Three-dimensional imaging of KNDy neurons in the mammalian brain using optical tissue clearing and multiple-label immunocytochemistry

[1]  R. Goodman,et al.  Evidence That Endogenous Somatostatin Inhibits Episodic, but Not Surge, Secretion of LH in Female Sheep , 2017, Endocrinology.

[2]  L. Coolen,et al.  Effects of Season and Estradiol on KNDy Neuron Peptides, Colocalization With D2 Dopamine Receptors, and Dopaminergic Inputs in the Ewe , 2017, Endocrinology.

[3]  Alain Chédotal,et al.  Tridimensional Visualization and Analysis of Early Human Development , 2017, Cell.

[4]  Alain Chédotal,et al.  Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains , 2016, Development.

[5]  L. Sinnett-Smith,et al.  Visualisation of Kiss1 Neurone Distribution Using a Kiss1‐CRE Transgenic Mouse , 2016, Journal of neuroendocrinology.

[6]  N. Plesnila,et al.  Shrinkage-mediated imaging of entire organs and organisms using uDISCO , 2016, Nature Methods.

[7]  L. Coolen,et al.  Prenatal testosterone exposure decreases colocalization of insulin receptors in kisspeptin/neurokinin B/dynorphin and agouti‐related peptide neurons of the adult ewe , 2016, The European journal of neuroscience.

[8]  R. Goodman,et al.  Impact of psychosocial stress on gonadotrophins and sexual behaviour in females: role for cortisol? , 2016, Reproduction.

[9]  Witold Konopka,et al.  Light-sheet microscopy imaging of a whole cleared rat brain with Thy1-GFP transgene , 2016, Scientific Reports.

[10]  Cheuk Y. Tang,et al.  Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes , 2016, Cell.

[11]  T. Plant.  60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-pituitary-gonadal axis. , 2015, The Journal of endocrinology.

[12]  L. Coolen,et al.  Evidence for Changes in Numbers of Synaptic Inputs onto KNDy and GnRH Neurones during the Preovulatory LH Surge in the Ewe , 2015, Journal of neuroendocrinology.

[13]  Martin K. Schwarz,et al.  Fluorescent-Protein Stabilization and High-Resolution Imaging of Cleared, Intact Mouse Brains , 2015, PloS one.

[14]  U. Boehm,et al.  Conditional Viral Tract Tracing Delineates the Projections of the Distinct Kisspeptin Neuron Populations to Gonadotropin-Releasing Hormone (GnRH) Neurons in the Mouse. , 2015, Endocrinology.

[15]  R. Goodman,et al.  Neural mechanisms controlling seasonal reproduction: Principles derived from the sheep model and its comparison with hamsters , 2015, Frontiers in Neuroendocrinology.

[16]  Jae K. Lee,et al.  3D Imaging of Axons in Transparent Spinal Cords from Rodents and Nonhuman Primates,, , 2015, eNeuro.

[17]  T. Plant.  The hypothalamo-pituitary-gonadal axis , 2015 .

[18]  Frank Bradke,et al.  A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous system. , 2014, Cell reports.

[19]  N. Renier,et al.  iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging , 2014, Cell.

[20]  M. Tena-Sempere,et al.  Disparate changes in kisspeptin and neurokinin B expression in the arcuate nucleus after sex steroid manipulation reveal differential regulation of the two KNDy peptides in rats. , 2014, Endocrinology.

[21]  E. Susaki,et al.  Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis , 2014, Cell.

[22]  L. Coolen,et al.  A Role for Neurokinin B in Pulsatile GnRH Secretion in the Ewe , 2013, Neuroendocrinology.

[23]  A. A. Romanovsky,et al.  Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes , 2013, Frontiers in Neuroendocrinology.

[24]  Aaron S. Andalman,et al.  Structural and molecular interrogation of intact biological systems , 2013, Nature.

[25]  R. Goodman,et al.  Neuroanatomy of the kisspeptin signaling system in mammals: comparative and developmental aspects. , 2013, Advances in experimental medicine and biology.

[26]  Frank Bradke,et al.  Three-dimensional imaging of solvent-cleared organs using 3DISCO , 2012, Nature Protocols.

[27]  L. Coolen,et al.  KNDy (kisspeptin/neurokinin B/dynorphin) neurons are activated during both pulsatile and surge secretion of LH in the ewe. , 2012, Endocrinology.

[28]  E. Theodorsson,et al.  Ovariectomy and 17β-estradiol replacement in rats and mice: a visual demonstration. , 2012, Journal of visualized experiments : JoVE.

[29]  R. Weiler,et al.  Chemical Clearing and Dehydration of GFP Expressing Mouse Brains , 2012, PloS one.

[30]  R. Goodman,et al.  Evidence of a role for kisspeptin and neurokinin B in puberty of female sheep. , 2012, Endocrinology.

[31]  A. Topaloğlu,et al.  Inactivating KISS1 mutation and hypogonadotropic hypogonadism. , 2012, The New England journal of medicine.

[32]  C. Caligioni,et al.  Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men. , 2012, Endocrinology.

[33]  R. Palmiter,et al.  Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse. , 2011, Endocrinology.

[34]  K. Grove,et al.  Characterisation of Arcuate Nucleus Kisspeptin/Neurokinin B Neuronal Projections and Regulation during Lactation in the Rat , 2011, Journal of neuroendocrinology.

[35]  R. Steiner,et al.  Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. , 2011, American journal of physiology. Endocrinology and metabolism.

[36]  L. Coolen,et al.  Anatomy of the kisspeptin neural network in mammals , 2010, Brain Research.

[37]  M. Tena-Sempere,et al.  Kisspeptins: Bridging energy homeostasis and reproduction , 2010, Brain Research.

[38]  M. Keller,et al.  Mapping of Kisspeptin Fibres in the Brain of the Pro‐Oestrous Rat , 2010, Journal of neuroendocrinology.

[39]  S. Seminara,et al.  Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus. , 2010, Endocrinology.

[40]  Michael N Lehman,et al.  Kisspeptin / Neurokinin B / Dynorphin ( KNDy ) Cells of the Arcuate Nucleus : A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion , 2010 .

[41]  Alda Pereira,et al.  Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells. , 2010, Endocrinology.

[42]  L. Coolen,et al.  The kisspeptin/neurokinin B/dynorphin (KNDy) cell population of the arcuate nucleus: sex differences and effects of prenatal testosterone in sheep. , 2010, Endocrinology.

[43]  J. T. Smith,et al.  Kisspeptin neurons in the ovine arcuate nucleus and preoptic area are involved in the preovulatory luteinizing hormone surge. , 2009, Endocrinology.

[44]  Joshua Kim,et al.  Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty. , 2009, American journal of physiology. Endocrinology and metabolism.

[45]  Donald K. Clifton,et al.  Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse , 2009, The Journal of Neuroscience.

[46]  Frank Reimann,et al.  TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction , 2009, Nature Genetics.

[47]  L. Coolen,et al.  Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. , 2007, Endocrinology.

[48]  Felecia Cerrato,et al.  Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice. , 2007, Endocrinology.

[49]  W. Colledge,et al.  Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene , 2007, Proceedings of the National Academy of Sciences.

[50]  D. Grattan,et al.  Differential Effects of Centrally‐Administered Oestrogen Antagonist ICI‐182,780 on Oestrogen‐Sensitive Functions in the Hypothalamus , 2007, Journal of neuroendocrinology.

[51]  P. Ciofi,et al.  Sexual dimorphism in the organization of the rat hypothalamic infundibular area , 2006, Neuroscience.

[52]  N. Rance,et al.  Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: Morphologic evidence of interrelated function within the arcuate nucleus , 2006, The Journal of comparative neurology.

[53]  J. T. Smith,et al.  Elevated KiSS‐1 Expression in the Arcuate Nucleus Prior to the Cyclic Preovulatory Gonadotrophin‐Releasing Hormone/Lutenising Hormone Surge in the Ewe Suggests a Stimulatory Role for Kisspeptin in Oestrogen‐Positive Feedback , 2006, Journal of neuroendocrinology.

[54]  G. Delsol,et al.  Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha , 2006, Neuroscience Letters.

[55]  R. Goodman,et al.  Colocalisation of Dynorphin A and Neurokinin B Immunoreactivity in the Arcuate Nucleus and Median Eminence of the Sheep , 2006, Journal of neuroendocrinology.

[56]  R. Steiner,et al.  Regulation of Kiss1 gene expression in the brain of the female mouse. , 2005, Endocrinology.

[57]  R. Goodman,et al.  Progesterone increases dynorphin a concentrations in cerebrospinal fluid and preprodynorphin messenger ribonucleic Acid levels in a subset of dynorphin neurons in the sheep. , 2005, Endocrinology.

[58]  S. O’Rahilly,et al.  The GPR54 gene as a regulator of puberty. , 2004, The New England journal of medicine.

[59]  F. Monsma,et al.  The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. , 2003, Biochemical and biophysical research communications.

[60]  E. Génin,et al.  Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[61]  L. Coolen,et al.  Colocalization of progesterone receptors in parvicellular dynorphin neurons of the ovine preoptic area and hypothalamus. , 2002, Endocrinology.

[62]  A. Herbison,et al.  Identification of neurokinin B-expressing neurons as an highly estrogen-receptive, sexually dimorphic cell group in the ovine arcuate nucleus. , 2000, Endocrinology.

[63]  R. O. Price,et al.  Sex steroid modulation of neurokinin B gene expression in the arcuate nucleus of adult male rats. , 1999, Brain research. Molecular brain research.

[64]  H. Jansen,et al.  The GnRH System of Seasonal Breeders: Anatomy and Plasticity , 1997, Brain Research Bulletin.

[65]  G. Prins,et al.  Presence of nuclear androgen receptor-like immunoreactivity in neurokinin B-containing neurons of the hypothalamic arcuate nucleus of the adult male rat , 1994, Neuroscience Letters.

[66]  N. Rance,et al.  Neurokinin B gene expression is increased in the arcuate nucleus of ovariectomized rats. , 1994, Neuroendocrinology.

[67]  M. Lehman,et al.  Immunocytochemical localization of luteinizing hormone‐releasing hormone (LHRH) pathways in the sheep brain during anestrus and the mid‐luteal phase of the estrous cycle , 1986, The Journal of comparative neurology.

[68]  I. Clarke,et al.  THE TEMPORAL RELATIONSHIP BETWEEN GONADOTROPIN RELEASING HORMONE (GnRH) AND LUTEINIZING HORMONE (LH) SECRETION IN OVARIECTOMIZED EWES1 , 1982 .

[69]  I. Clarke,et al.  The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. , 1982, Endocrinology.