Neural melanocortin receptors in obesity and related metabolic disorders.

[1]  Linh Vong,et al.  Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons , 2013, Cell.

[2]  D. Marks,et al.  Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques , 2013, Diabetes.

[3]  T. Roux,et al.  Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons , 2013, Proceedings of the National Academy of Sciences.

[4]  S. Luquet,et al.  Hypothalamic AgRP‐neurons control peripheral substrate utilization and nutrient partitioning , 2012, The EMBO journal.

[5]  Iain J. Clarke,et al.  Neurochemical Characterization and Sexual Dimorphism of Projections from the Brain to Abdominal and Subcutaneous White Adipose Tissue in the Rat , 2012, The Journal of Neuroscience.

[6]  P. Even,et al.  Below Thermoneutrality, Changes in Activity Do Not Drive Changes in Total Daily Energy Expenditure between Groups of Mice , 2012, Cell metabolism.

[7]  J. Elmquist,et al.  From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior , 2012, Nature Neuroscience.

[8]  R. Cone,et al.  Melanocortin-3 receptor regulates the normal fasting response , 2012, Proceedings of the National Academy of Sciences.

[9]  J. Hebebrand,et al.  Rescue of Melanocortin 4 Receptor (MC4R) Nonsense Mutations by Aminoglycoside‐Mediated Read‐Through , 2012, Obesity.

[10]  L. Heisler,et al.  Melanocortin-3 receptors are involved in adaptation to restricted feeding , 2012, Genes, brain, and behavior.

[11]  Jong-Woo Sohn,et al.  Functional Heterogeneity of Arcuate Nucleus Pro-Opiomelanocortin Neurons: Implications for Diverging Melanocortin Pathways , 2012, Molecular Neurobiology.

[12]  M. Tschöp,et al.  MC4R Dimerization in the Paraventricular Nucleus and GHSR/MC3R Heterodimerization in the Arcuate Nucleus: Is There Relevance for Body Weight Regulation? , 2012, Neuroendocrinology.

[13]  A. Hollenberg,et al.  NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways. , 2011, Cell metabolism.

[14]  D. Marks,et al.  Genetic Dissection of the Functions of the Melanocortin-3 Receptor, a Seven-transmembrane G-protein-coupled Receptor, Suggests Roles for Central and Peripheral Receptors in Energy Homeostasis* , 2011, The Journal of Biological Chemistry.

[15]  W. Wurst,et al.  Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo , 2011, The Pharmacogenomics Journal.

[16]  A. Butler,et al.  Homeostastic and non-homeostatic functions of melanocortin-3 receptors in the control of energy balance and metabolism , 2011, Physiology & Behavior.

[17]  T. Schöneberg,et al.  Mutually Opposite Signal Modulation by Hypothalamic Heterodimerization of Ghrelin and Melanocortin-3 Receptors* , 2011, The Journal of Biological Chemistry.

[18]  Y. Shrestha,et al.  Characterization of a novel melanocortin receptor-containing node in the SNS outflow circuitry to brown adipose tissue involved in thermogenesis , 2011, Brain Research.

[19]  M. Cowley,et al.  Leptin Action in the Dorsomedial Hypothalamus Increases Sympathetic Tone to Brown Adipose Tissue in Spite of Systemic Leptin Resistance , 2011, The Journal of Neuroscience.

[20]  J. Elmquist,et al.  Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels , 2011, Neuron.

[21]  D. Pearce,et al.  Cardiovascular effects of melanocortins. , 2011, European journal of pharmacology.

[22]  J. Elmquist,et al.  Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network. , 2011, European journal of pharmacology.

[23]  R. Cone,et al.  Physiological roles of the melanocortin MC₃ receptor. , 2011, European journal of pharmacology.

[24]  F. Carvajal,et al.  Assessment of voluntary ethanol consumption and the effects of a melanocortin (MC) receptor agonist on ethanol intake in mutant C57BL/6J mice lacking the MC-4 receptor. , 2011, Alcoholism, clinical and experimental research.

[25]  M. Low.  Agnostic about in vivo inverse agonism of agouti-related peptide. , 2011, Endocrinology.

[26]  S. O’Rahilly,et al.  Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion. , 2011, The Journal of clinical endocrinology and metabolism.

[27]  A. Leckstrom,et al.  Central melanocortin receptor agonist reduces hepatic lipogenic gene expression in streptozotocin-induced diabetic mice. , 2011, Life sciences.

[28]  B. Roth,et al.  Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. , 2011, The Journal of clinical investigation.

[29]  S. O’Rahilly,et al.  Loss of Agouti-Related Peptide Does Not Significantly Impact the Phenotype of Murine POMC Deficiency , 2011, Endocrinology.

[30]  B. Lowell,et al.  Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. , 2011, Cell metabolism.

[31]  J. Greenfield,et al.  Melanocortin Signalling and the Regulation of Blood Pressure in Human Obesity , 2011, Journal of neuroendocrinology.

[32]  K. Clément,et al.  Rare melanocortin-3 receptor mutations with in vitro functional consequences are associated with human obesity. , 2011, Human molecular genetics.

[33]  T. Gudermann,et al.  Alternative G protein coupling and biased agonism: New insights into melanocortin-4 receptor signalling , 2011, Molecular and Cellular Endocrinology.

[34]  N. Rowland,et al.  Effect of MTII on food intake and brain c-Fos in melanocortin-3, melanocortin-4, and double MC3 and MC4 receptor knockout mice , 2010, Peptides.

[35]  A. Zinn,et al.  A Serotonin and Melanocortin Circuit Mediates d-Fenfluramine Anorexia , 2010, The Journal of Neuroscience.

[36]  R. Lovell-Badge,et al.  Nestin-Cre Mice Are Affected by Hypopituitarism, Which Is Not Due to Significant Activity of the Transgene in the Pituitary Gland , 2010, PloS one.

[37]  S. Woods,et al.  Melanocortin signaling in the CNS directly regulates circulating cholesterol , 2010, Nature Neuroscience.

[38]  S. Chua,et al.  An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption , 2010, Journal of Lipid Research.

[39]  B. Lowell,et al.  Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. , 2010, Cell metabolism.

[40]  L. Kozak.  Brown fat and the myth of diet-induced thermogenesis. , 2010, Cell metabolism.

[41]  J. Hebebrand,et al.  Sympathetic function in human carriers of melanocortin-4 receptor gene mutations. , 2010, The Journal of clinical endocrinology and metabolism.

[42]  M. Krawczak,et al.  Genetic studies of common types of obesity: a critique of the current use of phenotypes , 2010, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[43]  J. Gimble,et al.  Central nervous system melanocortin‐3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[44]  J. Elmquist,et al.  Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons , 2010, The Journal of Neuroscience.

[45]  S. Sternson,et al.  AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training , 2010, Nature Neuroscience.

[46]  S. O’Rahilly,et al.  Modulation of blood pressure by central melanocortinergic pathways. , 2009, The New England journal of medicine.

[47]  H. Grill,et al.  Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins. , 2009, Endocrinology.

[48]  G. Bray,et al.  Potent and Selective Agonism of the Melanocortin Receptor 4 With MK‐0493 Does Not Induce Weight Loss in Obese Human Subjects: Energy Intake Predicts Lack of Weight Loss Efficacy , 2009, Clinical pharmacology and therapeutics.

[49]  T. Horvath,et al.  Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons , 2009, Diabetes.

[50]  R. Mistlberger.  Food‐anticipatory circadian rhythms: concepts and methods , 2009, The European journal of neuroscience.

[51]  A. Butler,et al.  The role of melanocortin neuronal pathways in circadian biology: a new homeostatic output involving melanocortin‐3 receptors? , 2009, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[52]  D. Schoeller,et al.  Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor. , 2009, The American journal of clinical nutrition.

[53]  M. Culler,et al.  Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice , 2009, Peptides.

[54]  T. Gudermann,et al.  Pertussis Toxin-sensitive Signaling of Melanocortin-4 Receptors in Hypothalamic GT1-7 Cells Defines Agouti-related Protein as a Biased Agonist* , 2009, The Journal of Biological Chemistry.

[55]  O. Gavrilova,et al.  Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation. , 2009, Cell metabolism.

[56]  A. A. da Silva,et al.  A Functional Melanocortin System May Be Required for Chronic CNS-Mediated Antidiabetic and Cardiovascular Actions of Leptin , 2009, Diabetes.

[57]  A. Grüters,et al.  Heterodimerization of Hypothalamic G-Protein-Coupled Receptors Involved in Weight Regulation , 2009, Obesity Facts.

[58]  Wei Zhang,et al.  The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis , 2009, BMC public health.

[59]  L. Pennacchio,et al.  Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. , 2009, Human molecular genetics.

[60]  H. Münzberg,et al.  The geometry of leptin action in the brain: more complicated than a simple ARC. , 2009, Cell metabolism.

[61]  M. Humphreys,et al.  Abnormal glucose metabolism in hypertensive mice with genetically interrupted gamma-melanocyte stimulating hormone signaling fed a high-sodium diet. , 2008, American journal of hypertension.

[62]  R. Cone,et al.  The Melanocortin-3 Receptor Is Required for Entrainment to Meal Intake , 2008, The Journal of Neuroscience.

[63]  Kevin W. Williams,et al.  5-HT2CRs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis , 2008, Neuron.

[64]  T. Mizuno,et al.  Regulation of hepatic PPARgamma2 and lipogenic gene expression by melanocortin. , 2008, Biochemical and biophysical research communications.

[65]  J. Ukropec,et al.  Inactivation of UCP1 and the Glycerol Phosphate Cycle Synergistically Increases Energy Expenditure to Resist Diet-induced Obesity* , 2008, Journal of Biological Chemistry.

[66]  S. O’Rahilly,et al.  Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity , 2008, Nature Clinical Practice Endocrinology &Metabolism.

[67]  Tamas L. Horvath,et al.  UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals , 2008, Nature.

[68]  C. K. Song,et al.  Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

[69]  Wei Zhang,et al.  Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity. , 2008, The Journal of endocrinology.

[70]  Subhajyoti De,et al.  Common variants near MC4R are associated with fat mass, weight and risk of obesity , 2008, Nature Genetics.

[71]  A. N. van den Pol,et al.  Agouti-Related Peptide and MC3/4 Receptor Agonists Both Inhibit Excitatory Hypothalamic Ventromedial Nucleus Neurons , 2008, The Journal of Neuroscience.

[72]  B. Lowell,et al.  Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. , 2008, The Journal of clinical investigation.

[73]  J. Wikberg,et al.  Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction , 2008, Nature Reviews Drug Discovery.

[74]  S. O’Rahilly,et al.  Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors. , 2008, Endocrinology.

[75]  M. Petroni,et al.  Sporadic mutations in melanocortin receptor 3 in morbid obese individuals , 2008, European Journal of Human Genetics.

[76]  M. Low,et al.  In Vivo Evidence for Inverse Agonism of Agouti-Related Peptide in the Central Nervous System of Proopiomelanocortin-Deficient Mice , 2008, Diabetes.

[77]  R. Cone,et al.  Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling. , 2007, Endocrinology.

[78]  J. Elmquist,et al.  Serotonin 2C Receptor Agonists Improve Type 2 Diabetes via Melanocortin-4 Receptor Signaling Pathways , 2007, Cell metabolism.

[79]  J. Stephens,et al.  Role of Adiponectin and Inflammation in Insulin Resistance of Mc3r and Mc4r Knockout Mice , 2007, Obesity.

[80]  C. K. Song,et al.  Differential activation of the sympathetic innervation of adipose tissues by melanocortin receptor stimulation. , 2007, Endocrinology.

[81]  S. O’Rahilly,et al.  The central melanocortin system directly controls peripheral lipid metabolism. , 2007, The Journal of clinical investigation.

[82]  Y. Lee,et al.  The role of melanocortin 3 receptor gene in childhood obesity. , 2007, Diabetes.

[83]  B. Lowell,et al.  Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity , 2007, Nature.

[84]  F. Horber,et al.  Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. , 2007, Human molecular genetics.

[85]  F. Ashcroft,et al.  Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. , 2007, Cell metabolism.

[86]  R. Cone,et al.  Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue. , 2007, Endocrinology.

[87]  T. Gudermann,et al.  The Natural Inverse Agonist Agouti-related Protein Induces Arrestin-mediated Endocytosis of Melanocortin-3 and -4 Receptors* , 2006, Journal of Biological Chemistry.

[88]  Olivier Boss,et al.  Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake , 2006, Neuron.

[89]  A. A. da Silva,et al.  Melanocortin-4 Receptor Mediates Chronic Cardiovascular and Metabolic Actions of Leptin , 2006, Hypertension.

[90]  Zhimin Xiang,et al.  Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist. , 2006, Biochemistry.

[91]  M. Hulver,et al.  Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. , 2006, Endocrinology.

[92]  H. Vaudry,et al.  Expression of Melanocortin MC3 and MC4 Receptor mRNAs by Neuropeptide Y Neurons in the Rat Arcuate Nucleus , 2006, Neuroendocrinology.

[93]  B. M. King,et al.  The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight , 2006, Physiology & Behavior.

[94]  S. O’Rahilly,et al.  A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. , 2006, Cell metabolism.

[95]  M. Low,et al.  Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice. , 2006, The Journal of clinical investigation.

[96]  A. Butler.  The melanocortin system and energy balance , 2006, Peptides.

[97]  M. Tschöp,et al.  A role for β-melanocyte-stimulating hormone in human body-weight regulation , 2006 .

[98]  Jiankang Liu,et al.  Does Obesity Induce Resistance to the Long-Term Cardiovascular and Metabolic Actions of Melanocortin 3/4 Receptor Activation? , 2006, Hypertension.

[99]  A. Murphy,et al.  Agouti-related protein-deficient mice display an age-related lean phenotype. , 2005, Cell metabolism.

[100]  G. Barsh,et al.  Effects of Hypothalamic Neurodegeneration on Energy Balance , 2005, PLoS biology.

[101]  Robert A. McGovern,et al.  Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure , 2005, Cell.

[102]  C. K. Song,et al.  Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue. , 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

[103]  R. Palmiter,et al.  NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates , 2005, Science.

[104]  A. Butler,et al.  Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake. , 2005, Endocrinology.

[105]  M. Ghatei,et al.  Postembryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[106]  Thorsten Buch,et al.  Agouti-related peptide–expressing neurons are mandatory for feeding , 2005, Nature Neuroscience.

[107]  J. Yanovski,et al.  Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity. , 2005, Diabetes.

[108]  G. Kilroy,et al.  Targeted deletion of melanocortin receptor subtypes 3 and 4, but not CART, alters nutrient partitioning and compromises behavioral and metabolic responses to leptin , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[109]  D. Stec,et al.  Melanocortin-4 Receptor–Deficient Mice Are Not Hypertensive or Salt-Sensitive Despite Obesity, Hyperinsulinemia, and Hyperleptinemia , 2005, Hypertension.

[110]  S. O’Rahilly,et al.  Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids. , 2005, Diabetes.

[111]  Y. Chagnon,et al.  Melanocortin-4 receptor gene and physical activity in the Québec Family Study , 2005, International Journal of Obesity.

[112]  A. Sharma,et al.  Obesity, hypertension and insulin resistance , 2005, Acta Diabetologica.

[113]  S. Olshansky,et al.  A potential decline in life expectancy in the United States in the 21st century. , 2005, The New England journal of medicine.

[114]  R. Petrovska,et al.  Melanocortin receptors form constitutive homo- and heterodimers. , 2005, Biochemical and biophysical research communications.

[115]  L. Rossetti,et al.  Melanocortin-independent Effects of Leptin on Hepatic Glucose Fluxes* , 2004, Journal of Biological Chemistry.

[116]  W. Rand,et al.  Effect of Agouti-related protein in regulation of the hypothalamic-pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse. , 2004, Endocrinology.

[117]  A. Penhoat,et al.  Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity. , 2004, Biochimica et biophysica acta.

[118]  J. Hebebrand,et al.  Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations , 2004, Molecular Psychiatry.

[119]  B. Lowell,et al.  Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis , 2004, Neuron.

[120]  A. A. da Silva,et al.  Role of Hypothalamic Melanocortin 3/4-Receptors in Mediating Chronic Cardiovascular, Renal, and Metabolic Actions of Leptin , 2004, Hypertension.

[121]  D. Macneil,et al.  Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. , 2004, Endocrinology.

[122]  J. Wikberg,et al.  Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the dopaminergic mesolimbic system in rats , 2004, Neuroscience Letters.

[123]  R. Cone,et al.  Ala67Thr polymorphism in the Agouti‐related peptide gene is associated with inherited leanness in humans , 2004, American journal of medical genetics. Part A.

[124]  J Dixon,et al.  Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[125]  T. Gudermann,et al.  Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. , 2004, American journal of human genetics.

[126]  J. Kuo,et al.  Role of Adrenergic Activity in Pressor Responses to Chronic Melanocortin Receptor Activation , 2004, Hypertension.

[127]  J. Wild,et al.  Melanocortin-4 receptor messenger ribonucleic acid expression in rat cardiorespiratory, musculoskeletal, and integumentary systems. , 2003, Endocrinology.

[128]  T. Gudermann,et al.  Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization. , 2003, Diabetes.

[129]  A. G. Roseberry,et al.  Transgenic Mice Expressing Green Fluorescent Protein under the Control of the Melanocortin-4 Receptor Promoter , 2003, The Journal of Neuroscience.

[130]  A. Mark,et al.  Role of Melanocortin-4 Receptors in Mediating Renal Sympathoactivation to Leptin and Insulin , 2003, The Journal of Neuroscience.

[131]  R. Cone,et al.  Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse. , 2003, The Journal of clinical investigation.

[132]  Nurhadi Ibrahim,et al.  Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels. , 2003, Endocrinology.

[133]  F. Horber,et al.  Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. , 2003, The New England journal of medicine.

[134]  Tim Cheetham,et al.  Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. , 2003, The New England journal of medicine.

[135]  A. Hinney,et al.  Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice. , 2003, Physiological genomics.

[136]  C. Saper,et al.  Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat , 2003, The Journal of comparative neurology.

[137]  J. Kuo,et al.  Hypothalamic Melanocortin Receptors and Chronic Regulation of Arterial Pressure and Renal Function , 2003, Hypertension.

[138]  Michael Esterman,et al.  The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis , 2003, Neuron.

[139]  M. Aubert,et al.  The Melanocortin Agonist Melanotan‐II Reduces the Orexigenic and Adipogenic Effects of Neuropeptide Y (NPY) but Does not Affect the NPY‐Driven Suppressive Effects on the Gonadotropic and Somatotropic Axes in the Male Rat , 2003, Journal of neuroendocrinology.

[140]  E. Air,et al.  The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins , 2002, The Journal of Neuroscience.

[141]  W. Rand,et al.  Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis. , 2002, Endocrinology.

[142]  S. Bhattacharyya,et al.  A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. , 2002, Human molecular genetics.

[143]  M. Low,et al.  Activation of Central Melanocortin Pathways by Fenfluramine , 2002, Science.

[144]  D. Macneil,et al.  Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice , 2002, Molecular and Cellular Biology.

[145]  L. E. Pritchard,et al.  Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity. , 2002, The Journal of endocrinology.

[146]  Y. Lee,et al.  A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity. , 2002, The Journal of clinical endocrinology and metabolism.

[147]  R. Leach,et al.  The worldwide obesity epidemic. , 2001, Obesity research.

[148]  L. Rossetti,et al.  Central melanocortin receptors regulate insulin action. , 2001, The Journal of clinical investigation.

[149]  R. Cone,et al.  Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat , 2001, Nature Neuroscience.

[150]  C. Dina,et al.  Naturally occurring mutations in the melanocortin receptor 3 gene are not associated with type 2 diabetes mellitus in French Caucasians. , 2001, The Journal of clinical endocrinology and metabolism.

[151]  M. Low,et al.  Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus , 2001, Nature.

[152]  C. Haskell-Luevano,et al.  Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor , 2001, Regulatory Peptides.

[153]  Z. Abdel‐Malek.  Melanocortin receptors: their functions and regulation by physiological agonists and antagonists , 2001, Cellular and Molecular Life Sciences CMLS.

[154]  R. Palmiter,et al.  A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[155]  R. Cone,et al.  The central melanocortin system can directly regulate serum insulin levels. , 2000, Endocrinology.

[156]  R. Cone,et al.  A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse. , 2000, Endocrinology.

[157]  Yue Feng,et al.  Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass , 2000, Nature Genetics.

[158]  E. Stopa,et al.  Hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in the human hypothalamus are innervated by neuropeptide Y, agouti-related protein, and alpha-melanocyte-stimulating hormone. , 2000, The Journal of clinical endocrinology and metabolism.

[159]  H. Vaudry,et al.  Melanocortin‐3 Receptor mRNA Expression in Pro‐Opiomelanocortin Neurones of the Rat Arcuate Nucleus , 2000, Journal of neuroendocrinology.

[160]  S. Woods,et al.  Central nervous system control of food intake , 2000, Nature.

[161]  J. Metzger,et al.  Role of the melanocortin-4 receptor in metabolic rate and food intake in mice , 2000, Transgenic Research.

[162]  S. Bloom,et al.  The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. , 2000, The Journal of clinical investigation.

[163]  K. Clément,et al.  Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. , 2000, The Journal of clinical investigation.

[164]  S. O’Rahilly,et al.  Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. , 2000, The Journal of clinical investigation.

[165]  R. Palmiter,et al.  Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues , 1999, Brain Research.

[166]  G. Barsh,et al.  Anatomy of an Endogenous Antagonist: Relationship between Agouti-Related Protein and Proopiomelanocortin in Brain , 1999, The Journal of Neuroscience.

[167]  L. Yaswen,et al.  Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin , 1999, Nature Medicine.

[168]  R. Cone,et al.  Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus Evidence of a Cellular Basis for the Adipostat , 1999, Neuron.

[169]  Clifford B Saper,et al.  Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area , 1999, Neuron.

[170]  T. Hökfelt,et al.  The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[171]  C. Saper,et al.  Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord , 1998, Neuron.

[172]  K. Clément,et al.  A frameshift mutation in human MC4R is associated with a dominant form of obesity , 1998, Nature Genetics.

[173]  S. O’Rahilly,et al.  A frameshift mutation in MC4R associated with dominantly inherited human obesity , 1998, Nature Genetics.

[174]  Michael W. Schwartz,et al.  Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons , 1998, Nature Neuroscience.

[175]  K. Nakao,et al.  Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system , 1998, Neuroscience Letters.

[176]  A. Grüters,et al.  Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans , 1998, Nature Genetics.

[177]  M. Dallman,et al.  Hypothalamic Ventromedial Nuclei Amplify Circadian Rhythms: Do They Contain a Food-Entrained Endogenous Oscillator? , 1998, The Journal of Neuroscience.

[178]  G. Barsh,et al.  Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo. , 1998, Genes & development.

[179]  S. Woods,et al.  Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus , 1997, Diabetes.

[180]  J. Shutter,et al.  Overexpression of Agrt leads to obesity in transgenic mice , 1997, Nature Genetics.

[181]  G. Barsh,et al.  Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. , 1997, Science.

[182]  R. Steiner,et al.  Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. , 1997, Endocrinology.

[183]  J. Shutter,et al.  Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. , 1997, Genes & development.

[184]  R. Cone,et al.  Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice , 1997, Cell.

[185]  Victor J. Hruby,et al.  Role of melanocortinergic neurons in feeding and the agouti obesity syndrome , 1997, Nature.

[186]  P. Morgan,et al.  Coexpression of Leptin Receptor and Preproneuropeptide Y mRNA in Arcuate Nucleus of Mouse Hypothalamus , 1996, Journal of neuroendocrinology.

[187]  B. Lowell,et al.  Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action , 1995, Nature Medicine.

[188]  G. Barsh,et al.  Expression and transgenic studies of the mouse agouti gene provide insight into the mechanisms by which mammalian coat color patterns are generated. , 1995, Development.

[189]  R. Cone,et al.  Differential effects of melanocortin peptides on neural melanocortin receptors. , 1994, Molecular pharmacology.

[190]  Richard P. Woychik,et al.  Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor , 1994, Nature.

[191]  W. Wilkison,et al.  Molecular structure and chromosomal mapping of the human homolog of the agouti gene. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[192]  M. Mortrud,et al.  Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. , 1994, Molecular endocrinology.

[193]  Y. Konda,et al.  Molecular cloning, expression, and characterization of a fifth melanocortin receptor. , 1994, Biochemical and biophysical research communications.

[194]  P. Sokoloff,et al.  Molecular cloning and characterization of the rat fifth melanocortin receptor. , 1994, Biochemical and biophysical research communications.

[195]  M. Parmentier,et al.  Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues. , 1994, Biochemistry.

[196]  M. Parmentier,et al.  Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene. , 1994, The Biochemical journal.

[197]  P. Morgan,et al.  Cloning and expression of a new member of the melanocyte-stimulating hormone receptor family. , 1994, Journal of molecular endocrinology.

[198]  M. Mortrud,et al.  Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[199]  J. Wikberg,et al.  Molecular cloning of a novel human melanocortin receptor. , 1993, Biochemical and biophysical research communications.

[200]  S. Watson,et al.  Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. , 1993, The Journal of biological chemistry.

[201]  M. Mortrud,et al.  Cloning and Functional Characterization of a Family of Receptors for the Melanotropic Peptides , 1993, Annals of the New York Academy of Sciences.

[202]  S. Watson,et al.  Molecular cloning of a novel melanocortin receptor. , 1993, The Journal of biological chemistry.

[203]  R. Woychik,et al.  Molecular characterization of the mouse agouti locus , 1992, Cell.

[204]  J. Wikberg,et al.  Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA , 1992, FEBS letters.

[205]  M. Mortrud,et al.  The cloning of a family of genes that encode the melanocortin receptors. , 1992, Science.

[206]  B. Nadeau,et al.  Absence of increased oxygen consumption in brown adipose tissue of rats exhibiting "cafeteria" diet-induced thermogenesis. , 1988, Canadian journal of physiology and pharmacology.

[207]  A. Vergoni,et al.  ACTH-(1–24) and α-MSH antagonize feeding behavior stimulated by kappa opiate agonists , 1986, Peptides.

[208]  C. Sisk,et al.  Anticipation of 24-hr feeding schedules in rats with lesions of the suprachiasmatic nucleus. , 1979, Behavioral and neural biology.

[209]  D. Krieger,et al.  Suprachiasmatic nuclear lesions do not abolish food-shifted circadian adrenal and temperature rhythmicity. , 1977, Science.

[210]  S. W. Ranson,et al.  Hypothalamic lesions and adiposity in the rat , 1940 .

[211]  K. Mountjoy.  Distribution and function of melanocortin receptors within the brain. , 2010, Advances in experimental medicine and biology.

[212]  G. Nikiforovich,et al.  Constitutive activity of neural melanocortin receptors. , 2010, Methods in enzymology.

[213]  S. O’Rahilly,et al.  Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor. , 2009, Endocrinology.

[214]  B. Caballero.  The global epidemic of obesity: an overview. , 2007, Epidemiologic reviews.

[215]  W. Richards,et al.  Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice. , 2004, Endocrinology.

[216]  G. Barsh,et al.  Behavioral / Systems / Cognitive Interaction between-Melanocyte-Stimulating Hormone and Corticotropin-Releasing Hormone in the Regulation of Feeding and Hypothalamo-Pituitary-Adrenal Responses , 2003 .

[217]  R. Adan,et al.  AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor. , 2001, Molecular endocrinology.

[218]  J. Flier,et al.  Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. , 2001, The Journal of clinical investigation.

[219]  S. Woods,et al.  Food intake and the regulation of body weight. , 2000, Annual review of psychology.

[220]  W. Rand,et al.  a-Melanocyte-Stimulating Hormone Is Contained in Nerve Terminals Innervating Thyrotropin-Releasing Hormone-Synthesizing Neurons in the Hypothalamic Paraventricular Nucleus and Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Gene Expression , 2000 .

[221]  A. Mark,et al.  Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. , 1999, Hypertension.

[222]  R. Palmiter,et al.  Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides , 1999, Nature Genetics.

[223]  J. Massagué.  TGF-beta signal transduction. , 1998, Annual review of biochemistry.

[224]  H. Schiöth,et al.  Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. , 1998, Endocrinology.

[225]  W. Wilkison,et al.  Interactions of alpha-melanotropin and agouti on B16 melanoma cells: evidence for inverse agonism of agouti. , 1997, Journal of receptor and signal transduction research.