3テスラMRIによる中脳黒質neuromelanin-related contrastの描出:正常およびパーキンソン病における比較

3テスラMRIにて正常者とパーキンソン病（PD）例の黒質神経メラニンをneuromelanin-related contrast（NRC）として画像化し半定量した．正常加齢でNRCは増加した．PDで高度に減少し，重症度・罹病期間と負相関をみとめた．幻覚あり群で高度に低下し，嗅覚障害の有無で差がなく，レム睡眠行動異常で中間的な値を示し，症状発現時期に依存すると推定した．PDのNRCの減少は腹外側から正中に向かって進行した．レビー小体型認知症で減少しているがPD症状があるとより高度に減少した．NRCは既知の病理所見と整合性をみとめたが，NRCの意義や特異性および近縁疾患での検討を重ねる必要がある．

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