Image registration issues in the analysis of multiple injection 15O H2O PET studies: BRAINFIT

Spatial registration of functional and structural data is a vital first step in the regional analysis of images obtained from functional imaging techniques. We present a set of procedures that produce accurate, objective, and robust registrations between PET and MR images that are highly automated and user-friendly. These techniques have been shown to be both reliable and valid. Because the method is automated and therefore efficient, each injection of the PET experiment can be individually fit to overcome errors introduced because of subject movement between PET injections.

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