The management of respiratory motion in radiation oncology report of AAPM Task Group 76.

This document is the report of a task group of the AAPM and has been prepared primarily to advise medical physicists involved in the external-beam radiation therapy of patients with thoracic, abdominal, and pelvic tumors affected by respiratory motion. This report describes the magnitude of respiratory motion, discusses radiotherapy specific problems caused by respiratory motion, explains techniques that explicitly manage respiratory motion during radiotherapy and gives recommendations in the application of these techniques for patient care, including quality assurance (QA) guidelines for these devices and their use with conformal and intensity modulated radiotherapy. The technologies covered by this report are motion-encompassing methods, respiratory gated techniques, breath-hold techniques, forced shallow-breathing methods, and respiration-synchronized techniques. The main outcome of this report is a clinical process guide for managing respiratory motion. Included in this guide is the recommendation that tumor motion should be measured (when possible) for each patient for whom respiratory motion is a concern. If target motion is greater than 5mm, a method of respiratory motion management is available, and if the patient can tolerate the procedure, respiratory motion management technology is appropriate. Respiratory motion management is also appropriate when the procedure will increase normal tissue sparing. Respiratory motion management involves further resources, education and the development of and adherence to QA procedures.

[1]  O. Wade,et al.  Movements of the thoracic cage and diaphragm in respiration * , 1954, The Journal of physiology.

[2]  J. M. K. Spalding,et al.  THE MECHANICAL BASIS OF RESPIRATION , 1970 .

[3]  E. Potchen,et al.  Assessment of hepatic respiratory excursion. , 1972, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[4]  G Harauz,et al.  Comparison of the liver's respiratory motion in the supine and upright positions: concise communication. , 1979, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[5]  S Kramer,et al.  A prospective randomized study of various irradiation doses and fractionation schedules in the treatment of inoperable non‐oat‐cell carcinoma of the lung. Preliminary report by the radiation therapy oncology group , 1980, Cancer.

[6]  N. Choi,et al.  Improved survival of patients with unresectable non‐small‐cell bronchogenic carcinoma by an innovated high‐dose En‐Bloc radiotherapeutic approach , 1981, Cancer.

[7]  J. Haaga,et al.  Respiratory movement of the pancreas: an ultrasonic study. , 1984, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[8]  I. Suramo,et al.  Cranio-Caudal Movements of the Liver, Pancreas and Kidneys in Respiration , 1984, Acta radiologica: diagnosis.

[9]  R B Smith,et al.  High frequency ventilation. , 1988, International anesthesiology clinics.

[10]  C. Perez,et al.  Impact of tumor control on survival in carcinoma of the lung treated with irradiation. , 1986, International journal of radiation oncology, biology, physics.

[11]  P. Rubin,et al.  Long‐term observations of the patterns of failure in patients with unresectable non‐oat cell carcinoma of the lung treated with definitive radiotherapy report by the radiation therapy oncology group , 1987, Cancer.

[12]  P. Rodrigus,et al.  The value of treatment portal films in radiotherapy for bronchial carcinoma. , 1987, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[13]  High-frequency ventilation. , 1987, Yonsei medical journal.

[14]  J. Leong,et al.  Implementation of random positioning error in computerised radiation treatment planning systems as a result of fractionation. , 1987, Physics in medicine and biology.

[15]  W. Stanford,et al.  Analysis of movement of intrathoracic neoplasms using ultrafast computerized tomography. , 1990, International journal of radiation oncology, biology, physics.

[16]  B J Mijnheer,et al.  Accuracy in tangential breast treatment set-up: a portal imaging study. , 1991, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[17]  R C Grimm,et al.  Respiratory kinematics of the upper abdominal organs: A quantitative study , 1992, Magnetic resonance in medicine.

[18]  Icru Prescribing, recording, and reporting photon beam therapy , 1993 .

[19]  I. Lax Target dose versus extratarget dose in stereotactic radiosurgery. , 1993, Acta oncologica.

[20]  A G Visser,et al.  Quality assurance using portal imaging: the accuracy of patient positioning in irradiation of breast cancer. , 1993, International journal of radiation oncology, biology, physics.

[21]  M. Halliwell,et al.  Ultrasound quantitation of respiratory organ motion in the upper abdomen. , 1994, The British journal of radiology.

[22]  I. Lax,et al.  Stereotactic radiotherapy of malignancies in the abdomen. Methodological aspects. , 1994, Acta oncologica.

[23]  J. Palta,et al.  Comprehensive QA for Radiation Oncology , 1994 .

[24]  J. Palta,et al.  Comprehensive QA for radiation oncology: report of AAPM Radiation Therapy Committee Task Group 40. , 1994, Medical physics.

[25]  Melvin L. Griem,et al.  Prescribing, Recording, and Reporting Photon Beam Therapy , 1994 .

[26]  I. Lax,et al.  Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients. , 1995, Acta oncologica.

[27]  P Okunieff,et al.  Radiation dose-response of human tumors. , 1995, International journal of radiation oncology, biology, physics.

[28]  P. Robbins,et al.  Non-stationarity of breath-by-breath ventilation and approaches to modelling the phenomenon. , 1995, Advances in experimental medicine and biology.

[29]  P Schraube,et al.  Estimation of pneumonitis risk in three-dimensional treatment planning using dose-volume histogram analysis. , 1995, International journal of radiation oncology, biology, physics.

[30]  H. Kubo,et al.  Respiration gated radiotherapy treatment: a technical study. , 1996, Physics in medicine and biology.

[31]  E. Bruce,et al.  Temporal variations in the pattern of breathing. , 1996, Journal of applied physiology.

[32]  Dwight Viehland,et al.  A Raman scattering study of the ferroelectric ordering in rhombohedral and tetragonal La‐modified lead zirconate titanate ceramics , 1996 .

[33]  M. Ciocca,et al.  Clinical target volume localization using conventional methods (anatomy and palpation) and ultrasonography in early breast cancer post-operative external irradiation. , 1997, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[34]  D A Jaffray,et al.  The effects of intra-fraction organ motion on the delivery of dynamic intensity modulation. , 1998, Physics in medicine and biology.

[35]  V. Budach,et al.  Verification of set-up deviations in patients with breast cancer using portal imaging in clinical practice. , 1998, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].

[36]  R K Ten Haken,et al.  Radiation pneumonitis as a function of mean lung dose: an analysis of pooled data of 540 patients. , 1998, International journal of radiation oncology, biology, physics.

[37]  T. Landberg,et al.  What margins should be added to the clinical target volume in radiotherapy treatment planning for lung cancer? , 1998, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[38]  Alvaro A. Martinez M. D. Facr,et al.  Active breathing control (ABC) for Hodgkin's disease: Reduction in normal tissue irradiation with deep inspiration and implications for treatment , 1998 .

[39]  N. MacIntyre High-Frequency Ventilation , 2000, Seminars in respiratory and critical care medicine.

[40]  E. Larsen,et al.  A method for incorporating organ motion due to breathing into 3D dose calculations. , 1999, Medical physics.

[41]  J. Wong,et al.  The use of active breathing control (ABC) to reduce margin for breathing motion. , 1999, International journal of radiation oncology, biology, physics.

[42]  Frank J Lagerwaard,et al.  2206 Variability in contouring target volumes for lung cancer - evaluation of a treatment planning protocol for 3-D conformal radiotherapy , 1999 .

[43]  C. Hess,et al.  Accuracy of alignment in breast irradiation: a retrospective analysis of clinical practice. , 1999, The British journal of radiology.

[44]  J C Stroom,et al.  Inclusion of geometrical uncertainties in radiotherapy treatment planning by means of coverage probability. , 1999, International journal of radiation oncology, biology, physics.

[45]  G J Kutcher,et al.  Deep inspiration breath-hold technique for lung tumors: the potential value of target immobilization and reduced lung density in dose escalation. , 1999, International journal of radiation oncology, biology, physics.

[46]  J T Booth,et al.  Set-up error & organ motion uncertainty: a review. , 1999, Australasian physical & engineering sciences in medicine.

[47]  C. Ramsey,et al.  Clinical efficacy of respiratory gated conformal radiation therapy. , 1999, Medical dosimetry : official journal of the American Association of Medical Dosimetrists.

[48]  B. Murray,et al.  Setup reproducibility in radiation therapy for lung cancer: a comparison between T-bar and expanded foam immobilization devices. , 1999, International journal of radiation oncology, biology, physics.

[49]  F. Lohr,et al.  Noninvasive patient fixation for extracranial stereotactic radiotherapy. , 1999, International journal of radiation oncology, biology, physics.

[50]  S Senan,et al.  Evaluation of a target contouring protocol for 3D conformal radiotherapy in non-small cell lung cancer. , 1999, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[51]  Shinichi Shimizu,et al.  Real-time tumour-tracking radiotherapy , 1999, The Lancet.

[52]  J A Purdy,et al.  Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC) , 1999, International journal of radiation oncology, biology, physics.

[53]  R K Ten Haken,et al.  Estimation of tumor control probability model parameters from 3-D dose distributions of non-small cell lung cancer patients. , 1999, Lung cancer.

[54]  M. V. van Herk,et al.  Physical aspects of a real-time tumor-tracking system for gated radiotherapy. , 2000, International journal of radiation oncology, biology, physics.

[55]  W. Manning,et al.  Reduction of cardiac volume in left-breast treatment fields by respiratory maneuvers: a CT study. , 2000, International journal of radiation oncology, biology, physics.

[56]  J C Rosenwald,et al.  Evaluation of microscopic tumor extension in non-small-cell lung cancer for three-dimensional conformal radiotherapy planning. , 2000, International journal of radiation oncology, biology, physics.

[57]  F Lohr,et al.  Extracranial stereotactic radiation therapy: set-up accuracy of patients treated for liver metastases. , 2000, International journal of radiation oncology, biology, physics.

[58]  H. Mostafavi,et al.  Breathing-synchronized radiotherapy program at the University of California Davis Cancer Center. , 2000, Medical physics.

[59]  U Oppitz,et al.  Stereotactic radiotherapy of extracranial targets: CT-simulation and accuracy of treatment in the stereotactic body frame. , 2000, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[60]  H Shirato,et al.  Use of an implanted marker and real-time tracking of the marker for the positioning of prostate and bladder cancers. , 2000, International journal of radiation oncology, biology, physics.

[61]  J. Galvin,et al.  An optimized forward-planning technique for intensity modulated radiation therapy. , 2000, Medical physics.

[62]  J. Krishnan,et al.  High-frequency ventilation for acute lung injury and ARDS. , 2000, Chest.

[63]  Gikas S. Mageras,et al.  Phase I dose escalation study using the deep inspiration breath hold technique to safely increase dose to 81 Gy in the treatment of inoperable non-small cell lung cancer , 2000 .

[64]  J Szanto,et al.  Respiratory-induced prostate motion: quantification and characterization. , 2000, International journal of radiation oncology, biology, physics.

[65]  S Webb,et al.  The dosimetric consequences of inter-fractional patient movement on conventional and intensity-modulated breast radiotherapy treatments. , 2000, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[66]  K. Forster,et al.  Image-guided radiosurgery for the spine and pancreas. , 2000, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[67]  G. Benchetrit Breathing pattern in humans: diversity and individuality. , 2000, Respiration physiology.

[68]  H D Kubo,et al.  Compatibility of Varian 2100C gated operations with enhanced dynamic wedge and IMRT dose delivery. , 2000, Medical physics.

[69]  C C Ling,et al.  The deep inspiration breath-hold technique in the treatment of inoperable non-small-cell lung cancer. , 2000, International journal of radiation oncology, biology, physics.

[70]  M. V. van Herk,et al.  The probability of correct target dosage: dose-population histograms for deriving treatment margins in radiotherapy. , 2000, International journal of radiation oncology, biology, physics.

[71]  C. Ling,et al.  Technical aspects of the deep inspiration breath-hold technique in the treatment of thoracic cancer. , 2000, International journal of radiation oncology, biology, physics.

[72]  S Minohara,et al.  Respiratory gated irradiation system for heavy-ion radiotherapy. , 2000, International journal of radiation oncology, biology, physics.

[73]  A L McKenzie,et al.  How should breathing motion be combined with other errors when drawing margins around clinical target volumes? , 2000, The British journal of radiology.

[74]  H Shirato,et al.  Impact of respiratory movement on the computed tomographic images of small lung tumors in three-dimensional (3D) radiotherapy. , 2000, International journal of radiation oncology, biology, physics.

[75]  R. K. Münch,et al.  A novel tracking technique for the continuous precise measurement of tumour positions in conformal radiotherapy. , 2000, Physics in medicine and biology.

[76]  Chester R. Ramsey,et al.  Clinical experience with a commercial respiratory gating system , 2000 .

[77]  J. Adler,et al.  Robotic Motion Compensation for Respiratory Movement during Radiosurgery , 2000, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[78]  R. Mohan,et al.  Motion adaptive x-ray therapy: a feasibility study , 2001, Physics in medicine and biology.

[79]  J C Rosenwald,et al.  Conformal radiotherapy (CRT) planning for lung cancer: analysis of intrathoracic organ motion during extreme phases of breathing. , 2001, International journal of radiation oncology, biology, physics.

[80]  M T Munley,et al.  Radiation-induced pulmonary toxicity: a dose-volume histogram analysis in 201 patients with lung cancer. , 2001, International journal of radiation oncology, biology, physics.

[81]  J Hanson,et al.  Dosimetric evaluation of lung tumor immobilization using breath hold at deep inspiration. , 2001, International journal of radiation oncology, biology, physics.

[82]  Gikas S. Mageras,et al.  Fluoroscopic evaluation of diaphragmatic motion reduction with a respiratory gated radiotherapy system , 2001, Journal of applied clinical medical physics.

[83]  S Senan,et al.  Multiple "slow" CT scans for incorporating lung tumor mobility in radiotherapy planning. , 2001, International journal of radiation oncology, biology, physics.

[84]  H Shirato,et al.  Detection of lung tumor movement in real-time tumor-tracking radiotherapy. , 2001, International journal of radiation oncology, biology, physics.

[85]  P. Voet,et al.  Dosimetric consequences of tumor mobility in radiotherapy of stage I non-small cell lung cancer--an analysis of data generated using 'slow' CT scans. , 2001, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[86]  R Mohan,et al.  Determining parameters for respiration-gated radiotherapy. , 2001, Medical physics.

[87]  B. Murray,et al.  Held-breath self-gating technique for radiotherapy of non-small-cell lung cancer: a feasibility study. , 2001, International journal of radiation oncology, biology, physics.

[88]  F. Yin,et al.  Extracranial radiosurgery: immobilizing liver motion in dogs using high-frequency jet ventilation and total intravenous anesthesia. , 2001, International journal of radiation oncology, biology, physics.

[89]  S. Webb,et al.  A simulation of the effects of set-up error and changes in breast volume on conventional and intensity-modulated treatments in breast radiotherapy. , 2001, Physics in medicine and biology.

[90]  J. Ciezki,et al.  Fluoroscopic study of tumor motion due to breathing: facilitating precise radiation therapy for lung cancer patients. , 2001, Medical physics.

[91]  K. Langen,et al.  Organ motion and its management. , 2001, International journal of radiation oncology, biology, physics.

[92]  Y. Ung,et al.  Deep inspiration breath hold to reduce irradiated heart volume in breast cancer patients , 2001 .

[93]  R K Ten Haken,et al.  The reproducibility of organ position using active breathing control (ABC) during liver radiotherapy. , 2001, International journal of radiation oncology, biology, physics.

[94]  T Mizowaki,et al.  The effectiveness of an immobilization device in conformal radiotherapy for lung tumor: reduction of respiratory tumor movement and evaluation of the daily setup accuracy. , 2001, International journal of radiation oncology, biology, physics.

[95]  B J Mijnheer,et al.  Variability in target volume delineation on CT scans of the breast. , 2001, International journal of radiation oncology, biology, physics.

[96]  M Engelsman,et al.  The effect of breathing and set-up errors on the cumulative dose to a lung tumor. , 2001, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[97]  G Starkschall,et al.  Respiratory-driven lung tumor motion is independent of tumor size, tumor location, and pulmonary function. , 2001, International journal of radiation oncology, biology, physics.

[98]  P Pemler,et al.  Influence of respiration-induced organ motion on dose distributions in treatments using enhanced dynamic wedges. , 2001, Medical physics.

[99]  P. Remeijer,et al.  Set-up verification using portal imaging; review of current clinical practice. , 2001, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[100]  C. Ling,et al.  Effect of respiratory gating on quantifying PET images of lung cancer. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[101]  C. Ling,et al.  Evaluation of respiratory movement during gated radiotherapy using film and electronic portal imaging. , 2002, International journal of radiation oncology, biology, physics.

[102]  Andrew Jackson,et al.  Dose-volume factors contributing to the incidence of radiation pneumonitis in non-small-cell lung cancer patients treated with three-dimensional conformal radiation therapy. , 2002, International journal of radiation oncology, biology, physics.

[103]  Arjan Bel,et al.  Definition of gross tumor volume in lung cancer: inter-observer variability. , 2002, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[104]  A. Norman,et al.  Accuracy of set-up of thoracic radiotherapy: prospective analysis of 24 patients treated with radiotherapy for lung cancer. , 2002, The British journal of radiology.

[105]  Marcel van Herk,et al.  The effect of set-up uncertainties, contour changes, and tissue inhomogeneities on target dose-volume histograms. , 2002, Medical physics.

[106]  Steve B. Jiang,et al.  Effects of intra-fraction motion on IMRT dose delivery: statistical analysis and simulation. , 2002, Physics in medicine and biology.

[107]  Y. Kodama,et al.  Feasibility study of hypofractionated gated irradiation using a real-time tumor-tracking radiation therapy system for malignant liver tumors , 2002 .

[108]  Kenneth E Rosenzweig,et al.  Evaluation of deep inspiration breath-hold lung treatment plans with Monte Carlo dose calculation. , 2002, International journal of radiation oncology, biology, physics.

[109]  M. V. van Herk,et al.  Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy. , 2002, International journal of radiation oncology, biology, physics.

[110]  C. Ling,et al.  Effect of respiratory gating on reducing lung motion artifacts in PET imaging of lung cancer. , 2002, Medical physics.

[111]  R. Fisher,et al.  Measurement of lung tumor volumes using three-dimensional computer planning software. , 2002, International journal of radiation oncology, biology, physics.

[112]  Bernard Dubray,et al.  Conformal radiotherapy for lung cancer: different delineation of the gross tumor volume (GTV) by radiologists and radiation oncologists. , 2002, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[113]  Martin J Murphy,et al.  Issues in respiratory motion compensation during external-beam radiotherapy. , 2002, International journal of radiation oncology, biology, physics.

[114]  Joos V Lebesque,et al.  Inclusion of geometric uncertainties in treatment plan evaluation. , 2002, International journal of radiation oncology, biology, physics.

[115]  Quynh-Thu Le,et al.  The effectiveness of breath-holding to stabilize lung and pancreas tumors during radiosurgery. , 2002, International journal of radiation oncology, biology, physics.

[116]  Shinichi Shimizu,et al.  Three-dimensional intrafractional movement of prostate measured during real-time tumor-tracking radiotherapy in supine and prone treatment positions. , 2002, International journal of radiation oncology, biology, physics.

[117]  Shinichi Shimizu,et al.  Registration accuracy and possible migration of internal fiducial gold marker implanted in prostate and liver treated with real-time tumor-tracking radiation therapy (RTRT). , 2002, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[118]  P J Keall,et al.  A fluence-convolution method to calculate radiation therapy dose distributions that incorporate random set-up error. , 2002, Physics in medicine and biology.

[119]  Michael B Sharpe,et al.  Significant reductions in heart and lung doses using deep inspiration breath hold with active breathing control and intensity-modulated radiation therapy for patients treated with locoregional breast irradiation. , 2003, International journal of radiation oncology, biology, physics.

[120]  Joos V Lebesque,et al.  Biologic and physical fractionation effects of random geometric errors. , 2003, International journal of radiation oncology, biology, physics.

[121]  Radhe Mohan,et al.  Patient training in respiratory-gated radiotherapy. , 2003, Medical dosimetry : official journal of the American Association of Medical Dosimetrists.

[122]  Kenneth E Rosenzweig,et al.  Reduction of respiratory motion artifacts in PET imaging of lung cancer by respiratory correlated dynamic PET: methodology and comparison with respiratory gated PET. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[123]  Indrin J Chetty,et al.  A fluence convolution method to account for respiratory motion in three-dimensional dose calculations of the liver: a Monte Carlo study. , 2003, Medical physics.

[124]  Joos V Lebesque,et al.  Comparing different NTCP models that predict the incidence of radiation pneumonitis. Normal tissue complication probability. , 2003, International journal of radiation oncology, biology, physics.

[125]  Mark Ruschin,et al.  Digital fluoroscopy to quantify lung tumor motion: potential for patient-specific planning target volumes. , 2003, International journal of radiation oncology, biology, physics.

[126]  Koichi Yamazaki,et al.  Feasibility of insertion/implantation of 2.0-mm-diameter gold internal fiducial markers for precise setup and real-time tumor tracking in radiotherapy. , 2003, International journal of radiation oncology, biology, physics.

[127]  Marcel van Herk,et al.  Portal imaging to assess set-up errors, tumor motion and tumor shrinkage during conformal radiotherapy of non-small cell lung cancer. , 2001, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[128]  Stephanie Frost,et al.  Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer. , 2003, Chest.

[129]  Y. Ung,et al.  Reproducibility of lung tumor position and reduction of lung mass within the planning target volume using active breathing control (ABC). , 2003, International journal of radiation oncology, biology, physics.

[130]  Shinichi Shimizu,et al.  Tumor location, cirrhosis, and surgical history contribute to tumor movement in the liver, as measured during stereotactic irradiation using a real-time tumor-tracking radiotherapy system. , 2003, International journal of radiation oncology, biology, physics.

[131]  Ellen Yorke,et al.  Respiratory gating for liver tumors: use in dose escalation. , 2001, International journal of radiation oncology, biology, physics.

[132]  Di Yan,et al.  Three-dimensional evaluation of intra- and interfraction immobilization of lung and chest wall using active breathing control: a reproducibility study with breast cancer patients. , 2003, International journal of radiation oncology, biology, physics.

[133]  Di Yan,et al.  Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer: a comparison of intensity-modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation. , 2003, International journal of radiation oncology, biology, physics.

[134]  Linda Hong,et al.  The effects of intra-fraction organ motion on the delivery of intensity-modulated field with a multileaf collimator. , 2003, Medical physics.

[135]  E. Yorke,et al.  Respiratory gating for liver tumors: Use in dose escalation , 2003 .

[136]  Michael B Sharpe,et al.  Initial clinical experience with moderate deep-inspiration breath hold using an active breathing control device in the treatment of patients with left-sided breast cancer using external beam radiation therapy. , 2003, International journal of radiation oncology, biology, physics.

[137]  Jun Duan,et al.  Validation of target volume and position in respiratory gated CT planning and treatment. , 2003, Medical physics.

[138]  G. Christensen,et al.  A method for the reconstruction of four-dimensional synchronized CT scans acquired during free breathing. , 2003, Medical physics.

[139]  Di Yan,et al.  Potential for reduced toxicity and dose escalation in non-operable non-small cell lung cancer: a comparison of intensity-modulation, 3D-conformal radiation, and elective nodal irradiation , 2003 .

[140]  Katsuyuki Taguchi,et al.  Temporal resolution and the evaluation of candidate algorithms for four-dimensional CT. , 2003, Medical physics.

[141]  L. Papie,et al.  The leaf sweep algorithm for an immobile and moving target as an optimal control problem in radiotherapy delivery , 2003 .

[142]  Jun Duan,et al.  Dosimetric effect of respiration-gated beam on IMRT delivery. , 2003, Medical physics.

[143]  C. Ling,et al.  Respiration-correlated spiral CT: a method of measuring respiratory-induced anatomic motion for radiation treatment planning. , 2002, Medical physics.

[144]  R. Mohan,et al.  Acquiring a four-dimensional computed tomography dataset using an external respiratory signal. , 2003, Physics in medicine and biology.

[145]  R. Timmerman,et al.  Extracranial Stereotactic Radioablation Physical Principles , 2003, Acta oncologica.

[146]  Steve B. Jiang,et al.  An experimental investigation on intra-fractional organ motion effects in lung IMRT treatments. , 2003, Physics in medicine and biology.

[147]  Lech Papiez,et al.  Extracranial Stereotactic Radiation Delivery: Expansion of Technology Beyond the Brain , 2003, Technology in cancer research & treatment.

[148]  R. Mohan,et al.  Quantifying the effect of intrafraction motion during breast IMRT planning and dose delivery. , 2003, Medical physics.

[149]  R. Mohan,et al.  Quantifying the predictability of diaphragm motion during respiration with a noninvasive external marker. , 2003, Medical physics.

[150]  Curtis B Caldwell,et al.  Can PET provide the 3D extent of tumor motion for individualized internal target volumes? A phantom study of the limitations of CT and the promise of PET. , 2003, International journal of radiation oncology, biology, physics.

[151]  Steve B Jiang,et al.  Synchronized moving aperture radiation therapy (SMART): average tumour trajectory for lung patients. , 2003, Physics in medicine and biology.

[152]  Suresh Senan,et al.  Are multiple CT scans required for planning curative radiotherapy in lung tumors of the lower lobe? , 2003, International journal of radiation oncology, biology, physics.

[153]  Eric C Ford,et al.  Measurement of lung tumor motion using respiration-correlated CT. , 2004, International journal of radiation oncology, biology, physics.

[154]  Suresh Senan,et al.  Four-dimensional CT scans for treatment planning in stereotactic radiotherapy for stage I lung cancer. , 2004, International journal of radiation oncology, biology, physics.

[155]  Achim Schweikard,et al.  Respiration tracking in radiosurgery. , 2004, Medical physics.

[156]  R. Emery,et al.  Clinical experience using respiratory gated radiation therapy: comparison of free-breathing and breath-hold techniques. , 2004, International journal of radiation oncology, biology, physics.

[157]  R Mohan,et al.  Predicting respiratory motion for four-dimensional radiotherapy. , 2004, Medical physics.

[158]  Suresh Senan,et al.  Literature-based recommendations for treatment planning and execution in high-dose radiotherapy for lung cancer. , 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[159]  George Starkschall,et al.  Evaluation of internal lung motion for respiratory-gated radiotherapy using MRI: Part II-margin reduction of internal target volume. , 2004, International journal of radiation oncology, biology, physics.

[160]  Stine Korreman,et al.  Breathing adapted radiotherapy of breast cancer: reduction of cardiac and pulmonary doses using voluntary inspiration breath-hold. , 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[161]  Martin J Murphy,et al.  Tracking moving organs in real time. , 2004, Seminars in radiation oncology.

[162]  Y. Shibamoto,et al.  Recovery from sublethal damage during intermittent exposures in cultured tumor cells: implications for dose modification in radiosurgery and IMRT. , 2004, International journal of radiation oncology, biology, physics.

[163]  George Starkschall,et al.  Correlation of gross tumor volume excursion with potential benefits of respiratory gating. , 2004, International journal of radiation oncology, biology, physics.

[164]  Jean-Philippe Pignol,et al.  Correlation of lung tumor motion with external surrogate indicators of respiration. , 2004, International journal of radiation oncology, biology, physics.

[165]  R. T. Ten Haken,et al.  Defining target volumes for non-small cell lung carcinoma. , 2004, Seminars in radiation oncology.

[166]  George Starkschall,et al.  Evaluation of internal lung motion for respiratory-gated radiotherapy using MRI: Part I--correlating internal lung motion with skin fiducial motion. , 2004, International journal of radiation oncology, biology, physics.

[167]  John D Fenwick,et al.  A challenge to traditional radiation oncology. , 2004, International journal of radiation oncology, biology, physics.

[168]  Steve B. Jiang,et al.  Internal target volume determined with expansion margins beyond composite gross tumor volume in three-dimensional conformal radiotherapy for lung cancer. , 2004, International journal of radiation oncology, biology, physics.

[169]  Lech Papiez,et al.  DMLC leaf‐pair optimal control of IMRT delivery for a moving rigid target , 2004 .

[170]  E. Yorke,et al.  Deep inspiration breath hold and respiratory gating strategies for reducing organ motion in radiation treatment. , 2004, Seminars in radiation oncology.

[171]  Y Suh,et al.  A feasibility study on the prediction of tumour location in the lung from skin motion. , 2004, The British journal of radiology.

[172]  Gregory C Sharp,et al.  Prediction of respiratory tumour motion for real-time image-guided radiotherapy. , 2004, Physics in medicine and biology.

[173]  T. Pan,et al.  4D-CT imaging of a volume influenced by respiratory motion on multi-slice CT. , 2004, Medical physics.

[174]  Y. Tsunashima,et al.  Correlation between the respiratory waveform measured using a respiratory sensor and 3D tumor motion in gated radiotherapy. , 2004, International journal of radiation oncology, biology, physics.

[175]  R. Jeraj,et al.  Treatment plan optimization incorporating respiratory motion. , 2004, Medical physics.

[176]  Y Suh,et al.  Aperture maneuver with compelled breath (AMC) for moving tumors: a feasibility study with a moving phantom. , 2004, Medical physics.

[177]  Hans-Ulrich Kauczor,et al.  Analysis of intrathoracic tumor mobility during whole breathing cycle by dynamic MRI. , 2004, International journal of radiation oncology, biology, physics.

[178]  Steve B. Jiang,et al.  Effects of motion on the total dose distribution. , 2004, Seminars in radiation oncology.

[179]  T. Guerrero,et al.  Acquiring 4D thoracic CT scans using a multislice helical method. , 2004, Physics in medicine and biology.

[180]  Alireza Kassaee,et al.  Analysis of interfraction and intrafraction variation during tangential breast irradiation with an electronic portal imaging device. , 2003, International journal of radiation oncology, biology, physics.

[181]  Lech Papiez,et al.  Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma: phase I study. , 2005, International journal of radiation oncology, biology, physics.

[182]  Steve B Jiang,et al.  A technique for respiratory-gated radiotherapy treatment verification with an EPID in cine mode , 2005 .

[183]  Steve B. Jiang,et al.  A technique for respiratory-gated radiotherapy treatment verification with an EPID in cine mode , 2005, Physics in medicine and biology.

[184]  George T. Y. Chen,et al.  Four-dimensional image-based treatment planning: Target volume segmentation and dose calculation in the presence of respiratory motion. , 2005, International journal of radiation oncology, biology, physics.

[185]  George T. Y. Chen,et al.  A phantom evaluation of a stereo-vision surface imaging system for radiotherapy patient setup. , 2005, Medical physics.

[186]  Steve B. Jiang,et al.  Residual motion of lung tumours in gated radiotherapy with external respiratory surrogates , 2005, Physics in medicine and biology.

[187]  W. Curran,et al.  Higher BED is Associated with Improved Local-regional Control and Survival for NSCLC Treated with Chemoradiotherapy: An RTOG Analysis , 2005 .

[188]  Cedric X. Yu,et al.  Real-time intra-fraction-motion tracking using the treatment couch: a feasibility study , 2005, Physics in medicine and biology.

[189]  John Wong,et al.  Accuracy of a wireless localization system for radiotherapy. , 2005, International journal of radiation oncology, biology, physics.

[190]  圭介 喜多村 Tumor location, cirrhosis, and surgical history contribute to tumor movement in the liver, as measured during stereotactic irradiation using a real-time tumor-tracking radiotherapy system , 2005 .

[191]  S Webb,et al.  Limitations of a simple technique for movement compensation via movement-modified fluence profiles , 2005, Physics in medicine and biology.

[192]  Kurt Baier,et al.  Dose-response in stereotactic irradiation of lung tumors. , 2005, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[193]  Gig S Mageras,et al.  Comparison of end normal inspiration and expiration for gated intensity modulated radiation therapy (IMRT) of lung cancer. , 2005, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[194]  Suresh Senan,et al.  Use of maximum intensity projections (MIP) for target volume generation in 4DCT scans for lung cancer. , 2005, International journal of radiation oncology, biology, physics.

[195]  Lena Specht,et al.  Breathing adapted radiotherapy for breast cancer: comparison of free breathing gating with the breath-hold technique. , 2005, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[196]  P J Keall,et al.  The application of the sinusoidal model to lung cancer patient respiratory motion. , 2005, Medical physics.

[197]  S Webb,et al.  The effect on IMRT conformality of elastic tissue movement and a practical suggestion for movement compensation via the modified dynamic multileaf collimator (dMLC) technique , 2005, Physics in medicine and biology.

[198]  W. Curran,et al.  Effect of overall treatment time on outcomes after concurrent chemoradiation for locally advanced non-small-cell lung carcinoma: analysis of the Radiation Therapy Oncology Group (RTOG) experience. , 2005, International journal of radiation oncology, biology, physics.

[199]  Robert Jeraj,et al.  Confirmation, refinement, and extension of a study in intrafraction motion interplay with sliding jaw motion. , 2005, Medical physics.

[200]  Gikas S. Mageras,et al.  Interfractional anatomic variation in patients treated with respiration‐gated radiotherapy , 2005, Journal of applied clinical medical physics.

[201]  George T. Y. Chen,et al.  A phantom evaluation of a stereo-vision surface imaging system for radiotherapy patient setup. , 2005, Medical physics.

[202]  R Mohan,et al.  Is the diaphragm motion probability density function normally distributed? , 2005, Medical physics.

[203]  Sasa Mutic,et al.  Quantitation of the reconstruction quality of a four-dimensional computed tomography process for lung cancer patients. , 2005, Medical physics.

[204]  Steve Webb,et al.  Quantifying the effect of respiratory motion on lung tumour dosimetry with the aid of a breathing phantom with deforming lungs , 2006, Physics in medicine and biology.

[205]  Steve B. Jiang,et al.  “4D” IMRT Delivery , 2006 .

[206]  S Webb,et al.  Does elastic tissue intrafraction motion with density changes forbid motion-compensated radiotherapy? , 2006, Physics in medicine and biology.

[207]  Jan-Jakob Sonke,et al.  Mid-ventilation CT scan construction from four-dimensional respiration-correlated CT scans for radiotherapy planning of lung cancer patients. , 2006, International journal of radiation oncology, biology, physics.

[208]  Radhe Mohan,et al.  Audio-visual biofeedback for respiratory-gated radiotherapy: impact of audio instruction and audio-visual biofeedback on respiratory-gated radiotherapy. , 2006, International journal of radiation oncology, biology, physics.

[209]  S Webb,et al.  Quantification of the fluence error in the motion-compensated dynamic MLC (DMLC) technique for delivering intensity-modulated radiotherapy (IMRT) , 2006, Physics in medicine and biology.

[210]  Steve B. Jiang,et al.  Synchronized moving aperture radiation therapy (SMART): improvement of breathing pattern reproducibility using respiratory coaching , 2006, Physics in medicine and biology.

[211]  D. Moseley,et al.  Respiratory Correlated Cone Beam CT in the Assessment of Non-small Cell Lung Cancer during Radiotherapy , 2008 .

[212]  Shinichi Shimizu,et al.  Real-time tumor-tracking radiotherapy for adrenal tumors. , 2008, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.