Ferroptosis regulation by methylation in cancer.

[1]  Liucun Zhu,et al.  Identification and Validation of Ferroptosis-Related DNA Methylation Signature for Predicting the Prognosis and Guiding the Treatment in Cutaneous Melanoma , 2022, International journal of molecular sciences.

[2]  Jinglin Mi,et al.  m6A demethylase FTO renders radioresistance of nasopharyngeal carcinoma via promoting OTUB1-mediated anti-ferroptosis , 2022, Translational oncology.

[3]  W. Xue,et al.  USP7 accelerates FMR1-mediated ferroptosis by facilitating TBK1 ubiquitination and DNMT1 deubiquitination after renal ischemia–reperfusion injury , 2022, Inflammation Research.

[4]  Qingzhi Guo,et al.  Development and validation of four ferroptosis-related gene signatures and their correlations with immune implication in hepatocellular carcinoma , 2022, Frontiers in Immunology.

[5]  Haihua Yang,et al.  A Novel Prognosis Signature Based on Ferroptosis-Related Gene DNA Methylation Data for Lung Squamous Cell Carcinoma , 2022, Journal of oncology.

[6]  Jia Peng,et al.  KMT2B-dependent RFK transcription activates the TNF-α/NOX2 pathway and enhances ferroptosis caused by myocardial ischemia-reperfusion. , 2022, Journal of molecular and cellular cardiology.

[7]  Hongjun Xie,et al.  Identification of m6A- and ferroptosis-related lncRNA signature for predicting immune efficacy in hepatocellular carcinoma , 2022, Frontiers in Immunology.

[8]  B. Henkelmann,et al.  A non-canonical vitamin K cycle is a potent ferroptosis suppressor , 2022, Nature.

[9]  B. Stockwell Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications , 2022, Cell.

[10]  Yuanbin Chen,et al.  PCDHB14 promotes ferroptosis and is a novel tumor suppressor in hepatocellular carcinoma , 2022, Oncogene.

[11]  Juan Chen,et al.  GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis , 2022, Frontiers in Cardiovascular Medicine.

[12]  C. Zhuang,et al.  The N6‐methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma , 2022, Clinical and translational medicine.

[13]  Kellen L. Olszewski,et al.  A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers , 2022, Nature Communications.

[14]  Yuting He,et al.  Alveolar macrophage-derived exosomal tRF-22-8BWS7K092 activates Hippo signaling pathway to induce ferroptosis in acute lung injury. , 2022, International immunopharmacology.

[15]  Chun Fu,et al.  Hypoxia Enhances HIF1α Transcription Activity by Upregulating KDM4A and Mediating H3K9me3, Thus Inducing Ferroptosis Resistance in Cervical Cancer Cells , 2022, Stem cells international.

[16]  Feng Zhang,et al.  m6A methylation is required for dihydroartemisinin to alleviate liver fibrosis by inducing ferroptosis in hepatic stellate cells. , 2022, Free radical biology & medicine.

[17]  Jiayi Wang,et al.  Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma , 2022, Cancer communications.

[18]  Jianglin Wang,et al.  Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis in gastric cancer. , 2022, Free radical biology & medicine.

[19]  Yiming Xu,et al.  METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification , 2022, Cancer cell international.

[20]  Jiansheng Li,et al.  Histone methyltransferase SETDB1 inhibits TGF-β-induced epithelial-mesenchymal transition in pulmonary fibrosis by regulating SNAI1 expression and the ferroptosis signaling pathway. , 2021, Archives of biochemistry and biophysics.

[21]  B. Pang,et al.  RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m6A-dependent manner , 2022, Cell death & disease.

[22]  G. Gkoutos,et al.  IRON-MEDIATED EPIGENETIC ACTIVATION OF NRF2 TARGETS. , 2021, The Journal of nutritional biochemistry.

[23]  Shujun Liu,et al.  Gold Nanorods Exhibit Intrinsic Therapeutic Activity via Controlling N6-Methyladenosine-Based Epitranscriptomics in Acute Myeloid Leukemia. , 2021, ACS nano.

[24]  M. Shu,et al.  Hypoxia blocks ferroptosis of hepatocellular carcinoma via suppression of METTL14 triggered YTHDF2‐dependent silencing of SLC7A11 , 2021, Journal of cellular and molecular medicine.

[25]  M. Weng,et al.  Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of CBS in gastric cancer , 2021, Journal of advanced research.

[26]  Feng Zhang,et al.  N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells , 2021, Redox biology.

[27]  Hui Wang,et al.  Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications , 2021, Frontiers in Oncology.

[28]  Zhifu Sun,et al.  A novel ferroptosis phenotype‐related clinical‐molecular prognostic signature for hepatocellular carcinoma , 2021, Journal of cellular and molecular medicine.

[29]  Yuan Guo,et al.  Molecular mechanism of cell ferroptosis and research progress in regulation of ferroptosis by noncoding RNAs in tumor cells , 2021, Cell death discovery.

[30]  Xiaofeng Dai,et al.  Methylation multiplicity and its clinical values in cancer , 2021, Expert Reviews in Molecular Medicine.

[31]  Y. Tao,et al.  Emerging mechanisms and targeted therapy of ferroptosis in cancer. , 2021, Molecular therapy : the journal of the American Society of Gene Therapy.

[32]  Gang Jia,et al.  Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis. , 2021, Life sciences.

[33]  Quan Zhang,et al.  Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells , 2021, Journal of Hematology & Oncology.

[34]  Li Li,et al.  The role of the Hippo pathway in the pathogenesis of inflammatory bowel disease , 2021, Cell death & disease.

[35]  Y. Huh,et al.  Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. , 2020, Proceedings of the National Academy of Sciences of the United States of America.

[36]  T. Tong,et al.  CRL4DCAF8 dependent opposing stability control over the chromatin remodeler LSH orchestrates epigenetic dynamics in ferroptosis , 2020, Cell Death & Differentiation.

[37]  X. Zhang,et al.  The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function , 2020, Redox biology.

[38]  Zhiying Ai,et al.  Discovery of a novel ferroptosis inducer-talaroconvolutin A—killing colorectal cancer cells in vitro and in vivo , 2020, Cell Death & Disease.

[39]  Amit Kumar,et al.  Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases , 2020, Neurobiology of Disease.

[40]  Yanzhang Li,et al.  Corrigendum to “IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer” , 2020, Oxidative medicine and cellular longevity.

[41]  T. Efferth,et al.  Cytotoxicity of apigenin toward multiple myeloma cell lines and suppression of iNOS and COX-2 expression in STAT1-transfected HEK293 cells. , 2020, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[42]  W. Xue,et al.  SUV39H1 deficiency suppresses clear cell renal cell carcinoma growth by inducing ferroptosis , 2020, Acta pharmaceutica Sinica. B.

[43]  Bao Huang,et al.  Homocysteine Induces Oxidative Stress and Ferroptosis of Nucleus Pulposus Via Enhancing Methylation of GPX4. , 2020, Free radical biology & medicine.

[44]  P. Singh,et al.  A Novel Redox Modulator Induces a GPX4-mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species. , 2020, Journal of medicinal chemistry.

[45]  Y. Zhong,et al.  FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells. , 2020, Life sciences.

[46]  B. Stockwell,et al.  Emerging Mechanisms and Disease Relevance of Ferroptosis. , 2020, Trends in cell biology.

[47]  D. Tang,et al.  Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death , 2020, Cancer Gene Therapy.

[48]  I. Yanatori,et al.  Ferroptosis at the crossroads of infection, aging and cancer , 2020, Cancer science.

[49]  Shouping Xu,et al.  Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin , 2020, Journal of cellular physiology.

[50]  P. Clemons,et al.  Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles , 2020, Nature Chemical Biology.

[51]  Zhen Zou,et al.  Arsenite induces testicular oxidative stress in vivo and in vitro leading to ferroptosis. , 2020, Ecotoxicology and environmental safety.

[52]  Min Yu,et al.  Characteristics of iron status, oxidation response, and DNA methylation profile in response to occupational iron oxide nanoparticles exposure , 2020, Toxicology and industrial health.

[53]  Chengliang Zhang,et al.  Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11 , 2020, FEBS open bio.

[54]  Xiaohong Wang,et al.  m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC , 2020, Molecular Cancer.

[55]  Y. Liu,et al.  Expression and prognostic potential of GPX1 in human cancers based on data mining. , 2020, Annals of translational medicine.

[56]  S. Mou,et al.  The N6‐methyladenosine mRNA methylase METTL14 promotes renal ischemic reperfusion injury via suppressing YAP1 , 2020, Journal of cellular biochemistry.

[57]  C. Thompson,et al.  Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. , 2019, Cell metabolism.

[58]  Edward W. Tate,et al.  FSP1 is a glutathione-independent ferroptosis suppressor , 2019, Nature.

[59]  J. Olzmann,et al.  The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis , 2019, Nature.

[60]  D. Hsu,et al.  The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma. , 2019, Cell reports.

[61]  B. Stockwell,et al.  A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System. , 2019, Cell metabolism.

[62]  B. Stockwell,et al.  Intercellular interaction dictates cancer cell ferroptosis via Merlin-YAP signalling , 2019, Nature.

[63]  D. Krysko,et al.  Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion , 2019, Nature Reviews Cancer.

[64]  K. Guan,et al.  The Hippo Pathway: Biology and Pathophysiology. , 2019, Annual review of biochemistry.

[65]  W. Cui,et al.  Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53 , 2019, EMBO reports.

[66]  B. Stockwell,et al.  Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model. , 2019, Cell chemical biology.

[67]  D. Pang,et al.  Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells , 2019, Cell Death & Disease.

[68]  M. Jackson,et al.  Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells , 2019, Scientific Reports.

[69]  A. Chinnaiyan,et al.  CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy , 2019, Nature.

[70]  W. Gu,et al.  ALOX12 is required for p53-mediated tumor suppression through a distinct ferroptosis pathway , 2019, Nature Cell Biology.

[71]  P. Vandenabeele,et al.  The molecular machinery of regulated cell death , 2019, Cell Research.

[72]  B. Gan,et al.  Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1 , 2019, Cell cycle.

[73]  Na Liu,et al.  Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA , 2019, Cell Death & Differentiation.

[74]  Junying Yuan,et al.  Chaperone-mediated autophagy is involved in the execution of ferroptosis , 2019, Proceedings of the National Academy of Sciences.

[75]  W. Fan,et al.  DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin , 2019, Free radical biology & medicine.

[76]  F. Gao,et al.  Ferroptosis as a target for protection against cardiomyopathy , 2019, Proceedings of the National Academy of Sciences.

[77]  Yunyan Gu,et al.  RHPCG: a database of the Regulation of the Hippo Pathway in Cancer Genome , 2019, Database J. Biol. Databases Curation.

[78]  Yi Chen,et al.  Iron Metabolism in Cancer , 2018, International journal of molecular sciences.

[79]  Yang Liu,et al.  Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway. , 2018, European journal of medicinal chemistry.

[80]  Wei Li,et al.  BAP1 links metabolic regulation of ferroptosis to tumor suppression , 2018, Nature Cell Biology.

[81]  Lianhua Liu,et al.  Iron chelation inhibits cancer cell growth and modulates global histone methylation status in colorectal cancer , 2018, BioMetals.

[82]  P. Shang,et al.  Alterations in Cellular Iron Metabolism Provide More Therapeutic Opportunities for Cancer , 2018, International journal of molecular sciences.

[83]  G. Ateş,et al.  Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System , 2018, Front. Neurosci..

[84]  B. Stockwell,et al.  FINO2 Initiates Ferroptosis Through GPX4 Inactivation and Iron Oxidation , 2018, Nature Chemical Biology.

[85]  J. Lemasters,et al.  Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells☆ , 2018, Biochemical pharmacology.

[86]  S. Lipton,et al.  Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 , 2018, Cell Death & Differentiation.

[87]  A. Sfera,et al.  Ferrosenescence: The iron age of neurodegeneration? , 2017, Mechanisms of Ageing and Development.

[88]  B. Stockwell,et al.  Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease , 2017, Cell.

[89]  Xiaojiang Li,et al.  The protective role of TET2 in erythroid iron homeostasis against oxidative stress and erythropoiesis. , 2017, Cellular signalling.

[90]  C. Philpott,et al.  Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells. , 2017, Blood cells, molecules & diseases.

[91]  G. Kroemer,et al.  The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. , 2017, Cell reports.

[92]  Y. Tao,et al.  EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes , 2017, Theranostics.

[93]  Jill P. Mesirov,et al.  Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway , 2017, Nature.

[94]  S. Lowe,et al.  Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function , 2017, Molecular cell.

[95]  S. Giulitti,et al.  YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate , 2017, Nature Communications.

[96]  D. Birnbaum,et al.  Salinomycin kills cancer stem cells by sequestering iron in lysosomes , 2017, Nature Chemistry.

[97]  Zhenyu Li,et al.  Ferroptosis: A Novel Anti-tumor Action for Cisplatin , 2017, Cancer research and treatment : official journal of Korean Cancer Association.

[98]  L. Schöckel,et al.  Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells , 2017, Cell Death and Disease.

[99]  S. Rivella,et al.  Targeting iron metabolism in drug discovery and delivery , 2017, Nature Reviews Drug Discovery.

[100]  A. Suzuki,et al.  Targeting the Hippo signalling pathway for cancer treatment. , 2016, Journal of biochemistry.

[101]  J. Roh,et al.  Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis , 2016, Redox biology.

[102]  V. Ellenrieder,et al.  Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon? , 2016, Gut.

[103]  B. Stockwell,et al.  Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis , 2016, Proceedings of the National Academy of Sciences.

[104]  D. Tang,et al.  Metallothionein‐1G facilitates sorafenib resistance through inhibition of ferroptosis , 2016, Hepatology.

[105]  B. Stockwell,et al.  Global Survey of Cell Death Mechanisms Reveals Metabolic Regulation of Ferroptosis , 2016, Nature chemical biology.

[106]  L. Yin,et al.  Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells , 2016, Oncotarget.

[107]  L. Saso,et al.  Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants , 2016, Oxidative medicine and cellular longevity.

[108]  D. Tang,et al.  Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells , 2016, Hepatology.

[109]  Xiaozhou He,et al.  Decreased expression of ferroportin in prostate cancer. , 2015, Oncology letters.

[110]  F. Zhan,et al.  Decreased ferroportin promotes myeloma cell growth and osteoclast differentiation. , 2015, Cancer research.

[111]  J. Mandl,et al.  Ferroptosis is Involved in Acetaminophen Induced Cell Death , 2015, Pathology & Oncology Research.

[112]  Nils Eling,et al.  Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells , 2015, Oncoscience.

[113]  T. Vellai,et al.  The mechanism of ageing: primary role of transposable elements in genome disintegration , 2015, Cellular and Molecular Life Sciences.

[114]  W. Gu,et al.  Ferroptosis as a p53-mediated activity during tumour suppression , 2015, Nature.

[115]  Caiguo Zhang,et al.  Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities , 2014, Protein & Cell.

[116]  B. Chauffert,et al.  Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors. , 2014, Anticancer research.

[117]  D. Buzas,et al.  Epigenetic role for the conserved Fe-S cluster biogenesis protein AtDRE2 in Arabidopsis thaliana , 2014, Proceedings of the National Academy of Sciences.

[118]  Jonathan A. Cooper,et al.  Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus. , 2014, Cancer cell.

[119]  Frans van Roy,et al.  Beyond E-cadherin: roles of other cadherin superfamily members in cancer , 2014, Nature Reviews Cancer.

[120]  Matthew E. Welsch,et al.  Regulation of Ferroptotic Cancer Cell Death by GPX4 , 2014, Cell.

[121]  I. Pogribny,et al.  Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents. , 2013, International journal of oncology.

[122]  M. Dawson,et al.  Cancer Epigenetics: From Mechanism to Therapy , 2012, Cell.

[123]  M. R. Lamprecht,et al.  Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death , 2012, Cell.

[124]  P. Mandal,et al.  Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity. , 2010, Neoplasia.

[125]  Paolo Sassone-Corsi,et al.  Decoding the Epigenetic Language of Neuronal Plasticity , 2008, Neuron.

[126]  N. Plesnila,et al.  Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. , 2008, Cell metabolism.

[127]  V. Skiada,et al.  Redox signaling and cancer: the role of "labile" iron. , 2008, Cancer letters.

[128]  B. Stockwell,et al.  RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels , 2007, Nature.

[129]  Gustavo Helguera,et al.  The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells. , 2006, Clinical immunology.

[130]  G. Berx,et al.  Modulation of iron transport proteins in human colorectal carcinogenesis , 2006, Gut.

[131]  P. Maher,et al.  Oxytosis: A novel form of programmed cell death. , 2001, Current topics in medicinal chemistry.

[132]  D. Piani,et al.  Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons. , 1994, Journal of immunology.

[133]  T. Murphy,et al.  Calcium-dependent glutamate cytotoxicity in a neuronal cell line , 1988, Brain Research.

[134]  K. Piez,et al.  The biosynthesis of cystine in human cell cultures. , 1961, The Journal of biological chemistry.

[135]  F. De Ritis,et al.  [Enzymatic mechanisms of transsulfuration in biology and clinical practice]. , 1956, Giornale di clinica medica.

[136]  H. Eagle,et al.  Nutrition needs of mammalian cells in tissue culture. , 1955, Science.

[137]  OUP accepted manuscript , 2022, Rheumatology.

[138]  A. Walch,et al.  ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. , 2017, Nature chemical biology.

[139]  H. Kasai,et al.  DNA methylation by dimethyl sulfoxide and methionine sulfoxide triggered by hydroxyl radical and implications for epigenetic modifications. , 2010, Bioorganic & medicinal chemistry letters.

[140]  Matthias W. Hentze,et al.  Two to Tango: Regulation of Mammalian Iron Metabolism , 2010, Cell.