GWAS meta-analysis followed by Mendelian randomization revealed potential control mechanisms for circulating α-Klotho levels
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Till F. M. Andlauer | W. März | B. Müller-Myhsok | G. Smith | S. Movérare-Skrtic | C. Ohlsson | T. Andlauer | Nazanin Mirza-Schreiber | B. Krämer | J. Voelkl | J. Tobias | Jie Zheng | V. Brandenburg | Daniel Richard | I. Gergei | L. Falk
[1] J. Erdmann,et al. Genomewide Association Study of Severe Covid-19 with Respiratory Failure , 2020, The New England journal of medicine.
[2] F. Martinez,et al. Severe Covid-19. , 2020, The New England journal of medicine.
[3] Tom M Palmer,et al. Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis , 2020, PLoS medicine.
[4] James R. Apgar,et al. Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease , 2020, The Journal of Biological Chemistry.
[5] J. Navarro-González,et al. Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: a case-control study , 2020, Aging.
[6] Xiaokun Li. The FGF metabolic axis , 2019, Frontiers of Medicine.
[7] David A. Drew,et al. Performance of soluble Klotho assays in clinical samples of kidney disease , 2019, Clinical kidney journal.
[8] Mark R. Hurle,et al. Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases , 2019, bioRxiv.
[9] Weiping Xia,et al. Klotho gene polymorphisms are associated with healthy aging and longevity: Evidence from a meta-analysis , 2019, Mechanisms of Ageing and Development.
[10] E. Zeggini,et al. Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures , 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[11] Di Zou,et al. The role of klotho in chronic kidney disease , 2018, BMC Nephrology.
[12] M. Kuro-o. The Klotho proteins in health and disease , 2018, Nature Reviews Nephrology.
[13] Sina A. Gharib,et al. Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis , 2018, bioRxiv.
[14] Rong Wang,et al. Correlation between Soluble α-Klotho and Renal Function in Patients with Chronic Kidney Disease: A Review and Meta-Analysis , 2018, BioMed research international.
[15] M. Gawaz,et al. Therapeutic Interference With Vascular Calcification—Lessons From Klotho-Hypomorphic Mice and Beyond , 2018, Front. Endocrinol..
[16] F. Windmeijer,et al. An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings , 2018, bioRxiv.
[17] J. Xie,et al. New Insights into the Mechanism of Action of Soluble Klotho , 2017, Front. Endocrinol..
[18] J. Michael Cherry,et al. The Encyclopedia of DNA elements (ENCODE): data portal update , 2017, Nucleic Acids Res..
[19] Michael H. Guo,et al. Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height , 2017, eLife.
[20] Nicola J. Rinaldi,et al. Genetic effects on gene expression across human tissues , 2017, Nature.
[21] Tom R. Gaunt,et al. PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics , 2017, bioRxiv.
[22] Fernando Pires Hartwig,et al. Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption , 2017, bioRxiv.
[23] N. Sheehan,et al. Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic , 2016, International journal of epidemiology.
[24] Christian Gieger,et al. Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation , 2016, Science Advances.
[25] Tom R. Gaunt,et al. LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis , 2016, bioRxiv.
[26] David M. Evans,et al. Mendelian Randomization: New Applications in the Coming Age of Hypothesis-Free Causality. , 2015, Annual review of genomics and human genetics.
[27] M. Daly,et al. An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.
[28] G. Davey Smith,et al. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression , 2015, International journal of epidemiology.
[29] M. Mohammadi,et al. The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody. , 2015, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
[30] G. Davey Smith,et al. Mendelian randomization: genetic anchors for causal inference in epidemiological studies , 2014, Human molecular genetics.
[31] M. Daly,et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.
[32] A. Ortiz,et al. Hyperlipidemia-Associated Renal Damage Decreases Klotho Expression in Kidneys from ApoE Knockout Mice , 2013, PloS one.
[33] C. Wallace,et al. Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics , 2013, PLoS genetics.
[34] O. Delaneau,et al. Supplementary Information for ‘ Improved whole chromosome phasing for disease and population genetic studies ’ , 2012 .
[35] Eurie L. Hong,et al. Annotation of functional variation in personal genomes using RegulomeDB , 2012, Genome research.
[36] David Haussler,et al. The UCSC genome browser and associated tools , 2012, Briefings Bioinform..
[37] J. Marchini,et al. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing , 2012, Nature Genetics.
[38] D. Fiete,et al. Peptide-specific Transfer of N-Acetylgalactosamine to O-Linked Glycans by the Glycosyltransferases β1,4-N-Acetylgalactosaminyl Transferase 3 (β4GalNAc-T3) and β4GalNAc-T4* , 2012, The Journal of Biological Chemistry.
[39] D. Lawlor,et al. Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort , 2012, International journal of epidemiology.
[40] D. Lawlor,et al. Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children , 2012, International journal of epidemiology.
[41] P. Visscher,et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits , 2012, Nature Genetics.
[42] K. Rosenblatt,et al. Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation , 2011, Diabetes.
[43] M. Econs,et al. Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. , 2010, Biochemical and biophysical research communications.
[44] Yun Li,et al. METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..
[45] D. Besselsen,et al. Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis. , 2010, Gastroenterology.
[46] Aaron R. Quinlan,et al. BIOINFORMATICS APPLICATIONS NOTE , 2022 .
[47] P. Donnelly,et al. A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies , 2009, PLoS genetics.
[48] S. Leeman,et al. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17 , 2007, Proceedings of the National Academy of Sciences.
[49] Manuel A. R. Ferreira,et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.
[50] Daniel L. Koller,et al. The role of mutant UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 3 in regulating serum intact fibroblast growth factor 23 and matrix extracellular phosphoglycoprotein in heritable tumoral calcinosis. , 2006, The Journal of clinical endocrinology and metabolism.
[51] S. Ebrahim,et al. 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? , 2003, International journal of epidemiology.
[52] Monica M. Palcic,et al. The structural basis for specificity in human ABO(H) blood group biosynthesis , 2002, Nature Structural Biology.
[53] Daniel S. Roseman,et al. The Mannose/N-Acetylgalactosamine-4-SO4Receptor Displays Greater Specificity for Multivalent than Monovalent Ligands* , 2001, The Journal of Biological Chemistry.
[54] W. März,et al. Rationale and design of the LURIC study--a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease. , 2001, Pharmacogenomics.
[55] R. Nagai,et al. Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases , 2000, Cellular and Molecular Life Sciences CMLS.
[56] V. Luria,et al. Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase , 1998, Transgenic Research.
[57] D. Fiete,et al. The macrophage/endothelial cell mannose receptor cDNA encodes a protein that binds oligosaccharides terminating with SO4-4-GalNAcbeta1,4GlcNAcbeta or Man at independent sites. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[58] C. Eun. A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene. , 2007 .
[59] S. Kumar,et al. Circulatory half-life but not interaction with the lutropin/chorionic gonadotropin receptor is modulated by sulfation of bovine lutropin oligosaccharides. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[60] O. Hindsgaul,et al. A hepatic reticuloendothelial cell receptor specific for SO4-4GalNAc beta 1,4GlcNAc beta 1,2Man alpha that mediates rapid clearance of lutropin. , 1991, Cell.