It was studied the effect of diet enriched with selenium on the clinical and biochemical status, psycho-emotional and adaptive capacity of the organism in patients with diseases of the cardiovascular system. We examined 59 patients with cardiovascular disease and obesity, treated for 3 weeks antiatherogenic reduced calorie diet. Of these 36 patients from the index group took on the back of ground diet selenium containing diet product (part of alimentotherapy). Patients underwent clinical examination, biochemical parameters and the availability of selenium were measured. To assess the adaptive capacity of the organism we used Program Apparatus Complex. Quality of life of patients, overall health, level of anxiety and the dynamics of mental processes were assessed using SAS procedures, Spielberger-Hanin anxiety test, Serdyuk Quality of Life Questionnaire, Kraepelin's counting test. The results indicate positive changes in clinical and biochemical status, availability of selenium, adaptive capacity, psycho-emotional state of patients with cardiovascular disease and obesity because of the diet enriched with organic form of selenium. We revealed increase in activity, improvement of overall health and cognitive functions, mood stabilization, reduction of anxiety and emotional lability. The main differences observed between the groups identified in the leveling of the anxiety radical in psycho-emotional status of patients.