Application of inkjet printing to tissue engineering

Recent advances in organ printing technology for applications relating to medical interventions and organ replacement are described. Organ printing refers to the placement of various cell types into a soft scaffold fabricated according to a computer‐aided design template using a single device. Computer aided scaffold topology design has recently gained attention as a viable option to achieve function and mass transport requirements within tissue engineering scaffolds. An exciting advance pioneered in our laboratory is that of simultaneous printing of cells and biomaterials, which allows precise placement of cells and proteins within 3‐D hydrogel structures. This advance raises the possibility of spatially controlling not only the scaffold structure, but also the type of tissue that can be grown within the scaffold and the thickness of the tissue as capillaries and vessels could be constructed within the scaffolds. Here we summarize recent advances in printing cells and materials using the same device.

[1]  James J. Yoo,et al.  Tissue-engineered autologous bladders for patients needing cystoplasty , 2006, The Lancet.

[2]  W. Saltzman,et al.  PC12 CELL AGGREGATION AND NEURITE GROWTH IN GELS OF COLLAGEN, LAMININ AND FIBRONECTIN , 1996, International Journal of Developmental Neuroscience.

[3]  K. Leong,et al.  Solid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs. , 2003, Biomaterials.

[4]  N. Yamamoto,et al.  Microarray fabrication with covalent attachment of DNA using Bubble Jet technology , 2000, Nature Biotechnology.

[5]  J. Vacanti,et al.  Injectable alginate seeded with chondrocytes as a potential treatment for vesicoureteral reflux. , 1993, The Journal of urology.

[6]  Marco Lanzetta,et al.  Pathological score for the evaluation of allograft rejection in human hand (composite tissue) allotransplantation. , 2005, European journal of dermatology : EJD.

[7]  J. Vacanti,et al.  Tissue engineering : Frontiers in biotechnology , 1993 .

[8]  Vladimir Mironov,et al.  Organ printing: computer-aided jet-based 3D tissue engineering. , 2003, Trends in biotechnology.

[9]  R R Markwald,et al.  Mixed cultures of avian blastoderm cells and the quail mesoderm cell line QCE-6 provide evidence for the pluripotentiality of early mesoderm. , 1997, Developmental biology.

[10]  L. Rayleigh.  On The Instability Of Jets , 1878 .

[11]  H. Sirringhaus,et al.  High-Resolution Ink-Jet Printing of All-Polymer Transistor Circuits , 2000, Science.

[12]  Joe Alper.  Bioengineering. Biology and the inkjets. , 2004, Science.

[13]  P. Ma,et al.  Biodegradable polymer scaffolds with well-defined interconnected spherical pore network. , 2001, Tissue engineering.

[14]  Dietmar W Hutmacher,et al.  Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems. , 2004, Trends in biotechnology.

[15]  Peter Molnar,et al.  Electrophysiological and Morphological Characterization of Rat Embryonic Motoneurons in a Defined System , 2003, Biotechnology progress.

[16]  H W Li,et al.  Dewetting of conducting polymer inkjet droplets on patterned surfaces , 2004, Nature materials.

[17]  T. Boland,et al.  Cell and organ printing 2: fusion of cell aggregates in three-dimensional gels. , 2003, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology.

[18]  Joe Alper.  Biology and the Inkjets , 2004, Science.

[19]  Thomas Boland,et al.  A quantitative approach to studying structures and orientation at self-assembled monolayer/fluid interfaces. , 2003, Journal of colloid and interface science.

[20]  T. Boland,et al.  Inkjet printing for high-throughput cell patterning. , 2004, Biomaterials.

[21]  Sangeeta N Bhatia,et al.  Three-dimensional tissue fabrication. , 2004, Advanced drug delivery reviews.

[22]  David K. C. Cooper,et al.  Activation of Cytomegalovirus in Pig-to-Primate Organ Xenotransplantation , 2002, Journal of Virology.

[23]  W Cris Wilson,et al.  Cell and organ printing 1: protein and cell printers. , 2003, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology.

[24]  Mohammad Masoud Mohebi,et al.  A drop-on-demand ink-jet printer for combinatorial libraries and functionally graded ceramics. , 2002, Journal of combinatorial chemistry.

[25]  D. J. Rose,et al.  Inkjet dispensing technology: applications in drug discovery. , 1998, Current opinion in biotechnology.

[26]  Yudong D. He,et al.  Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer , 2001, Nature Biotechnology.

[27]  T. Boland,et al.  Inkjet printing of viable mammalian cells. , 2005, Biomaterials.

[28]  F A Auger,et al.  A completely biological tissue‐engineered human blood vessel , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[29]  Tao Xu,et al.  Viability and electrophysiology of neural cell structures generated by the inkjet printing method. , 2006, Biomaterials.

[30]  A. Hart,et al.  Measurement of soluble L-lactate in dairy products using screen-printed sensors in batch mode. , 1996, Biosensors & bioelectronics.

[31]  S. Hollister.  Porous scaffold design for tissue engineering , 2005, Nature materials.

[32]  Andrea Remuzzi,et al.  Vascular Tissue Engineering , 2006, Cell transplantation.

[33]  A. Roda,et al.  Protein microdeposition using a conventional ink-jet printer. , 2000, BioTechniques.