Pituitary-Adrenal Influences on Fear Responding

In a passive avoidance situation, hypophysectomized male rats show less fear than normal rats, whereas adrenalectomized rats show greater fear than normals. These results probably occur because hypophysectomized rats lack adrenocorticotrophic hormone, which increases arousal or emotionality, whereas adrenalectomized animals lack certain adrenal steroids, which inhibit excitatory effects. The results indicate that adrenocorticotrophic hormone and certain adrenal steroids have opposite effects in regulating fear-motivated behavior.

[1]  J. Davidson,et al.  Feedback regulation of adrenocorticotropin secretion in "basal" and "stress" conditions: acute and chronic effects of intrahypothalamic corticoid implantation. , 1968, Endocrinology.

[2]  B. Bohus,et al.  Inhibitory and Facilitatory Effect of Two Related Peptides on Extinction of Avoidance Behavior , 1966, Science.

[3]  D. Wied.  Inhibitory Effect of ACTH and Related Peptides on Extinction of Conditioned Avoidance Behavior in Rats , 1966 .

[4]  S. Levine,et al.  ADRENOCORTICOTROPIC HORMONE (ACTH) AND PASSIVE AVOIDANCE LEARNING. , 1965, Journal of comparative and physiological psychology.

[5]  M. Jones,et al.  Changes in pituitary corticotrophic function in the adrenalectomized rat , 1964, The Journal of physiology.

[6]  P. G. Smelik.  Relation Between Blood Level of Corticoids and Their Inhibiting Effect on the Hypophyseal Stress Response , 1963, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[7]  J. R. Hodges,et al.  The effect of injected corticosterone on the release of adrenocorticotrophic hormone in rats exposed to acute stress , 1963, The Journal of physiology.

[8]  A. Barrett,et al.  The effect of housing conditions and simple experimental procedures upon the corticosterone level in the plasma of rats. , 1963, The Journal of endocrinology.

[9]  S. Levine,et al.  An effect of adrenal demedullation on the acquisition of a conditioned avoidance response. , 1962, Journal of comparative and physiological psychology.

[10]  R. Miller,et al.  The effect of adrenocorticotrophic hormone (ACTH) on avoidance conditioning in the adrenalectomized rat. , 1962, Journal of comparative and physiological psychology.

[11]  F. Yates,et al.  Interaction between plasma corticosterone concentration and adrenocorticotropin-releasing stimuli in the rat: evidence for the reset of an endocrine feedback control. , 1961, Endocrinology.

[12]  K. Moyer,et al.  Effect of adrenal demedullation, operative stress, and noise stress on emotional elimination. , 1960, The Journal of genetic psychology.

[13]  Moyer Ke,et al.  Effect of adrenal demedullation on an avoidance response in the rat. , 1959 .

[14]  J. Vernikos,et al.  The effect of adrenalectomy on the circulating level of adrenocorticotrophic hormone in the rat. , 1958, The Journal of endocrinology.

[15]  K. Moyer,et al.  Effect of adrenalectomy on anxiety motivated behavior. , 1958, The Journal of genetic psychology.

[16]  K. Moyer,et al.  Effect of adrenalectomy on emotional elimination. , 1958, The Journal of genetic psychology.

[17]  A. Brodish,et al.  Changes in blood ACTH under various experimental conditions studied by means of a cross-circulation technique. , 1956, Endocrinology.

[18]  Murphy Jv,et al.  The effect of adrenocorticotrophic hormone (ACTH) on avoidance conditioning in the rat. , 1955 .

[19]  W. Gray,et al.  The rapidity of the adrenocorticotropic response of the pituitary to the intravenous administration of histamine. , 1951, Endocrinology.

[20]  G. Sayers,et al.  Regulatory Effect of Adrenal Cortical Extract on Elaboration of Pituitary Adrenotropic Hormone.∗ , 1945, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.