Efficacy of leukotriene receptor antagonist in bronchial hyperresponsiveness and hypersensitivity to analgesic in aspirin‐intolerant asthma

Albeit its exact pathogenesis is still ambiguous; aspirin‐intolerant asthma is one of several types of asthma for which antileukotriene therapy is useful, because it is widely accepted that bronchial over‐production of leukotrienes may be involved in its pathogenesis. Pranlukast (8‐[p‐(4‐phenylbutyloxy) benzol] amino‐2‐(tetrazol‐5‐yl)‐4‐oxo‐4H‐1‐benzopyran hemihydrate), a selective cysteinyl leukotriene receptor antagonist, is now widely used in the treatment of asthma.

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