The Protease Activated Receptor2 Promotes Rab5a Mediated Generation of Pro-metastatic Microvesicles

[1]  P. Sen,et al.  Triple-negative breast cancer-derived microvesicles transfer microRNA221 to the recipient cells and thereby promote epithelial-to-mesenchymal transition , 2019, The Journal of Biological Chemistry.

[2]  P. Sen,et al.  Coagulation factor VIIa-mediated protease-activated receptor 2 activation leads to β-catenin accumulation via the AKT/GSK3β pathway and contributes to breast cancer progression , 2017, The Journal of Biological Chemistry.

[3]  M. Nevalainen,et al.  Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype , 2016, Molecular Cancer Research.

[4]  Mary L. Alpaugh,et al.  Breast Cancer-Derived Extracellular Vesicles: Characterization and Contribution to the Metastatic Phenotype , 2015, BioMed research international.

[5]  Wengong Wang,et al.  Proteinase-activated Receptor 2 Promotes Cancer Cell Migration through RNA Methylation-mediated Repression of miR-125b* , 2015, The Journal of Biological Chemistry.

[6]  L. O’Driscoll,et al.  Biological properties of extracellular vesicles and their physiological functions , 2015, Journal of extracellular vesicles.

[7]  M. Hollenberg,et al.  Proteinase-activated Receptor 2 (PAR2) Decreases Apoptosis in Colonic Epithelial Cells* , 2014, The Journal of Biological Chemistry.

[8]  G. Scita,et al.  A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination , 2014, The Journal of cell biology.

[9]  A. Hidalgo-Miranda,et al.  MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer , 2014, OncoTargets and therapy.

[10]  G. Semenza,et al.  Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis , 2014, Proceedings of the National Academy of Sciences.

[11]  D. Thabut,et al.  The emerging roles of microvesicles in liver diseases , 2014, Nature Reviews Gastroenterology &Hepatology.

[12]  M. Porta,et al.  Human mesenchymal stem cell-derived microvesicles modulate T cell response to islet antigen glutamic acid decarboxylase in patients with type 1 diabetes , 2014, Diabetologia.

[13]  P. Doevendans,et al.  Microvesicles and exosomes for intracardiac communication. , 2014, Cardiovascular research.

[14]  Maarten Hulsmans,et al.  MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. , 2013, Cardiovascular research.

[15]  X. Chen,et al.  Microvesicle-mediated Transfer of MicroRNA-150 from Monocytes to Endothelial Cells Promotes Angiogenesis* , 2013, The Journal of Biological Chemistry.

[16]  Biao Wu,et al.  TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCα and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620 , 2013, Tumor Biology.

[17]  N. Bauer,et al.  On the origin of microparticles: From “platelet dust” to mediators of intercellular communication , 2013, Pulmonary circulation.

[18]  Graça Raposo,et al.  Extracellular vesicles: Exosomes, microvesicles, and friends , 2013, The Journal of cell biology.

[19]  T. Lüscher,et al.  AngiomiR-126 expression and secretion from circulating CD34(+) and CD14(+) PBMCs: role for proangiogenic effects and alterations in type 2 diabetics. , 2013, Blood.

[20]  R. Monteiro,et al.  Protease-activated receptor-2 (PAR2) mediates VEGF production through the ERK1/2 pathway in human glioblastoma cell lines , 2012 .

[21]  C. Horng,et al.  Rab5A is associated with axillary lymph node metastasis in breast cancer patients , 2011, Cancer science.

[22]  Xiang-mei Chen,et al.  Knockdown of Rab5a expression decreases cancer cell motility and invasion through integrin-mediated signaling pathway , 2011, Journal of Biomedical Science.

[23]  A. Bohm,et al.  Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins , 2011, Proceedings of the National Academy of Sciences.

[24]  G. Camussi,et al.  Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury. , 2011, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[25]  Jared L. Johnson,et al.  Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells , 2011, Proceedings of the National Academy of Sciences.

[26]  K. Menon,et al.  The role of Rab5a GTPase in endocytosis and post-endocytic trafficking of the hCG-human luteinizing hormone receptor complex , 2011, Cellular and Molecular Life Sciences.

[27]  Graca Raposo,et al.  ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles , 2009, Current Biology.

[28]  O. Destaing,et al.  Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions , 2009, Journal of Cell Science.

[29]  Y Sheng,et al.  Proteinase-activated receptor 2 expression in breast cancer and its role in breast cancer cell migration , 2009, Oncogene.

[30]  A. Blum The possible role of red blood cell microvesicles in atherosclerosis. , 2009, European journal of internal medicine.

[31]  A. Kawabata,et al.  PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells. , 2008, Biochemical and biophysical research communications.

[32]  M. Fresno,et al.  Rab5 Activation by Toll‐Like Receptor 2 is Required for Trypanosoma cruzi Internalization and Replication in Macrophages , 2008, Traffic.

[33]  A. Guha,et al.  Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells , 2008, Nature Cell Biology.

[34]  J. Lötvall,et al.  Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells , 2007, Nature Cell Biology.

[35]  J. Condeelis,et al.  Regulation of the actin cytoskeleton in cancer cell migration and invasion. , 2007, Biochimica et biophysica acta.

[36]  I. Jordens,et al.  Rab Proteins, Connecting Transport and Vesicle Fusion , 2005, Traffic.

[37]  J. Guan,et al.  Wound-healing assay. , 2005, Methods in molecular biology.

[38]  M. Hollenberg,et al.  Selective Tryptic Cleavage at the Tethered Ligand Site of the Amino Terminal Domain of Proteinase-Activated Receptor-2 in Intact Cells , 2003, Journal of Pharmacology and Experimental Therapeutics.

[39]  M. Salis,et al.  Protease-Activated Receptor-2 Stimulates Angiogenesis and Accelerates Hemodynamic Recovery in a Mouse Model of Hindlimb Ischemia , 2002, Circulation research.

[40]  J. Hedges,et al.  A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration* , 1999, The Journal of Biological Chemistry.

[41]  E. Bearer,et al.  Role of actin polymerization in cell locomotion: molecules and models. , 1993, American journal of respiratory cell and molecular biology.