Masking of mRNA by Y‐box proteins

The Y‐box proteins are defined by their ability to bind to Y‐box promoter elements and to help regulate transcription of a wide variety of genes. However, Y‐box proteins are also identified as abundant proteins in the cytoplasm of germ cells, where they are found bound to stored mRNA molecules. Binding of Y‐box proteins to mRNA sequences, both in vitro and in vivo, has been shown to effect their translational repression (“masking” ). Here we discuss the ability of Y box proteins to recognize different nucleic acid structures and to become involved in regulation of both transcription and translation.—Sommerville, J., Ladomery, M. Masking of mRNA by Y‐box proteins. FASEB J. 10, 435‐443 (1996)

[1]  A. Wolffe,et al.  Sequence-specific RNA Recognition by the Xenopus Y-box Proteins , 1995, The Journal of Biological Chemistry.

[2]  W. Keller,et al.  No end yet to messenger RNA 3′ processing! , 1995, Cell.

[3]  P. Evans,et al.  The RNP domain: a sequence-specific RNA-binding domain involved in processing and transport of RNA. , 1995, Trends in biochemical sciences.

[4]  M. Marahiel,et al.  Mutational analysis of the putative nucleic acid‐binding surface of the cold‐shock domain, CspB, revealed an essential role of aromatic and basic residues in binding of single‐stranded DNA containing the Y‐box motif , 1995, Molecular microbiology.

[5]  Phillip D Zamore,et al.  Translational regulation in development , 1995, Cell.

[6]  J. Ting,et al.  The Transcriptional Regulatory Protein, YB-1, Promotes Single-stranded Regions in the DRA Promoter (*) , 1995, The Journal of Biological Chemistry.

[7]  C. L. Wei,et al.  The Major Protein of Messenger Ribonucleoprotein Particles in Somatic Cells Is a Member of the Y-box Binding Transcription Factor Family (*) , 1995, The Journal of Biological Chemistry.

[8]  G. Gallia,et al.  Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[9]  M. Muckenthaler,et al.  Promoter control of translation in Xenopus oocytes. , 1995, Nucleic acids research.

[10]  A. Firulli,et al.  DNA triplexes and regulation of the c-myc gene. , 1994, Gene.

[11]  D. Bartsch,et al.  Characterization of a Y-Box factor from Aplysia californica. , 1994, Gene.

[12]  Hélène Jacquemin-Sablon,et al.  Nucleic acid binding and intracellular localization of unr, a protein with five cold shock domains , 1994, Nucleic Acids Res..

[13]  K Ito,et al.  A novel growth-inducible gene that encodes a protein with a conserved cold-shock domain. , 1994, Nucleic acids research.

[14]  G. Montelione,et al.  Solution NMR structure of the major cold shock protein (CspA) from Escherichia coli: identification of a binding epitope for DNA. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[15]  M. Inouye,et al.  Crystal structure of CspA, the major cold shock protein of Escherichia coli. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[16]  T. Ley,et al.  A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes. , 1994, The Journal of biological chemistry.

[17]  A. Wolffe.  Structural and functional properties of the evolutionarily ancient Y‐box family of nucleic acid binding proteins , 1994, BioEssays : news and reviews in molecular, cellular and developmental biology.

[18]  A. Wolffe,et al.  Selective recruitment of masked maternal mRNA from messenger ribonucleoprotein particles containing FRGY2 (mRNP4). , 1993, The Journal of biological chemistry.

[19]  A. Colman,et al.  A more efficient and specific strategy in the ablation of mRNA in Xenopus laevis using mixtures of antisense oligos. , 1993, Nucleic acids research.

[20]  A. Wolffe,et al.  Masking mRNA from translation in somatic cells. , 1993, Genes & development.

[21]  M. Czisch,et al.  Structure in solution of the major cold-shock protein from Bacillus subtilis , 1993, Nature.

[22]  Hermann Schindelin,et al.  Universal nucleic acid-binding domain revealed by crystal structure of the B. subtilis major cold-shock protein , 1993, Nature.

[23]  N. Hecht,et al.  Proteins homologous to the Xenopus germ cell-specific RNA-binding proteins p54/p56 are temporally expressed in mouse male germ cells. , 1993, Developmental biology.

[24]  A. Wolffe,et al.  A mouse Y box protein, MSY1, is associated with paternal mRNA in spermatocytes. , 1993, The Journal of biological chemistry.

[25]  J. Manley,et al.  Transcriptional repression by the Drosophila even-skipped protein: definition of a minimal repression domain. , 1993, Genes & development.

[26]  B. Turner,et al.  Histone H4 acetylation and transcription in amphibian chromatin , 1993, The Journal of cell biology.

[27]  J. Sommerville,et al.  Binding of Xenopus oocyte masking proteins to mRNA sequences. , 1992, Nucleic acids research.

[28]  A. Wolffe,et al.  DNA gyrase, CS7.4, and the cold shock response in Escherichia coli , 1992, Journal of bacteriology.

[29]  S. Deschamps,et al.  mRNP4, a major mRNA-binding protein from Xenopus oocytes is identical to transcription factor FRG Y2. , 1992, The Journal of biological chemistry.

[30]  J. Sommerville.  What the papers say: RNA‐binding proteins: Masking proteins revealed , 1992 .

[31]  A. Wolffe,et al.  DNA binding, multimerization, and transcription stimulation by the Xenopus Y box proteins in vitro. , 1992, The New biologist.

[32]  A. Wolffe,et al.  The Y-box factors: a family of nucleic acid binding proteins conserved from Escherichia coli to man. , 1992, The New biologist.

[33]  D. Landsman,et al.  The product of unr, the highly conserved gene upstream of N-ras, contains multiple repeats similar to the cold-shock domain (CSD), a putative DNA-binding motif. , 1992, The New biologist.

[34]  Rukmini Kolluri,et al.  A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif , 1992, Nucleic Acids Res..

[35]  C. Gualerzi,et al.  Identification of a cold shock transcriptional enhancer of the Escherichia coli gene encoding nucleoid protein H-NS. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[36]  C. Murphy,et al.  Small nuclear ribonucleoproteins and heterogeneous nuclear ribonucleoproteins in the amphibian germinal vesicle: loops, spheres, and snurposomes , 1991, The Journal of cell biology.

[37]  W. Franke,et al.  Different forms of soluble cytoplasmic mRNA binding proteins and particles in Xenopus laevis oocytes and embryos , 1991, The Journal of cell biology.

[38]  A. Wolffe,et al.  Xenopus Y-box transcription factors: molecular cloning, functional analysis and developmental regulation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[39]  A. Chambers,et al.  A nuclear translational block imposed by the HIV-1 U3 region is relieved by the Tat-TAR interaction , 1990, Cell.

[40]  J. Sommerville,et al.  Multiple modifications in the phosphoproteins bound to stored messenger RNA in Xenopus oocytes. , 1989, Biochimica et biophysica acta.

[41]  D. K. Didier,et al.  Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[42]  J. Richter,et al.  Photocrosslinking of proteins to maternal mRNA in Xenopus oocytes. , 1988, Developmental biology.

[43]  J. Sommerville,et al.  Protein kinase activity associated with stored messenger ribonucleoprotein particles of Xenopus oocytes , 1988, The Journal of cell biology.

[44]  J. Sommerville,et al.  Phosphorylation of a 60 kDa polypeptide from Xenopus oocytes blocks messenger RNA translation. , 1987, Nucleic acids research.

[45]  J. Richter,et al.  Reversible inhibition of translation by Xenopus oocyte-specific proteins , 1984, Nature.

[46]  J. Gurdon,et al.  Use of Frog Eggs and Oocytes for the Study of Messenger RNA and its Translation in Living Cells , 1971, Nature.

[47]  M. Ladomery,et al.  A role for Y-box proteins in cell proliferation. , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[48]  M. Ladomery,et al.  Binding of Y-box proteins to RNA: involvement of different protein domains. , 1994, Nucleic acids research.

[49]  M. Muckenthaler,et al.  Intron-less RNA injected into the nucleus of Xenopus oocytes accesses a regulated translation control pathway. , 1994, Nucleic acids research.

[50]  C. Burd,et al.  hnRNP proteins and the biogenesis of mRNA. , 1993, Annual review of biochemistry.

[51]  J. Sommerville.  RNA-binding proteins: masking proteins revealed. , 1992, BioEssays : news and reviews in molecular, cellular and developmental biology.

[52]  J. Sommerville.  RNA-binding phosphoproteins and the regulation of maternal mRNA in Xenopus. , 1990, Journal of reproduction and fertility. Supplement.

[53]  P. Ford,et al.  Identification in Xenopus laevis of a class of oocyte-specific proteins bound to messenger RNA. , 1981, European journal of biochemistry.