  M. Kristensen,et al.  Dietary fibres in the regulation of appetite and food intake. Importance of viscosity , 2011, Appetite.

[39]  L. Malcolmson,et al.  Dietary Milled Flaxseed and Flaxseed Oil Improve N-3 Fatty Acid Status and Do Not Affect Glycemic Control in Individuals with Well-Controlled Type 2 Diabetes , 2010, Journal of the American College of Nutrition.

[40]  D. Rodriguez-Leyva,et al.  Experimental and clinical research findings on the cardiovascular benefits of consuming flaxseed. , 2009, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[41]  O. Franco,et al.  Meta-analysis of the effects of flaxseed interventions on blood lipids. , 2009, The American journal of clinical nutrition.

[42]  D. Rousseau,et al.  Effect of flaxseed gum on reduction of blood glucose and cholesterol in type 2 diabetic patients , 2009, International journal of food sciences and nutrition.

[43]  W. Demark-Wahnefried,et al.  Effects of a Flaxseed-Derived Lignan Supplement in Type 2 Diabetic Patients: A Randomized, Double-Blind, Cross-Over Trial , 2007, PloS one.

[44]  G. Tsujimoto,et al.  Free fatty acids administered into the colon promote the secretion of glucagon-like peptide-1 and insulin. , 2006, Biochemical and biophysical research communications.

[45]  Duo Li,et al.  What is the role of α-linolenic acid for mammals? , 2002, Lipids.

[46]  H. Keen,et al.  Mortality and causes of death in the WHO multinational study of vascular disease in diabetes , 2001, Diabetologia.

[47]  J. Sterne,et al.  Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. , 2000, Journal of clinical epidemiology.

[48]  K. Prasad.  Flaxseed: a source of hypocholesterolemic and antiatherogenic agents. , 2000, Drug news & perspectives.

[49]  D. Finegood,et al.  A Comparison of the Effects of n-3 Fatty Acids From Linseed Oil and Fish Oil in Well-Controlled Type II Diabetes , 1996, Diabetes Care.

[50]  N. Costa,et al.  Effects of brown and golden flaxseed on the lipid profile, glycemia, inflammatory biomarkers, blood pressure and body composition in overweight adolescents. , 2015, Nutrition.

[51]  D. Barre,et al.  High dose flaxseed oil supplementation may affect fasting blood serum glucose management in human type 2 diabetics. , 2008, Journal of oleo science.