Potential cellular and molecular causes of hypertrophic scar formation.

[1]  David Julius,et al.  Cellular and Molecular Mechanisms of Pain , 2009, Cell.

[2]  Ihor V. Yosypiv.  A new role for the renin-angiotensin system in the development of the ureteric bud and renal collecting system. , 2008, The Keio journal of medicine.

[3]  C. Hellerbrand,et al.  Hepatic stellate cells display a functional vascular smooth muscle cell phenotype in a three-dimensional co-culture model with endothelial cells. , 2008, Differentiation; research in biological diversity.

[4]  P. Dziewulski,et al.  The relationship between protease/anti-protease profile, angiogenesis and re-epithelialisation in acute burn wounds. , 2008, Burns : journal of the International Society for Burn Injuries.

[5]  T. Wynn,et al.  Cellular and molecular mechanisms of fibrosis , 2008, The Journal of pathology.

[6]  P. Murphy,et al.  Chemokine Receptor CX3CR1 Mediates Skin Wound Healing by Promoting Macrophage and Fibroblast Accumulation and Function1 , 2008, The Journal of Immunology.

[7]  S. Myers,et al.  Epidermal repair results from activation of follicular and epidermal progenitor keratinocytes mediated by a growth factor cascade , 2007, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[8]  Ichiro Ono,et al.  Basic fibroblast growth factor reduces scar formation in acute incisional wounds , 2007, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[9]  Ye-yang Li,et al.  Recombinant human decorin inhibits cell proliferation and downregulates TGF-beta1 production in hypertrophic scar fibroblasts. , 2007, Burns : journal of the International Society for Burn Injuries.

[10]  D. Greenhalgh,et al.  Cutaneous Wound Healing , 2007, Journal of burn care & research : official publication of the American Burn Association.

[11]  E. Middelkoop,et al.  Expression profile of proteins involved in scar formation in the healing process of full‐thickness excisional wounds in the porcine model , 2007, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[12]  C. Heldin,et al.  Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. , 2007, The Biochemical journal.

[13]  Sabine Werner,et al.  Keratinocyte-fibroblast interactions in wound healing. , 2007, The Journal of investigative dermatology.

[14]  I. Ono,et al.  Basic fibroblast growth factor in an artificial dermis promotes apoptosis and inhibits expression of α‐smooth muscle actin, leading to reduction of wound contraction , 2007, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[15]  Z. Shayan,et al.  Dermatology Life Quality Index (DLQI) Scores in Burn Victims After Revival , 2007, Journal of burn care & research : official publication of the American Burn Association.

[16]  R. Ogawa,et al.  Variations in Gap Junctional Intercellular Communication and Connexin Expression in Fibroblasts Derived from Keloid and Hypertrophic Scars , 2007, Plastic and reconstructive surgery.

[17]  B. Hinz.  Formation and function of the myofibroblast during tissue repair. , 2007, The Journal of investigative dermatology.

[18]  L. Glimcher,et al.  Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13 , 2007, Proceedings of the National Academy of Sciences.

[19]  J. Mathis,et al.  Effect of adenoviral mediated overexpression of fibromodulin on human dermal fibroblasts and scar formation in full-thickness incisional wounds , 2007, Journal of Molecular Medicine.

[20]  A. Mukhopadhyay,et al.  Epithelial–mesenchymal interactions in keloid pathogenesis modulate vascular endothelial growth factor expression and secretion , 2007, The Journal of pathology.

[21]  P. Milazzo,et al.  Low-dose enalapril in the treatment of surgical cutaneous hypertrophic scar and keloid--two case reports and literature review. , 2006, MedGenMed : Medscape general medicine.

[22]  Glenn D Prestwich,et al.  Molecular stenting with a crosslinked hyaluronan derivative inhibits collagen gel contraction. , 2006, The Journal of investigative dermatology.

[23]  V. Kaartinen,et al.  Transforming growth factor‐β3 affects plasminogen activator inhibitor‐1 expression in fetal mice and modulates fibroblast‐mediated collagen gel contraction , 2006, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[24]  T. Krieg,et al.  Molecular mechanisms of VEGF-A action during tissue repair. , 2006, The journal of investigative dermatology. Symposium proceedings.

[25]  K. Chayama,et al.  Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis. , 2006, Biochemical and biophysical research communications.

[26]  A. Mukhopadhyay,et al.  Upregulation of secretory connective tissue growth factor (CTGF) in keratinocyte‐fibroblast coculture contributes to keloid pathogenesis , 2006, Journal of cellular physiology.

[27]  D. Steed.  Clinical Evaluation of Recombinant Human Platelet-Derived Growth Factor for the Treatment of Lower Extremity Ulcers , 2006, Plastic and reconstructive surgery.

[28]  D. Heffernan,et al.  Local arginine supplementation results in sustained wound nitric oxide production and reductions in vascular endothelial growth factor expression and granulation tissue formation. , 2006, The Journal of surgical research.

[29]  Shi-rong Li,et al.  [Influence of substance P on the release of histamine in the human hypertrophic scar tissue]. , 2006, Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.

[30]  K. Sayama,et al.  A Novel Function of Angiotensin II in Skin Wound Healing , 2006, Journal of Biological Chemistry.

[31]  P. Koolwijk,et al.  Fibrin structure and wound healing , 2006, Journal of thrombosis and haemostasis : JTH.

[32]  L. Claesson‐Welsh,et al.  VEGF receptor signalling ? in control of vascular function , 2006, Nature Reviews Molecular Cell Biology.

[33]  A. Hirano,et al.  The Quality of Pediatric Burn Scars Is Improved by Early Administration of Basic Fibroblast Growth Factor , 2006, Journal of burn care & research : official publication of the American Burn Association.

[34]  Glenn D Prestwich,et al.  Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing. , 2006, Tissue engineering.

[35]  Chung-Hyun Cho,et al.  COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[36]  M. Delehanty,et al.  Polarized Th2 cytokine production in patients with hypertrophic scar following thermal injury. , 2006, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[37]  U. Mrowietz,et al.  Quality of life of patients with keloid and hypertrophic scarring , 2006, Archives of Dermatological Research.

[38]  C A Harrison,et al.  Investigation of keratinocyte regulation of collagen I synthesis by dermal fibroblasts in a simple in vitro model , 2006, The British journal of dermatology.

[39]  Shinji Takai,et al.  Cutaneous tissue angiotensin-converting enzyme may participate in pathologic scar formation in human skin. , 2006, Journal of the American Academy of Dermatology.

[40]  L. DiPietro,et al.  Novel function for vascular endothelial growth factor receptor-1 on epidermal keratinocytes. , 2005, The American journal of pathology.

[41]  M. Longaker,et al.  Hypertrophic Scar Fibroblasts Have Increased Connective Tissue Growth Factor Expression after Transforming Growth Factor-β Stimulation , 2005, Plastic and reconstructive surgery.

[42]  D. Brenner,et al.  Liver fibrogenesis: a new role for the renin-angiotensin system. , 2005, Antioxidants & redox signaling.

[43]  Qin Yu,et al.  The dynamic roles of angiopoietins in tumor angiogenesis. , 2005, Future oncology.

[44]  A. Ghahary,et al.  Identification of fibrocytes in postburn hypertrophic scar , 2005, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[45]  C. Linge,et al.  Hypertrophic scar cells fail to undergo a form of apoptosis specific to contractile collagen-the role of tissue transglutaminase. , 2005, The Journal of investigative dermatology.

[46]  T. Huizinga,et al.  Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels. , 2005, Biochimica et biophysica acta.

[47]  S. Dooley,et al.  Abrogation of Transforming Growth Factor-β Signaling by SMAD7 Inhibits Collagen Gel Contraction of Human Dermal Fibroblasts* , 2005, Journal of Biological Chemistry.

[48]  Bishara S Atiyeh,et al.  Keloid or Hypertrophic Scar: The Controversy: Review of the Literature , 2005, Annals of plastic surgery.

[49]  C. Baum,et al.  Normal Cutaneous Wound Healing: Clinical Correlation with Cellular and Molecular Events , 2005, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[50]  S. Werner,et al.  Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts , 2005, Journal of Cell Science.

[51]  K. Hajjar,et al.  Molecular mechanisms of fibrinolysis , 2005, British journal of haematology.

[52]  K. Rodgers,et al.  Effect of NorLeu3‐A(1‐7) on scar formation over time after full‐thickness incision injury in the rat , 2005, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[53]  V. Moulin,et al.  Epidermis promotes dermal fibrosis: role in the pathogenesis of hypertrophic scars , 2005, The Journal of pathology.

[54]  T. Huizinga,et al.  The type of collagen cross-link determines the reversibility of experimental skin fibrosis. , 2005, Biochimica et biophysica acta.

[55]  M. Stacey,et al.  Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone marrow. , 2005, Experimental cell research.

[56]  M. Tomic-Canic,et al.  Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing , 2005, Biology of the cell.

[57]  A. Desmoulière,et al.  Perspective Article: Tissue repair, contraction, and the myofibroblast , 2005, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[58]  M. Yamauchi,et al.  Overexpression of Lysyl Hydroxylase‐2b Leads to Defective Collagen Fibrillogenesis and Matrix Mineralization , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[59]  S. Werner,et al.  Wound-healing studies in transgenic and knockout mice , 2004, Molecular biotechnology.

[60]  M. Longaker,et al.  Complex epithelial–mesenchymal interactions modulate transforming growth factor‐β expression in keloid‐derived cells , 2004, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[61]  M. Yamauchi,et al.  Lysyl Hydroxylase‐2b Directs Collagen Cross‐Linking Pathways in MC3T3‐E1 Cells , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[62]  T. Wynn.  Fibrotic disease and the TH1/TH2 paradigm , 2004, Nature Reviews Immunology.

[63]  E. Middelkoop,et al.  Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon. , 2004, Matrix biology : journal of the International Society for Matrix Biology.

[64]  G. Kirfel,et al.  Migration of epidermal keratinocytes: mechanisms, regulation, and biological significance , 2004, Protoplasma.

[65]  H. Ehrlich,et al.  Mast cells promote fibroblast populated collagen lattice contraction through gap junction intercellular communication , 2004, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[66]  D. Grimm,et al.  Vascular endothelial growth factor serum level is strongly enhanced after burn injury and correlated with local and general tissue edema. , 2004, Burns : journal of the International Society for Burn Injuries.

[67]  Hui Xue,et al.  Gene expression profiles from hypertrophic scar fibroblasts before and after IL‐6 stimulation , 2004, The Journal of pathology.

[68]  K. Flanders,et al.  Smad3 as a mediator of the fibrotic response , 2004, International journal of experimental pathology.

[69]  T. Moore,et al.  Protection from Fluorescein Isothiocyanate-Induced Fibrosis in IL-13-Deficient, but Not IL-4-Deficient, Mice Results from Impaired Collagen Synthesis by Fibroblasts1 , 2004, The Journal of Immunology.

[70]  M. Hanasono,et al.  The effect of silicone gel on basic fibroblast growth factor levels in fibroblast cell culture. , 2004, Archives of facial plastic surgery.

[71]  V. Moulin,et al.  Normal skin wound and hypertrophic scar myofibroblasts have differential responses to apoptotic inductors , 2004, Journal of cellular physiology.

[72]  S. Miyagawa,et al.  Expression of p53 family in scars. , 2004, Journal of dermatological science.

[73]  W. Timens,et al.  Hypertrophic scar formation is associated with an increased number of epidermal Langerhans cells , 2004, The Journal of pathology.

[74]  R. Kalluri,et al.  Epithelial-mesenchymal transition and its implications for fibrosis. , 2003, The Journal of clinical investigation.

[75]  Tsuneki Sugihara,et al.  Keratinocytes promote proliferation and inhibit apoptosis of the underlying fibroblasts: an important role in the pathogenesis of keloid. , 2003, The Journal of investigative dermatology.

[76]  C. Wijmenga,et al.  Identification of PLOD2 as Telopeptide Lysyl Hydroxylase, an Important Enzyme in Fibrosis* , 2003, Journal of Biological Chemistry.

[77]  V. Hentz,et al.  Three-dimensional hyaluronic acid grafts promote healing and reduce scar formation in skin incision wounds. , 2003, Journal of biomedical materials research. Part B, Applied biomaterials.

[78]  Giulio Gabbiani,et al.  Mechanisms of force generation and transmission by myofibroblasts. , 2003, Current opinion in biotechnology.

[79]  D. Mercer,et al.  Identification, expression, and tissue distribution of the three rat lysyl hydroxylase isoforms. , 2003, Biochemical and biophysical research communications.

[80]  P. Coulombe,et al.  Wound Epithelialization: Accelerationg the Pace of Discovery , 2003 .

[81]  S. Werner,et al.  Regulation of wound healing by growth factors and cytokines. , 2003, Physiological reviews.

[82]  M. Stacey,et al.  Identification of Circulating Fibrocytes as Precursors of Bronchial Myofibroblasts in Asthma1 , 2003, The Journal of Immunology.

[83]  A. Nakao,et al.  IFN-γ fails to antagonize fibrotic effect of TGF-β on keloid-derived dermal fibroblasts , 2003 .

[84]  W. Laug,et al.  Increased plasminogen activator inhibitor-1 in keloid fibroblasts may account for their elevated collagen accumulation in fibrin gel cultures. , 2003, The American journal of pathology.

[85]  K. Flanders,et al.  Smad3: A Key Player in Pathogenetic Mechanisms Dependent on TGF‐β , 2003, Annals of the New York Academy of Sciences.

[86]  B. Gruber.  Mast cells in the pathogenesis of fibrosis , 2003, Current rheumatology reports.

[87]  M. Giacca,et al.  Effect of recombinant adeno-associated virus vector-mediated vascular endothelial growth factor gene transfer on wound healing after burn injury* , 2003, Critical care medicine.

[88]  K. Rodgers,et al.  Acceleration of healing, reduction of fibrotic scar, and normalization of tissue architecture by an angiotensin analogue, NorLeu3-A(1-7). , 2003, Plastic and reconstructive surgery.

[89]  R. Groves,et al.  Increased migration of murine keratinocytes under hypoxia is mediated by induction of urokinase plasminogen activator. , 2002, The Journal of investigative dermatology.

[90]  F. Yeh,et al.  Deficient transforming growth factor beta and interleukin-10 responses contribute to the septic death of burned patients. , 2002, Burns : journal of the International Society for Burn Injuries.

[91]  J. Giuffre,et al.  Peripheral Blood Fibrocytes from Burn Patients: Identification and Quantification of Fibrocytes in Adherent Cells Cultured from Peripheral Blood Mononuclear Cells , 2002, Laboratory Investigation.

[92]  C. V. van Blitterswijk,et al.  Effect of fibroblasts on epidermal regeneration , 2002, The British journal of dermatology.

[93]  T. Ling,et al.  Synthetic TGF‐β antagonist accelerates wound healing and reduces scarring , 2002 .

[94]  Hung Huynh,et al.  Fibroblasts cocultured with keloid keratinocytes: normal fibroblasts secrete collagen in a keloidlike manner. , 2002, American journal of physiology. Cell physiology.

[95]  S. Cross,et al.  Angiogenesis induction and regression in human surgical wounds , 2002, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[96]  James B. Mitchell,et al.  Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. , 2002, The American journal of pathology.

[97]  Hans Kresse,et al.  Proteoglycans of the extracellular matrix and growth control , 2001, Journal of cellular physiology.

[98]  J. Gailit,et al.  The differentiation and function of myofibroblasts is regulated by mast cell mediators. , 2001, The Journal of investigative dermatology.

[99]  Y. Akasaka,et al.  Detection of apoptosis in keloids and a comparative study on apoptosis between keloids, hypertrophic scars, normal healed flat scars, and dermatofibroma , 2001, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[100]  A. Ghahary,et al.  Myofibroblasts and apoptosis in human hypertrophic scars: the effect of interferon-alpha2b. , 2001, Surgery.

[101]  D. Graves,et al.  IL-1 Plays a Critical Role in Oral, But Not Dermal, Wound Healing , 2001, The Journal of Immunology.

[102]  A. Cowin,et al.  Expression of TGF-beta and its receptors in murine fetal and adult dermal wounds. , 2001, European journal of dermatology : EJD.

[103]  M. A. Croce,et al.  Hyaluronan affects protein and collagen synthesis by in vitro human skin fibroblasts. , 2001, Tissue & cell.

[104]  J. Davidson,et al.  Wound-healing defects in mice lacking fibrinogen. , 2001, Blood.

[105]  W. Timens,et al.  Keratinocyte‐derived growth factors play a role in the formation of hypertrophic scars , 2001, The Journal of pathology.

[106]  RICHARD A.F. CLARK,et al.  Fibrin and Wound Healing , 2001 .

[107]  M. Tomic-Canic,et al.  Keratins and the keratinocyte activation cycle. , 2001, The Journal of investigative dermatology.

[108]  N. Fusenig,et al.  Organotypic cocultures with genetically modified mouse fibroblasts as a tool to dissect molecular mechanisms regulating keratinocyte growth and differentiation. , 2001, The Journal of investigative dermatology.

[109]  L. Hang,et al.  Interleukin-8 receptor knockout mice have subepithelial neutrophil entrapment and renal scarring following acute pyelonephritis. , 2000, The Journal of infectious diseases.

[110]  N. Fusenig,et al.  c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin , 2000, Cell.

[111]  Gina A. Taylor,et al.  Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis , 2000, Cell.

[112]  M. Longaker,et al.  Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair. , 2000, The American journal of pathology.

[113]  T. Crombleholme,et al.  Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair. , 2000, Journal of pediatric surgery.

[114]  A. Ghahary,et al.  Hypertrophic scar tissues and fibroblasts produce more transforming growth factor‐β1 mRNA and protein than normal skin and cells , 2000, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[115]  A. Ghahary,et al.  Delayed appearance of decorin in healing burn scars , 2000, Histopathology.

[116]  Gary R. Grotendorst,et al.  Connective tissue growth factor mediates transforming growth factor β‐induced collagen synthesis: down‐regulation by cAMP , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[117]  M Kon,et al.  On the nature of hypertrophic scars and keloids: a review. , 1999, Plastic and reconstructive surgery.

[118]  M. Robson,et al.  Effect of TGF-beta2 on proliferative scar fibroblast cell kinetics. , 1999, Annals of plastic surgery.

[119]  C. Castagnoli,et al.  Expression and role of IL-15 in post-burn hypertrophic scars. , 1999, The Journal of investigative dermatology.

[120]  R. Kiss,et al.  Critical roles for IL-4, IL-5, and eosinophils in chronic skin allograft rejection. , 1999, The Journal of clinical investigation.

[121]  T. H. van der Kwast,et al.  Epidermal participation in post-burn hypertrophic scar development , 1999, Virchows Archiv.

[122]  G. Abatangelo,et al.  Functions of hyaluronan in wound repair , 1999, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[123]  W. L. Lin,et al.  Changes in circulating levels of interleukin 6 in burned patients. , 1999, Burns : journal of the International Society for Burn Injuries.

[124]  A. Kayıkçıoğlu,et al.  A new flap model in the rat: the pectoral skin flap. , 1999, Annals of plastic surgery.

[125]  M. Kon,et al.  The Use of Silicone Occlusive Sheeting (Sil‐K) and Silicone Occlusive Gel (Epiderm) in the Prevention of Hypertrophic Scar Formation , 1998, Plastic and reconstructive surgery.

[126]  L. Díaz de León,et al.  Cytokine expression is downregulated by collagen-polyvinylpyrrolidone in hypertrophic scars. , 1998, The Journal of investigative dermatology.

[127]  P. C. van de Kerkhof,et al.  Hypertrophic scarring is associated with epidermal abnormalities: an immunohistochemical study , 1998, The Journal of pathology.

[128]  A. Ghahary,et al.  Transforming growth factor-β in thermally injured patients with hypertrophic scars : Effects of interferon α-2b , 1998 .

[129]  G. Canonica,et al.  IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts. , 1998, International immunology.

[130]  F. Jirik,et al.  Anti‐IL‐4 treatment prevents dermal collagen deposition in the tight‐skin mouse model of scleroderma , 1998, European journal of immunology.

[131]  D. Greenhalgh,et al.  The role of apoptosis in wound healing. , 1998, The international journal of biochemistry & cell biology.

[132]  G. Saed,et al.  Analysis of p53 gene mutations in keloids using polymerase chain reaction-based single-strand conformational polymorphism and DNA sequencing. , 1998, Archives of dermatology.

[133]  W. Garner,et al.  Epidermal Regulation of Dermal Fibroblast Activity , 1998, Plastic and reconstructive surgery.

[134]  R. C. Lee,et al.  The problem scar. , 1998, Clinics in plastic surgery.

[135]  P. Gallagher,et al.  Mast cells in pathological and surgical scars , 1998, The British journal of ophthalmology.

[136]  I. Leigh,et al.  Activated keratinocytes in the epidermis of hypertrophic scars. , 1998, The American journal of pathology.

[137]  A. Ghahary,et al.  Fibroblasts from post-burn hypertrophic scar tissue synthesize less decorin than normal dermal fibroblasts. , 1998, Clinical science.

[138]  M. Robson,et al.  Differential production of apoptosis-modulating proteins in patients with hypertrophic burn scar. , 1998, The Journal of surgical research.

[139]  George,et al.  Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar. , 1998, The American journal of pathology.

[140]  R. Bucala,et al.  Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes. , 1998, Journal of immunology.

[141]  C. Castagnoli,et al.  Characterization of T-cell subsets infiltrating post-burn hypertrophic scar tissues. , 1997, Burns : journal of the International Society for Burn Injuries.

[142]  A. Ghahary,et al.  Determination of plasma Nτ-methylhistamine in vivo by isotope dilution using benchtop gas chromatography-mass spectrometry , 1997 .

[143]  Paul Martin,et al.  Wound Healing--Aiming for Perfect Skin Regeneration , 1997, Science.

[144]  R. Clark,et al.  Fibronectin provides a conduit for fibroblast transmigration from collagenous stroma into fibrin clot provisional matrix. , 1997, Journal of cell science.

[145]  R. Jaenisch,et al.  Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[146]  E. Zycband,et al.  Collagen fibrillogenesis in situ: Fibril segments become long fibrils as the developing tendon matures , 1997, Developmental dynamics : an official publication of the American Association of Anatomists.

[147]  Gary R. Grotendorst,et al.  Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. , 1996, The Journal of investigative dermatology.

[148]  D. Young,et al.  Species-specific in situ hybridization with fluorochrome-labeled DNA probes to study vascularization of human skin grafts on athymic mice. , 1996, The Journal of burn care & rehabilitation.

[149]  T. Moriguchi,et al.  Reduced collagenase gene expression in fibroblasts from hypertrophic scar tissue , 1996, The British journal of dermatology.

[150]  F. Levi-Schaffer,et al.  The role of mast cell-derived histamine in the closure of an in vitro wound , 1996, Inflammation Research.

[151]  C. Jun,et al.  Control of scarring in adult wounds using antisense transforming growth factor‐β1 oligodeoxynucleotides , 1996, Immunology and cell biology.

[152]  Gary R. Grotendorst,et al.  Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. , 1996, The Journal of investigative dermatology.

[153]  A. Ghahary,et al.  Collagenase production is lower in post-burn hypertrophic scar fibroblasts than in normal fibroblasts and is reduced by insulin-like growth factor-1. , 1996, The Journal of investigative dermatology.

[154]  S. Phan,et al.  Increased types I and III collagen and transforming growth factor-beta 1 mRNA and protein in hypertrophic burn scar. , 1995, The Journal of investigative dermatology.

[155]  A. Ghahary,et al.  Immunohistochemical localization of the proteoglycans decorin, biglycan and versican and transforming growth factor‐β in human post‐burn hypertrophic and mature scars , 1995, Histopathology.

[156]  F. Maquart,et al.  Stimulation of sulphated glycosaminoglycan and decorin production in adult dermal fibroblasts by recombinant human interleukin-4. , 1995, The Biochemical journal.

[157]  D. Foreman,et al.  Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. , 1995, Journal of cell science.

[158]  H. Lorenz,et al.  A model of scarless human fetal wound repair is deficient in transforming growth factor beta. , 1995, Journal of pediatric surgery.

[159]  R. Bucala,et al.  Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair , 1994, Molecular medicine.

[160]  I. K. Cohen,et al.  Morphological and immunochemical differences between keloid and hypertrophic scar. , 1994, The American journal of pathology.

[161]  T. Wong,et al.  Intralesional interferon α‐2b has no effect in the treatment of keloids , 1994 .

[162]  D. Heimbach,et al.  Basic fibroblast growth factor in the early human burn wound. , 1994, The Journal of surgical research.

[163]  David J. Smith,et al.  Phenotypic differences in cytokine responsiveness of hypertrophic scar versus normal dermal fibroblasts. , 1993, The Journal of investigative dermatology.

[164]  P. Hebda,et al.  Mast cell and myofibroblast in wound healing. , 1993, Dermatologic clinics.

[165]  M. Heckmann,et al.  Biphasic effects of interleukin-1 alpha on dermal fibroblasts: enhancement of chemotactic responsiveness at low concentrations and of mRNA expression for collagenase at high concentrations. , 1993, The Journal of investigative dermatology.

[166]  D. Olivieri,et al.  Mast cells in fibrotic lung disorders. , 1993, Chest.

[167]  J. Engel,et al.  Polymerization of pNcollagen I and copolymerization of pNcollagen I with collagen I. A kinetic, thermodynamic, and morphologic study. , 1992, The Journal of biological chemistry.

[168]  I. Maruyama,et al.  Marked increase in plasma interleukin-6 in burn patients. , 1992, The Journal of laboratory and clinical medicine.

[169]  H. Katai,et al.  Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. , 1992, The Journal of clinical investigation.

[170]  C. Sumners,et al.  Changes in skin angiotensin II receptors in rats during wound healing. , 1992, Biochemical and biophysical research communications.

[171]  J. Banchereau,et al.  Interleukin-4 stimulates collagen synthesis by normal and scleroderma fibroblasts in dermal equivalents. , 1992, Cellular and molecular biology.

[172]  F. Arnold,et al.  Angiogenesis in wound healing. , 1991, Pharmacology & therapeutics.

[173]  F. Kerdel,et al.  The Mast Cell in Fibrosis , 1991, International journal of dermatology.

[174]  E. Ruoslahti,et al.  Negative regulation of transforming growth factor-β by the proteoglycan decorin , 1990, Nature.

[175]  B. Magun,et al.  Cellular Mechanisms of TGF-β Action , 1990 .

[176]  J. Spencer,et al.  Immunoproliferative small-intestinal disease. An immunohistochemical study. , 1989, The American journal of surgical pathology.

[177]  J. Seyer,et al.  Modulation of fibroblast functions by interleukin 1: increased steady- state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 alpha and beta , 1988, The Journal of cell biology.

[178]  J. Elias,et al.  Synergistic stimulation of fibroblast prostaglandin production by recombinant interleukin 1 and tumor necrosis factor. , 1987, Journal of immunology.

[179]  C. J. Smith,et al.  The possible role of mast cells (allergy) in the production of keloid and hypertrophic scarring. , 1987, The Journal of burn care & rehabilitation.

[180]  R. Clark,et al.  Mast cells and fibrosis. , 1987, Archives of dermatology.

[181]  M. Khatami,et al.  Stimulation of Retinal Capillary Pericyte Protein and Collagen Synthesis in Culture by High-Glucose Concentration , 1984, Diabetes.

[182]  T. Koob,et al.  Quantitation of hydroxypyridinium crosslinks in collagen by high-performance liquid chromatography. , 1984, Analytical biochemistry.

[183]  E. Deitch,et al.  Hypertrophic burn scars: analysis of variables. , 1983, The Journal of trauma.

[184]  T. Hayakawa,et al.  Changes in type of collagen during the development of human post-burn hypertrophic scars. , 1979, Clinica chimica acta; international journal of clinical chemistry.

[185]  T. Moriguchi,et al.  Crosslink of collagen in hypertrophic scar. , 1979, The Journal of investigative dermatology.

[186]  C. H. Wells,et al.  TISSUE GASES IN HUMAN HYPERTROPHIC BURN SCARS , 1978, Plastic and reconstructive surgery.

[187]  T. E. Miller,et al.  Analysis of Variables , 2008 .

[188]  R. Puri,et al.  IL-13 signaling through the IL-13α2 receptor is involved in induction of TGF-β1 production and fibrosis , 2006, Nature Medicine.

[189]  R. Puri,et al.  IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. , 2006, Nature medicine.

[190]  T. Seki,et al.  An Immunohistochemical Study , 2006 .

[191]  T. Wess,et al.  Collagen fibril form and function. , 2005, Advances in protein chemistry.

[192]  A. Bayat,et al.  Studies of transforming growth factors beta 1-3 and their receptors I and II in fibroblast of keloids and hypertrophic scars. , 2005, Acta dermato-venereologica.

[193]  C. Svanborg,et al.  Natural history of renal scarring in susceptible mIL-8Rh-/- mice. , 2005, Kidney international.

[194]  D. Brigstock.  Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61) , 2004, Angiogenesis.

[195]  T. Wynn.  Fibrotic disease and the T(H)1/T(H)2 paradigm. , 2004, Nature reviews. Immunology.

[196]  Luís Cristóvão Porto,et al.  Vascularization pattern in hypertrophic scars and keloids: a stereological analysis. , 2003, Pathology, research and practice.

[197]  P. Coulombe,et al.  Wound epithelialization: accelerating the pace of discovery. , 2003, The Journal of investigative dermatology.

[198]  A. Nakao,et al.  IFN-gamma fails to antagonize fibrotic effect of TGF-beta on keloid-derived dermal fibroblasts. , 2003, Journal of dermatological science.

[199]  T. Ling,et al.  Synthetic TGF-beta antagonist accelerates wound healing and reduces scarring. , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[200]  R. Coffman,et al.  Interleukin-10 and the interleukin-10 receptor. , 2001, Annual review of immunology.

[201]  Gary R. Grotendorst,et al.  Connective tissue growth factor mediates transforming growth factor b-induced collagen synthesis : down-regulation by cAMP , 1999 .

[202]  A. Desmoulière,et al.  Apoptosis during wound healing, fibrocontractive diseases and vascular wall injury. , 1997, The international journal of biochemistry & cell biology.

[203]  M. Longaker,et al.  Fibrotic healing of adult and late gestation fetal wounds correlates with increased hyaluronidase activity and removal of hyaluronan. , 1997, The international journal of biochemistry & cell biology.

[204]  S. Galli,et al.  Promotion of mouse fibroblast proliferation by IgE-dependent activation of mouse mast cells: Role for mast cell tumor necrosis factor-α and transforming growth factor-β1 , 1997 .

[205]  A. Ghahary,et al.  Determination of plasma Ntau-methylhistamine in vivo by isotope dilution using benchtop gas chromatography-mass spectrometry. , 1997, Journal of chromatography. B, Biomedical sciences and applications.

[206]  D. Steed.  Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity diabetic ulcers. Diabetic Ulcer Study Group. , 1995, Journal of vascular surgery.

[207]  Melinda Fitzgerald,et al.  Immunol. Cell Biol. , 1995 .

[208]  T. Wong,et al.  Intralesional interferon alpha-2b has no effect in the treatment of keloids. , 1994, The British journal of dermatology.

[209]  E. Ruoslahti,et al.  Negative regulation of transforming growth factor-beta by the proteoglycan decorin. , 1990, Nature.

[210]  P. Scuderi,et al.  Increased fibronectin production by cell lines from hypertrophic scar and keloid. , 1989, Connective tissue research.

[211]  J. Wrana,et al.  Transforming growth factor-beta regulation of collagenase, 72 kDa-progelatinase, TIMP and PAI-1 expression in rat bone cell populations and human fibroblasts. , 1989, Connective tissue research.

[212]  C. Kischer,et al.  Hypertrophic scars and keloids: a review and new concept concerning their origin. , 1982, Scanning electron microscopy.

[213]  R. Frank,et al.  Collagen production by cultured retinal capillary pericytes. , 1980, Investigative ophthalmology & visual science.

[214]  J. Galloway,et al.  A Review of the , 1901 .