CT and MRI Rating of White Matter Lesions

Rating scales play an important role in the evaluation of computed tomography (CT) or magnetic resonance-detected white matter lesions (WML). Unfortunately, this type of visual semiquantitative assessment is not yet an optimal tool because commonly agreed concepts regarding its use are lacking. To generate a discussion platform for further improvement of CT and MRI rating, we will provide some basic definitions, summarize the advantages and disadvantages of scoring schemes and review current efforts towards the improvement of this tool. Future research will have to concentrate on deepening our understanding of the histopathologic substrates of WML and on strategies to document their progression.

[1]  F. Buonanno,et al.  Clinicopathologic correlations of cranial magnetic resonance imaging of periventricular white matter , 1990, Neurology.

[2]  P. Scheltens,et al.  Progression of cerebral white matter hyperintensities on MRI is related to diastolic blood pressure , 1998, Neurology.

[3]  P. Scheltens,et al.  A New Rating Scale for Age-Related White Matter Changes Applicable to MRI and CT , 2001, Stroke.

[4]  岩本俊彦.  Leuko-araiosis と血管性痴呆 , 1996 .

[5]  P M Moodie,et al.  COHORT , 1971, The Medical journal of Australia.

[6]  F. Barkhof,et al.  Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis , 1998, Neurology.

[7]  J A Frank,et al.  Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis , 1998, Annals of neurology.

[8]  Reinhold Schmidt,et al.  Pathophysiologic Mechanisms in the Development of Age-Related White Matter Changes of the Brain , 1998, Dementia and Geriatric Cognitive Disorders.

[9]  F. Barkhof,et al.  Histopathologic correlates of white matter changes on MRI in Alzheimer's disease and normal aging , 1995, Neurology.

[10]  Frederik Barkhof,et al.  White Matter Changes on CT and MRI: An Overview of Visual Rating Scales , 1998, European Neurology.

[11]  P. Koudstaal,et al.  Grading white matter lesions on CT and MRI: a simple scale. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[12]  O Salonen,et al.  Variable agreement between visual rating scales for white matter hyperintensities on MRI. Comparison of 13 rating scales in a poststroke cohort. , 1997, Stroke.

[13]  J. Garcìa,et al.  The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review. , 1995, Stroke.

[14]  F. Fazekas,et al.  Pathologic correlates of incidental MRI white matter signal hyperintensities , 1993, Neurology.

[15]  H. Bokura,et al.  Distinguishing silent lacunar infarction from enlarged Virchow-Robin spaces: a magnetic resonance imaging and pathological study , 1998, Journal of Neurology.