Comparison of GATE/GEANT4 with EGSnrc and MCNP for electron dose calculations at energies between 15 keV and 20 MeV

The GATE Monte Carlo simulation platform based on the GEANT4 toolkit has come into widespread use for simulating positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging devices. Here, we explore its use for calculating electron dose distributions in water. Mono-energetic electron dose point kernels and pencil beam kernels in water are calculated for different energies between 15 keV and 20 MeV by means of GATE 6.0, which makes use of the GEANT4 version 9.2 Standard Electromagnetic Physics Package. The results are compared to the well-validated codes EGSnrc and MCNP4C. It is shown that recent improvements made to the GEANT4/GATE software result in significantly better agreement with the other codes. We furthermore illustrate several issues of general interest to GATE and GEANT4 users who wish to perform accurate simulations involving electrons. Provided that the electron step size is sufficiently restricted, GATE 6.0 and EGSnrc dose point kernels are shown to agree to within less than 3% of the maximum dose between 50 keV and 4 MeV, while pencil beam kernels are found to agree to within less than 4% of the maximum dose between 15 keV and 20 MeV.

[1]  D. Schaart The scaling method applied to beta particle line sources with a finite diameter. , 2002, Medical physics.

[2]  Iwan Kawrakow,et al.  NRC User Codes for EGSnrc , 2010 .

[3]  O. Chibani,et al.  Monte Carlo dose calculations in homogeneous media and at interfaces: a comparison between GEPTS, EGSnrc, MCNP, and measurements. , 2002, Medical physics.

[4]  R Jeraj,et al.  Parameter dependence of the MCNP electron transport in determining dose distributions. , 2002, Medical physics.

[5]  T. Koi,et al.  Geant 4 Developments and Applications , 2013 .

[6]  I. Kawrakow Accurate condensed history Monte Carlo simulation of electron transport. I. EGSnrc, the new EGS4 version. , 2000, Medical physics.

[7]  J. F. Briesmeister MCNP-A General Monte Carlo N-Particle Transport Code , 1993 .

[8]  Ravinder Nath,et al.  Dose calculation formalisms and consensus dosimetry parameters for intravascular brachytherapy dosimetry: recommendations of the AAPM Therapy Physics Committee Task Group No. 149. , 2007, Medical physics.

[9]  D. Schaart,et al.  The radial depth-dose distribution of a 188W/188Re beta line source measured with novel, ultra-thin TLDs in a PMMA phantom: comparison with Monte Carlo simulations. , 2002, Physics in medicine and biology.

[10]  I. Kawrakow Accurate condensed history Monte Carlo simulation of electron transport. II. Application to ion chamber response simulations. , 2000, Medical physics.

[11]  H. W. Lewis Multiple Scattering in an Infinite Medium , 1950 .

[12]  L. Urb Multiple scattering model in Geant4 , 2002 .

[13]  R. Jeraj,et al.  Comparisons between MCNP, EGS4 and experiment for clinical electron beams. , 1999, Physics in medicine and biology.

[14]  D. Schaart,et al.  A comparison of intravascular source designs based on the beta particle emitter 114mIn/114In. Line source versus stepping source. , 2002, Cardiovascular radiation medicine.

[15]  W. Nelson,et al.  Monte Carlo Transport of Electrons and Photons , 1988 .

[16]  Barry N. Taylor,et al.  Guidelines for Evaluating and Expressing the Uncertainty of Nist Measurement Results , 2017 .

[17]  Dennis R Schaart,et al.  A comparison of MCNP4C electron transport with ITS 3.0 and experiment at incident energies between 100 keV and 20 MeV: influence of voxel size, substeps and energy indexing algorithm. , 2002, Physics in medicine and biology.

[18]  J J Battista,et al.  Generation of photon energy deposition kernels using the EGS Monte Carlo code. , 1988, Physics in medicine and biology.

[19]  Vladimir Ivanchenko,et al.  GEANT4 simulation of electron energy deposition in extended media , 2007 .

[20]  Iwan Kawrakow,et al.  Calculation of photon energy deposition kernels and electron dose point kernels in water. , 2005, Medical physics.

[21]  Frank Verhaegen,et al.  Accuracy of the photon and electron physics in GEANT4 for radiotherapy applications. , 2005, Medical physics.

[22]  S. Elles,et al.  Geant4 and Fano cavity test: where are we? , 2008 .

[23]  Manuel Bardiès,et al.  Implementing dosimetry in GATE: dose-point kernel validation with GEANT4 4.8.1. , 2007, Cancer biotherapy & radiopharmaceuticals.

[24]  L Maigne,et al.  Validation of a dose deposited by low-energy photons using GATE/GEANT4 , 2008, Physics in medicine and biology.

[25]  C Lartizien,et al.  GATE: a simulation toolkit for PET and SPECT. , 2004, Physics in medicine and biology.

[26]  A F Bielajew,et al.  Differences in electron depth-dose curves calculated with EGS and ETRAN and improved energy-range relationships. , 1986, Medical physics.

[27]  Ravinder Nath,et al.  Dose calculation formalisms and consensus dosimetry parameters for intravascular brachytherapy dosimetry: Recommendations of the AAPM Therapy Physics Committee Task Group No. 149. , 2007, Medical physics.

[28]  S. Incerti,et al.  Geant4 developments and applications , 2006, IEEE Transactions on Nuclear Science.

[29]  M. Tomsej,et al.  Monte Carlo treatment planning for photon and electron beams , 2007 .

[30]  W G Cross,et al.  Beta-ray dose distributions from point sources in an infinite water medium. , 1992, Health physics.

[31]  E. Poon,et al.  Accuracy of the photon and electron physics in GEANT4 for radiotherapy applications. , 2005, Medical physics.