Near-fatal asthma in South Australia: descriptive features and medication use.

BACKGROUND Self-reported prior morbidity levels and medication use among survivors of a near-fatal asthma attack (NFA) were studied. AIMS To identify deficiencies in asthma management and opportunities for intervention. METHODS A hundred and twenty-seven consecutive patients aged 15 years or more presenting with a NFA to accident and emergency departments of teaching hospitals were interviewed. RESULTS High levels of morbidity due to asthma were reported. Most cases (79%) reported symptoms occurring at least weekly in the three months before their NFA. A mean of 20.8 days was reportedly lost from work, school or other usual daily activity in the 12 months before these events. Regular use of beta agonist as nebuliser solution was reported by 27% of cases, increasing to 34.5% in response to increased symptoms, while 41% reported use of nebulised beta agonist in response to the NFA event. Less than half of all cases (46%) reported using an inhaled corticosteroid on a regular basis. Oral corticosteroids were used by 33% of cases at times of increased symptoms in the preceding 12 months. However, only 7% of cases reported initiating or increasing oral corticosteroids at the time of the NFA. CONCLUSIONS Despite high levels of prior asthma morbidity, regular preventive inhaled corticosteroid use was not widespread in this series of NFA asthmatics. By comparison, over-reliance on regular beta agonist medication was common. Oral corticosteroids were rarely commenced in response to the NFA.

[1]  P. Frith,et al.  A comparison of asthma deaths and near-fatal asthma attacks in South Australia. , 1994, The European respiratory journal.

[2]  N. Clark,et al.  Management of asthma by patients and families. , 1994, American journal of respiratory and critical care medicine.

[3]  P. Frith,et al.  Near fatal asthma attacks: the reliability of descriptive information collected from close acquaintances. , 1993, Thorax.

[4]  C. Feldman,et al.  Determinants of near fatality in acute severe asthma. , 1993, The American journal of medicine.

[5]  P. Gibson,et al.  Association between availability of non-prescription beta 2 agonist inhalers and undertreatment of asthma. , 1993, BMJ.

[6]  A. Buist,et al.  Is the association between inhaled beta-agonist use and life-threatening asthma because of confounding by severity? , 1993, The American review of respiratory disease.

[7]  A. Buist,et al.  Risk of fatal and near-fatal asthma in relation to inhaled corticosteroid use. , 1992, JAMA.

[8]  F. Saulnier,et al.  Long-term prognosis of near-fatal asthma. A 6-year follow-up study of 145 asthmatic patients who underwent mechanical ventilation for a near-fatal attack of asthma. , 1992, The American review of respiratory disease.

[9]  Pierre Ernst,et al.  The Use of β-Agonists and the Risk of Death and near Death from Asthma , 1992 .

[10]  T. Haahtela,et al.  Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma. , 1991, The New England journal of medicine.

[11]  R. Ruffin,et al.  Longitudinal study of near fatal asthma. , 1991, Chest.

[12]  C. Print,et al.  Regular inhaled beta-agonist treatment in bronchial asthma , 1990, The Lancet.

[13]  F. Hargreave,et al.  The assessment and treatment of asthma: a conference report. , 1990, The Journal of allergy and clinical immunology.

[14]  C. Robertson,et al.  Deaths from asthma in Victoria: a 12‐month survey , 1990, The Medical journal of Australia.

[15]  A. Woolcock,et al.  Asthma management plan, 1989 , 1989 .

[16]  S. Holgate,et al.  A self management plan in the treatment of adult asthma. , 1989, Thorax.

[17]  C. Jenkins,et al.  Effect of prednisone and beclomethasone dipropionate on airway responsiveness in asthma: a comparative study. , 1988, Thorax.

[18]  R. Beaglehole,et al.  A case-control study of deaths from asthma. , 1986, Thorax.

[19]  B. Harrison,et al.  NEED FOR INTRAVENOUS HYDROCORTISONE IN ADDITION TO ORAL PREDNISOLONE IN PATIENTS ADMITTED TO HOSPITAL WITH SEVERE ASTHMA WITHOUT VENTILATORY FAILURE , 1986, The Lancet.

[20]  J. Paterson,et al.  The treatment of asthma: Part 2. Practical aspects of management , 1985 .

[21]  S. Fiel,et al.  Efficacy of short-term corticosteroid therapy in outpatient treatment of acute bronchial asthma. , 1983, The American journal of medicine.

[22]  N. Masters Death from asthma in two regions of England , 1982 .

[23]  E. Juniper,et al.  Long-term stability of bronchial responsiveness to histamine. , 1982, Thorax.

[24]  T. Clark,et al.  Time course of response to prednisolone in chronic airflow obstruction. , 1981, Thorax.