Assessment of MR‐based R2* and quantitative susceptibility mapping for the quantification of liver iron concentration in a mouse model at 7T

To assess the feasibility of quantifying liver iron concentration (LIC) using R2* and quantitative susceptibility mapping (QSM) at a high field strength of 7 Tesla (T).

[1]  Olga Veksler,et al.  Fast approximate energy minimization via graph cuts , 2001, Proceedings of the Seventh IEEE International Conference on Computer Vision.

[2]  Zhi Liu,et al.  Oxidation-Induced Degradable Nanogels for Iron Chelation , 2016, Scientific Reports.

[3]  J. Fish,et al.  Insidious iron burden in pediatric patients with acute lymphoblastic leukemia , 2011, Pediatric blood & cancer.

[4]  S. Reeder,et al.  Multipeak fat‐corrected complex R2* relaxometry: Theory, optimization, and clinical validation , 2013, Magnetic resonance in medicine.

[5]  S. Reeder,et al.  Comparison of R2* correction methods for accurate fat quantification in fatty liver , 2013, Journal of magnetic resonance imaging : JMRI.

[6]  S. Reeder,et al.  Sensitivity of chemical shift‐encoded fat quantification to calibration of fat MR spectrum , 2016, Magnetic resonance in medicine.

[7]  Ferdinand Schweser,et al.  Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study , 2012, NeuroImage.

[8]  M. Kami,et al.  Hepatic iron concentration and total body iron stores in thalassemia major. , 2000, The New England journal of medicine.

[9]  Yi Wang,et al.  Morphology enabled dipole inversion for quantitative susceptibility mapping using structural consistency between the magnitude image and the susceptibility map , 2012, NeuroImage.

[10]  S. Reeder,et al.  Quantification of liver fat in the presence of iron overload , 2017, Journal of magnetic resonance imaging : JMRI.

[11]  Scott B Reeder,et al.  Quantification of hepatic steatosis with T1-independent, T2-corrected MR imaging with spectral modeling of fat: blinded comparison with MR spectroscopy. , 2011, Radiology.

[12]  P J Diaz,et al.  MR susceptometry: an external‐phantom method for measuring bulk susceptibility from field‐echo phase reconstruction maps , 1994, Journal of magnetic resonance imaging : JMRI.

[13]  Scott B Reeder,et al.  Magnetic susceptibility as a B0 field strength independent MRI biomarker of liver iron overload , 2013, Magnetic resonance in medicine.

[14]  W. Sly,et al.  HFE gene knockout produces mouse model of hereditary hemochromatosis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[15]  T. Coates,et al.  MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. , 2005, Blood.

[16]  Raja Muthupillai,et al.  MRI measurement of hepatic magnetic susceptibility—Phantom validation and normal subject studies , 2004, Magnetic resonance in medicine.

[17]  G. Adam,et al.  MRI‐based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload: Comparison with SQUID‐based biomagnetic liver susceptometry , 2017, Magnetic resonance in medicine.

[18]  A. Sherry,et al.  Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla* , 2008, Journal of Lipid Research.

[19]  May P. Xiong,et al.  Enzymatically Biodegradable Polyrotaxane-Deferoxamine Conjugates for Iron Chelation. , 2016, ACS applied materials & interfaces.

[20]  M. Haider,et al.  R2* as a surrogate measure of ferriscan iron quantification in thalassemia , 2014, Journal of magnetic resonance imaging : JMRI.

[21]  G. Sebastiani,et al.  Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing , 2012, Journal of Molecular Medicine.

[22]  Yi Wang,et al.  Background field removal by solving the Laplacian boundary value problem , 2014, NMR in biomedicine.

[23]  Massimo Midiri,et al.  Multicenter validation of the magnetic resonance t2* technique for segmental and global quantification of myocardial iron , 2009, Journal of magnetic resonance imaging : JMRI.

[24]  T. S. St. Pierre,et al.  Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. , 2005, Blood.

[25]  G. Spanos,et al.  MRI assessment of liver iron content in thalassamic patients with three different protocols: comparisons and correlations , 2009, European journal of haematology.

[26]  Dianne P. O'Leary,et al.  Variable projection for nonlinear least squares problems , 2012, Computational Optimization and Applications.

[27]  P. Sestili,et al.  The C57BL/6 genetic background confers cardioprotection in iron-overloaded mice. , 2013, Blood transfusion = Trasfusione del sangue.

[28]  P Kellman,et al.  Joint estimation of water/fat images and field inhomogeneity map , 2008, Magnetic resonance in medicine.

[29]  H. Bonkovsky,et al.  Hepatic iron concentration: noninvasive estimation by means of MR imaging techniques. , 1999, Radiology.

[30]  Mark A Westwood,et al.  Multi-center validation of the transferability of the magnetic resonance T2* technique for the quantification of tissue iron. , 2006, Haematologica.

[31]  M. Hudson,et al.  Trends in transfusion burden among long-term survivors of childhood hematological malignancies , 2013, Leukemia & lymphoma.

[32]  James R. Moore,et al.  Evaluation of iron overload by single voxel MRS measurement of liver T2 , 2002, Journal of magnetic resonance imaging : JMRI.

[33]  N. Ghugre,et al.  Relaxivity‐iron calibration in hepatic iron overload: Probing underlying biophysical mechanisms using a Monte Carlo model , 2011, Magnetic resonance in medicine.

[34]  L. Golberg,et al.  Observations on subcutaneous macrophages. Phago-cytosis of iron-dextran and ferritin synthesis. , 1961, Quarterly journal of experimental physiology and cognate medical sciences.

[35]  G. Richter.  The iron-loaded cell--the cytopathology of iron storage. A review. , 1978, The American journal of pathology.

[36]  E. Neufeld,et al.  R2 and R2* are equally effective in evaluating chronic response to iron chelation , 2013, American journal of hematology.

[37]  Yi Wang,et al.  Quantitative susceptibility mapping (QSM): Decoding MRI data for a tissue magnetic biomarker , 2014, Magnetic resonance in medicine.

[38]  S. Reeder,et al.  Multiecho water‐fat separation and simultaneous R  2* estimation with multifrequency fat spectrum modeling , 2008, Magnetic resonance in medicine.

[39]  S. Reeder,et al.  Addressing phase errors in fat‐water imaging using a mixed magnitude/complex fitting method , 2012, Magnetic resonance in medicine.

[40]  Maili Liu,et al.  A selective NMR method for detecting choline containing compounds in liver tissue: the 1H-14N HSQC experiment. , 2010, Journal of the American Chemical Society.

[41]  Stephen J. Wright,et al.  Numerical Optimization (Springer Series in Operations Research and Financial Engineering) , 2000 .

[42]  G. Pinkus,et al.  A mouse model of juvenile hemochromatosis. , 2005, The Journal of clinical investigation.

[43]  Randall William Holt.  MRI susceptometry: Theory and robustness of an external phantom method for measuring bulk susceptibility from MRI field echo phase reconstruction maps applied to human liver iron overload , 1993 .

[44]  Mark Fogel,et al.  International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers , 2010, Journal of magnetic resonance imaging : JMRI.

[45]  E. Cassinerio,et al.  An update on iron chelation therapy. , 2012, Blood transfusion = Trasfusione del sangue.

[46]  A. Piga,et al.  Monitoring Long‐Term Efficacy of Iron Chelation Treatment with Biomagnetic Liver Susceptometry , 2005, Annals of the New York Academy of Sciences.

[47]  J. Schenck.  The role of magnetic susceptibility in magnetic resonance imaging: MRI magnetic compatibility of the first and second kinds. , 1996, Medical physics.

[48]  Huanzhou Yu,et al.  On the performance of T2* correction methods for quantification of hepatic fat content , 2012, Magnetic resonance in medicine.

[49]  C. Hillenbrand,et al.  R2* magnetic resonance imaging of the liver in patients with iron overload. , 2009, Blood.

[50]  P. Brissot,et al.  MRI quantification of splenic iron concentration in mouse , 2010, Journal of magnetic resonance imaging : JMRI.

[51]  S. Sheth,et al.  Noninvasive methods for quantitative assessment of transfusional iron overload in sickle cell disease. , 2001, Seminars in hematology.

[52]  John S Leigh,et al.  Quantifying arbitrary magnetic susceptibility distributions with MR , 2004, Magnetic resonance in medicine.

[53]  Mark A Westwood,et al.  Interscanner reproducibility of cardiovascular magnetic resonance T2* measurements of tissue iron in thalassemia , 2003, Journal of magnetic resonance imaging : JMRI.

[54]  S. Reeder,et al.  Quantitative susceptibility mapping in the abdomen as an imaging biomarker of hepatic iron overload , 2015, Magnetic resonance in medicine.

[55]  D. Pennell,et al.  Calibration of Improved T2*Method for the Estimation of Liver Iron Concentration in Transfusional Iron Overload , 2009 .

[56]  A. Gouliamos,et al.  Quantification of liver iron overload by T2 quantitative magnetic resonance imaging in thalassemia: impact of chronic hepatitis C on measurements. , 1999, Journal of pediatric hematology/oncology.

[57]  Wei Lin,et al.  Relationships between MR transverse relaxation parameters R  *2 , R2 and R  ′2 and hepatic iron content in thalassemic mice at 1.5 T and 3 T , 2008, NMR in biomedicine.

[58]  G. Brittenham,et al.  Noninvasive measurement of iron: report of an NIDDK workshop. , 2003, Blood.

[59]  D G Mitchell,et al.  Abdominal iron deposition: metabolism, MR findings, and clinical importance. , 1996, Radiology.

[60]  P. Kellman,et al.  Chemical shift–based water/fat separation: A comparison of signal models , 2010, Magnetic resonance in medicine.

[61]  K. Vigen,et al.  T1 independent, T2* corrected chemical shift based fat–water separation with multi‐peak fat spectral modeling is an accurate and precise measure of hepatic steatosis , 2011, Journal of magnetic resonance imaging : JMRI.

[62]  Laurence H. Jackson,et al.  Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of β-thalassemia , 2017, Scientific Reports.

[63]  B. Bacon,et al.  Duration of Hepatic Iron Exposure Increases the Risk of Significant Fibrosis in Hereditary Hemochromatosis: A New Role for Magnetic Resonance Imaging , 2005, The American Journal of Gastroenterology.

[64]  Joel Kullberg,et al.  Three‐dimensional water/fat separation and T  2* estimation based on whole‐image optimization—Application in breathhold liver imaging at 1.5 T , 2012, Magnetic resonance in medicine.

[65]  H. Rienhoff,et al.  The use of appropriate calibration curves corrects for systematic differences in liver R2* values measured using different software packages , 2013, British journal of haematology.

[66]  Ruitian Song,et al.  Simultaneous field and R  2* mapping to quantify liver iron content using autoregressive moving average modeling , 2012, Journal of magnetic resonance imaging : JMRI.

[67]  Y Gandon,et al.  Hemochromatosis: diagnosis and quantification of liver iron with gradient-echo MR imaging. , 1994, Radiology.

[68]  P. Storey,et al.  R2* imaging of transfusional iron burden at 3T and comparison with 1.5T , 2007, Journal of magnetic resonance imaging : JMRI.

[69]  P. Sestili,et al.  Iron excretion in iron dextran-overloaded mice. , 2014, Blood transfusion = Trasfusione del sangue.

[70]  B. Ghetti,et al.  Expression of a Mutant Form of the Ferritin Light Chain Gene Induces Neurodegeneration and Iron Overload in Transgenic Mice , 2008, The Journal of Neuroscience.

[71]  C. Sirlin,et al.  In vivo characterization of the liver fat 1H MR spectrum , 2011, NMR in biomedicine.

[72]  S. Reeder,et al.  Quantification of liver iron with MRI: State of the art and remaining challenges , 2014, Journal of magnetic resonance imaging : JMRI.

[73]  E Biondetti,et al.  The Effect of Large Slice Thickness and Spacing and Low Coverage on the Accuracy of Susceptibility Mapping , 2016 .

[74]  Diego Hernando,et al.  Robust water/fat separation in the presence of large field inhomogeneities using a graph cut algorithm , 2009, Magnetic resonance in medicine.

[75]  R. Gillum,et al.  Iron and Heart Disease , 2005 .

[76]  Jian Zhi Hu,et al.  Studies of Secondary Melanoma on C57BL/6J Mouse Liver Using 1H NMR Metabolomics , 2013, Metabolites.

[77]  P. Harmatz,et al.  Severity of Iron Overload in Patients with Sickle Cell Disease Receiving Chronic Red Blood Cell Transfusion Therapy , 2000, Blood.

[78]  J. Tripp,et al.  Magnetic-susceptibility measurement of human iron stores. , 1982, The New England journal of medicine.

[79]  H. M. Sonawat,et al.  Multivariate modelling with 1H NMR of pleural effusion in murine cerebral malaria , 2011, Malaria Journal.

[80]  M. Schocke,et al.  Evaluation of MR imaging with T1 and T2* mapping for the determination of hepatic iron overload , 2012, European Radiology.

[81]  K. Batts.  Iron overload syndromes and the liver , 2007, Modern Pathology.

[82]  David N. Firmin,et al.  Intercentre Reproducibility of Magnetic Resonance T2* Measurements of Myocardial Iron in Thalassaemia , 2005, The International Journal of Cardiovascular Imaging.

[83]  Ann Shimakawa,et al.  R  2* mapping in the presence of macroscopic B0 field variations , 2012, Magnetic resonance in medicine.

[84]  P. Rebulla,et al.  Clinical and histological characterization of liver disease in patients with transfusion-dependent β-thalassemia . A multicenter study of 117 cases , 2004 .

[85]  Richter Gw.  The iron-loaded cell--the cytopathology of iron storage. A review. , 1978 .

[86]  O. Ernst,et al.  Hepatic iron overload: diagnosis and quantification with MR imaging. , 1997, AJR. American journal of roentgenology.

[87]  Thomas D. Coates,et al.  Cardiac Iron Determines Cardiac T2*, T2, and T1 in the Gerbil Model of Iron Cardiomyopathy , 2005, Circulation.

[88]  K. Stüben,et al.  Multigrid methods: Fundamental algorithms, model problem analysis and applications , 1982 .