The antipsychotic drug chlorpromazine inhibits HERG potassium channels

[1]  Dierk Thomas,et al.  Bertosamil blocks HERG potassium channels in their open and inactivated states , 2002, British journal of pharmacology.

[2]  Dierk Thomas,et al.  The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene (HERG) potassium channels. , 2002, The Journal of pharmacology and experimental therapeutics.

[3]  A H Glassman,et al.  Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. , 2001, The American journal of psychiatry.

[4]  James Kramer,et al.  Comparison of block among cloned cardiac potassium channels by non-antiarrhythmic drugs , 2001 .

[5]  R. Stanford,et al.  Torsades de Pointes Associated with Chlorpromazine: Case Report and Review of Associated Ventricular Arrhythmias , 2001, Pharmacotherapy.

[6]  A. Brown,et al.  High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872. , 2001, The Journal of pharmacology and experimental therapeutics.

[7]  S. Kathöfer,et al.  Antiarrhythmic drug carvedilol inhibits HERG potassium channels. , 2001, Cardiovascular research.

[8]  D J Triggle,et al.  Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG. , 2001, Molecular pharmacology.

[9]  P. C. Viswanathan,et al.  Novel characteristics of a misprocessed mutant HERG channel linked to hereditary long QT syndrome. , 2000, American journal of physiology. Heart and circulatory physiology.

[10]  J. Idle The heart of psychotropic drug therapy , 2000, The Lancet.

[11]  S. Ayis,et al.  QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients , 2000, The Lancet.

[12]  John S. Mitcheson,et al.  Trapping of a Methanesulfonanilide by Closure of the Herg Potassium Channel Activation Gate , 2000, The Journal of general physiology.

[13]  G. Naccarelli,et al.  Amiodarone: clinical trials. , 2000, Current opinion in cardiology.

[14]  S. Viskin Long QT syndromes and torsade de pointes , 1999, The Lancet.

[15]  W. Kübler,et al.  Deletion of Protein Kinase A Phosphorylation Sites in the HERG Potassium Channel Inhibits Activation Shift by Protein Kinase A* , 1999, The Journal of Biological Chemistry.

[16]  B. Suh,et al.  Chlorpromazine-induced inhibition of catecholamine secretion by a differential blockade of nicotinic receptors and L-type Ca2+ channels in rat pheochromocytoma cells. , 1999, Biochemical pharmacology.

[17]  J. Hancox,et al.  Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline , 1999, British journal of pharmacology.

[18]  W. Kübler,et al.  Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels , 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.

[19]  B. Drolet,et al.  Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current. , 1999, The Journal of pharmacology and experimental therapeutics.

[20]  A. Brown,et al.  Molecular determinants of dofetilide block of HERG K+ channels. , 1998, Circulation research.

[21]  K. Kudo,et al.  Plasma concentrations of antipsychotic drugs in psychiatric inpatients. , 1997, Nihon hoigaku zasshi = The Japanese journal of legal medicine.

[22]  G. Quamme Chlorpromazine activates chloride currents in Xenopus oocytes. , 1997, Biochimica et biophysica acta.

[23]  B Attali,et al.  The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes , 1997, British journal of pharmacology.

[24]  A. Brown,et al.  Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide. , 1996, Circulation.

[25]  F. Lang,et al.  Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole , 1996, FEBS letters.

[26]  Gary Yellen,et al.  The inward rectification mechanism of the HERG cardiac potassium channel , 1996, Nature.

[27]  M. Sanguinetti,et al.  A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel , 1995, Cell.

[28]  J. Warmke,et al.  A family of potassium channel genes related to eag in Drosophila and mammals. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[29]  M. Crismon,et al.  Chlorpromazine Accumulation and Sudden Death in a Patient with Renal Insufficiency , 1988, Drug intelligence & clinical pharmacy.