Cholesteryl Ester Transfer Protein (CETP) Genetic Variation and Early Onset of Non‐Fatal Myocardial Infarction

Although Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesteryl esters and triglycerides between lipoprotein particles and thus plays a crucial role in reverse cholesterol transport, the association of variations in the CETP gene with acute myocardial infarction (MI) remains unclear. In this study we examined whether common genetic variation in the CETP gene is related to early‐onset non‐fatal MI risk in a population‐based case‐control study from western Washington State.

[1]  M. Khoury,et al.  Family History as a Risk Factor for Early-Onset Stroke/Transient Ischemic Attack among Adults in the United States , 2009, Public Health Genomics.

[2]  D. Siscovick,et al.  SREBP-2 and SCAP isoforms and risk of early onset myocardial infarction. , 2008, Atherosclerosis.

[3]  Lyle J. Palmer,et al.  Cholesteryl ester transfer protein gene haplotypes, plasma high-density lipoprotein levels and the risk of coronary heart disease , 2007, Human Genetics.

[4]  B. Wolffenbuttel,et al.  An increased coronary risk is paradoxically associated with common cholesteryl ester transfer protein gene variations that relate to higher high-density lipoprotein cholesterol: a population-based study. , 2006, The Journal of clinical endocrinology and metabolism.

[5]  A. V. van Roon,et al.  Plasma cholesteryl ester transfer is a determinant of intima-media thickness in type 2 diabetic and nondiabetic subjects: role of CETP and triglycerides. , 2005, Diabetes.

[6]  Johnf . Thompson,et al.  CETP polymorphisms associated with HDL cholesterol may differ from those associated with cardiovascular disease. , 2005, Atherosclerosis.

[7]  J. Kastelein,et al.  A review of CETP and its relation to atherosclerosis Published, JLR Papers in Press, September 1, 2004. DOI 10.1194/jlr.R400007-JLR200 , 2004, Journal of Lipid Research.

[8]  V. Herrera,et al.  Analysis of gender-specific atherosclerosis susceptibility in transgenic[hCETP]25DS rat model. , 2004, Atherosclerosis.

[9]  D. Cox,et al.  Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels , 2004, Human Genomics.

[10]  R. Peters,et al.  Plasma Levels of Cholesteryl Ester Transfer Protein and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women: The Prospective EPIC (European Prospective Investigation into Cancer and nutrition)–Norfolk Population Study , 2004, Circulation.

[11]  Nilesh J Samani,et al.  Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study. , 2004, European heart journal.

[12]  M Nauck,et al.  Haplotypes of the cholesteryl ester transfer protein gene predict lipid-modifying response to statin therapy , 2003, The Pharmacogenomics Journal.

[13]  N. Samani,et al.  A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study. , 2003, European heart journal.

[14]  Johnf . Thompson,et al.  Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease Published, JLR Papers in Press, March 16, 2003. DOI 10.1194/jlr.R200018-JLR200 , 2003, Journal of Lipid Research.

[15]  K. Roeder,et al.  Evolutionary‐based association analysis using haplotype data , 2003 .

[16]  F. Cambien,et al.  Common genetic variation of the cholesteryl ester transfer protein gene strongly predicts future cardiovascular death in patients with coronary artery disease. , 2003, Journal of the American College of Cardiology.

[17]  J. Reich,et al.  Single Nucleotide Polymorphism Haplotypes in the Cholesteryl-Ester Transfer Protein (CETP) Gene and Lipid Phenotypes , 2003, Human Heredity.

[18]  T. Okamura,et al.  Haplotype analyses of cholesteryl ester transfer protein gene promoter: a clue to an unsolved mystery of TaqIB polymorphism , 2003, Journal of Molecular Medicine.

[19]  A. Zwinderman,et al.  Haplotype analysis of the CETP gene: not TaqIB, but the closely linked -629C-->A polymorphism and a novel promoter variant are independently associated with CETP concentration. , 2003, Human molecular genetics.

[20]  Kathryn Roeder,et al.  Evolutionary‐based association analysis using haplotype data , 2003, Genetic epidemiology.

[21]  Laurent Essioux,et al.  Common haplotypes in five genes influence genetic variance of LDL and HDL cholesterol in the general population. , 2002, Human molecular genetics.

[22]  D. Schaid,et al.  Score tests for association between traits and haplotypes when linkage phase is ambiguous. , 2002, American journal of human genetics.

[23]  A. Rantala,et al.  Variation at the cholesteryl ester transfer protein gene in relation to plasma high density lipoproteins cholesterol levels and carotid intima‐media thickness , 2001, European journal of clinical investigation.

[24]  M. Xiong,et al.  Haplotypes vs single marker linkage disequilibrium tests: what do we gain? , 2001, European Journal of Human Genetics.

[25]  P. Donnelly,et al.  A new statistical method for haplotype reconstruction from population data. , 2001, American journal of human genetics.

[26]  B. Nordestgaard,et al.  Common Cholesteryl Ester Transfer Protein Mutations, Decreased HDL Cholesterol, and Possible Decreased Risk of Ischemic Heart Disease: The Copenhagen City Heart Study , 2000, Circulation.

[27]  K. Wakitani,et al.  A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits , 2000, Nature.

[28]  L Tiret,et al.  Extensive association analysis between the CETP gene and coronary heart disease phenotypes reveals several putative functional polymorphisms and gene‐environment interaction , 2000, Genetic epidemiology.

[29]  P. Wilson,et al.  Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[30]  F. Cambien,et al.  New functional promoter polymorphism, CETP/-629, in cholesteryl ester transfer protein (CETP) gene related to CETP mass and high density lipoprotein cholesterol levels: role of Sp1/Sp3 in transcriptional regulation. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[31]  V. Gudnason,et al.  Cholesteryl ester transfer protein gene effect on CETP activity and plasma high‐density lipoprotein in European populations , 1999, European journal of clinical investigation.

[32]  W D Plummer,et al.  Power and sample size calculations for studies involving linear regression. , 1998, Controlled clinical trials.

[33]  C. G. Stevenson.  Cholesterol ester transfer protein: a molecule with three faces? , 1998, Critical reviews in clinical laboratory sciences.

[34]  J. F. Thompson,et al.  Sequencing of the cholesteryl ester transfer protein 5' regulatory region using artificial transposons. , 1997, Gene.

[35]  H. Kothari,et al.  Inhibition of cholesterol ester transfer protein CGS 25159 and changes in lipoproteins in hamsters. , 1997, Atherosclerosis.

[36]  A. Tall,et al.  Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels. , 1996, The Journal of clinical investigation.

[37]  R. Havel,et al.  Cholesteryl ester transfer protein: friend or foe? , 1996, The Journal of clinical investigation.

[38]  S. Kihara,et al.  Atherosclerotic disease in marked hyperalphalipoproteinemia. Combined reduction of cholesteryl ester transfer protein and hepatic triglyceride lipase. , 1995, Arteriosclerosis, thrombosis, and vascular biology.

[39]  A. Tall,et al.  Cholesteryl ester transfer proteins, reverse cholesterol transport, and atherosclerosis , 1995, Current Opinion in Lipidology.

[40]  L H Kuller,et al.  Surveillance and ascertainment of cardiovascular events. The Cardiovascular Health Study. , 1995, Annals of epidemiology.

[41]  E. Boerwinkle,et al.  A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. I. Basic theory and an analysis of alcohol dehydrogenase activity in Drosophila. , 1987, Genetics.

[42]  C. Fielding,et al.  Cloning and sequencing of human cholesteryl ester transfer protein cDNA , 1987, Nature.

[43]  W. Kannel,et al.  Predicting coronary heart disease in siblings--a multivariate assessment: the Framingham Heart Study. , 1982, American journal of epidemiology.

[44]  C. Carlson,et al.  Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. , 2004, American journal of human genetics.

[45]  Zhu Yan.  Association of cholesteryl ester transfer protein TaqIB polymorphism with blood lipid profile , 2004 .

[46]  V. Gudnason,et al.  Cholesteryl ester transfer protein gene effect on CETP activity and plasma high-density lipoprotein in European populations. The EARS Group. , 1999, European journal of clinical investigation.