Validity of the small swine model for human electrical safety risks

Small swine are the most common model now used for electrical safety studies. Because of the significant anatomical and electrophysiological differences and the effect of animal size on the ventricular fibrillation (VF) threshold, there are concerns that these differences may exaggerate the risks of electrical devices to humans. We chose, as an illustrative and relevant example, swine studies of the TASER® conducted electrical weapon (CEW) as it has numerous published VF studies. We reviewed the published electrical swine safety studies for CEWs and compared them to finite element modeling studies, electrical safety standards, and epidemiological experience from field usage. We also compared the body weights of the swine to those of law enforcement arrest-related deaths. Studies of small swine exaggerate the risks of CEWs to humans. This conclusion may be extrapolated to suggest that the use of small swine for electrical safety studies should be questioned in general.

[1]  N. Kostomitsopoulos,et al.  A comparative anatomic and physiologic overview of the porcine heart. , 2014, Journal of the American Association for Laboratory Animal Science : JAALAS.

[2]  D. Zipes,et al.  Cocaine-induced supersensitivity and arrhythmogenesis. , 1988, Journal of the American College of Cardiology.

[3]  D. P. Zipes.  Response to kroll et al , 2014 .

[4]  Dorin Panescu,et al.  Cardiac fibrillation risks with TASER conducted electrical weapons , 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[5]  D. Zipes.  Sudden Cardiac Arrest and Death Following Application of Shocks From a TASER Electronic Control Device , 2012, Circulation.

[6]  Dorin Panescu,et al.  Electrical safety of conducted electrical weapons relative to requirements of relevant electrical standards , 2013, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[7]  K. Nagy,et al.  TASER X26 discharges in swine produce potentially fatal ventricular arrhythmias. , 2008, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[8]  J. Jauchem,et al.  Blood factors of Sus scrofa following a series of three TASER electronic control device exposures. , 2008, Forensic science international.

[9]  D. Zipes.  Electrophysiological Mechanisms Involved in Ventricular Fibrillation , 1975, Circulation.

[10]  J. Papp,et al.  Analysis of the mechanism of adrenergic actions on ventricular vulnerability. , 1968, European journal of pharmacology.

[11]  Patrick J. Tchou,et al.  Abstract 115: Relationship of Body Mass Index (BMI) to Minimum Distance from Skin Surface to Myocardium: Implications for Neuromuscular Incapacitating Devices (NMID) , 2007 .

[12]  John G Webster,et al.  Safety of pulsed electric devices , 2009, Physiological measurement.

[13]  R. Hamlin,et al.  Ventricular activation process in minipigs. , 1975, Journal of Electrocardiology.

[14]  G. Vilke,et al.  Restraint in police use of force events: examining sudden in custody death for prone and not-prone positions. , 2015, Journal of forensic and legal medicine.

[15]  G. Moe,et al.  Adrenergic Effects on Ventricular Vulnerability , 1964, Circulation research.

[16]  J. Jauchem,et al.  Acute effects of an alternative electronic-control-device waveform in swine , 2009, Forensic science, medicine, and pathology.

[17]  J. Miner,et al.  Acidosis and catecholamine evaluation following simulated law enforcement "use of force" encounters. , 2010, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[18]  J. Miner,et al.  Effect of an electronic control device exposure on a methamphetamine-intoxicated animal model. , 2010, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[19]  J. Strote,et al.  Taser Use in Restraint-Related Deaths , 2006, Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors.

[20]  Gregory P. Walcott,et al.  Ventricular fibrillation: are swine a sensitive species? , 2015, Journal of Interventional Cardiac Electrophysiology.

[21]  Jeffrey D Ho,et al.  An evaluation of two conducted electrical weapons and two probe designs using a swine comparative cardiac safety model , 2013, Forensic Science, Medicine, and Pathology.

[22]  S. Stratton.  Sudden In-Custody Death , 2009 .

[23]  K. Nagy,et al.  Taser X26 discharges in swine: ventricular rhythm capture is dependent on discharge vector. , 2008, The Journal of trauma.

[24]  M. Štengl.  Experimental models of spontaneous ventricular arrhythmias and of sudden cardiac death. , 2010, Physiological research.

[25]  Hugh Pratt,et al.  Transthoracic ventricular fibrillation charge thresholds , 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[26]  Andrew F. Hinz,et al.  Cardiac effects of varying pulse charge and polarity of TASER® conducted electrical weapons , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[27]  J. Brewer,et al.  Cardiac Safety of Neuromuscular Incapacitating Defensive Devices , 2005, Pacing and clinical electrophysiology : PACE.

[28]  Mark W. Kroll,et al.  Ventricular fibrillation risk estimation for conducted electrical weapons: Critical convolutions , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[29]  Dorin Panescu,et al.  Transthoracic cardiac stimulation thresholds for short pulses , 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[30]  H. Hutson,et al.  Conducted electrical weapon use by law enforcement: an evaluation of safety and injury. , 2010, The Journal of trauma.

[31]  J. Jauchem,et al.  Acidosis, lactate, electrolytes, muscle enzymes, and other factors in the blood of Sus scrofa following repeated TASER exposures. , 2006, Forensic science international.

[32]  B. Bécour.  Conducted Electrical Weapons or Stun Guns: A Review of 46 Cases Examined in Casualty , 2013, The American journal of forensic medicine and pathology.

[33]  Hongyu Sun,et al.  Taser Dart-to-Heart Distance That Causes Ventricular Fibrillation in Pigs , 2007, IEEE Transactions on Biomedical Engineering.

[34]  E. Downar,et al.  Cardiac electrophysiological consequences of neuromuscular incapacitating device discharges. , 2006, Journal of the American College of Cardiology.

[35]  W. B. Murray,et al.  The Effects of Continuous Application of the TASER X26 Waveform on Sus scrofa , , 2013, Journal of forensic sciences.

[36]  Robert H. Anderson,et al.  Anatomy of the pig heart: comparisons with normal human cardiac structure , 1998, Journal of anatomy.

[37]  J. Webster,et al.  Estimating the probability that the Taser® directly causes human ventricular fibrillation , 2010, Journal of medical engineering & technology.

[38]  C. F. Dalziel,et al.  Reevaluation of Lethal Electric Currents , 1968 .

[39]  R. Stracbucker,et al.  Cardiac safety of high voltage TASER X26 waveform , 2003, Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439).

[40]  A. Gardner,et al.  Conducted Electrical Weapon (TASER) Use Against Minors: A Shocking Analysis , 2012, Pediatric emergency care.

[41]  Zipes Dp.  Electrophysiological mechanisms involved in ventricular fibrillation. , 1975 .

[42]  Dhanunjaya R. Lakkireddy,et al.  Effects of cocaine intoxication on the threshold for stun gun induction of ventricular fibrillation. , 2006, Journal of the American College of Cardiology.

[44]  David O. Martin,et al.  Cardiac Effects of Electrical Stun Guns: Does Position of Barbs Contact Make a Difference? , 2008, Pacing and clinical electrophysiology : PACE.

[45]  J. Pippin.  Taser research in pigs not helpful. , 2007, Journal of the American College of Cardiology.

[46]  Alexander L. Eastman,et al.  Conductive electrical devices: a prospective, population-based study of the medical safety of law enforcement use. , 2008, The Journal of trauma.

[47]  Hongyu Sun,et al.  Taser Blunt Probe Dart-To-Heart Distance Causing Ventricular Fibrillation in Pigs , 2008, IEEE Transactions on Biomedical Engineering.

[48]  K. Nagy,et al.  Acute effects of TASER X26 discharges in a swine model. , 2007, The Journal of trauma.

[49]  Donald M Dawes,et al.  An evaluation of two conducted electrical weapons using a swine comparative cardiac safety model , 2014, Forensic Science, Medicine, and Pathology.

[50]  Dorin Panescu,et al.  Essentials of low-power electrocution: Established and speculated mechanisms , 2012, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[51]  Douglas P. Zipes,et al.  TASER Electronic Control Devices Can Cause Cardiac Arrest in Humans , 2014, Circulation.

[52]  Gregory P. Walcott,et al.  Ventricular fibrillation threshold of rapid short pulses , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[53]  William P. Bozeman,et al.  Transcardiac conducted electrical weapon (TASER) probe deployments: incidence and outcomes. , 2012, The Journal of emergency medicine.

[54]  Dorin Panescu,et al.  Limitations of animal electrical cardiac safety models , 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[55]  M. B. Maron.  Dose-response relationship between plasma epinephrine concentration and alveolar liquid clearance in dogs. , 1998, Journal of applied physiology.

[56]  Brian P. Martin,et al.  Safety and injury profile of conducted electrical weapons used by law enforcement officers against criminal suspects. , 2009, Annals of emergency medicine.