Stimulation of IRE-BP activity of IRF by tetrahydrobiopterin and cytokine dependent induction of nitric oxide synthase.

[1]  G Werner-Felmayer,et al.  Translational regulation via iron‐responsive elements by the nitric oxide/NO‐synthase pathway. , 1993, The EMBO journal.

[2]  G. Werner-Felmayer,et al.  Comparative Effects of Heme and Metalloporphyrins on Interferon-γ-Mediated Pathways in Monocytic Cells (THP-1) , 1993, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[3]  N. Gray,et al.  Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells. , 1993, The Journal of biological chemistry.

[4]  M. Dierich,et al.  Association between immune activation, changes of iron metabolism and anaemia in patients with HIV infection , 1993, European journal of haematology.

[5]  E. Werner,et al.  Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP. , 1993, The Journal of biological chemistry.

[6]  R. Klausner,et al.  Regulating the fate of mRNA: The control of cellular iron metabolism , 1993, Cell.

[7]  E. Werner,et al.  Ca2+/calmodulin-dependent nitric oxide synthase activity in the human cervix carcinoma cell line ME-180. , 1993, The Biochemical journal.

[8]  S. Krantz,et al.  Progress in understanding the pathogenesis of the anemia of chronic disease. , 1992, Blood.

[9]  R. Klausner,et al.  Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[10]  E. Werner,et al.  Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1. , 1992, Experimental hematology.

[11]  N. Gray,et al.  Identification of a novel iron‐responsive element in murine and human erythroid delta‐aminolevulinic acid synthase mRNA. , 1991, The EMBO journal.

[12]  T. Cox,et al.  Human erythroid 5‐aminolevulinate synthase: promoter analysis and identification of an iron‐responsive element in the mRNA. , 1991, The EMBO journal.

[13]  P. Argos,et al.  Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase. , 1991, Nucleic acids research.

[14]  R. Klausner,et al.  Structural relationship between an iron-regulated RNA-binding protein (IRE-BP) and aconitase: Functional implications , 1991, Cell.

[15]  E. Werner,et al.  Immune activation and the anaemia associated with chronic inflammatory disorders , 1991, European journal of haematology.

[16]  E. Werner,et al.  Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts , 1990, The Journal of experimental medicine.

[17]  E. Werner,et al.  Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present. , 1990, The Journal of biological chemistry.

[18]  C. Nathan,et al.  Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. , 1989, The Journal of biological chemistry.

[19]  M. Marletta,et al.  Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. , 1989, The Journal of biological chemistry.

[20]  Barbara Neupert,et al.  A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA , 1989, Cell.

[21]  R D Klausner,et al.  Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction. , 1989, Science.

[22]  M. Hentze,et al.  The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressor. , 1988, The Journal of biological chemistry.

[23]  R D Klausner,et al.  A model for the structure and functions of iron-responsive elements. , 1988, Gene.

[24]  Lukas C. Kühn,et al.  A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm , 1988, Cell.

[25]  R. Leventis,et al.  Interactions of cationic lipid vesicles with negatively charged phospholipid vesicles and biological membranes. , 1988, Biochemistry.

[26]  J. Drapier,et al.  Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells. , 1988, Journal of immunology.

[27]  H. Munro,et al.  Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[28]  R D Klausner,et al.  Identification of the iron-responsive element for the translational regulation of human ferritin mRNA. , 1987, Science.

[29]  O. Uhlenbeck,et al.  Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates. , 1987, Nucleic acids research.

[30]  J. Drapier,et al.  Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible. , 1986, The Journal of clinical investigation.

[31]  D. Fuchs,et al.  Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma , 1984, The Journal of experimental medicine.

[32]  S. Kaufman.  THE STRUCTURE OF THE PHENYLALANINE-HYDROXYLATION COFACTOR. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[33]  G. K. Smith,et al.  Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin. , 1985, Annual review of biochemistry.

[34]  E. Weinberg.  Iron withholding: a defense against infection and neoplasia. , 1984, Physiological reviews.