Electrical Stimulation to Restore Vestibular Function Development of a 3-D Vestibular Prosthesis

Patients who fail to compensate for bilateral loss of vestibular sensory function are disabled by disequilibrium and illusory movement of the visual field during head movement. An implantable prosthesis that restores vestibular sensation could significantly improve quality of life for these patients. To be effective, such a device should encode head rotation in all 3 dimensions. We describe the 3-dimensional angular vestibulo-ocular reflex of normal chinchillas and vestibular-deficient chinchillas undergoing functional electrical stimulation of the vestibular nerve. We also describe the design and fabrication of a head-mounted, 8 electrode vestibular prosthesis that encodes head movement in 3 dimensions

[1]  C Wall,et al.  The chinchilla's vestibulo-ocular reflex. , 1989, Acta oto-laryngologica.

[2]  Daniel M Merfeld,et al.  Vestibular adaptation studied with a prosthetic semicircular canal. , 2003, Journal of vestibular research : equilibrium & orientation.

[3]  D. Merfeld,et al.  Prototype Neural Semicircular Canal Prosthesis using Patterned Electrical Stimulation , 2000, Annals of Biomedical Engineering.

[4]  G. Kaufman,et al.  Video-oculography in the gerbil , 2002, Brain Research.

[5]  Lloyd B. Minor,et al.  Inexpensive system for real-time 3-dimensional video-oculography using a fluorescent marker array , 2005, Journal of Neuroscience Methods.

[6]  J. Goldberg,et al.  Vestibular-nerve inputs to the vestibulo-ocular reflex: a functional- ablation study in the squirrel monkey , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[7]  Daniel M. Merfeld,et al.  System design and performance of a unilateral horizontal semicircular canal prosthesis , 2002, IEEE Transactions on Biomedical Engineering.

[8]  Joseph L. Demer,et al.  Dynamic visual acuity during transient and sinusoidal yaw rotation in normal and unilaterally vestibulopathic humans , 2001, Experimental Brain Research.

[9]  M. B. Bender,et al.  XVI Eye Movements from Semicircular Canal Nerve Stimulation in the Cat , 1964, Annals of Otology, Rhinology and Laryngology.

[10]  M. S. Cohen,et al.  Response of cat semicircular canal afferents to sinusoidal polarizing currents: implications for input-output properties of second-order neurons. , 1983, Journal of neurophysiology.

[11]  J. Goldberg,et al.  Relation between discharge regularity and responses to externally applied galvanic currents in vestibular nerve afferents of the squirrel monkey. , 1984, Journal of neurophysiology.

[12]  Lloyd B. Minor,et al.  The three-dimensional vestibulo-ocular reflex evoked by high-acceleration rotations in the squirrel monkey , 2004, Experimental Brain Research.

[13]  H Collewijn,et al.  Vestibulo‐ocular and optokinetic reactions to rotation and their interaction in the rabbit , 1974, The Journal of physiology.