The Diagnosis of Asthma using Hilbert-Huang Transform and Deep Learning on Lung Sounds

Lung auscultation is the most effective and indispensable method for diagnosing various respiratory disorders by using the sounds from the airways during inspirium and exhalation using a stethoscope. In this study, the statistical features are calculated from intrinsic mode functions that are extracted by applying the HilbertHuang Transform to the lung sounds from 12 different auscultation regions on the chest and back. The classification of the lung sounds from asthma and healthy subjects is performed using Deep Belief Networks (DBN). The DBN classifier model with two hidden layers has been tested using 5-fold cross validation method. The proposed DBN separated lung sounds from asthmatic and healthy subjects with high classification performance rates of 84.61%, 85.83%, and 77.11% for overall accuracy, sensitivity, and selectivity, respectively using frequencytime analysis. Keywords—Deep Learning; Lung Auscultation, HilbertHuang Transform; Deep Belief Networks; Asthma;

[1]  Gabriel Rilling,et al.  Empirical mode decomposition as a filter bank , 2004, IEEE Signal Processing Letters.

[2]  Naoki Nakamura,et al.  Detection of patients considering observation frequency of continuous and discontinuous adventitious sounds in lung sounds , 2016, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[3]  M. Studnicka,et al.  Diagnosis and management of asthma – Statement on the 2015 GINA Guidelines , 2016, Wiener klinische Wochenschrift.

[4]  Marcin Wisniewski,et al.  Digital analysis methods of wheezes in asthma , 2010, ICSES 2010 International Conference on Signals and Electronic Circuits.

[5]  Paul H. King,et al.  Representation and Classification of Breath Sounds Recorded in an Intensive Care Setting Using Neural Networks , 2004, Journal of Clinical Monitoring and Computing.

[6]  Gorkem Serbes,et al.  A lung sound classification system based on the rational dilation wavelet transform , 2016, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[7]  Mahesh Pawar,et al.  Analysis of Deformities in Lung Using Short Time Fourier Transform Spectrogram Analysis on Lung Sound , 2011, 2011 International Conference on Computational Intelligence and Communication Networks.

[8]  H S Hira,et al.  LUNG SOUNDS , 1978, The Journal of the Association of Physicians of India.

[9]  Sueharu Miyahara,et al.  Detection of abnormal lung sounds taking into account duration distribution for adventitious sounds , 2012, 2012 Proceedings of the 20th European Signal Processing Conference (EUSIPCO).

[10]  Gokhan Altan,et al.  Multimedia Respiratory Database (RespiratoryDatabase@TR): Auscultation Sounds and Chest X-rays , 2017, ArXiv.

[11]  S. Braman The global burden of asthma. , 2006, Chest.

[12]  Y. Kutlu,et al.  A review on respiratory sound analysis using machine learning , 2016, 2016 20th National Biomedical Engineering Meeting (BIYOMUT).

[13]  Yasemin P. Kahya,et al.  Classification of respiratory signals by linear analysis , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[14]  D. Jackson,et al.  Asthma: diagnosis and management in adults , 2016, Medicine.

[15]  P. Alapat,et al.  Validation of Automatic Wheeze Detection in Patients with Obstructed Airways and in Healthy Subjects , 2008, The Journal of asthma : official journal of the Association for the Care of Asthma.

[16]  Ashutosh Kumar Singh,et al.  Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 , 2016, Lancet.

[17]  M. Bahoura,et al.  Respiratory sounds classification using cepstral analysis and Gaussian mixture models , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[18]  R. Jane,et al.  Analysis of Wheezes in Asthmatic Patients during Spontaneous Respiration , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[19]  L. Nieman,et al.  Pulmonary auscultatory skills during training in internal medicine and family practice. , 1999, American journal of respiratory and critical care medicine.

[20]  B. Aleraj,et al.  [Epidemiology of allergic diseases]. , 2011, Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti.

[21]  Z. Moussavi,et al.  Finding the Lung sound-Flow Relationship in Normal and Asthmatic Subjects , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[22]  Yee Whye Teh,et al.  A Fast Learning Algorithm for Deep Belief Nets , 2006, Neural Computation.

[23]  N. Huang,et al.  The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis , 1998, Proceedings of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.