TGF‐β activates pericytes via induction of the epithelial‐to‐mesenchymal transition protein SLUG in glioblastoma

In primary central nervous system tumours, epithelial‐to‐mesenchymal transition (EMT) gene expression is associated with increased malignancy. However, it has also been shown that EMT factors in gliomas are almost exclusively expressed by glioma vessel‐associated pericytes (GA‐Peris). In this study, we aimed to identify the mechanism of EMT in GA‐Peris and its impact on angiogenic processes.

[1]  R. Adams,et al.  NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy , 2018, Nature Communications.

[2]  Guojun Sheng,et al.  Epithelial-mesenchymal transition in haematopoietic stem cell development and homeostasis. , 2018, Journal of biochemistry.

[3]  M. Seifert,et al.  Pericytes/vessel-associated mural cells (VAMCs) are the major source of key epithelial-mesenchymal transition (EMT) factors SLUG and TWIST in human glioma , 2018, Oncotarget.

[4]  A. Moustakas,et al.  TGF-β Family Signaling in Ductal Differentiation and Branching Morphogenesis. , 2018, Cold Spring Harbor perspectives in biology.

[5]  K. Plate,et al.  Functional morphology of the blood-brain barrier in health and disease , 2018, Acta Neuropathologica.

[6]  A. Colquhoun.  Cell biology-metabolic crosstalk in glioma. , 2017, The international journal of biochemistry & cell biology.

[7]  S. Niclou,et al.  Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors. , 2017, International journal of oncology.

[8]  J. Finek,et al.  [Epithelial-mesenchymal Transition in Tumor Tissue and Its Role for Metastatic Spread of Cancer]. , 2017, Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti.

[9]  U. Naumann,et al.  Viscumins functionally modulate cell motility-associated gene expression. , 2017, International journal of oncology.

[10]  M. Goel,et al.  Tumor progression, metastasis, and modulators of epithelial-mesenchymal transition in endometrioid endometrial carcinoma: an update. , 2016, Endocrine-related cancer.

[11]  Michael Seifert,et al.  Comparative transcriptomics reveals similarities and differences between astrocytoma grades , 2015, BMC Cancer.

[12]  A. Taguchi,et al.  Brain Vascular Pericytes Following Ischemia Have Multipotential Stem Cell Activity to Differentiate Into Neural and Vascular Lineage Cells , 2015, Stem cells.

[13]  David Fortin,et al.  Transforming growth factor-beta and its implication in the malignancy of gliomas , 2015, Targeted Oncology.

[14]  J. Barnholtz-Sloan,et al.  Glioblastoma survival: has it improved? Evidence from population-based studies. , 2014, Current opinion in neurology.

[15]  Lei Han,et al.  Multidimensional analysis of gene expression reveals TGFB1I1-induced EMT contributes to malignant progression of astrocytomas , 2014, Oncotarget.

[16]  A. Moustakas,et al.  TGFβ and matrix-regulated epithelial to mesenchymal transition. , 2014, Biochimica et biophysica acta.

[17]  S. Martinez,et al.  Glioblastoma: A Pathogenic Crosstalk between Tumor Cells and Pericytes , 2014, PloS one.

[18]  W. Wick,et al.  Immature mesenchymal stem cell-like pericytes as mediators of immunosuppression in human malignant glioma , 2013, Journal of Neuroimmunology.

[19]  U. Naumann,et al.  YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells , 2013, Journal of Translational Medicine.

[20]  V. Balasubramaniyan,et al.  TGF-β as a therapeutic target in high grade gliomas - promises and challenges. , 2013, Biochemical pharmacology.

[21]  H. Augustin,et al.  Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF‐A and TGFβ2 in vascular abnormalization , 2012, The Journal of pathology.

[22]  D. Zagzag,et al.  Mechanisms of glioma-associated neovascularization. , 2012, The American journal of pathology.

[23]  K. Miyazono,et al.  Tumor-promoting functions of transforming growth factor-β in progression of cancer , 2012, Upsala journal of medical sciences.

[24]  Ben Davidson,et al.  Epithelial–Mesenchymal Transition in Ovarian Carcinoma , 2012, Front. Oncol..

[25]  N. Jordan,et al.  Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer , 2011, Cell cycle.

[26]  M. Campone,et al.  Hypoxia and the Malignant Glioma Microenvironment: Regulation and Implications for Therapy , 2009 .

[27]  B. Scheithauer,et al.  The 2007 WHO Classification of Tumours of the Central Nervous System , 2007, Acta Neuropathologica.

[28]  Thomas D. Wu,et al.  Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. , 2006, Cancer cell.

[29]  Markus Bredel,et al.  Vascular Patterns in Glioblastoma Influence Clinical Outcome and Associate with Variable Expression of Angiogenic Proteins: Evidence for Distinct Angiogenic Subtypes , 2003, Brain pathology.

[30]  A. Ruifrok,et al.  Quantification of histochemical staining by color deconvolution. , 2001, Analytical and quantitative cytology and histology.

[31]  S. Kügler,et al.  Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand. , 2001, Cancer research.

[32]  M. Weller,et al.  Accumulation of mutant p53(V143A) modulates the growth, clonogenicity, and radiochemosensitivity of malignant glioma cells independent of endogenous p53 status. , 1999, Experimental cell research.

[33]  A. Merlo,et al.  Frequent Co‐Alterations of TP53, p16/CDKN2A, p14ARF, PTEN Tumor Suppressor Genes in Human Glioma Cell Lines. , 1999, Brain pathology.

[34]  M. Verbeek,et al.  Rapid Degeneration of Cultured Human Brain Pericytes by Amyloid β Protein , 1997 .

[35]  H. Levine,et al.  Epithelial mesenchymal transition ( EMT ) , a spectrum of states : role in lung development , homeostasis and disease , 2017 .

[36]  B. Kamińska,et al.  TGF beta signaling and its role in glioma pathogenesis. , 2013, Advances in experimental medicine and biology.

[37]  D. Gisselsson,et al.  Bone marrow multipotent mesenchymal stroma cells act as pericyte-like migratory vehicles in experimental gliomas. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

[38]  M. Verbeek,et al.  Rapid degeneration of cultured human brain pericytes by amyloid beta protein. , 1997, Journal of neurochemistry.

[39]  A. D. Brink,et al.  Minimum cross-entropy threshold selection , 1996, Pattern Recognit..

[40]  R. Barnard,et al.  The classification of tumours of the central nervous system. , 1982, Neuropathology and applied neurobiology.