Solution structure and dynamics of anti-CRISPR AcrIIA4, the Cas9 inhibitor

[1]  D. Patel,et al.  Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9. , 2017, Molecular cell.

[2]  Eugene V Koonin,et al.  Diversity, classification and evolution of CRISPR-Cas systems. , 2017, Current opinion in microbiology.

[3]  Lei S. Qi.  Faculty of 1000 evaluation for Biology and applications of CRISPR systems: harnessing nature's toolbox for genome engineering. , 2017 .

[4]  Zhi Xiong,et al.  Structural basis of CRISPR–SpyCas9 inhibition by an anti-CRISPR protein , 2017, Nature.

[5]  Jennifer A. Doudna,et al.  Disabling Cas9 by an anti-CRISPR DNA mimic , 2017, Science Advances.

[6]  G. Lander,et al.  Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex , 2017, Cell.

[7]  Nevan J. Krogan,et al.  Inhibition of CRISPR-Cas9 with Bacteriophage Proteins , 2017, Cell.

[8]  Yan Zhang,et al.  Naturally Occurring Off-Switches for CRISPR-Cas9 , 2016, Cell.

[9]  M. Wolf-Watz,et al.  Protein dynamics and function from solution state NMR spectroscopy , 2016, Quarterly Reviews of Biophysics.

[10]  Jennifer A. Doudna,et al.  Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering , 2016, Cell.

[11]  Wenyan Jiang,et al.  CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems. , 2015, Annual review of microbiology.

[12]  Jennifer A. Doudna,et al.  A Cas9–guide RNA complex preorganized for target DNA recognition , 2015, Science.

[13]  J. Doudna,et al.  Expanding the Biologist's Toolkit with CRISPR-Cas9. , 2015, Molecular cell.

[14]  David W. Taylor,et al.  Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation , 2014, Science.

[15]  Sylvain Moineau,et al.  Revenge of the phages: defeating bacterial defences , 2013, Nature Reviews Microbiology.

[16]  Alan R. Davidson,et al.  Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system , 2012, Nature.

[17]  Wei Li,et al.  A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis , 2011, Science.

[18]  A. Bax,et al.  TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts , 2009, Journal of biomolecular NMR.

[19]  Stan J. J. Brouns,et al.  Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes , 2008, Science.

[20]  R. Barrangou,et al.  CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes , 2007, Science.

[21]  G. Marius Clore,et al.  Using Xplor‐NIH for NMR Molecular Structure Determination , 2006 .

[22]  M. Dreyfus,et al.  A mutation in T7 RNA polymerase that facilitates promoter clearance , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Barbara J. Graves,et al.  The Structural and Dynamic Basis of Ets-1 DNA Binding Autoinhibition* , 2005, Journal of Biological Chemistry.

[24]  R. Kaptein,et al.  Structure and Flexibility Adaptation in Nonspecific and Specific Protein-DNA Complexes , 2004, Science.

[25]  C D Schwieters,et al.  The VMD-XPLOR visualization package for NMR structure refinement. , 2001, Journal of magnetic resonance.

[26]  G. Wagner,et al.  Identification by NMR Spectroscopy of Residues at Contact Surfaces in Large, Slowly Exchanging Macromolecular Complexes , 1999 .

[27]  G. Marius Clore,et al.  Improving the Packing and Accuracy of NMR Structures with a Pseudopotential for the Radius of Gyration , 1999 .

[28]  A M Gronenborn,et al.  Direct structure refinement against residual dipolar couplings in the presence of rhombicity of unknown magnitude. , 1998, Journal of magnetic resonance.

[29]  A. Bax,et al.  Anisotropic rotational diffusion of perdeuterated HIV protease from 15N NMR relaxation measurements at two magnetic fields , 1996, Journal of biomolecular NMR.

[30]  S. Grzesiek,et al.  NMRPipe: A multidimensional spectral processing system based on UNIX pipes , 1995, Journal of biomolecular NMR.

[31]  A M Gronenborn,et al.  The impact of direct refinement against proton chemical shifts on protein structure determination by NMR. , 1995, Journal of magnetic resonance. Series B.

[32]  Bruce A. Johnson,et al.  NMR View: A computer program for the visualization and analysis of NMR data , 1994, Journal of biomolecular NMR.

[33]  L. Kay,et al.  A heteronuclear correlation experiment for simultaneous determination of 15N longitudinal decay and chemical exchange rates of systems in slow equilibrium , 1994, Journal of biomolecular NMR.

[34]  D. G. Davis,et al.  Direct measurements of the dissociation-rate constant for inhibitor-enzyme complexes via the T1 rho and T2 (CPMG) methods. , 1994, Journal of magnetic resonance. Series B.

[35]  J. Thornton,et al.  PROCHECK: a program to check the stereochemical quality of protein structures , 1993 .

[36]  A. Gronenborn,et al.  Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints. Application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 2. , 1988, Protein engineering.

[37]  Timothy F. Havel,et al.  Protein structures in solution by nuclear magnetic resonance and distance geometry. The polypeptide fold of the basic pancreatic trypsin inhibitor determined using two different algorithms, DISGEO and DISMAN. , 1987, Journal of molecular biology.

[38]  M. Nilges,et al.  Three-dimensional structure of phoratoxin in solution: combined use of nuclear magnetic resonance, distance geometry, and restrained molecular dynamics , 1987 .

[39]  M Karplus,et al.  The three‐dimensional structure of α1‐purothionin in solution: combined use of nuclear magnetic resonance, distance geometry and restrained molecular dynamics , 1986, The EMBO journal.

[40]  D. S. Garrett,et al.  A common sense approach to peak picking in two-, three-, and four-dimensional spectra using automatic computer analysis of contour diagrams. 1991. , 2011, Journal of magnetic resonance.

[41]  A. Bax,et al.  Dipolar couplings in macromolecular structure determination. , 2001, Methods in enzymology.