Nonparametric de‐noising filter optimization using structure‐based microscopic image classification

The Local Polynomial Approximation (LPA) is a nonparametric filter that performs pixel‐wise polynomial fit on a certain neighborhood. This filter can be supported by the Intersection of Confidence Interval rule (ICI) as an adaptation algorithm to identify the most suited neighborhood at which the polynomial assumptions provide superior fit for the observations. However, the LPA‐ICI is considered to be a near‐optimal de‐noising filter. Moreover, the ICI rule has several parameters that affect its performance. The current study applied an optimization algorithm, namely the Particle swarm optimization (PSO) to determine the optimal ICI parameter values for microscopic images de‐noising. As the ICI parameters are image's structure based, bag‐of‐features classifier is used to classify the images based on their structure into different classes. Afterward, a generated optimal ICI parameters' table was created using the LPA‐ICI‐PSO for further direct use without optimization. This table included the optimal ICI parameters based on the image structure. Based on the image category, the generated table can be used to attain the suitable ICI optimal parameters without using PSO. This guarantees less computational time along with the optimal de‐noising compared to the LPA‐ICI as established by the performance metrics. The experimental results established the superiority of the proposed LPA‐ICI‐PSO over the classical LPA‐ICI filter.