Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.
暂无分享,去创建一个
X. Wang | C. Deng | E. Appella | Sangsoo Kim | T. Ried | R. Jia | Hyun-Seok Kim | Liu Cao | Xiaoling Xu | Cuiling Li | Zhi-Ming Zheng | B. Chilton | C. Xiao | Ruihong Wang | K. Sengupta | Yin Zheng | Ruihong Wang
[1] W. Hahn,et al. The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth , 2008, PloS one.
[2] Jin Woo Kim,et al. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. , 2008, Cancer research.
[3] Junjie Chen,et al. DBC1 is a negative regulator of SIRT1 , 2008, Nature.
[4] J. Qin,et al. Negative regulation of the deacetylase SIRT1 by DBC1 , 2008, Nature.
[5] Lee Baker,et al. Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator , 2007, Cancer cell.
[6] M. Salto‐Tellez,et al. Function of the SIRT1 protein deacetylase in cancer. , 2007, Biotechnology journal.
[7] Jun Wang,et al. Resveratrol suppresses prostate cancer progression in transgenic mice. , 2007, Carcinogenesis.
[8] Tan Li,et al. Resveratrol induces apoptosis, influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo. , 2007, International immunopharmacology.
[9] D. Reinberg,et al. NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs , 2007, Oncogene.
[10] E. Verdin,et al. Sirtuins: critical regulators at the crossroads between cancer and aging , 2007, Oncogene.
[11] T. Nagy,et al. SIRT1 is significantly elevated in mouse and human prostate cancer. , 2007, Cancer research.
[12] William Arbuthnot Sir Lane,et al. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. , 2007, Molecular cell.
[13] Y. Kubo,et al. Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease , 2007, Archives of Dermatological Research.
[14] G. Park,et al. SIRT1 promotes DNA repair activity and deacetylation of Ku70 , 2007, Experimental & Molecular Medicine.
[15] P. Puigserver,et al. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.
[16] Thomas Ried,et al. Spectral karyotyping analysis of human and mouse chromosomes , 2006, Nature Protocols.
[17] P. Puigserver,et al. Resveratrol improves health and survival of mice on a high-calorie diet , 2006, Nature.
[18] L. Guarente,et al. Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. , 2006, Genes & development.
[19] M. Carpenter,et al. Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats , 2006, Journal of carcinogenesis.
[20] D. Colin,et al. Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. , 2006, Current drug targets.
[21] Eivind Hovig,et al. Options available for profiling small samples: a review of sample amplification technology when combined with microarray profiling , 2006, Nucleic acids research.
[22] S. Baylin,et al. Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses , 2005, Cell.
[23] C. Bradbury,et al. Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors , 2005, Leukemia.
[24] Wilhelm Haas,et al. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1 , 2005, Nature.
[25] C. Deng,et al. BRCA1, Histone H2AX Phosphorylation, and Male Meiotic Sex Chromosome Inactivation , 2004, Current Biology.
[26] C. Deng,et al. A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[27] J. Kobayashi,et al. Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through FHA/BRCT domain. , 2004, Journal of radiation research.
[28] N. Seeram,et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. , 2004, Anticancer research.
[29] L. Guarente,et al. The Sir2 family of protein deacetylases. , 2004, Annual review of biochemistry.
[30] Phuong Chung,et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan , 2003, Nature.
[31] F. Alt,et al. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[32] T. Ried,et al. H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility , 2003, Cell.
[33] P. Lansdorp,et al. The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis , 2003, Molecular and Cellular Biology.
[34] S. Gasser,et al. The molecular biology of the SIR proteins. , 2001, Gene.
[35] F. Alt,et al. DNA double strand break repair and chromosomal translocation: Lessons from animal models , 2001, Oncogene.
[36] Curtis C. Harris,et al. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis , 2001, Nature Genetics.
[37] C. Deng,et al. Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice. , 2001, Mutation research.
[38] V. Yamazaki,et al. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage , 2000, Current Biology.
[39] L. Guarente,et al. Sir2 links chromatin silencing, metabolism, and aging. , 2000, Genes & development.
[40] J. Murray,et al. DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p , 1999, Current Biology.
[41] L. Guarente,et al. MEC1-Dependent Redistribution of the Sir3 Silencing Protein from Telomeres to DNA Double-Strand Breaks , 1999, Cell.
[42] C. Deng,et al. A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability , 1998, Oncogene.
[43] J. Kato,et al. Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae , 1997, Nature.
[44] F. Alt,et al. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[45] P. Leder,et al. Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth , 1996, Cell.
[46] J. Roder,et al. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[47] L. Donehower,et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours , 1992, Nature.
[48] Chang-Su Lim. SIRT1: tumor promoter or tumor suppressor? , 2006, Medical hypotheses.
[49] N. Ahmad,et al. Prevention of Ultraviolet-B Radiation Damage by Resveratrol in Mouse Skin Is Mediated via Modulation in Survivin¶ , 2005, Photochemistry and photobiology.
[50] C. Deng,et al. Generation and analysis of Brca1 conditional knockout mice. , 2004, Methods in molecular biology.
[51] J. Denu. Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases. , 2003, Trends in biochemical sciences.
[52] A. Antoccia,et al. Chromosomal sensitivity to clastogenic agents and cell cycle perturbations in Nijmegen breakage syndrome lymphoblastoid cell lines. , 1997, International journal of radiation biology.