Loss of consciousness and post-traumatic stress disorder

Post-traumatic stress disorder (PTSD) is a condition that appears to be becoming increasingly prevalent in psychiatric and general practice. Davidson (1992) reports a lifetime prevalence of 1–9% in the community, with high levels of chroniciry and comorbidity. It routinely features in the general as well as medical literature following major traumas such as the Herald of free enterprise disaster. PTSD is also growing more important in medicolegal terms, as the recent police attempt to obtain compensation for their experiences in the Hillsborough tragedy demonstrates. Despite the high profile of the condition and the repeated descriptions of its development and (partial) resolution after every major disaster, there is very little research into the most effective means of preventing or treating PTSD. The usual approach of debriefing has been shown to be without effect (Deahl et al, 1994) and a recent review of drug treatments revealed only a few small-scale studies, none of which would be suitable tor [he licensing of a drug for this disorder (Davidson, 1992). This may be because most drug treatments are initiated well after the trauma, which may be too late to prevent the laying down of immutable brain traces for the memories, behaviours and affect that trauma causes and which develop into PTSD.

[1]  D. Nutt,et al.  A pilot controlled study of the effects of flumazenil in posttraumatic stress disorder , 1997, Biological Psychiatry.

[2]  C. Harley,et al.  Estimating the synaptic concentration of norepinephrine in dentate gyrus which produces β-receptor mediated long-lasting potentiation in vivo using microdialysis and intracerebroventricular norepinephrine , 1996, Brain Research.

[3]  J. Krystal,et al.  Effects of the benzodiazepine antagonist flumazenil in PTSD , 1995, Biological Psychiatry.

[4]  T. Bliss,et al.  Memories of NMDA receptors and LTP , 1995, Trends in Neurosciences.

[5]  M Srinivasan,et al.  Psychological Sequelae Following the Gulf War , 1994, British Journal of Psychiatry.

[6]  Richard Mayou,et al.  Psychiatric consequences of road traffic accidents. , 1993, BMJ.

[7]  C. A. Morgan,et al.  Abnormal noradrenergic function in posttraumatic stress disorder. , 1993, Archives of general psychiatry.

[8]  J. Davidson Drug Therapy of Post-traumatic Stress Disorder , 1992, British Journal of Psychiatry.

[9]  T. McMillan Post-traumatic Stress Disorder and Severe Head Injury , 1991, British Journal of Psychiatry.

[10]  B. Lerer,et al.  Core symptoms of posttraumatic stress disorder unimproved by alprazolam treatment. , 1990, The Journal of clinical psychiatry.

[11]  J. Davidson,et al.  Tribulin in post-traumatic stress disorder , 1988, Psychological Medicine.

[12]  A. Adler TWO DIFFERENT TYPES OF POST-TRAUMATIC NEUROSES , 1945 .

[13]  A. Adler NEUROPSYCHIATRIC COMPLICATIONS IN VICTIMS OF BOSTON'S COCOANUT GROVE DISASTER , 1943 .

[14]  T. Peters,et al.  Alcohol: the drug. , 1994, British medical bulletin.

[15]  I. Izquierdo,et al.  GABAA receptor modulation of memory: the role of endogenous benzodiazepines. , 1991, Trends in pharmacological sciences.

[16]  A. Adler MENTAL SYMPTOMS FOLLOWING HEAD INJURY: A STATISTICAL ANALYSIS OF TWO HUNDRED CASES , 1945 .