Protective Effect of Quercetin in LPS-Induced Murine Acute Lung Injury Mediated by cAMP-Epac Pathway

[1]  Laila M Fadda,et al.  Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats , 2017, Acta pharmaceutica.

[2]  Xiao‐Yu Hu,et al.  Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1 , 2016, Acta Pharmacologica Sinica.

[3]  Z. Lv,et al.  Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression. , 2016, Genetics and molecular research : GMR.

[4]  M. Balaan,et al.  Acute Respiratory Distress Syndrome , 2016, Critical care nursing quarterly.

[5]  U. Sener,et al.  The Effects of Quercetin on Acute Lung Injury and Biomarkers of Inflammation and Oxidative Stress in the Rat Model of Sepsis , 2016, Inflammation.

[6]  Á. Simonyi,et al.  Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1 , 2015, PloS one.

[7]  S. Cuzzocrea,et al.  Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice , 2015, British Journal of Nutrition.

[8]  Ri-hong Huang,et al.  Quercetin protects against lipopolysaccharide-induced acute lung injury in rats through suppression of inflammation and oxidative stress , 2015, Archives of medical science : AMS.

[9]  Na Ye,et al.  Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window” , 2015, Scientific Reports.

[10]  G. Forlani,et al.  Quercetin and quercetin-3-O-glucoside interact with different components of the cAMP signaling cascade in human retinal pigment epithelial cells. , 2015, Life sciences.

[11]  T. Kawabe,et al.  Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury , 2014, Respiratory Research.

[12]  Hao Li,et al.  Protective effect of quercetin on lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammatory cell influx , 2014, Experimental biology and medicine.

[13]  O. Salis,et al.  The therapeutic effects of anti-oxidant and anti-inflammatory drug quercetin on aspiration-induced lung injury in rats , 2014, Journal of Molecular Histology.

[14]  E. Taşlıdere,et al.  Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats , 2014, Experimental lung research.

[15]  P. Boor,et al.  Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses , 2013, Proceedings of the National Academy of Sciences.

[16]  H. Rehmann Epac-Inhibitors: Facts and Artefacts , 2013, Scientific Reports.

[17]  S. Saponara,et al.  Quercetin relaxes rat tail main artery partly via a PKG‐mediated stimulation of KCa1.1 channels , 2013, Acta physiologica.

[18]  U. Kukongviriyapan,et al.  Preventive and therapeutic effects of quercetin on lipopolysaccharide-induced oxidative stress and vascular dysfunction in mice. , 2012, Canadian journal of physiology and pharmacology.

[19]  Buwei Yu,et al.  Differential Roles of PKA and Epac on the Production of Cytokines in the Endotoxin-Stimulated Primary Cultured Microglia , 2011, Journal of Molecular Neuroscience.

[20]  S. Pyo,et al.  ROS/Epac1-mediated Rap1/NF-kappaB activation is required for the expression of BAFF in Raw264.7 murine macrophages. , 2011, Cellular signalling.

[21]  T. Kawabe,et al.  Attenuation of transforming growth factor-β-stimulated collagen production in fibroblasts by quercetin-induced heme oxygenase-1. , 2011, American journal of respiratory cell and molecular biology.

[22]  C. Bai,et al.  The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine , 2010, Expert review of respiratory medicine.

[23]  Jae Ho Park,et al.  Protective effect of quercetin against paraquat-induced lung injury in rats. , 2010, Life sciences.

[24]  A. Birukova,et al.  Rac GTPase is a hub for protein kinase A and Epac signaling in endothelial barrier protection by cAMP. , 2010, Microvascular research.

[25]  J. Auchampach,et al.  Adenosine Suppresses Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production by Murine Macrophages through a Protein Kinase A- and Exchange Protein Activated by cAMP-Independent Signaling Pathway , 2009, Journal of Pharmacology and Experimental Therapeutics.

[26]  T. Seyama,et al.  Effects of hyperin, isoquercitrin and quercetin on lipopolysaccharide‐induced nitrite production in rat peritoneal macrophages , 2008, Phytotherapy research : PTR.

[27]  K. Racké,et al.  Role of Epac1 in mediating anti-proliferative effects of prostanoid EP2 receptors and cAMP in human lung fibroblasts , 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

[28]  Elena Alekseeva,et al.  Epac/Rap and PKA are novel mechanisms of ANP‐induced Rac‐mediated pulmonary endothelial barrier protection , 2008, Journal of cellular physiology.

[29]  D. Lee,et al.  Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. , 2008, Biochemical pharmacology.

[30]  S. Døskeland,et al.  Cyclic nucleotide analogs as probes of signaling pathways , 2008, Nature Methods.

[31]  S. Peters,et al.  Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and β2-agonist use , 2006, Respiratory research.

[32]  Hui-Lin Huang,et al.  Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. , 2004, Biochemical pharmacology.

[33]  Sheng-Nan Wu,et al.  Differential effects of quercetin, a natural polyphenolic flavonoid, on L‐Type calcium current in pituitary tumor (GH3) cells and neuronal NG108‐15 cells , 2003, Journal of cellular physiology.

[34]  L. Luo,et al.  Rac GTPases control axon growth, guidance and branching , 2002, Nature.

[35]  D. Koop,et al.  Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide. , 2001, Chemico-biological interactions.

[36]  N. Voelkel,et al.  Dibutyryl-cAMP blocks endotoxin-induced lung injury in rats. , 1989, The American review of respiratory disease.

[37]  J. Cazenave,et al.  Role of cyclic AMP in the inhibition of human platelet aggregation by quercetin, a flavonoid that potentiates the effect of prostacyclin. , 1982, Biochemical pharmacology.

[38]  D. Priebat,et al.  Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. , 1982, The Journal of investigative dermatology.

[39]  Juan Zhang,et al.  The critical role of quercetin in autophagy and apoptosis in HeLa cells , 2015, Tumor Biology.

[40]  Jian Cheng,et al.  Preventive and therapeutic effects of quercetin on experimental radiation induced lung injury in mice. , 2015, Asian Pacific journal of cancer prevention : APJCP.