The Thrombin Receptor Restricts Subventricular Zone Neural Stem Cell Expansion and Differentiation

[1]  Jose E. Schutt-Aine,et al.  Characteristics , 1895, The Dental register.

[2]  Qigui Yu,et al.  MMPs/TIMPs imbalances in the peripheral blood and cerebrospinal fluid are associated with the pathogenesis of HIV-1-associated neurocognitive disorders , 2017, Brain, Behavior, and Immunity.

[3]  M. Oğuz,et al.  State transition model: vorapaxar added to standard antiplatelet therapy to prevent thrombosis post myocardial infarction or peripheral artery disease , 2017, Current medical research and opinion.

[4]  A. Tselepis,et al.  Increased Benefit With Vorapaxar Use in Patients With a History of Myocardial Infarction and Diabetes Mellitus , 2017, Journal of cardiovascular pharmacology and therapeutics.

[5]  R. Franklin,et al.  Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice , 2017, Stem cell reports.

[6]  S. Goldman Progenitor cell-based treatment of glial disease. , 2017, Progress in brain research.

[7]  M. Hollenberg,et al.  Proteinases, Their Extracellular Targets, and Inflammatory Signaling , 2016, Pharmacological Reviews.

[8]  F. Doetsch,et al.  A mosaic world: puzzles revealed by adult neural stem cell heterogeneity , 2016, Wiley interdisciplinary reviews. Developmental biology.

[9]  I. Scarisbrick,et al.  Targeting the thrombin receptor modulates inflammation and astrogliosis to improve recovery after spinal cord injury , 2016, Neurobiology of Disease.

[10]  E. Granieri,et al.  Interplay between Matrix Metalloproteinase-9, Matrix Metalloproteinase-2, and Interleukins in Multiple Sclerosis Patients , 2016, Disease markers.

[11]  K. Ogita,et al.  Protease-activated receptor-1 negatively regulates proliferation of neural stem/progenitor cells derived from the hippocampal dentate gyrus of the adult mouse. , 2016, Journal of pharmacological sciences.

[12]  F. Gheyas,et al.  Effect of Vorapaxar Alone and in Combination with Aspirin on Bleeding Time and Platelet Aggregation in Healthy Adult Subjects , 2016, Clinical and translational science.

[13]  O. Kehinde,et al.  Vorapaxar: A novel agent to be considered in the secondary prevention of myocardial infarction , 2016, Journal of pharmacy & bioallied sciences.

[14]  Gerald J. Sun,et al.  Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation , 2015, Nature Neuroscience.

[15]  M. Fehlings,et al.  Genetic targeting of protease activated receptor 2 reduces inflammatory astrogliosis and improves recovery of function after spinal cord injury , 2015, Neurobiology of Disease.

[16]  C. Esmon,et al.  PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells , 2015, Nature Medicine.

[17]  G. Fishell,et al.  Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination , 2015, Nature.

[18]  C. Catsman-Berrevoets,et al.  Gray matter–related proteins are associated with childhood-onset multiple sclerosis , 2015, Neurology: Neuroimmunology & Neuroinflammation.

[19]  Johannes E. Schindelin,et al.  The ImageJ ecosystem: An open platform for biomedical image analysis , 2015, Molecular reproduction and development.

[20]  B. Becher,et al.  Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury. , 2015, Cell reports.

[21]  S. Goldman,et al.  Glia Disease and Repair-Remyelination. , 2015, Cold Spring Harbor perspectives in biology.

[22]  I. Scarisbrick,et al.  The thrombin receptor is a critical extracellular switch controlling myelination , 2015, Glia.

[23]  R. Franklin,et al.  The translational biology of remyelination: Past, present, and future , 2014, Glia.

[24]  A. Álvarez-Buylla,et al.  Adult neural stem cells stake their ground , 2014, Trends in Neurosciences.

[25]  O. Raineteau,et al.  GSK3β regulates oligodendrogenesis in the dorsal microdomain of the subventricular zone via Wnt‐β‐catenin signaling , 2014, Glia.

[26]  S. Bäumer,et al.  Proteinase-Activated Receptor 1 (PAR1) Regulates Leukemic Stem Cell Functions , 2014, PloS one.

[27]  M. Fehlings,et al.  Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity , 2013, Journal of neurochemistry.

[28]  Richard D. Smith,et al.  Gray Matter Is Targeted in First-Attack Multiple Sclerosis , 2013, PloS one.

[29]  I. Scarisbrick,et al.  Critical role for PAR1 in kallikrein 6‐mediated oligodendrogliopathy , 2013, Glia.

[30]  Felipe Ortega,et al.  Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling , 2013, Nature Cell Biology.

[31]  A. Brunet,et al.  Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain , 2013, Nature Cell Biology.

[32]  J. Uhm,et al.  Clinical significance and novel mechanism of action of kallikrein 6 in glioblastoma. , 2013, Neuro-oncology.

[33]  M. Cayre,et al.  Ciliary Neurotrophic Factor Controls Progenitor Migration during Remyelination in the Adult Rodent Brain , 2013, The Journal of Neuroscience.

[34]  O. Raineteau,et al.  Intraventricular injection of FGF‐2 promotes generation of oligodendrocyte‐lineage cells in the postnatal and adult forebrain , 2012, Glia.

[35]  Xinyu Zhao,et al.  Isolation of multipotent neural stem or progenitor cells from both the dentate gyrus and subventricular zone of a single adult mouse , 2012, Nature Protocols.

[36]  J. Flanagan,et al.  RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues. , 2012, The Journal of molecular diagnostics : JMD.

[37]  L. Luo,et al.  Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma , 2011, Cell.

[38]  Gerald J. Sun,et al.  In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics , 2011, Cell.

[39]  H. Hartung,et al.  The complex world of oligodendroglial differentiation inhibitors , 2011, Annals of neurology.

[40]  Beth A. Cloud,et al.  Functional Role of Kallikrein 6 in Regulating Immune Cell Survival , 2011, PloS one.

[41]  T. Kilpatrick,et al.  Remyelination Is Altered by Bone Morphogenic Protein Signaling in Demyelinated Lesions , 2011, The Journal of Neuroscience.

[42]  S. Couillard-Després,et al.  Deciphering the oligodendrogenic program of neural progenitors: cell intrinsic and extrinsic regulators. , 2010, Stem cells and development.

[43]  K. Hirschi,et al.  Diverse roles of the vasculature within the neural stem cell niche. , 2009, Regenerative medicine.

[44]  J. García-Verdugo,et al.  Epidermal Growth Factor Induces the Progeny of Subventricular Zone Type B Cells to Migrate and Differentiate into Oligodendrocytes , 2009, Stem cells.

[45]  A. Agarwal,et al.  Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis. , 2009, Cancer research.

[46]  Arnold Kriegstein,et al.  The glial nature of embryonic and adult neural stem cells. , 2009, Annual review of neuroscience.

[47]  T. Olsson,et al.  Identification of novel candidate protein biomarkers for the post-polio syndrome - implications for diagnosis, neurodegeneration and neuroinflammation. , 2009, Journal of proteomics.

[48]  D. Seilhean,et al.  Remyelination in multiple sclerosis. , 2009, Progress in brain research.

[49]  M. Blaber,et al.  Protease‐activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines , 2008, Journal of neurochemistry.

[50]  F. Gage,et al.  Directed differentiation of hippocampal stem/progenitor cells in the adult brain , 2008, Nature Neuroscience.

[51]  C. Wegner,et al.  Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. , 2008, Brain : a journal of neurology.

[52]  E. Diamandis,et al.  Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration , 2008, Biological chemistry.

[53]  M. Hollenberg,et al.  Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more , 2008, British journal of pharmacology.

[54]  I. Scarisbrick The multiple sclerosis degradome: enzymatic cascades in development and progression of central nervous system inflammatory disease. , 2008, Current topics in microbiology and immunology.

[55]  V. Gallo,et al.  Reduced EGFR signaling in progenitor cells of the adult subventricular zone attenuates oligodendrogenesis after demyelination. , 2007, Neuron glia biology.

[56]  R. Reynolds,et al.  Remyelination can be extensive in multiple sclerosis despite a long disease course , 2007, Neuropathology and applied neurobiology.

[57]  I. Bièche,et al.  PAR‐1 activation has different effects on the angiogenic activity of endothelial progenitor cells derived from human adult and cord blood , 2006, Journal of thrombosis and haemostasis : JTH.

[58]  Hans Lassmann,et al.  Remyelination is extensive in a subset of multiple sclerosis patients. , 2006, Brain : a journal of neurology.

[59]  Oscar Gonzalez-Perez,et al.  Origin of Oligodendrocytes in the Subventricular Zone of the Adult Brain , 2006, The Journal of Neuroscience.

[60]  L. Green,et al.  Thrombin and PAR‐1 stimulate differentiation of bone marrow‐derived endothelial progenitor cells , 2006, Journal of thrombosis and haemostasis : JTH.

[61]  M. Götz,et al.  Neuronal fate determinants of adult olfactory bulb neurogenesis , 2005, Nature Neuroscience.

[62]  Stephen F Traynelis,et al.  Activation of Protease-Activated Receptor-1 Triggers Astrogliosis after Brain Injury , 2005, The Journal of Neuroscience.

[63]  S. Fancy,et al.  Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS , 2004, Molecular and Cellular Neuroscience.

[64]  D. Brat,et al.  The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[65]  Anne Baron-Van Evercooren,et al.  Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[66]  David J. Anderson,et al.  The bHLH Transcription Factor Olig2 Promotes Oligodendrocyte Differentiation in Collaboration with Nkx2.2 , 2001, Neuron.

[67]  M. Krug,et al.  Four different types of protease‐activated receptors are widely expressed in the brain and are up‐regulated in hippocampus by severe ischemia , 2001, The European journal of neuroscience.

[68]  B. Trapp,et al.  NG2-Positive Oligodendrocyte Progenitor Cells in Adult Human Brain and Multiple Sclerosis Lesions , 2000, The Journal of Neuroscience.

[69]  L. Decker,et al.  Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination , 1999, The European journal of neuroscience.

[70]  C. Heldin,et al.  Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis. , 1998, Brain : a journal of neurology.

[71]  A. Álvarez-Buylla,et al.  Stem cells in the developing and adult nervous system. , 1998, Journal of neurobiology.

[72]  G. Wolswijk Chronic Stage Multiple Sclerosis Lesions Contain a Relatively Quiescent Population of Oligodendrocyte Precursor Cells , 1998, The Journal of Neuroscience.

[73]  J. Goldman,et al.  Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS , 1997, Neuron.

[74]  E. Parati,et al.  Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[75]  Angelo L. Vescovi,et al.  bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells , 1993, Neuron.

[76]  S. Weiss,et al.  Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. , 1992, Science.