Regulation of iron acquisition and iron distribution in mammals.

[1]  E. Neufeld,et al.  Urinary hepcidin in congenital chronic anemias , 2007, Pediatric blood & cancer.

[2]  T. Ganz Molecular pathogenesis of anemia of chronic disease , 2006, Pediatric blood & cancer.

[3]  N. Andrews,et al.  Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice. , 2006, Blood.

[4]  E. Beutler Hemochromatosis: genetics and pathophysiology. , 2006, Annual review of medicine.

[5]  Xiaoling Xu,et al.  A Role of Smad4 in Iron Metabolism through the Positive Regulation of Hepcidin Expression , 2022 .

[6]  M. Garrick,et al.  Iron Imports. II. Iron uptake at the apical membrane in the intestine. , 2005, American journal of physiology. Gastrointestinal and liver physiology.

[7]  N. Andrews,et al.  Hemojuvelin Acts as a Bone Morphogenetic Protein Co-Receptor To Regulate Hepcidin Expression. , 2005 .

[8]  D. Swinkels,et al.  Novel urine hepcidin assay by mass spectrometry. , 2005, Blood.

[9]  G. Ramm,et al.  Hepatotoxicity of iron overload: mechanisms of iron-induced hepatic fibrogenesis. , 2005, Seminars in liver disease.

[10]  J. J. Sharp,et al.  Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells , 2005, Nature Genetics.

[11]  N. Andrews,et al.  Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. , 2005, Blood.

[12]  A. West,et al.  Interaction of Hemojuvelin with Neogenin Results in Iron Accumulation in Human Embryonic Kidney 293 Cells* , 2005, Journal of Biological Chemistry.

[13]  Manuela M. Santos,et al.  Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading. , 2005, Blood.

[14]  C. Vulpe,et al.  Identification of an Intestinal Heme Transporter , 2005, Cell.

[15]  C. Woolf,et al.  Repulsive Guidance Molecule (RGMa), a DRAGON Homologue, Is a Bone Morphogenetic Protein Co-receptor* , 2005, Journal of Biological Chemistry.

[16]  V. Viprakasit,et al.  Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin. , 2005, Blood.

[17]  T. Ganz,et al.  The molecular basis of ferroportin-linked hemochromatosis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[18]  J. Cook Diagnosis and management of iron-deficiency anaemia. , 2005, Best practice & research. Clinical haematology.

[19]  E. Debnam,et al.  Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression , 2005, Gut.

[20]  T. Ganz,et al.  Hepcidin in iron overload disorders. , 2005, Blood.

[21]  N. Andrews,et al.  Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. , 2005, The Journal of clinical investigation.

[22]  S. David,et al.  A role for iron-sulfur clusters in DNA repair. , 2005, Current opinion in chemical biology.

[23]  A. Donovan,et al.  The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. , 2005, Cell metabolism.

[24]  T. Ganz,et al.  Hepcidin is decreased in TFR2 hemochromatosis. , 2005, Blood.

[25]  T. Ganz,et al.  Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. , 2005, Blood.

[26]  E. Beutler,et al.  Regulation of hepcidin transcription by interleukin-1 and interleukin-6. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[27]  W. Stremmel,et al.  Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes. , 2005, Gastroenterology.

[28]  J. Prchal,et al.  Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. , 2005, Blood.

[29]  Jerry Kaplan,et al.  Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization , 2004, Science.

[30]  M. Wessling-Resnick,et al.  Regulation of transferrin receptor 2 protein levels by transferrin. , 2004, Blood.

[31]  C. Enns,et al.  Diferric transferrin regulates transferrin receptor 2 protein stability. , 2004, Blood.

[32]  A. Chédotal,et al.  Repulsive guidance molecule/neogenin: a novel ligand‐receptor system playing multiple roles in neural development , 2004, Development, growth & differentiation.

[33]  P. Aisen,et al.  Transferrin receptor 1. , 2004, The international journal of biochemistry & cell biology.

[34]  C. Vulpe,et al.  Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis. , 2004, Biochimica et biophysica acta.

[35]  C. Vulpe,et al.  Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis , 2004, Gut.

[36]  C. Vulpe,et al.  Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE , 2004, British journal of haematology.

[37]  Srikanth Rajagopalan,et al.  Neogenin mediates the action of repulsive guidance molecule , 2004, Nature Cell Biology.

[38]  A. Pietrangelo Hereditary hemochromatosis--a new look at an old disease. , 2004, The New England journal of medicine.

[39]  V. Divoky,et al.  Severe hypochromic microcytic anemia caused by a congenital defect of the iron transport pathway in erythroid cells. , 2004, Blood.

[40]  Elizabeta Nemeth,et al.  IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. , 2004, The Journal of clinical investigation.

[41]  M. Hentze,et al.  Balancing Acts Molecular Control of Mammalian Iron Metabolism , 2004, Cell.

[42]  I. Bechmann,et al.  The Repulsive Guidance Molecule RGMa Is Involved in the Formation of Afferent Connections in the Dentate Gyrus , 2004, The Journal of Neuroscience.

[43]  G. Grimber,et al.  Functional differences between hepcidin 1 and 2 in transgenic mice. , 2004, Blood.

[44]  J. Gitlin,et al.  Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis. , 1998, The American journal of clinical nutrition.

[45]  C. Woolf,et al.  DRAGON: A Member of the Repulsive Guidance Molecule-Related Family of Neuronal- and Muscle-Expressed Membrane Proteins Is Regulated by DRG11 and Has Neuronal Adhesive Properties , 2004, The Journal of Neuroscience.

[46]  S. Arber,et al.  Repulsive Guidance Molecule (RGM) Gene Function Is Required for Neural Tube Closure But Not Retinal Topography in the Mouse Visual System , 2004, The Journal of Neuroscience.

[47]  M. Hentze,et al.  Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis , 2003, Nature Genetics.

[48]  Elizabeth C. Theil Ferritin: at the crossroads of iron and oxygen metabolism. , 2003, The Journal of nutrition.

[49]  N. Andrews,et al.  Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis , 2003, Nature Genetics.

[50]  Elizabeta Nemeth,et al.  Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. , 2003, Blood.

[51]  D. Purdie,et al.  Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis , 2003, The Lancet.

[52]  M. Loda,et al.  Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. , 2002, Blood.

[53]  W. Sly,et al.  Decreased liver hepcidin expression in the Hfe knockout mouse. , 2002, Blood cells, molecules & diseases.

[54]  H. Vogel,et al.  The Solution Structure of Human Hepcidin, a Peptide Hormone with Antimicrobial Activity That Is Involved in Iron Uptake and Hereditary Hemochromatosis* 210 , 2002, The Journal of Biological Chemistry.

[55]  D. Richardson,et al.  The role of iron in cell cycle progression and the proliferation of neoplastic cells. , 2002, Biochimica et biophysica acta.

[56]  Gaël Nicolas,et al.  The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. , 2002, The Journal of clinical investigation.

[57]  C. Beaumont,et al.  Severe iron deficiency anemia in transgenic mice expressing liver hepcidin , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[58]  P. Gros,et al.  Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. , 2001, Blood.

[59]  C. Vulpe,et al.  Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption. , 2001, Biochemical Society transactions.

[60]  W. Sly,et al.  Hepcidin: A putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[61]  C. Beaumont,et al.  Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[62]  A. Tavill Diagnosis and management of hemochromatosis , 2001, Hepatology.

[63]  Christina H. Park,et al.  Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver* , 2001, The Journal of Biological Chemistry.

[64]  Bruno Turlin,et al.  A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload* , 2001, The Journal of Biological Chemistry.

[65]  S. Moestrup,et al.  Identification of the haemoglobin scavenger receptor , 2001, Nature.

[66]  Peter Schulz-Knappe,et al.  LEAP‐1, a novel highly disulfide‐bonded human peptide, exhibits antimicrobial activity , 2000, FEBS letters.

[67]  N. Andrews,et al.  The molecular defect in hypotransferrinemic mice. , 2000, Blood.

[68]  Paolo Gasparini,et al.  The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22 , 2000, Nature Genetics.

[69]  Nancy Andrews,et al.  Transferrin receptor is necessary for development of erythrocytes and the nervous system , 1999, Nature Genetics.

[70]  R. Jurado Iron, infections, and anemia of inflammation. , 1997, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[71]  J. Cook,et al.  Effect of enhanced erythropoiesis on iron absorption. , 1992, The Journal of laboratory and clinical medicine.

[72]  M. Nathanson,et al.  Regulation of intestinal iron absorption and mucosal iron kinetics in hereditary hemochromatosis. , 1991, The Journal of laboratory and clinical medicine.

[73]  Lukas C. Kühn,et al.  A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm , 1988, Cell.

[74]  R D Klausner,et al.  Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation. , 1988, Science.

[75]  H. Munro,et al.  Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[76]  T. Bothwell,et al.  Body iron excretion in man: a collaborative study. , 1968, The American journal of medicine.

[77]  P. Porporato,et al.  Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload. , 2005, Haematologica.

[78]  Marie-Pierre Dubé,et al.  Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis , 2004, Nature Genetics.

[79]  D. Girelli,et al.  Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis , 2003, Nature Genetics.

[80]  N. Andrews Disorders of iron metabolism. , 1999, The New England journal of medicine.