Magnetic Resonance Imaging: Principles and Techniques: Lessons for Clinicians.

The development of magnetic resonance imaging (MRI) for use in medical investigation has provided a huge forward leap in the field of diagnosis, particularly with avoidance of exposure to potentially dangerous ionizing radiation. With decreasing costs and better availability, the use of MRI is becoming ever more pervasive throughout clinical practice. Understanding the principles underlying this imaging modality and its multiple applications can be used to appreciate the benefits and limitations of its use, further informing clinical decision-making. In this article, the principles of MRI are reviewed, with further discussion of specific clinical applications such as parallel, diffusion-weighted, and magnetization transfer imaging. MR spectroscopy is also considered, with an overview of key metabolites and how they may be interpreted. Finally, a brief view on how the use of MRI will change over the coming years is presented.

[1]  C. C. Smith,et al.  Oesophageal carcinoma demonstrated by whole-body nuclear magnetic resonance imaging. , 1981, British medical journal.

[2]  P. Bottomley Spatial Localization in NMR Spectroscopy in Vivo , 1987, Annals of the New York Academy of Sciences.

[3]  P. Basser,et al.  MR diffusion tensor spectroscopy and imaging. , 1994, Biophysical journal.

[4]  Yu-Chien Wu,et al.  Comparison of diffusion tensor imaging measurements at 3.0 T versus 1.5 T with and without parallel imaging. , 2006, Neuroimaging clinics of North America.

[5]  S F Keevil,et al.  Absolute metabolite quantification by in vivo NMR spectroscopy: II. A multicentre trial of protocols for in vivo localised proton studies of human brain. , 1998, Magnetic resonance imaging.

[6]  P. Barker,et al.  Diffusion magnetic resonance imaging: Its principle and applications , 1999, The Anatomical record.

[7]  B. Miller A review of chemical issues in 1H NMR spectroscopy: N‐acetyl‐l‐aspartate, creatine and choline , 1991, NMR in biomedicine.

[8]  S. Warach,et al.  Magnetic Resonance Imaging of Acute Stroke , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[9]  J. Frahm,et al.  Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. , 1999, AJNR. American journal of neuroradiology.

[10]  Derek K. Jones Fundamentals of diffusion MR imaging , 2004 .

[11]  P. Grenier,et al.  MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. , 1986, Radiology.

[12]  U. Klose Measurement sequences for single voxel proton MR spectroscopy. , 2008, European journal of radiology.

[13]  Sasumu Mori,et al.  Clinical MR Neuroimaging: MR tractography using diffusion tensor MR imaging , 2004 .

[14]  V. Jellús,et al.  Diffusion-weighted MR imaging of intracerebral masses: comparison with conventional MR imaging and histologic findings. , 2001, AJNR. American journal of neuroradiology.

[15]  G. Adam,et al.  Monitoring of Gustatory Stimulation of Salivary Glands by Diffusion-Weighted MR Imaging: Comparison of 1.5T and 3T , 2007, American Journal of Neuroradiology.

[16]  A. Elster,et al.  Calculation of apparent diffusion coefficients (ADCs) in brain using two-point and six-point methods. , 1998, Journal of computer assisted tomography.

[17]  Eva H. Baker,et al.  Normal regional fractional anisotropy and apparent diffusion coefficient of the brain measured on a 3 T MR scanner , 2008, Neuroradiology.

[18]  C. Kuhl,et al.  Sensitivity encoding for diffusion-weighted MR imaging at 3.0 T: intraindividual comparative study. , 2005, Radiology.

[19]  G Tedeschi,et al.  High-field proton MRS of human brain. , 2003, European journal of radiology.

[20]  J. Hajnal,et al.  Design and implementation of magnetization transfer pulse sequences for clinical use. , 1992, Journal of computer assisted tomography.

[21]  B S Worthington,et al.  Nuclear Magnetic Resonance (NMR) Tomography of the Brain: A Preliminary Clinical Assessment with Demonstration of Pathology , 1980, Journal of computer assisted tomography.

[22]  Derek K. Jones,et al.  The effect of gradient sampling schemes on measures derived from diffusion tensor MRI: A Monte Carlo study † , 2004, Magnetic resonance in medicine.

[23]  J. Hajnal,et al.  Prior knowledge for time domain quantification of in vivo brain or liver 31P MR spectra , 2003, NMR in biomedicine.

[24]  E. Purcell,et al.  Resonance Absorption by Nuclear Magnetic Moments in a Solid , 1946 .

[25]  S. Bluml,et al.  Proton‐Decoupled 31P Magnetic Resonance Spectroscopy Reveals Osmotic and Metabolic Disturbances in Human Hepatic Encephalopathy , 1998, Journal of neurochemistry.

[26]  Vanhamme,et al.  Improved method for accurate and efficient quantification of MRS data with use of prior knowledge , 1997, Journal of magnetic resonance.

[27]  M. Weiner,et al.  What might be the impact on neurology of the analysis of brain metabolism by in vivo magnetic resonance spectroscopy? , 1994, Journal of Neurology.

[28]  R. Kreis Issues of spectral quality in clinical 1H‐magnetic resonance spectroscopy and a gallery of artifacts , 2004, NMR in biomedicine.

[29]  T. A. Carpenter,et al.  Optimised diffusion-weighting for measurement of apparent diffusion coefficient (ADC) in human brain. , 1997, Magnetic resonance imaging.

[30]  Derek K. Jones,et al.  Diffusion‐tensor MRI: theory, experimental design and data analysis – a technical review , 2002 .

[31]  E. Merkle,et al.  A review of MR physics: 3T versus 1.5T. , 2007, Magnetic resonance imaging clinics of North America.

[32]  T. Chenevert,et al.  Anisotropic diffusion in human white matter: demonstration with MR techniques in vivo. , 1990, Radiology.

[33]  C. Kuhl,et al.  Acute and subacute ischemic stroke at high-field-strength (3.0-T) diffusion-weighted MR imaging: intraindividual comparative study. , 2005, Radiology.

[34]  J. Kurhanewicz,et al.  Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats. , 1990, AJNR. American journal of neuroradiology.

[35]  Carolyn Kaut,et al.  MRI in Practice , 1993 .

[36]  C. Thomsen,et al.  In vivo magnetic resonance diffusion measurement in the brain of patients with multiple sclerosis. , 1992, Magnetic resonance imaging.

[37]  J V Hajnal,et al.  Normal and abnormal white matter tracts shown by MR imaging using directional diffusion weighted sequences. , 1990, Journal of computer assisted tomography.

[38]  K. Kono,et al.  The role of diffusion-weighted imaging in patients with brain tumors. , 2001, AJNR. American journal of neuroradiology.

[39]  C. Beaulieu,et al.  The basis of anisotropic water diffusion in the nervous system – a technical review , 2002, NMR in biomedicine.

[40]  P. Bottomley The trouble with spectroscopy papers , 1992, Journal of magnetic resonance imaging : JMRI.

[41]  À. Rovira,et al.  Normalization of T2 signal abnormalities in hemispheric white matter with liver transplant , 2002, Neurology.

[42]  G. Barker,et al.  Detection of myelin breakdown products by proton magnetic resonance spectroscopy , 1993, The Lancet.

[43]  J Hennig,et al.  Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. , 1994, Gastroenterology.

[44]  J R Griffiths,et al.  31P-magnetic resonance spectroscopy studies of nucleated and non-nucleated erythrocytes; time domain data analysis (VARPRO) incorporating prior knowledge can give information on the binding of ADP. , 1996, Biochimica et biophysica acta.

[45]  N. Lundbom,et al.  Characterizing human adipose tissue lipids by long echo time 1H‐MRS in vivo at 1.5 Tesla: validation by gas chromatography , 2010, NMR in Biomedicine.

[46]  R. Balaban,et al.  Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo , 1989, Magnetic resonance in medicine.

[47]  Guy B. Williams,et al.  Looking for the optimal DTI acquisition scheme given a maximum scan time: are more b-values a waste of time? , 2009, Magnetic resonance imaging.

[48]  W. W. Hansen,et al.  The Nuclear Induction Experiment , 1946 .

[49]  D Matthaei,et al.  Multipurpose NMR imaging using stimulated echoes , 1986, Magnetic resonance in medicine.

[50]  À. Rovira,et al.  Magnetization transfer ratio values and proton MR spectroscopy of normal-appearing cerebral white matter in patients with liver cirrhosis. , 2001, AJNR. American journal of neuroradiology.

[51]  Linda Chang,et al.  Relationships among Brain Metabolites, Cognitive Function, and Viral Loads in Antiretroviral-Naı̈ve HIV Patients , 2002, NeuroImage.

[52]  William H. Oldendorf,et al.  N-Acetyl-L-Aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain , 1989, Neuroscience & Biobehavioral Reviews.