Guidelines on food fortification with micronutrients

Food and Agricultural Organization of the United Nations PA N I S F I A T G u id e in e s o n fo o d fo r tific atio n w th m ic r o n u tr ie n ts Interest in micronutrient malnutrition has increased greatly over the last few years. One of the main reasons is the realization that micronutrient malnutrition contributes substantially to the global burden of disease. Furthermore, although micronutrient malnutrition is more frequent and severe in the developing world and among disadvantaged populations, it also represents a public health problem in some industrialized countries. Measures to correct micronutrient deficiencies aim at ensuring consumption of a balanced diet that is adequate in every nutrient. Unfortunately, this is far from being achieved everywhere since it requires universal access to adequate food and appropriate dietary habits. Food fortification has the dual advantage of being able to deliver nutrients to large segments of the population without requiring radical changes in food consumption patterns.

[1]  J. Rivera,et al.  Vitamins A, and C and folate status in Mexican children under 12 years and women 12-49 years: a probabilistic national survey. , 2003, Salud publica de Mexico.

[2]  E. Hertrampf,et al.  Effect of supplementation with an iron-fortified milk on incidence of diarrhea and respiratory infection in urban-resident infants. , 1995, Scandinavian journal of infectious diseases.

[3]  W. Weiss,et al.  A trainers guide for baseline surveys and regular monitoring. Using LQAS for assessing field programs in community health in developing countries. , 2002 .

[4]  M. S. Rodríguez,et al.  A conspectus of research on vitamin A requirements of man. , 1972, The Journal of nutrition.

[5]  P. Dagnelie,et al.  High prevalence of rickets in infants on macrobiotic diets. , 1990, The American journal of clinical nutrition.

[6]  A. Briend Highly nutrient-dense spreads: a new approach to delivering multiple micronutrients to high-risk groups , 2001, British Journal of Nutrition.

[7]  Joseph J. Valadez,et al.  Assessing child survival programs in developing countries : testing lot quality assurance sampling , 1991 .

[8]  S. Horton,et al.  Economic consequences of iron deficiency , 1998 .

[9]  W. Gilmour,et al.  Effect of fluoridated salt intake in infancy: a blind caries and fluorosis study in 8th grade Hungarian pupils. , 1998, Community dentistry and oral epidemiology.

[10]  Robert M. Russell,et al.  Present Knowledge in Nutrition , 2001 .

[11]  F. Tartanac Incaparina and Other Incaparina-Based Foods: Experience of INCAP in Central America , 2000 .

[12]  N. Binkin,et al.  Declining prevalence of anemia in childhood in a middle-class setting: a pediatric success story? , 1987, Pediatrics.

[13]  J. Huo,et al.  Therapeutic effects of NaFeEDTA-fortified soy sauce in anaemic children in China. , 2002, Asia Pacific journal of clinical nutrition.

[14]  A. Kirksey,et al.  Pyridoxine supplementation of lactating mothers: relation to maternal nutrition status and vitamin B-6 concentrations in milk. , 1990, The American journal of clinical nutrition.

[15]  R. Longhurst Enriching Lives: Overcoming Vitamin and Mineral Malnutrition in Developing Countries , 1996 .

[16]  T. Prazuck,et al.  A new approach to combatting iodine deficiency in developing countries: the controlled release of iodine in water by a silicone elastomer. , 1993, American journal of public health.

[17]  L. Allen Ending Hidden Hunger : The History of Micronutrient Deficiency Control , 2005 .

[18]  J. Guinard,et al.  Sensory Trial to Assess the Acceptability of Zinc Fortificants Added to Iron‐fortified Wheat Products , 2002 .

[19]  D. Pelletier,et al.  An analysis of anemia and pregnancy-related maternal mortality. , 2001, The Journal of nutrition.

[20]  I. Desai,et al.  Studies on fortification of refined soybean oil with all-trans-retinyl palmitate in Brazil: Stability during cooking and storage , 1991 .

[21]  S. de Pee,et al.  Evaluating Food-Based Programmes for Their Reduction of Vitamin A Deficiency and Its Consequences , 2000 .

[22]  Å. Cederblad,et al.  Effect of protein level and protein source on zinc absorption in humans. , 1989, The Journal of nutrition.

[23]  L. Davidsson,et al.  Dietary fiber in weaning cereals: a study of the effect on stool characteristics and absorption of energy, nitrogen, and minerals in healthy infants. , 1996, Journal of pediatric gastroenterology and nutrition.

[24]  J. H. Skala,et al.  Laboratory tests for the assessment of nutritional status. , 1973, CRC critical reviews in clinical laboratory sciences.

[25]  L. Diosady,et al.  Stability of Iodine in Iodized Salt Used for Correction of Iodine-Deficiency Disorders , 1997 .

[26]  J. Cook,et al.  Ferrous fumarate fortification of a chocolate drink powder , 1991, British Journal of Nutrition.

[27]  H. Sarett,et al.  Effect of processing on availability of iron salts in liquid infant formula products. Experimental soy isolate formulas. , 1971, Journal of agricultural and food chemistry.

[28]  M. Zimmermann Iron status influences the efficacy of iodine prophylaxis in goitrous children in Côte d'Ivoire. , 2002, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[29]  P. Dodge The Damaged Brain of Iodine Deficiency , 1996 .

[30]  M. Hambidge,et al.  Human zinc deficiency. , 2000, The Journal of nutrition.

[31]  P. Dagnelie,et al.  Folate status during pregnancy in women is improved by long-term high vegetable intake compared with the average western diet. , 2001, The Journal of nutrition.

[32]  Dr Francisco Mardones-Santander,et al.  Nutritional interventions to prevent intrauterine growth retardation: evidence from randomized controlled trials , 1999, European Journal of Clinical Nutrition.

[33]  A. Sommer,et al.  Evaluation of the effect of vitamin A-fortified margarine on the vitamin A status of preschool Filipino children. , 1996, European journal of clinical nutrition.

[34]  Marie T Ruel,et al.  International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control. , 2004, Food and nutrition bulletin.

[35]  T. Bothwell,et al.  Fortification of curry powder with NaFe(111)EDTA in an iron-deficient population: report of a controlled iron-fortification trial. , 1989, The American journal of clinical nutrition.

[36]  R. Stoltzfus Iron-deficiency anemia: reexamining the nature and magnitude of the public health problem. Summary: implications for research and programs. , 2001, The Journal of nutrition.

[37]  J. Francis,et al.  Time Dependency of Cognitive Recovery with Cobalamin Replacement: Report or a Pilot Study , 1992, Journal of the American Geriatrics Society.

[38]  H. Mahmud,et al.  Helicobacter pylori infection, iron absorption, and gastric acid secretion in Bangladeshi children. , 2004, The American journal of clinical nutrition.

[39]  R Martorell,et al.  Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. Zinc Investigators' Collaborative Group. , 1999, The Journal of pediatrics.

[40]  D. Phillips,et al.  Iodine, milk, and the elimination of endemic goitre in Britain: the story of an accidental public health triumph. , 1997, Journal of epidemiology and community health.

[41]  G. Delong,et al.  Iodination of irrigation water as a method of supplying iodine to a severely iodine-deficient population in XinJiang, China , 1994, The Lancet.

[42]  K. Rusmil,et al.  Infant survival is improved by oral iodine supplementation. , 1997, The Journal of nutrition.

[43]  C. Pandav,et al.  Validation of spot-testing kits to determine iodine content in salt. , 2000, Bulletin of the World Health Organization.

[44]  K. Brown,et al.  Absorption of zinc from wheat products fortified with iron and either zinc sulfate or zinc oxide. , 2003, The American journal of clinical nutrition.

[45]  O. Brunser,et al.  Chronic iron intake and diarrhoeal disease in infants. A field study in a less-developed country. , 1993, European Journal of Clinical Nutrition.

[46]  C. Sempos,et al.  Effectiveness of food fortification in the United States: the case of pellagra. , 2000, American journal of public health.

[47]  R. Schwartz,et al.  Nutritional rickets in African American breast-fed infants. , 2000, The Journal of pediatrics.

[48]  B. Selz,et al.  Iodine deficiency diseases in Switzerland one hundred years after Theodor Kocher's survey: a historical review with some new goitre prevalence data. , 1990, Acta endocrinologica.

[49]  O. Catalano,et al.  Congenital anomalies , 2015, Histologic Basis of Ocular Disease in Animals.

[50]  B. Sandström,et al.  Dietary Pattern and Zinc Supply , 1989 .

[51]  P. Hinton,et al.  Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained women. , 2002, The American journal of clinical nutrition.

[52]  Alan D. Lopez,et al.  Health Dimensions of Sex and Reproduction , 1998 .

[53]  K. Hambidge,et al.  Zinc nutritional status of young middle-income children and effects of consuming zinc-fortified breakfast cereals. , 1979, The American journal of clinical nutrition.

[54]  M. Ruel CAN FOOD-BASED STRATEGIES HELP REDUCE VITAMIN A AND IRON DEFICIENCIES , 2001 .

[55]  H. M. Power,et al.  Iron fortification of infant milk formula: the effect on iron status and immune function. , 1991, Annals of tropical paediatrics.

[56]  H. Köksel,et al.  The effect of zinc-supplemented bread consumption on school children with asymptomatic zinc deficiency. , 1998, Journal of pediatric gastroenterology and nutrition.

[57]  G. Wortley,et al.  Iron absorption from a breakfast cereal: effects of EDTA compounds and ascorbic acid. , 2001, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[58]  L. Machlin Handbook of Vitamins , 1991 .

[59]  M. Alpers,et al.  The influence of zinc supplementation on morbidity due to Plasmodium falciparum: a randomized trial in preschool children in Papua New Guinea. , 2000, The American journal of tropical medicine and hygiene.

[60]  H. Burkett FLUORIDES and oral health. , 1995, Nutrition reviews.

[61]  R. Brookmeyer,et al.  Why do children become vitamin A deficient? , 2002, The Journal of nutrition.

[62]  A. Sommer,et al.  IMPACT OF VITAMIN A SUPPLEMENTATION ON CHILDHOOD MORTALITY A Randomised Controlled Community Trial , 1986, The Lancet.

[63]  P. Pootrakul,et al.  A WHO collaborative study on iron supplementation in Burma and in Thailand. , 1988, The American journal of clinical nutrition.

[64]  S. Filetti,et al.  Iodine-induced thyrotoxicosis in Kivu, Zaire , 1996, The Lancet.

[65]  Lindsay H Allen,et al.  Estimating the potential for vitamin A toxicity in women and young children. , 2002, The Journal of nutrition.

[66]  G. Arroyave The Program of Fortification of Sugar with Vitamin A in Guatemala , 1982 .

[67]  H. Blom,et al.  Homocysteine Determinants and the Evidence to What Extent Homocysteine Determines the Risk of Coronary Heart Disease , 2002, Pharmacological Reviews.

[68]  Dean T. Jamison,et al.  World development report 1993 : investing in health , 1993 .

[69]  D. Cole,et al.  Persistence of vitamin B12 insufficiency among elderly women after folic acid food fortification. , 2003, Clinical biochemistry.

[70]  E. Oken,et al.  Increase in thyrotoxicosis associated with iodine supplements in Zimbabwe , 1995, The Lancet.

[71]  E. Pollitt The developmental and probabilistic nature of the functional consequences of iron-deficiency anemia in children. , 2001, The Journal of nutrition.

[72]  M. Born,et al.  A metaanalysis of research on iodine and its relationship to cognitive development. , 1996 .

[73]  S. A. Areosa,et al.  Folic acid with or without vitamin B12 for cognition and dementia. , 2003, The Cochrane database of systematic reviews.

[74]  Z. Premji,et al.  An analysis of anemia and child mortality. , 2001, The Journal of nutrition.

[75]  Fluoride Use,et al.  Fluorides and oral health. Report of a WHO Expert Committee on Oral Health Status and Fluoride Use. , 1994, World Health Organization technical report series.

[76]  S. Nagataki,et al.  Impaired fetal and postnatal development and high perinatal death rate in a severe iodine deficient area , 1980 .

[77]  J. Gerberding,et al.  Folate status in women of childbearing age, by race/ethnicity--United States, 1999-2000. , 2002, MMWR. Morbidity and mortality weekly report.

[78]  E. Boy,et al.  Iron bioavailability from iron-fortified Guatemalan meals based on corn tortillas and black bean paste. , 2002, The American journal of clinical nutrition.

[79]  M. Zimmermann,et al.  Persistence of goiter despite oral iodine supplementation in goitrous children with iron deficiency anemia in Côte d'Ivoire. , 2000, The American journal of clinical nutrition.

[80]  Anne-Lise Bjørke Monsen,et al.  Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study. , 2000, The American journal of clinical nutrition.

[81]  J. Lawrence,et al.  Trends in serum folate after food fortification , 1999, The Lancet.

[82]  S. Gibson Iron intake and iron status of preschool children: associations with breakfast cereals, vitamin C and meat , 1999, Public Health Nutrition.

[83]  R. Butterworth,et al.  Maternal thiamine deficiency: still a problem in some world communities. , 2001, The American journal of clinical nutrition.

[84]  O. P. Kimball THE PREVENTION OF SIMPLE GOITER IN MAN , 1922 .

[85]  Sunny S. Kim,et al.  Iron compounds for food fortification: guidelines for Latin America and the Caribbean 2002. , 2002, Nutrition reviews.

[86]  J. T. Dunn,et al.  Salt iodization for the elimination of iodine deficiency , 1995 .

[87]  S. Hortona,et al.  The economics of iron deficiency , 2003 .

[88]  Y. Y. Cheng,et al.  The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. , 1990, Biomedical and environmental sciences : BES.

[89]  G. Romaña,et al.  Experience with Complementary Feeding in the FONCODES Project , 2000 .

[90]  J. Cook,et al.  Prevalence of iron deficiency with and without concurrent anemia in population groups with high prevalences of malaria and other infections: a study in Côte d'Ivoire. , 2001, The American journal of clinical nutrition.

[91]  Jun-shi Chen,et al.  Studies on the relations of selenium and Keshan disease , 1980, Biological Trace Element Research.

[92]  B. de Benoist,et al.  Complementary food supplements to achieve micronutrient adequacy for infants and young children. , 2003, Journal of pediatric gastroenterology and nutrition.

[93]  L. Allen Advantages and limitations of iron amino acid chelates as iron fortificants. , 2002, Nutrition reviews.

[94]  T. Campbell,et al.  Questioning riboflavin recommendations on the basis of a survey in China. , 1990, The American journal of clinical nutrition.

[95]  L. Allen,et al.  Vitamin A Requirements of Infants under Six Months of Age , 2001 .

[96]  T. Jørgensen,et al.  Thyroid disorders in mild iodine deficiency. , 2000, Thyroid : official journal of the American Thyroid Association.

[97]  W. Hamilton ENDEMIC CRETINISM , 1976, Developmental medicine and child neurology.

[98]  I. Egli Traditional food processing methods to increase mineral bioavailability from cereal and legume based weaning foods , 2001 .

[99]  M. Zimmermann,et al.  Addition of microencapsulated iron to iodized salt improves the efficacy of iodine in goitrous, iron-deficient children: a randomized, double-blind, controlled trial. , 2002, European journal of endocrinology.

[100]  C. Bates,et al.  Biochemical evidence of thiamine depletion during the Cuban neuropathy epidemic, 1992-1993. , 1996, The American journal of clinical nutrition.

[101]  C. Bates Vitamin A , 1995, The Lancet.

[102]  D. Lonsdale Thiamine deficiency and sudden deaths , 1990, The Lancet.

[103]  J. Desenclos,et al.  Epidemiological patterns of scurvy among Ethiopian refugees. , 1989, Bulletin of the World Health Organization.

[104]  Alan D. Lopez,et al.  The global burden of disease: a comprehensive assessment of mortality and disability from diseases injuries and risk factors in 1990 and projected to 2020. , 1996 .

[105]  N. Tandon,et al.  Prevalence and significance of low 25-hydroxyvitamin D concentrations in healthy subjects in Delhi. , 2000, The American journal of clinical nutrition.

[106]  K. Tucker,et al.  High intra/interindividual variance ratios for energy and nutrient intakes of pregnant women in rural Malawi show that many days are required to estimate usual intake. , 2002, The Journal of nutrition.

[107]  M. Khoury,et al.  Neural-tube defects. , 1999, The New England journal of medicine.

[108]  N. W. Flodin Handbook of Vitamins , 1987 .

[109]  S. Smitasiri,et al.  Social marketing vitamin A-rich foods in Thailand: a model nutrition communication for behavior change process. 2nd ed. , 1993 .

[110]  E. Hertrampf Iron fortification in the Americas. , 2002, Nutrition reviews.

[111]  D. Freidel,et al.  An interim report , 1986 .

[112]  R. Black,et al.  The need for maternal zinc supplementation in developing countries: an unresolved issue. , 2003, The Journal of nutrition.

[113]  J. Haas,et al.  Iron-Deficiency Anemia: Reexamining the Nature and Magnitude of the Public Health Problem Iron Deficiency and Reduced Work Capacity: A Critical Review of the Research to Determine a Causal Relationship 1,2 , 2001 .

[114]  Hong Wang,et al.  Correction: Prevention of Neural-Tube Defects with Folic Acid in China. , 1999, The New England journal of medicine.

[115]  A. Sommer,et al.  Night blindness during pregnancy and subsequent mortality among women in Nepal: effects of vitamin A and beta-carotene supplementation. , 2000, American journal of epidemiology.

[116]  T. J. Mathews,et al.  Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. , 2001, JAMA.

[117]  H. Delisle,et al.  Fortified foods contribute one half of recommended vitamin A intake in poor urban Guatemalan toddlers. , 1998, The Journal of nutrition.

[118]  A. Carriquiry,et al.  Development of an approach for estimating usual nutrient intake distributions at the population level. , 1997, The Journal of nutrition.

[119]  J. O. Mora,et al.  Food fortification to reduce vitamin A deficiency: International Vitamin A Consultative Group recommendations. , 2002, The Journal of nutrition.

[120]  R. L. King,et al.  CHEMICAL AND SENSORY EVALUATION OF IRON-FORTIFIED MILK , 1973 .

[121]  S. Boyages Clinical review 49: Iodine deficiency disorders. , 1993, The Journal of clinical endocrinology and metabolism.

[122]  C. Bloch EFFECTS OF DEFICIENCY IN VITAMINS IN INFANCY: CARIES OF THE TEETH AND VITAMINS , 1931 .

[123]  D. B. Wilson,et al.  Estimated folate intakes: data updated to reflect food fortification, increased bioavailability, and dietary supplement use. , 1999, The American journal of clinical nutrition.

[124]  G. McCabe,et al.  Vitamin B-6 status of Egyptian mothers: relation to infant behavior and maternal-infant interactions. , 1990, The American journal of clinical nutrition.

[125]  J. Danesh,et al.  Coronary heart disease and iron status: meta-analyses of prospective studies. , 1999, Circulation.

[126]  M. Rothschild,et al.  Carrots, Sticks, and Promises: A Conceptual Framework for the Management of Public Health and Social Issue Behaviors , 2000 .

[127]  S. Nakornchai,et al.  Effects of betel nut and fermented fish on the thiamin status of northeastern Thais. , 1975, The American journal of clinical nutrition.

[128]  J. Simpson,et al.  Postpartum thiamine deficiency in a Karen displaced population. , 2001, The American journal of clinical nutrition.

[129]  B. Greenwood,et al.  Riboflavin, folate and vitamin C status of Gambian women during pregnancy: a comparison between urban and rural communities. , 1987, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[130]  Thirty-Second Session JOINT FAO/WHO FOOD STANDARDS PROGRAMME , 2007 .

[131]  M. Lennon,et al.  School milk as a vehicle for fluoride in the United Kingdom. An interim report. , 2001, Community dental health.

[132]  D H Jernigan,et al.  Media Advocacy: Lessons from Community Experiences , 1996, Journal of public health policy.

[133]  James Howard Means,et al.  THE THYROID AND ITS DISEASES , 1938 .

[134]  M. Lennon,et al.  The use of school milk as a vehicle for fluoride in Knowsley, UK; an evaluation of effectiveness. , 2003, Community dental health.

[135]  S. Vollset,et al.  Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. , 2001, The American journal of clinical nutrition.

[136]  J. Cook,et al.  An evaluation of EDTA compounds for iron fortification of cereal-based foods. , 2000, The British journal of nutrition.

[137]  R. Martorell,et al.  Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. Revised ed. , 1993 .

[138]  G. Malenga,et al.  An outbreak of pellagra related to changes in dietary niacin among Mozambican refugees in Malawi. , 1993, International journal of epidemiology.

[139]  A. Carriquiry,et al.  A Semiparametric Transformation Approach to Estimating Usual Daily Intake Distributions , 1996 .

[140]  R. Hurrell How to ensure adequate iron absorption from iron-fortified food. , 2002, Nutrition reviews.

[141]  L. Caulfield,et al.  Zinc supplementation in infants born small for gestational age reduces mortality: a prospective, randomized, controlled trial. , 2001, Pediatrics.

[142]  G. Chan,et al.  A comparison of calcium, vitamin D, or both for nutritional rickets in Nigerian children. , 1999, The New England journal of medicine.

[143]  Ingo Potrykus,et al.  Fighting Iron Deficiency Anemia with Iron-Rich Rice , 2002, Journal of the American College of Nutrition.

[144]  D. Karyadi,et al.  Supplementation with vitamin A and iron for nutritional anaemia in pregnant women in West Java, Indonesia , 1993, The Lancet.

[145]  M. Dhansay,et al.  Long-term evaluation of a micronutrient-fortified biscuit used for addressing micronutrient deficiencies in primary school children , 2001, Public Health Nutrition.

[146]  W. Roper Health communication takes on new dimensions at CDC. , 1993, Public health reports.

[147]  R. Mariño,et al.  A community trial of fluoridated powdered milk in Chile. , 2001, Community dentistry and oral epidemiology.

[148]  L. Mejia,et al.  The effect of vitamin A fortification of sugar on the serum vitamin A levels of preschool Guatemalan children: a longitudinal evaluation. , 1981, The American journal of clinical nutrition.

[149]  L. Allen,et al.  Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers. , 2000, The American journal of clinical nutrition.

[150]  M. Sinclair,et al.  Water fluoridation, osteoporosis, fractures--recent developments. , 2001, Australian dental journal.

[151]  Kathleen M. Fairfield,et al.  Vitamins for chronic disease prevention in adults: scientific review. , 2002, JAMA.

[152]  N. Abdul-Ghaffar,et al.  Vitamin D deficiency in veiled Kuwaiti women. , 1996, European journal of clinical nutrition.

[153]  M. Olivares,et al.  Prevention of iron deficiency by milk fortification. II. A field trial with a full-fat acidified milk. , 1988, The American journal of clinical nutrition.

[154]  S. Fairweather-Tait,et al.  Oral ferrous sulfate supplements increase the free radical-generating capacity of feces from healthy volunteers. , 1999, The American journal of clinical nutrition.

[155]  O. Dary,et al.  Recovery of Retinol in Soft-Drink Beverages Made with Fortified Unrefined and Refined Sugar: Implications for National Fortification Programs☆☆☆ , 1998 .

[156]  L. Allen,et al.  Iron absorption from ferrous bisglycinate and ferric trisglycinate in whole maize is regulated by iron status. , 2000, The American journal of clinical nutrition.

[157]  Gatt Secretariat,et al.  The results of the Uruguay Round of Multilateral Trade Negotiations : the legal texts , 1994 .

[158]  A. Oestreich,et al.  Prospective study of vitamin D supplementation and rickets in China. , 1992, The Journal of pediatrics.

[159]  P. Arthur,et al.  Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods. , 2001, The American journal of clinical nutrition.

[160]  S. S. Arya,et al.  EFFECT of WATER ACTIVITY ON VITAMIN A DEGRADATION IN WHEAT FLOUR (ATTA) , 1990 .

[161]  L. Allen Impact of vitamin B-12 deficiency during lactation on maternal and infant health. , 2002, Advances in experimental medicine and biology.

[162]  J. Castenmiller,et al.  Bioavailability and bioconversion of carotenoids. , 1998, Annual review of nutrition.

[163]  C. Victora,et al.  Evaluation designs for adequacy, plausibility and probability of public health programme performance and impact. , 1999, International journal of epidemiology.

[164]  N. Krebs,et al.  Zinc absorption and intestinal losses of endogenous zinc in young Chinese women with marginal zinc intakes. , 1996, The American journal of clinical nutrition.

[165]  J. DiPietro,et al.  Adding zinc to prenatal iron and folate tablets improves fetal neurobehavioral development. , 1999, American journal of obstetrics and gynecology.

[166]  J. King Determinants of maternal zinc status during pregnancy. , 2000, The American journal of clinical nutrition.

[167]  M. Deitchler,et al.  Micronutrient report : current progress and trends in the control of vitamin A, iodine, and iron deficiencies , 2001 .

[168]  T. Cole,et al.  Effect of calcium supplementation on bone mineral accretion in gambian children accustomed to a low-calcium diet. , 2000, The American journal of clinical nutrition.

[169]  M. Garabédian,et al.  Subclinical vitamin D deficiency in neonates: definition and response to vitamin D supplements. , 1997, The American journal of clinical nutrition.

[170]  Sigrid A Gibso Iron intake and iron status of preschool children: associations with breakfast cereals, vitamin C and meat , 1999 .

[171]  J. Valadez,et al.  Using lot quality assurance sampling to assess measurements for growth monitoring in a developing country's primary health care system. , 1996, International journal of epidemiology.

[172]  M. Toole Micronutrient deficiencies in refugees , 1992, The Lancet.

[173]  C. Menéndez,et al.  Malaria-related anaemia. , 2000, Parasitology today.

[174]  D. Bunout,et al.  The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin B-12 deficiency in elderly people. , 2002, The Journal of nutrition.

[175]  L. Bailey,et al.  Absorption of folate from fortified cereal-grain products and of supplemental folate consumed with or without food determined by using a dual-label stable-isotope protocol. , 1997, The American journal of clinical nutrition.

[176]  Joint Fao,et al.  Evaluation of certain food additives and contaminants. , 2007, World Health Organization technical report series.

[177]  C. F. Mills Zinc in Human Biology , 1989, ILSI Human Nutrition Reviews.

[178]  L. Caulfield,et al.  Potential contribution of maternal zinc supplementation during pregnancy to maternal and child survival. , 1998, The American journal of clinical nutrition.

[179]  S. Leung,et al.  Bone mineral content of two populations of Chinese children with different calcium intakes. , 1993, Bone and mineral.

[180]  Joint Fao Evaluation of certain food additives. Fifty-first report of the Joint FAO/WHO Expert Committee on Food Additives. , 2000, World Health Organization technical report series.

[181]  Å. Cederblad,et al.  Absorption of zinc from Iupin (Lupinus angustifolius)-based foods , 1994, British Journal of Nutrition.

[182]  G. Wolf The Vitamins: Fundamental Aspects in Nutrition and Health , 1992 .

[183]  J. Beard,et al.  Iron deficiency in young rats alters the distribution of vitamin A between plasma and liver and between hepatic retinol and retinyl esters. , 1999, The Journal of nutrition.

[184]  P. Beyer,et al.  Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. , 2000, Science.

[185]  E. Lo,et al.  Effect of fluoridated milk on caries in primary teeth: 21-month results. , 2003, Community dentistry and oral epidemiology.

[186]  F. Paccaud,et al.  Blood thiamin status and determinants in the population of Seychelles (Indian Ocean). , 1998, Journal of epidemiology and community health.

[187]  G. Yang,et al.  The role of selenium in Keshan disease. , 1984, Advances in nutritional research.

[188]  P. Wilson,et al.  The effect of folic acid fortification on plasma folate and total homocysteine concentrations. , 1999, The New England journal of medicine.

[189]  M. Law,et al.  Homocysteine and ischemic heart disease: results of a prospective study with implications regarding prevention. , 1998, Archives of internal medicine.

[190]  N. Scrimshaw,et al.  Nutrition Policy Implementation , 1982 .

[191]  D. Wald,et al.  Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis , 2002, BMJ : British Medical Journal.

[192]  H. McNulty,et al.  Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation. , 2002, Clinical chemistry.

[193]  M. Krajčovičová-Kudláčková,et al.  Homocysteine Levels in Vegetarians versus Omnivores , 2000, Annals of Nutrition and Metabolism.

[194]  Stuart Gillespie,et al.  Major issues in the control of iron deficiency , 1998 .

[195]  J. Brust,et al.  Neurologic Aspects of Cobalamin Deficiency , 1991, Medicine.

[196]  B. Giray,et al.  Status of selenium and antioxidant enzymes of goitrous children is lower than healthy controls and nongoitrous children with high iodine deficiency , 2007, Biological Trace Element Research.

[197]  C. Castaneda,et al.  Prevalence of riboflavin deficiency among Guatemalan elderly people and its relationship to milk intake. , 1993, The American journal of clinical nutrition.

[198]  J. Cauley,et al.  Community water fluoridation, bone mineral density, and fractures: prospective study of effects in older women , 2000, BMJ : British Medical Journal.

[199]  Periconceptional folic acid exposure and risk of occurrent neural tube defects. , 1993 .

[200]  M. Cogswell,et al.  Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994. , 2002, The American journal of clinical nutrition.

[201]  A. Aro,et al.  Effects of supplementation of fertilizers on human selenium status in Finland. , 1995, The Analyst.

[202]  S. de Pee,et al.  Dietary carotenoids and their role in combating vitamin A deficiency: a review of the literature. , 1996, European journal of clinical nutrition.

[203]  L. Allen,et al.  A multinutrient-fortified beverage enhances the nutritional status of children in Botswana. , 2003, The Journal of nutrition.

[204]  R. Baez,et al.  Salt fluoridation and dental caries in Jamaica. , 2001, Community dentistry and oral epidemiology.

[205]  L. Allen,et al.  What works? A review of the efficacy and effectiveness of nutrition interventions. , 2001 .

[206]  B. de Benoist,et al.  Iodine deficiency in the world: where do we stand at the turn of the century? , 2001, Thyroid : official journal of the American Thyroid Association.

[207]  L. Davidsson,et al.  Iron absorption from fish sauce and soy sauce fortified with sodium iron EDTA. , 2003, The American journal of clinical nutrition.

[208]  I. Darnton-Hill,et al.  Fortification strategies to meet micronutrient needs: sucesses and failures , 2002, Proceedings of the Nutrition Society.

[209]  I. Darnton-Hill,et al.  Efficacy of a vitamin A-fortified wheat-flour bun on the vitamin A status of Filipino schoolchildren. , 2000, The American journal of clinical nutrition.

[210]  F. Karlsson,et al.  The use of sugar as a vehicle for iodine fortification in endemic iodine deficiency. , 1995, International journal of food sciences and nutrition.

[211]  F. R. Davidson,et al.  Assessment and control of vitamin A deficiency: the Annecy Accords. , 2002, The Journal of nutrition.

[212]  J. Driskell,et al.  Vitamin B-6 inadequacy is prevalent in rural and urban Indonesian children. , 2000, The Journal of nutrition.

[213]  A. Sommer,et al.  Impact of vitamin a supplementation on hematological indicators of iron metabolism and protein status in children , 1992 .

[214]  Tung-Ching Lee,et al.  Development and Evaluation of Iron-fortified Extruded Rice Grains , 2005 .

[215]  L. Bailey,et al.  Fetal malformations and folate metabolism: review of recent evidence. , 2009, Nutrition reviews.

[216]  Gary M Brittenham,et al.  Iron supplementation during pregnancy, anemia, and birth weight: a randomized controlled trial. , 2003, The American journal of clinical nutrition.

[217]  W. R. Aykroyd,et al.  Medical resurvey of nutrition in Newfoundland 1948. , 1949, Canadian Medical Association journal.

[218]  M. Zimmermann,et al.  Dual fortification of salt with iodine and microencapsulated iron: a randomized, double-blind, controlled trial in Moroccan schoolchildren. , 2003, The American journal of clinical nutrition.

[219]  Lester Breslow,et al.  S.O.S. for a Billion: The Conquest of Iodine Deficiency Disorders , 1995 .

[220]  B. de Benoist,et al.  Risks of iodine-induced hyperthyroidism after correction of iodine deficiency by iodized salt. , 1999, Thyroid : official journal of the American Thyroid Association.

[221]  S. Horton Opportunities for Investments in Nutrition in Low-income Asia , 1999, Asian Development Review.

[222]  S. Vollset,et al.  Plasma total cysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine Study. , 2000, The American journal of clinical nutrition.

[223]  L. Allen Folate and vitamin B12 status in the Americas. , 2004, Nutrition reviews.

[224]  L. Allen,et al.  Prevalence and Causes of Nutritional Anemias , 2000 .

[225]  D. Coakley,et al.  Vitamin D-Fortified Liquid Milk: Benefits for the Elderly Community-Based Population , 1998, Calcified Tissue International.

[226]  S. Ebrahim,et al.  Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men , 1995, The Lancet.

[227]  J. Dumont,et al.  Selenium deficiency mitigates hypothyroxinemia in iodine-deficient subjects. , 1993, The American journal of clinical nutrition.

[228]  O. Dary Lessons learned with iron fortification in Central America. , 2002, Nutrition reviews.

[229]  G. Combs The Vitamins: Fundamental Aspects in Nutrition and Health , 1991 .

[230]  P. Trumbo,et al.  Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. , 1998, Journal of the American Dietetic Association.

[231]  A. Prentice,et al.  Vitamin D status and parathyroid hormone concentrations in Chinese women and men from north-east of the People’s Republic of China , 2000, European Journal of Clinical Nutrition.

[232]  A M Prentice,et al.  The relative effectiveness of iron and iron with riboflavin in correcting a microcytic anaemia in men and children in rural Gambia. , 1983, Human nutrition. Clinical nutrition.

[233]  L. Allen,et al.  Kenyan school children have multiple micronutrient deficiencies, but increased plasma vitamin B-12 is the only detectable micronutrient response to meat or milk supplementation. , 2003, The Journal of nutrition.

[234]  T. Schaffner,et al.  The toxicology of iodate: a review of the literature. , 2001, Thyroid : official journal of the American Thyroid Association.

[235]  K. Német,et al.  Impact of iron fortification of milk formulas on infants growth and health , 1995 .

[236]  D. Karyadi,et al.  Vitamin A-fortified monosodium glutamate and health, growth, and survival of children: a controlled field trial. , 1988, The American journal of clinical nutrition.

[237]  O. Müller,et al.  Effect of zinc supplementation on malaria and other causes of morbidity in west African children: randomised double blind placebo controlled trial , 2001, BMJ : British Medical Journal.

[238]  V. Mannar,et al.  Iron fortification: country level experiences and lessons learned. , 2002, The Journal of nutrition.

[239]  L. Davidsson,et al.  Influence of ascorbic acid on iron absorption from an iron-fortified, chocolate-flavored milk drink in Jamaican children. , 1998, The American journal of clinical nutrition.

[240]  F. Karlsson,et al.  Control of iodine deficiency using iodination of water in a goitre endemic area. , 1997, International journal of food sciences and nutrition.

[241]  C. Cooper,et al.  Fluoride in drinking water and risk of hip fracture in the UK: a case-control study , 2000, The Lancet.

[242]  S. Murphy,et al.  Animal source foods to improve micronutrient nutrition and human function in developing countries. Proceedings of a conference. June 24-26, 2002. Washington, DC, USA. , 2003, The Journal of nutrition.

[243]  L. Davidsson,et al.  Comparison of Selenite and Selenate Apparent Absorption and Retention in Infants Using Stable Isotope Methodology , 2002, Pediatric Research.

[244]  B. Lönnerdal,et al.  Promoters and Antagonists of Zinc Absorption , 1989 .

[245]  L. Sokoll,et al.  Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. , 1991, Annals of internal medicine.

[246]  J. Gallagher,et al.  Dietary calcium and vitamin D intake in elderly women: effect on serum parathyroid hormone and vitamin D metabolites. , 1998, The American journal of clinical nutrition.

[247]  D. Jamison,et al.  Disease Control Priorities in Developing Countries , 1993 .

[248]  M. Holick,et al.  Nutrition and Bone Health , 2004, Nutrition and Health.

[249]  P. Kincaid‐smith,et al.  Scurvy in adult Africans; a clinical, haematological, and pathological study. , 1954, The American journal of clinical nutrition.

[250]  N. Binkin,et al.  Rapid Nutrition Surveys: How Many Clusters are Enough? , 1992, Disasters.

[251]  D. Cole,et al.  Association of neural tube defects and folic acid food fortification in Canada , 2002, The Lancet.

[252]  E. Hertrampf,et al.  Consumption of folic acid-fortified bread improves folate status in women of reproductive age in Chile. , 2003, The Journal of nutrition.

[253]  N. Krebs,et al.  Zinc supplementation during lactation: effects on maternal status and milk zinc concentrations. , 1995, The American journal of clinical nutrition.

[254]  O. Hernell,et al.  Iron, zinc, and copper concentrations in breast milk are independent of maternal mineral status. , 2004, The American journal of clinical nutrition.

[255]  J. Cook,et al.  Degradation of phytic acid in cereal porridges improves iron absorption by human subjects. , 2003, The American journal of clinical nutrition.

[256]  K Michael Hambidge,et al.  Zinc homeostasis in Malawian children consuming a high-phytate, maize-based diet. , 2002, The American journal of clinical nutrition.

[257]  V. Bosch,et al.  Early response to the effect of iron fortification in the Venezuelan population. , 1996, The American journal of clinical nutrition.

[258]  W. James,et al.  A life course approach to diet, nutrition and the prevention of chronic diseases , 2004, Public Health Nutrition.

[259]  L. Davidsson,et al.  A micronised, dispersible ferric pyrophosphate with high relative bioavailability in man , 2004, British Journal of Nutrition.

[260]  J. Cook,et al.  Regular consumption of NaFeEDTA-fortified fish sauce improves iron status and reduces the prevalence of anemia in anemic Vietnamese women. , 2003, The American journal of clinical nutrition.

[261]  M. Moffatt,et al.  Vitamin D deficiency in a Manitoba community. , 1993, Canadian journal of public health = Revue canadienne de sante publique.

[262]  N. Krebs,et al.  Zinc homeostasis during lactation in a population with a low zinc intake. , 2002, The American journal of clinical nutrition.

[263]  L. Caulfield,et al.  Maternal zinc supplementation does not affect size at birth or pregnancy duration in Peru. , 1999, The Journal of nutrition.

[264]  G. Yang,et al.  The epidemiology of selenium deficiency in the etiological study of endemic diseases in China. , 1993, The American journal of clinical nutrition.

[265]  F. W. Douglas,et al.  Color, Flavor, and Iron Bioavailability in Iron-Fortified Chocolate Milk , 1981 .

[266]  K. Cham,et al.  OUTBREAK OF BERI-BERI IN THE GAMBIA , 1989, The Lancet.

[267]  L. Allen,et al.  Complementary feeding of young children in developing countries: a review of current scientific knowledge. , 1998 .

[268]  M. Latham,et al.  Micronutrient dietary supplements--a new fourth approach. , 2001, Archivos latinoamericanos de nutricion.

[269]  L. Davidsson,et al.  Sodium iron EDTA [NaFe(III)EDTA] as a food fortificant: the effect on the absorption and retention of zinc and calcium in women. , 1994, The American journal of clinical nutrition.

[270]  S. Fomon,et al.  Infant feeding in the 20th century: formula and beikost. , 2001, The Journal of nutrition.

[271]  K. West Extent of vitamin A deficiency among preschool children and women of reproductive age. , 2002, The Journal of nutrition.

[272]  L. Braverman,et al.  Iodine-induced hyperthyroidism: occurrence and epidemiology. , 1998, Thyroid : official journal of the American Thyroid Association.

[273]  K. Ge,et al.  Vitamin D deficiency and associated factors in adolescent girls in Beijing. , 2001, The American journal of clinical nutrition.

[274]  C. Saade,et al.  Mobilizing the commercial sector for public health objectives: a practical guide. , 1996 .

[275]  T. Welch,et al.  Vitamin D-deficient rickets: the reemergence of a once-conquered disease. , 2000, The Journal of pediatrics.

[276]  F. Delange,et al.  The disorders induced by iodine deficiency. , 1994, Thyroid : official journal of the American Thyroid Association.

[277]  Nutrition Board,et al.  Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline , 2000 .

[278]  E. Demaeyer Preventing and controlling iron deficiency anaemia through primary health care: A guide for health administrators and programme managers , 1989 .

[279]  G. Ranhotra,et al.  Expanded cereal fortification: bioavailability and functionality (breadmaking) of various calcium sources. , 1980 .

[280]  M. Zimmermann,et al.  Comparison of the efficacy of wheat-based snacks fortified with ferrous sulfate, electrolytic iron, or hydrogen-reduced elemental iron: randomized, double-blind, controlled trial in Thai women. , 2005, The American journal of clinical nutrition.

[281]  A. Sreenivasan,et al.  PROBLEMS OF THIAMINE DEFICIENCY STATES AND THEIR AMELIORATION , 1962, Annals of the New York Academy of Sciences.

[282]  M. Jackson,et al.  TWO PREGNANCIES IN A PATIENT WITH ACRODERMATITIS ENTEROPATHICA TREATED WITH ZINC SULPHATE , 1981, The Lancet.

[283]  K. Krishnaswamy,et al.  Importance of folate in human nutrition , 2001, British Journal of Nutrition.

[284]  L. Allen,et al.  Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. , 2002, The American journal of clinical nutrition.

[285]  K. Stephen,et al.  Five-year double-blind fluoridated milk study in Scotland. , 1984, Community dentistry and oral epidemiology.

[286]  R. Black Therapeutic and preventive effects of zinc on serious childhood infectious diseases in developing countries. , 1998, The American journal of clinical nutrition.

[287]  P. Taylor,et al.  Body iron stores and the risk of cancer. , 1988, The New England journal of medicine.

[288]  P. Beyer,et al.  Golden Rice: introducing the beta-carotene biosynthesis pathway into rice endosperm by genetic engineering to defeat vitamin A deficiency. , 2002, The Journal of nutrition.

[289]  S. Oppenheimer Iron and its relation to immunity and infectious disease. , 2001, The Journal of nutrition.

[290]  June A. Flora,et al.  Social Marketing and Public Health Intervention , 1988, Health education quarterly.

[291]  J. Cook,et al.  The usefulness of elemental iron for cereal flour fortification: a SUSTAIN Task Force report. Sharing United States Technology to Aid in the Improvement of Nutrition. , 2002, Nutrition reviews.

[292]  V. Chavasit,et al.  Triple Fortification of Instant Noodles in Thailand , 1998 .

[293]  J. Rivera,et al.  Development, Production, and Quality Control of Nutritional Supplements for a National Supplementation Programme in Mexico , 2000 .