Particle therapy at the Heidelberg Ion Therapy Center (HIT) - Integrated research-driven university-hospital-based radiation oncology service in Heidelberg, Germany.

The Heidelberg Ion Therapy Center (HIT) offers treatment of particle therapy with variety of ion species for over 1300 patients yearly. In November 2009, patient treatment has begun. The aim of the center is to provide high-end radiotherapy, and to define the role of particle therapy through clinical trials.

[1]  H. Tsujii,et al.  Local control and recurrence of stage I non-small cell lung cancer after carbon ion radiotherapy. , 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[2]  Riwa Kishimoto,et al.  Overview of clinical experiences on carbon ion radiotherapy at NIRS. , 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[3]  Dirk De Ruysscher,et al.  A systematic literature review of the clinical and cost-effectiveness of hadron therapy in cancer. , 2007, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[4]  T. Obata,et al.  Results of the first prospective study of carbon ion radiotherapy for hepatocellular carcinoma with liver cirrhosis. , 2004, International journal of radiation oncology, biology, physics.

[5]  O Jäkel,et al.  The Heidelberg Ion Therapy Center. , 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[6]  Hirohiko Tsujii,et al.  Particle radiation therapy using proton and heavier ion beams. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[7]  M Scholz,et al.  Treatment planning for heavy-ion radiotherapy: calculation and optimization of biologically effective dose. , 2000, Physics in medicine and biology.

[8]  G. Reifenberger,et al.  NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[9]  J. Debus,et al.  Radiobiological evaluation and correlation with the local effect model (LEM) of carbon ion radiation therapy and temozolomide in glioblastoma cell lines , 2008, International journal of radiation biology.

[10]  R. T. Ten Haken,et al.  Partial volume tolerance of the liver to radiation. , 2005, Seminars in radiation oncology.

[11]  Christoph Bert,et al.  Target motion tracking with a scanned particle beam. , 2007, Medical physics.

[12]  A. von Deimling,et al.  Carbon ion radiation therapy for high-risk meningiomas. , 2010, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[13]  D. Schardt,et al.  Magnetic scanning system for heavy ion therapy , 1993 .

[14]  Michael Scholz,et al.  Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas. , 2007, International journal of radiation oncology, biology, physics.

[15]  K Parodi,et al.  Dose quantification from in-beam positron emission tomography. , 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[16]  J. Debus,et al.  Carbon ion radiotherapy of skull base chondrosarcomas. , 2007, International journal of radiation oncology, biology, physics.

[17]  Christoph Bert,et al.  Gated irradiation with scanned particle beams. , 2009, International journal of radiation oncology, biology, physics.

[18]  Katia Parodi,et al.  In-beam PET measurements of β+ radioactivity induced by proton beams , 2002 .

[19]  Katia Parodi,et al.  4D in-beam positron emission tomography for verification of motion-compensated ion beam therapy. , 2009, Medical physics.

[20]  J. Debus,et al.  The application of PET to quality assurance of heavy-ion tumor therapy , 1999, Strahlentherapie und Onkologie.

[21]  J. Debus,et al.  Carbon ion radiation therapy for chordomas and low grade chondrosarcomas--current status of the clinical trials at GSI. , 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[22]  A. Niemierko,et al.  Analysis of the relationship between tumor dose inhomogeneity and local control in patients with skull base chordoma. , 1999, International journal of radiation oncology, biology, physics.

[23]  Christoph Bert,et al.  Motion compensation with a scanned ion beam: a technical feasibility study , 2008, Radiation oncology.

[24]  Michael Scholz,et al.  Accuracy of the local effect model for the prediction of biologic effects of carbon ion beams in vitro and in vivo. , 2008, International journal of radiation oncology, biology, physics.

[25]  M. Scholz,et al.  The Increased Biological Effectiveness of Heavy Charged Particles: From Radiobiology to Treatment Planning , 2003, Technology in cancer research & treatment.

[26]  K Parodi,et al.  In-beam PET measurements of beta+ radioactivity induced by proton beams. , 2002, Physics in medicine and biology.

[27]  G Kraft,et al.  RBE of carbon ions: experimental data and the strategy of RBE calculation for treatment planning. , 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[28]  J. Debus,et al.  Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull base , 2009, Cancer.

[29]  Christoph Bert,et al.  Quantification of interplay effects of scanned particle beams and moving targets , 2008, Physics in medicine and biology.

[30]  J. Debus,et al.  Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques , 2005, Cancer.

[31]  O Jäkel,et al.  Treatment planning for heavy-ion radiotherapy: physical beam model and dose optimization. , 2000, Physics in medicine and biology.

[32]  K Parodi,et al.  Potential application of PET in quality assurance of proton therapy. , 2000, Physics in medicine and biology.

[33]  O Jäkel,et al.  Treatment planning for carbon ion radiotherapy in Germany: review of clinical trials and treatment planning studies. , 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[34]  Katia Parodi,et al.  In-beam PET measurements of biological half-lives of 12C irradiation induced β+-activity , 2008, Acta oncologica.

[35]  Christoph Bert,et al.  4D treatment planning for scanned ion beams , 2007, Radiation oncology.

[36]  Alessandra Bolsi,et al.  Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. , 2009, International journal of radiation oncology, biology, physics.

[37]  Tatsuaki Kanai,et al.  Carbon ion radiation therapy for prostate cancer: results of a prospective phase II study. , 2006, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.