Impaired corticostriatal connectivity in impulse control disorders in Parkinson disease

Objectives: To compare the striatum's resting-state functional connectivity in patients with Parkinson disease (PD) with and without impulse control disorders (ICDs). Methods: Twenty patients with PD and ICDs, 19 patients with PD but no ICDs, and 19 healthy controls underwent fMRI in the resting state. The ventral striatum, dorsal caudate, and anterior and posterior putamen were segmented semiautomatically. For each region of interest, a seed-based connectivity analysis was performed on preprocessed fMRI data mapped on the ipsilateral cortical surface. An additional cortical thickness analysis was used to assess and compare gray matter atrophy in the 3 study subgroups. Results: The presence of an ICD in patients with PD was associated with functional disconnection between the left anterior putamen and both the left inferior temporal gyrus and the left anterior cingulate gyrus, as well as a trend toward a functional disconnection between several motor and associative striatal regions and limbic, associative, and motor cortical regions. Patients without ICDs did not differ from healthy controls in corticostriatal connectivity. The cortical thickness analysis did not reveal any significant differences among the 3 study subgroups. Conclusions: In PD, ICDs are associated with altered connectivity between an associative striatal area (the left anterior putamen) and associative and limbic cortical regions (the left inferior temporal gyrus and the left anterior cingulate gyrus).

[1]  Mary Beth Nebel,et al.  Reduction of motion-related artifacts in resting state fMRI using aCompCor , 2014, NeuroImage.

[2]  Jan Booij,et al.  Reduced dopamine transporter binding predates impulse control disorders in Parkinson's disease , 2014, Movement disorders : official journal of the Movement Disorder Society.

[3]  T. Robbins,et al.  Selective serotonin reuptake inhibition modulates response inhibition in Parkinson’s disease , 2014, Brain : a journal of neurology.

[4]  Xiaoqi Huang,et al.  Reduced functional connectivity in early-stage drug-naive Parkinson's disease: a resting-state fMRI study , 2014, Neurobiology of Aging.

[5]  J. S. Lee,et al.  Extrastriatal dopaminergic changes in Parkinson’s disease patients with impulse control disorders , 2013, Journal of Neurology, Neurosurgery & Psychiatry.

[6]  Valerie Voon,et al.  Impulse control disorders in Parkinson's disease: decreased striatal dopamine transporter levels , 2013, Journal of Neurology, Neurosurgery & Psychiatry.

[7]  Janet B W Williams,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[8]  Marios Politis,et al.  Neural response to visual sexual cues in dopamine treatment-linked hypersexuality in Parkinson's disease. , 2013, Brain : a journal of neurology.

[9]  A. Snyder,et al.  Resting state functional connectivity of the striatum in Parkinson's disease. , 2012, Brain : a journal of neurology.

[10]  Ji Hyun Ko,et al.  Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: A [11C] FLB-457 and PET study , 2012, Neurobiology of Disease.

[11]  Rainer Goebel,et al.  Measuring structural–functional correspondence: Spatial variability of specialised brain regions after macro-anatomical alignment , 2012, NeuroImage.

[12]  M. Hallett,et al.  Functional connectivity of cortical motor areas in the resting state in Parkinson's disease , 2011, Human brain mapping.

[13]  A. Lang,et al.  Impulse control disorders in parkinson disease: A multicenter case–control study , 2011, Annals of neurology.

[14]  M. Hallett,et al.  Dopamine agonists and risk: impulse control disorders in Parkinson's disease. , 2011, Brain : a journal of neurology.

[15]  Marios Politis,et al.  Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours. , 2011, Brain : a journal of neurology.

[16]  Angelo Antonini,et al.  Pathological gambling in patients with Parkinson's disease is associated with fronto‐striatal disconnection: A path modeling analysis , 2011, Movement disorders : official journal of the Movement Disorder Society.

[17]  C. Clarke,et al.  Systematic review of levodopa dose equivalency reporting in Parkinson's disease , 2010, Movement disorders : official journal of the Movement Disorder Society.

[18]  S. Houle,et al.  Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD , 2010, Neurology.

[19]  A. Strafella,et al.  Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling , 2010, Neurobiology of Disease.

[20]  A. Lang,et al.  Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients. , 2010, Archives of neurology.

[21]  I. Toni,et al.  Spatial remapping of cortico-striatal connectivity in Parkinson's disease – a resting state fMRI study , 2009, NeuroImage.

[22]  M. Hallett,et al.  Mechanisms Underlying Dopamine-Mediated Reward Bias in Compulsive Behaviors , 2010, Neuron.

[23]  Bruce Fischl,et al.  Accurate and robust brain image alignment using boundary-based registration , 2009, NeuroImage.

[24]  Daniel Weintraub,et al.  Validation of the questionnaire for impulsive‐compulsive disorders in Parkinson's disease , 2009, Movement disorders : official journal of the Movement Disorder Society.

[25]  KJ Worsley,et al.  SurfStat: A Matlab toolbox for the statistical analysis of univariate and multivariate surface and volumetric data using linear mixed effects models and random field theory , 2009, NeuroImage.

[26]  C. Kelly,et al.  L-Dopa Modulates Functional Connectivity in Striatal Cognitive and Motor Networks: A Double-Blind Placebo-Controlled Study , 2009, NeuroImage.

[27]  S. Houle,et al.  Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study. , 2009, Brain : a journal of neurology.

[28]  A. Antonini,et al.  Functional abnormalities underlying pathological gambling in Parkinson disease. , 2008, Archives of neurology.

[29]  Thomas T. Liu,et al.  A component based noise correction method (CompCor) for BOLD and perfusion based fMRI , 2007, NeuroImage.

[30]  A. Lang,et al.  Prevalence of repetitive and reward-seeking behaviors in Parkinson disease , 2006, Neurology.

[31]  Rainer Goebel,et al.  Cortex-based independent component analysis of fMRI time-series , 2001, NeuroImage.

[32]  D Le Bihan,et al.  Detection of fMRI activation using Cortical Surface Mapping , 2001, Human brain mapping.

[33]  W. Gibb,et al.  THE SIGNIFICANCE OF THE LEWY BODY IN THE DIAGNOSIS OF IDIOPATHIC PARKINSON'S DISEASE , 1989, Neuropathology and applied neurobiology.

[34]  S. Folstein,et al.  “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician , 1975 .

[35]  M. Hoehn,et al.  Parkinsonism , 1967, Neurology.

[36]  H. Groenewegen,et al.  [Impulse control disorders in Parkinson's disease]. , 2011, Tijdschrift voor psychiatrie.

[37]  A. Bonnet,et al.  [The Unified Parkinson's Disease Rating Scale]. , 2000, Revue neurologique.

[38]  A. Dale,et al.  High‐resolution intersubject averaging and a coordinate system for the cortical surface , 1999, Human brain mapping.

[39]  D. Sheehan,et al.  The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. , 1998, The Journal of clinical psychiatry.

[40]  J M Smith,et al.  Compulsive buying: a report of 20 cases. , 1994, The Journal of clinical psychiatry.

[41]  S. Fahn Unified Parkinson's Disease Rating Scale , 1987 .