The common mouse protozoa Tritrichomonas muris alters mucosal T cell homeostasis and colitis susceptibility

Escalante et al. show that a highly prevalent mouse intestinal protozoa, Tritrichomonas muris, was found to be a confounding factor in murine colitis. Mice infected with this parasite had elevated baseline levels of Th1 cytokines and developed exacerbated Th1-mediated disease.

[1]  E. Amir,et al.  Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome , 2016, Cell.

[2]  D. Stark,et al.  Dientamoeba fragilis, the Neglected Trichomonad of the Human Bowel , 2016, Clinical Microbiology Reviews.

[3]  W. Garrett,et al.  Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut , 2016, Science.

[4]  H. Virgin,et al.  Transkingdom control of viral infection and immunity in the mammalian intestine , 2016, Science.

[5]  E. Pamer,et al.  Microbiota-mediated inflammation and antimicrobial defense in the intestine. , 2015, Annual review of immunology.

[6]  J. Carlton,et al.  What is the importance of zoonotic trichomonads for human health? , 2014, Trends in Parasitology.

[7]  C. Christodoulou,et al.  Murine Norovirus: Propagation, Quantification, and Genetic Manipulation , 2014, Current protocols in microbiology.

[8]  E. Ryan,et al.  Optimization of murine small intestine leukocyte isolation for global immune phenotype analysis. , 2014, Journal of immunological methods.

[9]  D. Philpott,et al.  NOD proteins: regulators of inflammation in health and disease , 2013, Nature Reviews Immunology.

[10]  M. Hattori,et al.  Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota , 2013, Nature.

[11]  D. Philpott,et al.  Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis , 2013, Gut microbes.

[12]  Philip Rosenstiel,et al.  NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. , 2013, The Journal of clinical investigation.

[13]  A. Macpherson,et al.  Interactions Between the Microbiota and the Immune System , 2012, Science.

[14]  K. Honda,et al.  The microbiome in infectious disease and inflammation. , 2012, Annual review of immunology.

[15]  D. Elliott,et al.  Helminth–host immunological interactions: prevention and control of immune‐mediated diseases , 2012, Annals of the New York Academy of Sciences.

[16]  E. Dei‐Cas,et al.  Molecular identification of Pentatrichomonas hominis in two patients with gastrointestinal symptoms , 2011, Journal of Clinical Pathology.

[17]  D. Philpott,et al.  Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands , 2011, European journal of immunology.

[18]  R. Xavier,et al.  Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine , 2010, Cell.

[19]  Dan R. Littman,et al.  Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria , 2009, Cell.

[20]  D. Ostanin,et al.  T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[21]  P. Treuting,et al.  Murine norovirus: an intercurrent variable in a mouse model of bacteria-induced inflammatory bowel disease. , 2008, Comparative medicine.

[22]  D. Lindsay,et al.  Biology of the Protozoa , 2008 .

[23]  D. G. Baker Parasites of Rats and Mice , 2008 .

[24]  F. Powrie,et al.  Interleukin-23 drives innate and T cell–mediated intestinal inflammation , 2006, The Journal of experimental medicine.

[25]  C. Wobus,et al.  STAT1-Dependent Innate Immunity to a Norwalk-Like Virus , 2003, Science.

[26]  C. Janeway,et al.  RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems , 2002, Nature.

[27]  P. Roach,et al.  The use of metronidazole, tinidazole and dimetridazole in eliminating trichomonads from laboratory mice , 1988, Laboratory animals.

[28]  P. Rosenstiel,et al.  NOD 2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer , 2013 .

[29]  Didier Raoult,et al.  Molecular identification by , 2000 .