Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease

[1]  D. Llewellyn,et al.  Which Risk Factors Causally Influence Dementia? A Systematic Review of Mendelian Randomization Studies , 2018, Journal of Alzheimer's disease : JAD.

[2]  M. Farrall,et al.  Lack of genetic support for shared aetiology of Coronary Artery Disease and Late-onset Alzheimer’s disease , 2018, Scientific Reports.

[3]  C. Glass,et al.  Oxidized Phospholipids are Proinflammatory and Proatherogenic in Hypercholesterolemic Mice , 2018, Nature.

[4]  Samuel E. Jones,et al.  Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry , 2018, bioRxiv.

[5]  P. Visscher,et al.  Meta-analysis of genome-wide association studies for height and body mass index in ∼700,000 individuals of European ancestry , 2018, bioRxiv.

[6]  W. M. van der Flier,et al.  Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease risk , 2018, bioRxiv.

[7]  O. Andreassen,et al.  Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies , 2018, PLoS medicine.

[8]  John Hardy,et al.  The genetic landscape of Alzheimer disease. , 2018, Handbook of clinical neurology.

[9]  Quincy M. Samus,et al.  Dementia prevention, intervention, and care , 2017, The Lancet.

[10]  S. Larsson,et al.  Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis , 2017, British Medical Journal.

[11]  Nick C Fox,et al.  Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease , 2017, Nature Genetics.

[12]  J. Danesh,et al.  Association analyses based on false discovery rate implicate new loci for coronary artery disease , 2017, Nature Genetics.

[13]  Story C. Landis,et al.  Preventing Cognitive Decline and Dementia: A Way Forward , 2017 .

[14]  K. Hao,et al.  A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease , 2017, Nature Neuroscience.

[15]  Giovanni Malerba,et al.  Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes , 2017, Nature Genetics.

[16]  S. Hägg,et al.  Genetic susceptibility to cardiovascular disease and risk of dementia , 2017, Translational Psychiatry.

[17]  C A Emdin,et al.  Apfeltyp erhöht Diabetes- und KHK-Risiko , 2017, DMW - Deutsche Medizinische Wochenschrift.

[18]  Lilah M. Besser,et al.  Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score , 2017, PLoS medicine.

[19]  Kevin L. Boehme,et al.  Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case–control study , 2017, PLoS medicine.

[20]  Sekar Kathiresan,et al.  Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease , 2017, JAMA.

[21]  E. Karageorgiou,et al.  Neuroimaging in Dementia , 2017, Seminars in Neurology.

[22]  James A. Eddy,et al.  Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases , 2016, Scientific Data.

[23]  R. Mahley Central Nervous System LipoproteinsHighlights , 2016 .

[24]  O. Andreassen,et al.  Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. , 2016, JAMA neurology.

[25]  Zhi-Sheng Jiang,et al.  Imbalanced cholesterol metabolism in Alzheimer's disease. , 2016, Clinica chimica acta; international journal of clinical chemistry.

[26]  Alison M. Goate,et al.  Alzheimer’s Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci , 2016, PloS one.

[27]  Magda Tsolaki,et al.  A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN , 2015, Molecular Psychiatry.

[28]  Adult Changes in Thought Study Investigators,et al.  Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses , 2015 .

[29]  H. Stefánsson,et al.  Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease , 2015, Circulation.

[30]  Kevin L. Boehme,et al.  Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study , 2015, PLoS medicine.

[31]  Sara M. Willems,et al.  The impact of low-frequency and rare variants on lipid levels , 2015, Nature Genetics.

[32]  Thomas E. Nichols,et al.  Common genetic variants influence human subcortical brain structures , 2015, Nature.

[33]  M. Daly,et al.  An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.

[34]  A Smith,et al.  Genetic overlap between Alzheimer’s disease and Parkinson’s disease at the MAPT locus , 2015, Molecular Psychiatry.

[35]  A. Levey,et al.  Quantitative phosphoproteomics of Alzheimer's disease reveals cross‐talk between kinases and small heat shock proteins , 2015, Proteomics.

[36]  Juan Zhang,et al.  Cholesterol metabolism and homeostasis in the brain , 2015, Protein & Cell.

[37]  K. Jellinger,et al.  The overlap between vascular disease and Alzheimer’s disease - lessons from pathology , 2014, BMC Medicine.

[38]  A. Singleton,et al.  Genetic variability in the regulation of gene expression in ten regions of the human brain , 2014, Nature Neuroscience.

[39]  Ian J. Deary,et al.  Common genetic variants associated with cognitive performance identified using the proxy-phenotype method , 2014, Proceedings of the National Academy of Sciences.

[40]  Francesco Bettella,et al.  Shared common variants in prostate cancer and blood lipids. , 2014, International journal of epidemiology.

[41]  Kristine Yaffe,et al.  Potential for primary prevention of Alzheimer's disease: an analysis of population-based data , 2014, The Lancet Neurology.

[42]  J. Nielsen,et al.  Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics. , 2014, Molecular & cellular proteomics : MCP.

[43]  O. Andreassen,et al.  Boosting the power of schizophrenia genetics by leveraging new statistical tools. , 2014, Schizophrenia bulletin.

[44]  Nick C Fox,et al.  Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease , 2013, Nature Genetics.

[45]  Tanya M. Teslovich,et al.  Discovery and refinement of loci associated with lipid levels , 2013, Nature Genetics.

[46]  M. Peters,et al.  Systematic identification of trans eQTLs as putative drivers of known disease associations , 2013, Nature Genetics.

[47]  D. Rujescu,et al.  Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate , 2013, PLoS genetics.

[48]  M. McCarthy,et al.  Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. , 2013, American journal of human genetics.

[49]  C. Reitz Dyslipidemia and the Risk of Alzheimer’s Disease , 2013, Current Atherosclerosis Reports.

[50]  K. Yaffe,et al.  The projected effect of risk factor reduction on Alzheimer's disease prevalence , 2011, The Lancet Neurology.

[51]  G. D. Paolo,et al.  Linking lipids to Alzheimer's disease: cholesterol and beyond , 2011, Nature Reviews Cancer.

[52]  Kristine Yaffe,et al.  The Projected impact of risk factor reduction on Alzheimer's disease prevalence , 2011, Alzheimer's & Dementia.

[53]  Saumitra Das,et al.  Interplay between NS3 protease and human La protein regulates translation-replication switch of Hepatitis C virus , 2011, Scientific reports.

[54]  G. D. Paolo,et al.  Linking lipids to Alzheimer's disease: cholesterol and beyond , 2011, Nature Reviews Neuroscience.

[55]  Howard J. Rosen,et al.  Neuroimaging in Dementia , 2011, Neurotherapeutics.

[56]  Frank W. Stearns One Hundred Years of Pleiotropy: A Retrospective , 2010, Genetics.

[57]  Anton P. Porsteinsson,et al.  Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders , 2010, Biological Psychiatry.

[58]  Børge G Nordestgaard,et al.  Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease. , 2008, JAMA.

[59]  Ellen M Wijsman,et al.  Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association. , 2007, Genomics.

[60]  D. Sparks Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Abeta through the liver. , 2007, Current Alzheimer research.

[61]  R. Mayeux,et al.  Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort. , 2001, American journal of epidemiology.

[62]  F Mosteller,et al.  Some Statistical Methods for Combining Experimental Results , 1990, International Journal of Technology Assessment in Health Care.