Black currant seed oil supplementation of mothers enhances IFN‐γ and suppresses IL‐4 production in breast milk

The first year of infancy is crucial for the development of atopic immune response. Inadequate early Th1 and Treg responses and increased production of Th2 cytokines are associated with atopy. Breast milk contains several immunomodulatory cytokines and other factors that might influence the maturation of the infant's immune system. We assessed the cytokines in breast milk of mother of newborn infants and their associations with black currant seed oil (BCSO) supplementation during pregnancy, mother's atopic status and the development of infant's atopic dermatitis.

[1]  M. Tang,et al.  Relationship between breast milk sCD14, TGF‐β1 and total IgA in the first month and development of eczema during infancy , 2013, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[2]  Y. Kohno,et al.  Cytokine Biomarker Candidates in Breast Milk Associated with the Development of Atopic Dermatitis in 6-Month-Old Infants , 2012, International Archives of Allergy and Immunology.

[3]  E. Savilahti,et al.  Impact of Maternal Allergy and Use of Probiotics during Pregnancy on Breast Milk Cytokines and Food Antibodies and Development of Allergy in Children until 5 Years , 2012, International Archives of Allergy and Immunology.

[4]  U. Hoppu,et al.  Probiotics and dietary counselling targeting maternal dietary fat intake modifies breast milk fatty acids and cytokines , 2012, European Journal of Nutrition.

[5]  M. Wickman,et al.  Breastfeeding, asthma, and allergy: a tale of two cities , 2012, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[6]  M. Rovers,et al.  Breastfeeding modulates neonatal innate immune responses: a prospective birth cohort study , 2012, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[7]  N. Kondo,et al.  Maternal psychosocial factors determining the concentrations of transforming growth factor‐beta in breast milk , 2011, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[8]  Shio‐Jean Lin,et al.  Infant feeding practices and physician diagnosed atopic dermatitis: a prospective cohort study in Taiwan , 2011, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[9]  S. Tomičić,et al.  Breast Milk Cytokine and IgA Composition Differ in Estonian and Swedish Mothers—Relationship to Microbial Pressure and Infant Allergy , 2010, Pediatric Research.

[10]  T. Vahlberg,et al.  Blackcurrant seed oil for prevention of atopic dermatitis in newborns: a randomized, double‐blind, placebo‐controlled trial , 2010, Clinical and Experimental Allergy.

[11]  J. Heinrich,et al.  Reduced IFN‐γ‐ and enhanced IL‐4‐producing CD4+ cord blood T cells are associated with a higher risk for atopic dermatitis during the first 2 yr of life , 2010, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[12]  A. Goldman.  The immune system in human milk and the developing infant. , 2007, Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.

[13]  H. Mykkänen,et al.  Black currant seed oil and fish oil supplements differ in their effects on fatty acid profiles of plasma lipids, and concentrations of serum total and lipoprotein lipids, plasma glucose and insulin. , 2005, The Journal of nutritional biochemistry.

[14]  E. Novembre,et al.  Scoring atopic dermatitis in infants and young children: distinctive features of the SCORAD index , 2005, Allergy.

[15]  C. Akdis,et al.  Apoptosis in tissue inflammation and allergic disease. , 2004, Current opinion in immunology.

[16]  P. Hartmann,et al.  The effect of supplementation with fish oil during pregnancy on breast milk immunoglobulin A, soluble CD14, cytokine levels and fatty acid composition , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[17]  Manabu T. Nakamura,et al.  STRUCTURE, FUNCTION, AND DIETARY REGULATION OF Δ6, Δ5, AND Δ9 DESATURASES , 2004 .

[18]  V. Piironen,et al.  Breast Milk Fatty Acids, Eicosanoids, and Cytokines in Mothers with and without Allergic Disease , 2003, Pediatric Research.

[19]  R. Gibson,et al.  A randomized trial of supplementation with docosahexaenoic acid-rich tuna oil and its effects on the human milk cytokines interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha. , 2002, The American journal of clinical nutrition.

[20]  P. Calder,et al.  Fatty acids and lymphocyte functions , 2002, British Journal of Nutrition.

[21]  J. German,et al.  Urinary excretion of catechin metabolites by human subjects after red wine consumption , 2002, British Journal of Nutrition.

[22]  V. V. D. van der Velden,et al.  Selective development of a strong Th2 cytokine profile in high‐risk children who develop atopy: risk factors and regulatory role of IFN‐γ, IL‐4 and IL‐10 , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[23]  C. Akdis,et al.  T cells and T cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis. , 1999, The Journal of investigative dermatology.

[24]  R. Garofalo,et al.  Cytokines in Breast Milk from Allergic and Nonallergic Mothers , 1999, International Archives of Allergy and Immunology.

[25]  P. Sly,et al.  Development of allergen-specific T-cell memory in atopic and normal children , 1999, The Lancet.

[26]  T. Ruzicka,et al.  Human eosinophils produce biologically active IL-12: implications for control of T cell responses. , 1998, Journal of immunology.

[27]  P. Sly,et al.  Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. , 1998, Journal of immunology.

[28]  H. Kallio,et al.  Characterization of seed oils of wild, edible Finnish berries , 1997 .

[29]  P. Holt,et al.  Primary allergic sensitization to environmental antigens: perinatal T cell priming as a determinant of responder phenotype in adulthood , 1996, The Journal of experimental medicine.

[30]  P. Braquet,et al.  Leukotriene B4 enhances IL-4-induced IgE production from normal human lymphocytes. , 1994, Cellular immunology.

[31]  J. Kolb,et al.  Leukotriene B4 induces interleukin 5 generation from human T lymphocytes , 1993, European journal of immunology.

[32]  M. Betz,et al.  Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. , 1991, Journal of immunology.

[33]  G. Rajka,et al.  Diagnostic Features of Atopic Dermatitis , 1980, Acta Dermato-Venereologica.

[34]  C. Akdis,et al.  Absence of T-regulatory cell expression and function in atopic dermatitis skin. , 2006, The Journal of allergy and clinical immunology.

[35]  Manabu T. Nakamura,et al.  Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. , 2004, Annual review of nutrition.

[36]  C. Miller,et al.  Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. , 2000, The American journal of clinical nutrition.

[37]  R. Garofalo,et al.  Cytokines in Breast Milk from Allergic and Nonallergic Mothers , 2000, Pediatric Research.