Azimuthal directional sensitivity of prepulse inhibition of the pinna startle reflex in decerebrate rats

Previous studies have indicated that the auditory midbrain, the inferior colliculus, is important for both sound localization and mediation of prepulse inhibition of the startle reflex. The present study investigated the azimuthal directional sensitivity of prepulse inhibition of the pinna startle reflex in decerebrate rats. The pinna startle reflex was measured by recording multi-unit action potentials from the cervicoauricular muscles. The startling noise burst (94 dB SPL) was produced by a stationary speaker at 0 degrees azimuth, and the non-startling prepulse noise burst (46 dB SPL) was produced by a movable speaker whose direction was changed in the frontal azimuthal plane. The interval between the onset of the prepulse sound and the onset of the startling sound was 100 ms. The pinna reflex to the startling sound was strongly inhibited by the prepulse sound, and the inhibited startle response exhibited a flat azimuthal directional curve. In addition to further confirming that the neural pathways mediating prepulse inhibition are located in the brainstem, the present results indicate that interaural disparities of binaural inputs used for sound localization are not capable of modulating prepulse inhibition of the startle reflex.

[1]  B. Frost,et al.  Azimuthal sensitivity of rat pinna reflex: EMG recordings from cervicoauricular muscles , 1996, Hearing Research.

[2]  L. Li,et al.  Inhibitory influence of the dorsal nucleus of the lateral lemniscus on binaural responses in the rat's inferior colliculus , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[3]  R. L. V. Buskirk.  Subcortical auditory and somatosensory afferents to hamster superior colliculus , 1983, Brain Research Bulletin.

[4]  J. Ison,et al.  Modification of the startle reflex in the rat by changes in the auditory and visual environments. , 1971, Journal of comparative and physiological psychology.

[5]  M. Fendt.  Enhancement of prepulse inhibition after blockade of GABA activity within the superior colliculus , 1999, Brain Research.

[6]  N. Swerdlow,et al.  Prepulse inhibition of acoustic startle in rats after lesions of the pedunculopontine tegmental nucleus. , 1993, Behavioral neuroscience.

[7]  J. Kelly,et al.  Contribution of the Dorsal Nucleus of the Lateral Lemniscus to Binaural Responses in the Inferior Colliculus of the Rat: Interaural Time Delays , 1996, The Journal of Neuroscience.

[8]  H. Hoffman,et al.  Reflex modification in the domain of startle: I. Some empirical findings and their implications for how the nervous system processes sensory input. , 1980, Psychological review.

[9]  H. Fibiger,et al.  Afferent connections of the laterodorsal and the pedunculopontine tegmental nuclei in the rat: A retro‐ and antero‐grade transport and immunohistochemical study , 1992, The Journal of comparative neurology.

[10]  J. Kelly,et al.  Sound frequency and binaural response properties of single neurons in rat inferior colliculus , 1991, Hearing Research.

[11]  H. Hoffman,et al.  Modification of the human glabella reflex by antecedent acoustic stimulation , 1980, Perception & psychophysics.

[12]  J. Syka,et al.  Projections from auditory structures to the superior colliculus in the rat , 1984, Neuroscience Letters.

[13]  B. Frost,et al.  Prepulse inhibition following lesions of the inferior colliculus: prepulse intensity functions , 1998, Physiology & Behavior.

[14]  J. Ison,et al.  Reflex inhibition in humans: Sensitivity to brief silent periods in white noise , 1983, Perception & psychophysics.

[15]  H. Hoffman,et al.  Inhibition of the glabella reflex by monaural and binaural stimulation. , 1980, Journal of experimental psychology. Human perception and performance.

[16]  Rudolf Hebel,et al.  Anatomy of the Laboratory Rat , 1976 .

[17]  J. Kelly,et al.  Two sources of inhibition affecting binaural evoked responses in the rat's inferior colliculus : the dorsal nucleus of the lateral lemniscus and the superior olivary complex , 1997, Hearing Research.

[18]  N. Swerdlow,et al.  Regulation of Prepulse Inhibition by Ventral Pallidal Projections , 1997, Brain Research Bulletin.

[19]  B. Wainer,et al.  Afferent projections to the cholinergic pedunculopontine tegmental nucleus and adjacent midbrain extrapyramidal area in the albino rat. I. Retrograde tracing studies , 1992, The Journal of comparative neurology.

[20]  J. Fox.  Habituation and prestimulus inhibition of the auditory startle reflex in decerebrate rats , 1979, Physiology & Behavior.

[21]  J. Kelly,et al.  Effects of superior olivary comples lesions on binaural responses in rat inferior colliculus , 1992, Brain Research.

[22]  Michael Davis.  The Mammalian Startle Response , 1984 .

[23]  Younglim Lee,et al.  A Primary Acoustic Startle Pathway: Obligatory Role of Cochlear Root Neurons and the Nucleus Reticularis Pontis Caudalis , 1996, The Journal of Neuroscience.

[24]  D. Bleyl.  R. Hebel und M. W. Stromberg: Anatomy of the Laboratory Rat. VIII und 173 S., 59 Abb. und 9 Tab. The Williams and Wilkins Company, Baltimore 1976. Preis: 19,95 $ , 1978 .

[25]  Paul W. Frankland,et al.  The acoustic startle reflex: neurons and connections , 1995, Brain Research Reviews.

[26]  B M Clopton,et al.  Neural responses in the inferior colliculus of albino rat to binaural stimuli. , 1975, The Journal of the Acoustical Society of America.

[27]  J. Kelly,et al.  Binaural responses in rat inferior colliculus following kainic acid lesions of the superior olive: Interaural intensity difference functions , 1992, Hearing Research.

[28]  M. Davis,et al.  Plasticity of the acoustic startle response in the acutely decerebrate rat. , 1977, Journal of comparative and physiological psychology.

[29]  P. Pilz,et al.  Comparative threshold studies of the acoustic pinna, jaw and startle reflex in the rat , 1988, Physiology & Behavior.

[30]  M. Koch,et al.  The acoustic startle response in rats—circuits mediating evocation, inhibition and potentiation , 1997, Behavioural Brain Research.

[31]  D. Irvine.  The Auditory Brainstem , 1986, Progress in Sensory Physiology.

[32]  M. Ito,et al.  Sound localization after transection of the commissure of Probst in the albino rat. , 1996, Journal of neurophysiology.

[33]  Michael Davis,et al.  Habituation, prepulse inhibition, fear conditioning, and drug modulation of the acoustically elicited pinna reflex in rats. , 1986, Behavioral neuroscience.

[34]  Inhibition of the cutaneous eyeblink reflex by unilateral and bilateral acoustic input: The persistence of contralateral antagonism in auditory processing , 1990, Perception & psychophysics.

[35]  C. Faingold,et al.  Stimulation or blockade of the dorsal nucleus of the lateral lemniscus alters binaural and tonic inhibition in contralateral inferior colliculus neurons , 1993, Hearing Research.

[36]  J. Kelly,et al.  GABAergic projections from the lateral lemniscus to the inferior colliculus of the rat , 1998, Hearing Research.

[37]  Prepulse inhibition of acoustic or trigeminal startle of rats by unilateral electrical stimulation of the inferior colliculus. , 1998 .

[38]  R. Schmidt,et al.  Progress in Sensory Physiology , 1991, Progress in Sensory Physiology.

[39]  M. Behan,et al.  Sources of subcortical GABAergic projections to the superior colliculus in the cat , 1990, The Journal of comparative neurology.

[40]  R. L. Marie.  Glutamatergic connections of the auditory midbrain: selective uptake and axonal transport of D-[3H]aspartate. , 1996 .

[41]  J. S Yeomans,et al.  Summation between acoustic and trigeminal stimuli evoking startle , 1999, Neuroscience.

[42]  J. Kelly,et al.  Sound localization after kainic acid lesions of the dorsal nucleus of the lateral lemniscus in the albino rat. , 1996, Behavioral neuroscience.

[43]  H. Hoffman,et al.  Eyeblink inhibition by monaural and binaural stimulation: one ear is better than two. , 1976, Science.

[44]  Temporal integration in the acoustic startle reflex of the rat. , 1973, Journal of comparative and physiological psychology.

[45]  M. Koch,et al.  Sensorimotor gating deficit after lesions of the superior colliculus. , 1994, Neuroreport.

[46]  H. Hoffman,et al.  Acoustic augmentation and inhibition of the human eyeblink. , 1981, Journal of experimental psychology. Human perception and performance.

[47]  D. S. Leitner,et al.  Role of the inferior colliculus in the inhibition of acoustic startle in the rat , 1985, Physiology & Behavior.

[48]  Inhibition of the human eyeblink reflex: an evaluation of the sensitivity of the Wendt-Yerkes method for threshold detection. , 1977, Journal of experimental psychology. Human perception and performance.