HA14-1 is Able to Reconstitute the Impaired Mitochondrial Pathway of Apoptosis in Renal Cell Carcinoma Cell Lines
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[1] Jun Peng,et al. sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell. , 2008, Cancer letters.
[2] S. Han,et al. Effect of betulinic acid on anticancer drug-resistant colon cancer cells. , 2007, Basic & clinical pharmacology & toxicology.
[3] A. Thorburn,et al. Tumor-derived Mutations in the TRAIL Receptor DR5 Inhibit TRAIL Signaling through the DR4 Receptor by Competing for Ligand Binding* , 2007, Journal of Biological Chemistry.
[4] C. Xing,et al. Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis. , 2007, Molecular pharmaceutics.
[5] C. Mahotka,et al. Differential gene expression in anticancer drug- and TRAIL-mediated apoptosis in renal cell carcinomas , 2007, Apoptosis.
[6] Christoph H Emmerich,et al. TRAIL signalling: decisions between life and death. , 2007, The international journal of biochemistry & cell biology.
[7] Hyung-Sub Kang,et al. Reactive oxygen species regulate Bax translocation and mitochondrial transmembrane potential, a possible mechanism for enhanced TRAIL-induced apoptosis by CCCP. , 2007, Oncology reports.
[8] Donald Wlodkowic,et al. Larger than life: Mitochondria and the Bcl-2 family. , 2007, Leukemia research.
[9] Philippe Juin,et al. Bax activation and mitochondrial insertion during apoptosis , 2007, Apoptosis.
[10] G. Kroemer,et al. Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway byCaspase-9 , 2006, Molecular and Cellular Biology.
[11] C. Scott,et al. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. , 2006, Cancer cell.
[12] W. El-Deiry,et al. What are caspases 3 and 7 doing upstream of the mitochondria? , 2006, Cancer biology & therapy.
[13] Keisuke Kuida,et al. Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis , 2006, Science.
[14] J. Houghton,et al. Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines. , 2005, Cancer research.
[15] M. Tang,et al. Bcl-2 Rescues Ceramide- and Etoposide-induced Mitochondrial Apoptosis through Blockage of Caspase-2 Activation* , 2005, Journal of Biological Chemistry.
[16] M. Tang,et al. Sequential Caspase-2 and Caspase-8 Activation Upstream of Mitochondria during Ceramideand Etoposide-induced Apoptosis* , 2004, Journal of Biological Chemistry.
[17] I. H. Engels,et al. Caspase-2 Can Function Upstream of Bid Cleavage in the TRAIL Apoptosis Pathway* , 2004, Journal of Biological Chemistry.
[18] S. Di Giovanni,et al. BOK and NOXA Are Essential Mediators of p53-dependent Apoptosis* , 2004, Journal of Biological Chemistry.
[19] S. Lowe,et al. Suppression of tumorigenesis by the p53 target PUMA. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[20] S. Chin,et al. p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[21] G. Häcker,et al. Functional evaluation of the apoptosome in renal cell carcinoma , 2003, British Journal of Cancer.
[22] Wafik S El-Deiry,et al. TRAIL and apoptosis induction by TNF-family death receptors , 2003, Oncogene.
[23] Andreas Villunger,et al. p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa , 2003, Science.
[24] M. V. Heiden,et al. Caspase-9 is activated in a cytochrome c-independent manner early during TNFα-induced apoptosis in murine cells , 2003, Cell Death and Differentiation.
[25] J. Tan,et al. HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death , 2003, Leukemia.
[26] C. Gerharz,et al. Apoptosis induction in renal cell carcinoma by TRAIL and γ-radiation is impaired by deficient caspase-9 cleavage , 2003, British Journal of Cancer.
[27] F. Beguinot,et al. Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Death-inducing Signaling Complex and Its Modulation by c-FLIP and PED/PEA-15 in Glioma Cells* , 2002, The Journal of Biological Chemistry.
[28] H. S. Kim,et al. Inactivating mutations of KILLER/DR5 gene in gastric cancers. , 2001, Gastroenterology.
[29] C. Gerharz,et al. Topotecan (Hycamtin) responsiveness in human renal carcinoma cell lines of the clear cell and papillary types. , 2001, Anticancer research.
[30] J. Martinou,et al. Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8. , 2001, Molecular cell.
[31] T. Rebbeck,et al. Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[32] Colin Adrain,et al. Executioner Caspase-3, -6, and -7 Perform Distinct, Non-redundant Roles during the Demolition Phase of Apoptosis* , 2001, The Journal of Biological Chemistry.
[33] Erwin G. Van Meir,et al. Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells. , 2001, Cancer research.
[34] C. Gerharz,et al. Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan , 2000, Cell Death and Differentiation.
[35] Xiaodong Wang,et al. Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition , 2000, Cell.
[36] Robert L Moritz,et al. Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins , 2000, Cell.
[37] S. Srinivasula,et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[38] E. Slee,et al. Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release , 2000, Cell Death and Differentiation.
[39] P. Krammer,et al. Deficient activation of CD95 (APO-1/ Fas)-mediated apoptosis: a potential factor of multidrug resistance in human renal cell carcinoma , 2000, British Journal of Cancer.
[40] Ingo Schmitz,et al. Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells* , 1999, The Journal of Biological Chemistry.
[41] G. Condorelli,et al. PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis , 1999, Oncogene.
[42] I. Jeremias,et al. Betulinic acid: A new cytotoxic agent against malignant brain‐tumor cells , 1999, International journal of cancer.
[43] P. Nicotera,et al. 1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis. , 1998, Molecular pharmacology.
[44] M. Peter,et al. Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. , 1997, Cancer research.
[45] Margot Thome,et al. Inhibition of death receptor signals by cellular FLIP , 1997, Nature.
[46] S. Störkel,et al. Ultrastructural appearance and cytoskeletal architecture of the clear, chromophilic, and chromophobe types of human renal cell carcinoma in vitro. , 1993, The American journal of pathology.
[47] R. Lewontin. Larger than life , 1985, Nature.
[48] Min Chen,et al. Delineation of the caspase-9 signaling cascade , 2007, Apoptosis.
[49] D. Golde,et al. Caspase-8 dependent trail-induced apoptosis in cancer cell lines is inhibited by vitamin C and catalase , 2006, Apoptosis.
[50] John Calvin Reed,et al. FLIP protein and TRAIL-induced apoptosis. , 2004, Vitamins and hormones.
[51] R. Moll,et al. Cytomorphological, cytogenetic, and molecular biological characterization of four new human renal carcinoma cell lines of the clear cell type , 2004, Virchows Archiv.