Interaction studies of E. coli uracil phosphoribosyltransferase with 5-fluorouracil for potent anti cancer activity

[1]  R. Swaminathan,et al.  A novel approach to segregate and identify functional loop regions in protein structures using their Ramachandran maps , 2010, Proteins.

[2]  S. Ghosh,et al.  Understanding apoptotic signaling pathways in cytosine deaminase-uracil phosphoribosyl transferase-mediated suicide gene therapy in vitro , 2009, Molecular and Cellular Biochemistry.

[3]  M. Renner,et al.  Suicide genes for cancer therapy. , 2007, Molecular aspects of medicine.

[4]  V. Hornak,et al.  Comparison of multiple Amber force fields and development of improved protein backbone parameters , 2006, Proteins.

[5]  Holger Gohlke,et al.  The Amber biomolecular simulation programs , 2005, J. Comput. Chem..

[6]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[7]  A. W. Schüttelkopf,et al.  PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. , 2004, Acta crystallographica. Section D, Biological crystallography.

[8]  H. Carlson Protein flexibility and drug design: how to hit a moving target. , 2002, Current opinion in chemical biology.

[9]  Michael W. Mahoney,et al.  A five-site model for liquid water and the reproduction of the density anomaly by rigid, nonpolarizable potential functions , 2000 .

[10]  S. Sakiyama,et al.  Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumoral effect of 5-fluorouracil and induces protective immunity , 2000, Cancer Gene Therapy.

[11]  D. Roos,et al.  Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding , 1998, The EMBO journal.

[12]  D. Roos,et al.  Expression, purification, and characterization of uracil phosphoribosyltransferase from Toxoplasma gondii. , 1997, Molecular and biochemical parasitology.

[13]  K. Jensen,et al.  Different oligomeric states are involved in the allosteric behavior of uracil phosphoribosyltransferase from Escherichia coli. , 1996, European journal of biochemistry.

[14]  T. Darden,et al.  A smooth particle mesh Ewald method , 1995 .

[15]  Peter A. Kollman,et al.  AMBER, a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to simulate the structural and energetic properties of molecules , 1995 .

[16]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[17]  J. Thornton,et al.  PROCHECK: a program to check the stereochemical quality of protein structures , 1993 .

[18]  I. Kuntz,et al.  Automated docking with grid‐based energy evaluation , 1992 .

[19]  Conrad C. Huang,et al.  The MIDAS display system , 1988 .

[20]  P. Nygaard,et al.  Purification and some properties of uracil phosphoribosyltransferase from Escherichia coli K12. , 1986, Biochimica et biophysica acta.

[21]  H. Berendsen,et al.  Molecular dynamics with coupling to an external bath , 1984 .

[22]  J M Blaney,et al.  A geometric approach to macromolecule-ligand interactions. , 1982, Journal of molecular biology.

[23]  G. Magni,et al.  Baker's yeast UMP:pyrophosphate phosphoribosyltransferase. Purification, enzymatic and kinetic properties. , 1979, The Journal of biological chemistry.

[24]  O. Sköld,et al.  Biochemical mechanism of uracil uptake regulation in Escherichia coli B. Allosteric effects on uracil phosphoribosyltransferase under stringent conditions. , 1977, The Journal of biological chemistry.

[25]  Chung F Wong,et al.  Flexible ligand-flexible protein docking in protein kinase systems. , 2008, Biochimica et biophysica acta.

[26]  足立 吉陽 Experimental Gene Therapy for Brain Tumors Using Adenovirus-Mediated Transfer of Cytosine Deaminase Gene and Uracil Phosphoribosyltransferase Gene with 5-Fluorocytosine , 2001 .

[27]  T. Tamiya,et al.  Experimental gene therapy for brain tumors using adenovirus-mediated transfer of cytosine deaminase gene and uracil phosphoribosyltransferase gene with 5-fluorocytosine. , 2000, Human gene therapy.

[28]  J. Neuhard Utilization of preformed pyrimidine bases and nucleosides , 1983 .

[29]  A. Munch-Petersen,et al.  Metabolism of nucleotides, nucleosides and nucleobases in microorganisms , 1983 .