Cholinergic Changes in the APP23 Transgenic Mouse Model of Cerebral Amyloidosis
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P. Kelly | B. Sommer | M. Staufenbiel | M. Jucker | A. Phinney | M. Calhoun | C. Sturchler-Pierrat | D. Abramowski | A. Enz | M. Stalder | L. Bondolfi | M. Pfeifer | S. Boncristiano | C. Sturchler-Pierrat, | Martina Stalder
[1] P. Kelly,et al. Progressive age-related impairment of cognitive behavior in APP23 transgenic mice , 2003, Neurobiology of Aging.
[2] M. Staufenbiel,et al. Amyloid-Associated Neuron Loss and Gliogenesis in the Neocortex of Amyloid Precursor Protein Transgenic Mice , 2002, The Journal of Neuroscience.
[3] C. Haass,et al. Protofibrils, the unifying toxic molecule of neurodegenerative disorders? , 2001, Nature Neuroscience.
[4] E. Mufson,et al. Neuropathology of Mice Carrying Mutant APPswe and/or PS1M146L Transgenes: Alterations in the p75NTR Cholinergic Basal Forebrain Septohippocampal Pathway , 2001, Experimental Neurology.
[5] E. McGowan,et al. Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes , 2001, Neuroreport.
[6] M. Staufenbiel,et al. Comparative Analysis of Amyloid-β Chemical Structure and Amyloid Plaque Morphology of Transgenic Mouse and Alzheimer's Disease Brains* , 2001, The Journal of Biological Chemistry.
[7] M. Staufenbiel,et al. Spontaneous Hemorrhagic Stroke in a Mouse Model of Cerebral Amyloid Angiopathy , 2001, The Journal of Neuroscience.
[8] D. Moechars,et al. Acetylcholinesterase-Positive Fiber Deafferentation and Cell Shrinkage in the Septohippocampal Pathway of Aged Amyloid Precursor Protein London Mutant Transgenic Mice , 2000, Neurobiology of Disease.
[9] J. Trojanowski,et al. Brain Trauma in Aged Transgenic Mice Induces Regression of Established Aβ Deposits , 2000, Experimental Neurology.
[10] I. Tesseur,et al. Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons , 2000, Neurobiology of Aging.
[11] T. Beach,et al. The Cholinergic Deficit Coincides with Aβ Deposition at the Earliest Histopathologic Stages of Alzheimer Disease , 2000, Journal of neuropathology and experimental neurology.
[12] T. Beach,et al. Cholinergic deafferentation of the rabbit cortex: a new animal model of Aβ deposition , 2000, Neuroscience Letters.
[13] B. Sommer,et al. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[14] O. Isacson,et al. Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[15] M. Frotscher,et al. Cerebral Amyloid Induces Aberrant Axonal Sprouting and Ectopic Terminal Formation in Amyloid Precursor Protein Transgenic Mice , 1999, The Journal of Neuroscience.
[16] D. Selkoe,et al. Translating cell biology into therapeutic advances in Alzheimer's disease , 1999, Nature.
[17] B. Sommer,et al. Association of microglia with amyloid plaques in brains of APP23 transgenic mice. , 1999, The American journal of pathology.
[18] Sarah Tomlin,et al. Microtechnology: Laying it on thick , 1999, Nature.
[19] K. Duff,et al. Reorganization of Cholinergic Terminals in the Cerebral Cortex and Hippocampus in Transgenic Mice Carrying Mutated Presenilin-1 and Amyloid Precursor Protein Transgenes , 1999, The Journal of Neuroscience.
[20] D. Ingram,et al. Hippocampal neuron and synaptophysin-positive bouton number in aging C57BL/6 mice , 1998, Neurobiology of Aging.
[21] B. Sommer,et al. Neuron loss in APP transgenic mice , 1998, Nature.
[22] John M. Lee,et al. Pharmacological Drug Treatment of Alzheimer Disease: The Cholinergic Hypothesis Revisited , 1998, Journal of neuropathology and experimental neurology.
[23] G. Halliday,et al. Neurofibrillary degeneration and cell loss in the nucleus basalis in comparison to cortical Alzheimer pathology , 1998, Neurobiology of Aging.
[24] R. Polinsky,et al. Dose‐dependent CSF acetylcholinesterase inhibition by SDZ ENA 713 in Alzheimer's disease , 1998, Acta neurologica Scandinavica.
[25] C. Geula,et al. Relationship Between Plaques, Tangles, and Loss of Cortical Cholinergic Fibers in Alzheimer Disease , 1998, Journal of neuropathology and experimental neurology.
[26] R. Quirion,et al. β-Amyloid peptides as direct cholinergic neuromodulators: a missing link? , 1998, Trends in Neurosciences.
[27] B. Sommer,et al. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[28] U. Ueberham,et al. In Vivo Regulation of Amyloid Precursor Protein Secretion in Rat Neocortex by Cholinergic Activity , 1997, European Journal of Neuroscience.
[29] L. Harrell,et al. Cholinergic activity and amyloid precursor protein metabolism , 1997, Brain Research Reviews.
[30] John Hardy,et al. Amyloid, the presenilins and Alzheimer's disease , 1997, Trends in Neurosciences.
[31] R. Powers,et al. Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain , 1997, Neurobiology of Aging.
[32] D. Selkoe,et al. Alzheimer's Disease--Genotypes, Phenotype, and Treatments , 1997, Science.
[33] M. Schachner,et al. Expression of the neural adhesion molecule L1 in the deafferented dentate gyrus , 1996, Neuroscience.
[34] S. Younkin,et al. Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice , 1996, Science.
[35] L. Mucke,et al. Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease , 1996, The Journal of Neuroscience.
[36] J. Blusztajn,et al. Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[37] M. Staufenbiel,et al. Electrophoretic Separation of βA4 Peptides (1–40) and (1–42) , 1996 .
[38] P. Paganetti,et al. Effect of alkalizing agents on the processing of the β-amyloid precursor protein , 1996, Brain Research.
[39] Claudia Linker,et al. Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme , 1996, Neuron.
[40] B. Sommer,et al. Expression of APP in transgenic mice: a Comparison of neuron-specific promoters , 1996, Neurobiology of Aging.
[41] F. Gage,et al. Essential role of neocortical acetylcholine in spatial memory , 1995, Nature.
[42] L. Mucke,et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein , 1995, Nature.
[43] K. Davis,et al. Neurochemical Correlates of Dementia Severity in Alzheimer's Disease: Relative Importance of the Cholinergic Deficits , 1995, Journal of neurochemistry.
[44] E. Pioro,et al. Neocortical infarction in subhuman primates leads to restricted morphological damage of the cholinergic neurons in the nucleus basalis of Meynert , 1994, Brain Research.
[45] J. Coyle,et al. Cholinergic innervation of mouse forebrain structures , 1994, The Journal of comparative neurology.
[46] J. Growdon,et al. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. , 1993, The Journal of biological chemistry.
[47] M. Goedert. Tau protein and the neurofibrillary pathology of Alzheimer's disease , 1993, Trends in Neurosciences.
[48] W. Benzing,et al. Immunocytochemical distribution of peptidergic and cholinergic fibers in the human amygdala: their depletion in Alzheimer's disease and morphologic alteration in non-demented elderly with numerous senile plaques , 1993, Brain Research.
[49] Mark J. West,et al. New stereological methods for counting neurons , 1993, Neurobiology of Aging.
[50] E. B. VEDEL JENSEN,et al. The rotator , 1993 .
[51] D. Selkoe,et al. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production , 1992, Nature.
[52] P. Greengard,et al. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[53] A. Shetter,et al. Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations , 1992 .
[54] J. Growdon,et al. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. , 1992, Science.
[55] E. Perry,et al. Convergent cholinergic activities in aging and Alzheimer's disease , 1992, Neurobiology of Aging.
[56] C. Geula,et al. Cholinesterases in the amyloid angiopathy of Alzheimer's disease , 1992, Annals of neurology.
[57] E. Hirsch,et al. Alzheimer's disease: Is the decrease of the cholinergic innervation of the hippocampus related to intrinsic hippocampal pathology? , 1992, Neuroscience.
[58] C V Howard,et al. Estimating neuron dendritic length in 3D from total vertical projections and from vertical slices , 1992, Acta neurologica Scandinavica. Supplementum.
[59] E. Mufson,et al. Ultrastructural localization of acetylcholinesterase in neurofibrillary tangles, neuropil threads and senile plaques in aged and Alzheimer's brain , 1992, Brain Research.
[60] H. Gundersen,et al. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator , 1991, The Anatomical record.
[61] R. Gaykema,et al. Cortical projection patterns of the medial septum‐diagonal band complex , 1990, The Journal of comparative neurology.
[62] R. Nieuwenhuys,et al. Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease , 1990, Neurobiology of Aging.
[63] J. Moossy,et al. A brain regional analysis of morphologic and cholinergic abnormalities in Alzheimer's disease. , 1989, Archives of neurology.
[64] Gwenn S. Smith. Animal models of Alzheimer's disease: experimental cholinergic denervation , 1988, Brain Research Reviews.
[65] H. J. G. GUNDERSEN,et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis , 1988, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
[66] D. Collerton,et al. Cholinergic function and intellectual decline in Alzheimer's disease , 1986, Neuroscience.
[67] D. Price,et al. A modified histochemical technique to visualize acetylcholinesterase-containing axons. , 1985, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[68] J. Grassi,et al. An Immunological Study of Rat Acetylcholinesterase: Comparison with Acetylcholinesterases from Other Vertebrates , 1984, Journal of neurochemistry.
[69] L. Iversen,et al. Correlation of cortical cholinergic and GABA deficits with quantitative neuropathological findings in senile dementia. , 1984, Brain : a journal of neurology.
[70] T. Powell,et al. Retrograde changes in cholinergic neurons in the basal forebrain of the rat following cortical damage , 1983, Brain Research.
[71] J. Coyle,et al. Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system , 1983, The Journal of comparative neurology.
[72] D L Price,et al. Alzheimer's disease: a disorder of cortical cholinergic innervation. , 1983, Science.
[73] M. Esiri,et al. Alzheimer's disease Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities , 1982, Journal of the Neurological Sciences.
[74] R. Bartus,et al. The cholinergic hypothesis of geriatric memory dysfunction. , 1982, Science.
[75] J. Coyle,et al. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. , 1982, Science.
[76] E. Perry,et al. Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes , 1981, Neurobiology of Aging.
[77] K. E. Moore,et al. Decrease of neocortical choline acetyltransferase after lesion of the globus pallidus in the rat , 1978, Experimental Neurology.
[78] F. Fonnum,et al. A rapid radiochemical method for the determination of choline acetyltransferase , 1975, Journal of neurochemistry.
[79] K. Courtney,et al. A new and rapid colorimetric determination of acetylcholinesterase activity. , 1961, Biochemical pharmacology.
[80] E. Mufson,et al. Colocalization of cholinesterases with β amyloid protein in aged and Alzheimer's brains , 2004, Acta Neuropathologica.
[81] B. Sommer,et al. Pathogenesis and Mechanism of Cerebral Amyloidosis in APP Transgenic Mice , 2001 .
[82] H. Braak,et al. Evolution of Alzheimer’s disease-related cytoskeletal changes in the basal nucleus of Meynert , 2000, Acta Neuropathologica.
[83] B. Hyman,et al. Microglial response to amyloid plaques in APPsw transgenic mice. , 1998, The American journal of pathology.
[84] D. Selkoe. Alzheimer's disease: genotypes, phenotypes, and treatments. , 1997, Science.
[85] J. Kornhuber,et al. Improved electrophoretic separation and immunoblotting of beta‐amyloid (Aβ) peptides 1–40, 1–42, and 1–43 , 1997, Electrophoresis.
[86] J. McArthur,et al. An unbiased method for estimation of total epidermal nerve fibre length , 1996, Journal of neurocytology.
[87] M. Staufenbiel,et al. Electrophoretic separation of betaA4 peptides (1-40) and (1-42). , 1996, Analytical biochemistry.
[88] M M Mesulam,et al. The systems-level organization of cholinergic innervation in the human cerebral cortex and its alterations in Alzheimer's disease. , 1996, Progress in brain research.
[89] P. Paganetti,et al. Effect of alkalizing agents on the processing of the beta-amyloid precursor protein. , 1996, Brain research.
[90] D. Selkoe,et al. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. , 1992, Nature.